WO2005092922A3 - Antigen des pm-2 antikörpers und dessen verwendung - Google Patents

Antigen des pm-2 antikörpers und dessen verwendung Download PDF

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Publication number
WO2005092922A3
WO2005092922A3 PCT/DE2005/000455 DE2005000455W WO2005092922A3 WO 2005092922 A3 WO2005092922 A3 WO 2005092922A3 DE 2005000455 W DE2005000455 W DE 2005000455W WO 2005092922 A3 WO2005092922 A3 WO 2005092922A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
relates
membrane glycoprotein
num
accession
Prior art date
Application number
PCT/DE2005/000455
Other languages
English (en)
French (fr)
Other versions
WO2005092922A2 (de
Inventor
Heinz Vollmers
Frank Hensel
Original Assignee
Oncomab Gmbh
Heinz Vollmers
Frank Hensel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomab Gmbh, Heinz Vollmers, Frank Hensel filed Critical Oncomab Gmbh
Priority to JP2007508715A priority Critical patent/JP2008502321A/ja
Priority to US10/599,297 priority patent/US20080281083A1/en
Priority to DE112005001260T priority patent/DE112005001260A5/de
Priority to EP05735145A priority patent/EP1727832A2/de
Publication of WO2005092922A2 publication Critical patent/WO2005092922A2/de
Publication of WO2005092922A3 publication Critical patent/WO2005092922A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Polypeptid, das als membranständiges Protein an der Zelloberfläche exprimiert wird, das an einer oder mehreren Stellen glykosiliert ist (Membranglykoprotein) und dessen Aminosäuresequenz teilweise oder ganz der des Integrin-Bindungsproteins p80 (accession # AJ131720) oder REV1 (accession # AF206019) entspricht, wobei das Membranglykoprotein von neoplastischen Zellen und nicht von nicht-neoplastischen Zellen exprimiert wird, und als Antigen den hu­manen monoklonalen Antikörper PM-2 (DSM Eingangsnummer: DSM ACC2600) spezifisch bindet, sowie N-glykosidisch und O-­glykosidisch glykosiliert ist. Die Erfindung lehrt außerdem ein Verfahren zur Isolation/Herstellung des Antigens und dessen Verwendung zur Herstellung eines Arzneimittel zur Immunisierung. Das isolierte Antigen dient auch zur I­dentifikation von Arzneimitteln mit apoptotischer oder zellproliferati­onsinhibierender Wirkung und darüberhinaus der Verwendung des Glykomembranproteins als Tumormarker.
PCT/DE2005/000455 2004-03-25 2005-03-10 Antigen des pm-2 antikörpers und dessen verwendung WO2005092922A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007508715A JP2008502321A (ja) 2004-03-25 2005-03-10 ポリペプチドとその使用法
US10/599,297 US20080281083A1 (en) 2004-03-25 2005-03-10 Antigen of the Pm-2 Antibody and Use Thereof
DE112005001260T DE112005001260A5 (de) 2004-03-25 2005-03-10 Antigen des PM-2 Antikörpers und dessen Verwendung
EP05735145A EP1727832A2 (de) 2004-03-25 2005-03-10 Antigen des pm-2 antikörpers und dessen verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004015179A DE102004015179A1 (de) 2004-03-25 2004-03-25 Antigen des PM-2 Antikörpers und dessen Verwendung
DE102004015179.2 2004-03-25

Publications (2)

Publication Number Publication Date
WO2005092922A2 WO2005092922A2 (de) 2005-10-06
WO2005092922A3 true WO2005092922A3 (de) 2006-07-27

Family

ID=34983001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/000455 WO2005092922A2 (de) 2004-03-25 2005-03-10 Antigen des pm-2 antikörpers und dessen verwendung

Country Status (5)

Country Link
US (1) US20080281083A1 (de)
EP (1) EP1727832A2 (de)
JP (1) JP2008502321A (de)
DE (2) DE102004015179A1 (de)
WO (1) WO2005092922A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005351A2 (en) 2002-07-04 2004-01-15 Oncomab Gmbh Neoplasm specific antibodies and uses thereof
DE10311248A1 (de) 2003-03-14 2004-09-30 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper
EP1531162A1 (de) 2003-11-14 2005-05-18 Heinz Vollmers Antikörper SAM-6, der spezifisch von Adenocarzinom ist, und dessen Verwendungen
DE10353175A1 (de) 2003-11-14 2005-06-16 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper mit fettsenkender Wirkung
AU2008340011A1 (en) * 2007-12-21 2009-07-02 Patrys Limited PM-2 antibodies and methods for treating metastasis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677442B1 (en) * 1999-10-29 2004-01-13 University Of Kentucky Research Foundation Nucleic acid encoding human REV1 protein
DE10230516A1 (de) * 2002-07-06 2004-01-15 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
DE4107154A1 (de) * 1990-10-11 1992-04-16 Boehringer Mannheim Gmbh Monoklonale antikoerper gegen melanom
US5639863A (en) * 1994-06-21 1997-06-17 Dan; Michael D. Human monoclonal antibodies specific to cell cycle independent glioma surface antigen
GB9822115D0 (en) * 1998-10-09 1998-12-02 King S College London Treatment of inflammatory disease
US7049132B1 (en) * 1999-06-28 2006-05-23 University Of Southern California Stress-responsive induction of a therapeutic agent and methods of use
ATE490271T1 (de) * 2001-07-24 2010-12-15 Debiovision Inc Rezeptor, dessen verwendung sowie mausantikörper
US20050123571A1 (en) * 2003-06-06 2005-06-09 Rossini Aldo A. Modulation of apoptosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677442B1 (en) * 1999-10-29 2004-01-13 University Of Kentucky Research Foundation Nucleic acid encoding human REV1 protein
DE10230516A1 (de) * 2002-07-06 2004-01-15 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI WIXLER V, accession no. AJ131720 *
GIBBS PEM ET AL.: "The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA, vol. 97, no. 8, 11 April 2000 (2000-04-11), pages 4186 - 4191, XP002374632 *
WIXLER V ET AL: "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 445, no. 2-3, 26 February 1999 (1999-02-26), pages 351 - 355, XP004259288, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
DE112005001260A5 (de) 2007-05-31
WO2005092922A2 (de) 2005-10-06
JP2008502321A (ja) 2008-01-31
EP1727832A2 (de) 2006-12-06
DE102004015179A1 (de) 2005-10-13
US20080281083A1 (en) 2008-11-13

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