Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
  • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings

Definitions

• Fungicidal composition comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting mitosis and cell division
• the present invention relates to novel fungicide compositions comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting mitosis and cell division.
• the present invention also relates to a method of combating or controlling phytopathogenic fungi by applying at a locus infested or liable to be infested such a composition.
• the present invention relates to a composition
• a composition comprising : a) a pyridylethylbenzamide derivative of general formula (I)
• - p is an integer equal to 1, 2, 3 or 4;
• - q is an integer equal to 1, 2, 3, 4 or 5;
• each substituent X is chosen, independently of the others, as being halogen, alkyl or haloalkyl
• - each substituent Y is chosen, independently of the others, as being halogen, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, amino, phenoxy, alkylthio, dialkylamino, acyl, cyano, ester, hydroxy, aminoalkyl, benzyl, haloalkoxy, halosulphonyl, halothioalkyl, alkoxyalkenyl, alkylsulphonamide, nitro, alkylsulphonyl, phenylsulphonyi or benzylsulphonyl; as to the N-oxides of 2-pyridine thereof; and b) a compound capable of inhibiting mitosis and cell division; in a (a) / (b) weight ratio of from 0.01 to 20.
• - halogen means chlorine, bromine, iodine or fluorine
• each of the alkyl or acyl radicals present in the molecule contains from 1 to 10 carbon atoms, preferably from 1 to 7 carbon atoms, more preferably from 1 to 5 carbon atoms, and may be linear or branched;
• each of the alkenyl or alkynyl radicals present in the molecule contains from 2 to 10 carbon atoms, preferably from 2 to 7 carbon atoms, more preferably from 2 to 5 carbon atoms, and may be linear or branched.
• the composition according to the present invention provides a synergistic effect. This synergistic effect allows a reduction of the chemical substances spread into the environment and a reduction of the cost of the fungal treatment.
• the term "synergistic effect” is defined by Colby according to the article entitled “Calculation of the synergistic and antagonistic responses of herbicide combinations" Weeds, (1967), 15, pages 20-22.
• E x + y - ⁇ y. 100 in which E represents the expected percentage of inhibition of the disease for the combination of the two fungicides at defined doses (for example equal to x and y respectively), x is the percentage of inhibition observed for the disease by the compound (I) at a defined dose (equal to x), y is the percentage of inhibition observed for the disease by the compound (II) at a defined dose (equal to y).
• E represents the expected percentage of inhibition of the disease for the combination of the two fungicides at defined doses (for example equal to x and y respectively)
• x is the percentage of inhibition observed for the disease by the compound (I) at a defined dose (equal to x)
• y is the percentage of inhibition observed for the disease by the compound (II) at a defined dose (equal to y).
• E represents the expected percentage of inhibition of the disease for the combination of the two fungicides at defined doses (for example equal to x and y respectively)
• x
• the present invention relates to a composition
• a composition comprising a pyridylethylbenzamide derivative of general formula (I) in which the different characteristics may be chosen alone or in combination as being : - as regards p, p is 2; - as regards q, q is 1 or 2. More preferably, q is 2; - as regards X, X is chosen, independently of the others, as being halogen or haloalkyl. More preferably, X is chosen, independently of the others, as being a chlorine atom or a trifluoromethyl group; - as regards Y, Y is chosen, independently of the others, as being halogen or haloalkyl.
• Y is chosen, independently of the others, as being a chlorine atom or a trifluoromethyl group; More preferably, the pyridylethylbenzamide derivative of general formula (I) present in the composition of the present invention is :
• the pyridylethylbenzamide derivative of general formula (I) present in the composition of the present invention is N- ⁇ 2-[3-chloro-5-
• the composition according to the present invention comprises a compound capable of inhibiting mitosis and cell division.
• the present invention relates to a composition comprising a compound capable of inhibiting mitosis and cell division selected from [5-Chloro-6-(2,4,6-trifluoro-phenyl)-[l,2,4]triazolo[l,5- ⁇ ]pyrimidin-7-yl]-((R)-l,2,2-trimethyl-propyl)-amine, [5-Chloro-6-(2,4,6-trifluoro- phenyl)-[l ,2,4]triazolo[l,5- ⁇ ]pyrimidin-7-yl]-((R)-l,2-dimethyl-propyl)-amine, 5- Chloro-7-(4-methyl-piperidin-l-yl)-6-(2,4,6-
• benzimidazole derivatives may for example be benomyl, carbendazim, fuberidazole or thiabendazole.
• the composition according to the present invention comprises (a) at least a pyridylethylbenzamide derivative of general formula (I) and (b) a compound capable of inhibiting mitosis and cell division in an (a) / (b) weight ratio of from 0.01 to 20; preferably of from 0.05 to 10; even more preferably, of from 0.1 to 5.
• the composition of the present invention may further comprise at least one other different fungicide active ingredient (c).
• the fungicidal active ingredient (c) may be selected from azaconazole, azoxystrobin, (Z)-N-[ ⁇ -(cyclopropylmethoxyimino)-2,3-difluoro-6- (trifluoromethyl)benzyl]-2-phenylacetamide, benalaxyl, benomyl, benthiavalicarb, biphenyl, bitertanol, blasticidin-S, boscalid, borax, bromuconazole, bupirimate, sec- butylamine, calcium polysulfide, captafol, captan, carbendazim, carboxin, carpropamid, chinomethionat, chlorothalonil, chlozolinate, copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, cuprous oxide
• this compound may be present in an amount of (a) : (b) : (c) weight ratio of from 1 : 0.01 : 0.01 to 1 : 20 : 20; the ratios of compound (a) and compound
• compositions may be cited to illustrate in a non-limited manner the present invention : compound 1 with [5-Chloro-6-(2,4,6-trifluoro-phenyl)- [ 1 ,2,4]triazolo[ 1 ,5- ⁇ ]pyrimidin-7-yl]-((R)- 1 ,2,2-trimethyl-propyl)-amine, compound 1 with [5-Chloro-6-(2,4,6-trifluoro-phenyl)-[l ,2,4]triazolo[l ,5- ]pyrimidin-7-yl]- ((R)-l,2-dimethyl-propyl)-amine, compound 1 with 5-Chloro-7-(4-methyl-piperidin- l-yl)-6-(2,4,6-trifluoro-
• the composition according to the present invention may further comprise an other additional component such as an agriculturally acceptable support, carrier or filler.
• an agriculturally acceptable support such as an agriculturally acceptable support, carrier or filler.
• the term "support” denotes a natural or synthetic, organic or inorganic material with which the active material is combined to make it easier to apply, notably to the parts of the plant. This support is thus generally inert and should be agriculturally acceptable.
• the support may be a solid or a liquid.
• suitable supports include clays, natural or synthetic silicates, silica, resins, waxes, solid fertilisers, water, alcohols, in particular butanol, organic solvents, mineral and plant oils and derivatives thereof. Mixtures of such supports may also be used.
• the composition may also comprise other additional components.
• the composition may further comprise a surfactant.
• the surfactant can be an emulsifier, a dispersing agent or a wetting agent of ionic or non-ionic type or a mixture of such surfactants.
• the presence of at least one surfactant is generally essential when the active material and/or the inert support are water-insoluble and when the vector agent for the application is water.
• surfactant content may be comprised between 5% and 40% by weight of the composition.
• Additional components may also be included, e.g. protective colloids, adhesives, thickeners, thixotropic agents, penetration agents, stabilisers, sequestering agents.
• the active materials can be combined with any solid or liquid additive, which complies with the usual formulation techniques.
• the composition according to the invention may contain from 0.05 to 99% (by weight) of active material, preferably 10 to 70% by weight.
• compositions according to the present invention can be used in various forms such as aerosol dispenser, capsule suspension, cold fogging concentrate, dustable powder, emulsifiable concentrate, emulsion oil in water, emulsion water in oil, encapsulated granule, fine granule, flowable concentrate for seed treatment, gas (under pressure), gas generating product, granule, hot fogging concentrate, macrogranule, microgranule, oil dispersible powder, oil miscible flowable concentrate, oil miscible liquid, paste, plant rodlet, powder for dry seed treatment, seed coated with a pesticide, soluble concentrate, soluble powder, solution for seed treatment, suspension concentrate (flowable concentrate), ultra low volume (ulv) liquid, ultra low volume (ulv) suspension, water dispersible granules or tablets, water dispersible powder for slurry treatment, water soluble granules or tablets, water soluble powder for seed treatment and wettable powder.
• These compositions include not only compositions which are ready to be applied to the plant or seed
• the fungicidal compositions of the present invention can be used to curatively or preventively control phytopathogenic fungi of crops.
• a method for preventively or curatively controlling phytopathogenic fungi of crops characterised in that a fungicidal composition as hereinbefore defined is applied to the seed, the plant and/or to the fruit of the plant or to the soil in which the plant is growing or in which it is desired to grow.
• the composition as used against phytopathogenic fungi of crops comprises an effective and non-phytotoxic amount of an active material of general formula (I).
• an amount of composition according to the invention means an amount of composition according to the invention which is sufficient to control or destroy the fungi present or liable to appear on the crops, and which does not entail any appreciable symptom of phytotoxicity for the said crops.
• Such an amount can vary within a wide range depending on the fungus to be combated or controlled, the type of crop, the climatic conditions and the compounds included in the fungicidal composition according to the invention. This amount can be determined by systematic field trials, which are within the capabilities of a person skilled in the art.
• the method of treatment according to the present invention is useful to treat propagation material such as tubers or rhizomes, but also seeds, seedlings or seedlings pricking out and plants or plants pricking out.
• This method of treatment can also be useful to treat roots.
• the method of treatment according to the present invention can also be useful to treat the overground parts of the plant such as trunks, stems or stalks, leaves, flowers and fruits of the concerned plant.
• the plants that can be protected by the method according to the invention mention may be made of cotton; flax; vine; fruit crops such as Rosaceae sp.
• leguminous crops such as Solanaceae sp. (for instance tomatoes), Liliaceae sp., Asteraceae sp. (for instance lettuces), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Papilionaceae sp. (for instance peas), Rosaceae sp. (for instance strawberries); big crops such as Graminae sp. (for instance maize, cereals such as wheat, rice, barley and triticale), Asteraceae sp. (for instance sunflower), Cruciferae sp.
• Solanaceae sp. for instance tomatoes
• Liliaceae sp. for instance lettuces
• Umbelliferae sp. for instance lettuces
• Cruciferae sp. Chenopodiaceae sp.
• Cucurbitaceae sp. for instance peas
• - wheat as regards controlling the following seed diseases: fusaria (Microdochium nivale and Fusarium roseum), stinking smut (Tilletia caries, Tilletia controversa or Tilletia indica), septoria disease (Septoria nodorum) and loose smut; - wheat, as regards controlling the following diseases of the aerial parts of the plant: cereal eyespot (Tapesia yallundae, Tapesia acuiformis), take-all (Gaeumannomyces graminis), foot blight (F. culmorum, F.
• the fungicidal composition according to the present invention may also be used against fungal diseases liable to grow on or inside timber.
• the term "timber" means all types of species of wood, and all types of working of this wood intended for construction, for example solid wood, high-density wood, laminated wood, and plywood.
• the method for treating timber according to the invention mainly consists in contacting one or more compounds of the present invention, or a composition according to the invention; this includes for example direct application, spraying, dipping, injection or any other suitable means.
• the fungicidal composition according to the present invention may also be used in the treatment of genetically modified organisms with the compounds according to the invention or the agrochemical compositions according to the invention.
• Genetically modified plants are plants into in which genome a heterologous gene encoding a protein of interest has been stably integrated.
• the expression "heterologous gene encoding a protein of interest” essentially means genes which give the transformed plant new agronomic properties, or genes for improving the agronomic quality of the transformed plant.
• the dose of active material usually applied in the treatment according to the present invention is generally and advantageously between 10 and 2000 g/ha, preferably between 20 and 1500 g/ha for applications in foliar treatment.
• the dose of active substance applied is generally and advantageously between 1 and 200 g per 100 kg of seed, preferably between 2 and 150 g per 100 kg of seed in the case of seed treatment. It is clearly understood that the doses indicated above are given as illustrative examples of the invention. A person skilled in the art will know how to adapt the application doses according to the nature of the crop to be treated.
• the compositions according to the present invention may also be used fore the preparation of composition useful to curatively or preventively treat human and animal fungal diseases such as, for example, mycoses, dermatoses, trichophyton diseases and candidiases or diseases caused by Aspergillus spp. or Candida spp., for example Aspergillus fumigatus or Candida albicans respectively.
• Example 1 Efficacy against Erysiphe ⁇ raminis f. sp. tritici of a composition containing N- (2- [3-chloro-5-(trifluoromethvD-2-pyridinvIl ethv -2- trifluoromethylbenzamide (Compound 1) and carbendazim
• the active ingredients tested are prepared by potter homogenisation in a mixture of acetone/tween/water . This suspension is then diluted with water to obtain the desired active material concentration.
• Wheat plants (Audace variety) in starter cups, sown on 50/50 peat soil-pozzolana substrate and grown at 12°C, are treated at the 1 -leaf stage (10 cm tall) by spraying with the aqueous suspension described above. Plants, used as controls, are treated with an aqueous solution not containing the active material. After 24 hours, the plants are contaminated by dusting them with Erysiphe graminis f. sp. tritici spores, the dusting being carried out using diseased plants. Grading is carried out 7 to 14 days after the contamination, in comparison with the control plants. The following table summarises the results obtained when tested compound 1 and carbendazim alone and in a 1 : 1 weight ratio mixture.

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• Life Sciences & Earth Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Dentistry (AREA)
• General Health & Medical Sciences (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)

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• 2004
  • 2004-02-12 EP EP04356018A patent/EP1563733A1/en not_active Withdrawn
• 2005
  • 2005-02-10 DE DE602005001552T patent/DE602005001552T2/de not_active Expired - Lifetime
  • 2005-02-10 JP JP2006552584A patent/JP4711974B2/ja not_active Expired - Fee Related
  • 2005-02-10 EP EP05726411A patent/EP1713336B1/en not_active Expired - Lifetime
  • 2005-02-10 WO PCT/EP2005/002565 patent/WO2005077180A1/en not_active Ceased
  • 2005-02-10 ES ES05726411T patent/ES2287909T3/es not_active Expired - Lifetime
  • 2005-02-10 AT AT05726411T patent/ATE366044T1/de not_active IP Right Cessation
  • 2005-02-10 US US10/588,534 patent/US7670990B2/en not_active Expired - Lifetime

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