WO2007112940A3 - Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same - Google Patents

Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same Download PDF

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Publication number
WO2007112940A3
WO2007112940A3 PCT/EP2007/002817 EP2007002817W WO2007112940A3 WO 2007112940 A3 WO2007112940 A3 WO 2007112940A3 EP 2007002817 W EP2007002817 W EP 2007002817W WO 2007112940 A3 WO2007112940 A3 WO 2007112940A3
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WO
WIPO (PCT)
Prior art keywords
albumin
entities
life
amino acid
therapeutic
Prior art date
Application number
PCT/EP2007/002817
Other languages
French (fr)
Other versions
WO2007112940A2 (en
Inventor
Hilde Adi Pierrette Revets
Hendricus Renerus J Hoogenboom
Els Beirnaert
Original Assignee
Ablynx Nv
Hilde Adi Pierrette Revets
Hendricus Renerus J Hoogenboom
Els Beirnaert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv, Hilde Adi Pierrette Revets, Hendricus Renerus J Hoogenboom, Els Beirnaert filed Critical Ablynx Nv
Publication of WO2007112940A2 publication Critical patent/WO2007112940A2/en
Publication of WO2007112940A3 publication Critical patent/WO2007112940A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to albumin-derived amino acid sequences that can be used to increase the half-life of therapeutic proteins and of other therapeutic compounds and entities.
PCT/EP2007/002817 2006-03-31 2007-03-29 Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same WO2007112940A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78825606P 2006-03-31 2006-03-31
US60/788,256 2006-03-31

Publications (2)

Publication Number Publication Date
WO2007112940A2 WO2007112940A2 (en) 2007-10-11
WO2007112940A3 true WO2007112940A3 (en) 2008-01-03

Family

ID=38477256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/002817 WO2007112940A2 (en) 2006-03-31 2007-03-29 Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same

Country Status (1)

Country Link
WO (1) WO2007112940A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2731617A1 (en) 2008-07-22 2010-01-28 Maria Joao Saraiva Amino acid sequences directed against multitarget scavenger receptors and polypeptides
IT1392551B1 (en) * 2008-11-25 2012-03-09 Bioindustry Park Del Canavese S P A BIOMARCERS FOR DIAGNOSIS AND TO DETECT THE PROGRESSION OF NEURODEGENERATIVE DISEASES, IN PARTICULAR OF AMIOTROPHIC LATERAL SCLEROSIS
CN102317315A (en) 2009-02-11 2012-01-11 诺维信生物制药丹麦公司 Albumin variants and conjugates
JP5841046B2 (en) * 2009-04-08 2016-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Human protein scaffold with controlled serum pharmacokinetics
JP2013509170A (en) 2009-10-30 2013-03-14 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ Albumin variant
WO2011073180A1 (en) 2009-12-14 2011-06-23 Ablynx N.V. Single variable domain antibodies against ox40l, constructs and therapeutic use
WO2011083141A2 (en) 2010-01-08 2011-07-14 Ablynx Nv Method for generation of immunoglobulin sequences by using lipoprotein particles
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
WO2011124718A1 (en) 2010-04-09 2011-10-13 Novozymes A/S Albumin derivatives and variants
CN102906118B (en) 2010-05-20 2017-07-28 埃博灵克斯股份有限公司 The biomaterial related to HER3
JP5933573B2 (en) 2010-11-08 2016-06-15 ノバルティス アーゲー CXCR2 binding polypeptide
RU2650784C2 (en) 2011-05-05 2018-04-17 Альбумедикс А/С Versions of albumin
UA117218C2 (en) 2011-05-05 2018-07-10 Мерк Патент Гмбх Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same
SI2726510T1 (en) 2011-05-27 2023-06-30 F. Hoffmann - La Roche Ag Dual targeting
WO2012163521A1 (en) 2011-05-27 2012-12-06 Dutalys Removal of monomeric targets
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
KR20140136934A (en) 2012-03-16 2014-12-01 노보자임스 바이오파마 디케이 에이/에스 Albumin variants
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
BR112015010318A2 (en) 2012-11-08 2017-08-22 Albumedix As ALBUMIN VARIANTS
CA2989966C (en) 2015-08-20 2024-04-30 Albumedix A/S Albumin variants and conjugates
WO2018014260A1 (en) 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
KR20200104333A (en) 2017-12-28 2020-09-03 난징 레전드 바이오테크 씨오., 엘티디. Single-domain antibodies to TIGIT and variants thereof
CA3084518A1 (en) 2018-01-15 2019-07-18 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against pd-1
US11958903B2 (en) 2018-03-30 2024-04-16 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies against LAG-3 and uses thereof
CN110988361B (en) * 2019-12-13 2020-09-18 山东民康生物科技有限公司 Human serum albumin removing kit
WO2024083843A1 (en) 2022-10-18 2024-04-25 Confo Therapeutics N.V. Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003060071A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2004041863A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003060071A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2004041863A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DOCKAL M ET AL: "The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 274, no. 41, 8 October 1999 (1999-10-08), pages 29303 - 29310, XP002990741, ISSN: 0021-9258 *
FASANO M ET AL: "The extraordinary ligand binding properties of human serum albumin", IUBMB LIFE, TAYLOR AND FRANCIS, LONDON,, GB, vol. 57, no. 12, December 2005 (2005-12-01), pages 787 - 796, XP009090343, ISSN: 1521-6543 *
GIBBS W W: "NANOBODIES", SCIENTIFIC AMERICAN, SCIENTIFIC AMERICAN INC., NEW YORK, NY, US, vol. 293, no. 2, August 2005 (2005-08-01), pages 67 - 71, XP001238880, ISSN: 0036-8733 *
KRAGH-HANSEN U: "Structure and ligand binding properties of human serum albumin", DANISH MEDICAL BULLETIN, DANISH MEDICAL ASSOCIATION, COPENHAGEN, DK, vol. 37, no. 1, 1990, pages 57 - 84, XP009090324, ISSN: 0007-8916 *
REVETS H ET AL: "NANOBODIES AS NOVEL AGENTS FOR CANCER THERAPY", EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 5, no. 1, 2005, pages 111 - 124, XP009076361, ISSN: 1471-2598 *
SMITH B J ET AL: "Prolonged in vivo residence times of antibody fragments associated with albumin", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 12, no. 5, September 2001 (2001-09-01), pages 750 - 756, XP002270731, ISSN: 1043-1802 *
WANG W ET AL: "AlbuBNP, a Recombinant B-Type Natriuretic Peptide and Human Serum Albumin Fusion Hormone, as a Long-Term Therapy of Congestive Heart Failure", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 21, no. 11, November 2004 (2004-11-01), pages 2105 - 2110, XP003014318, ISSN: 0724-8741 *

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