WO2005074825A1 - Orthopedic distraction implants and techniques - Google Patents
Orthopedic distraction implants and techniques Download PDFInfo
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- WO2005074825A1 WO2005074825A1 PCT/US2005/001612 US2005001612W WO2005074825A1 WO 2005074825 A1 WO2005074825 A1 WO 2005074825A1 US 2005001612 W US2005001612 W US 2005001612W WO 2005074825 A1 WO2005074825 A1 WO 2005074825A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8085—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates with pliable or malleable elements or having a mesh-like structure, e.g. small strips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7059—Cortical plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
Definitions
- Adjacent bony portions can require treatment to obtain the desired surgical result.
- the adjacent bony portions may require the application and/or maintenance of distraction forces therebetween in order to provide proper positioning and alignment of the adjacent bony portions for the desired surgical correction and healing to occur.
- an implant includes a body attachable to adjacent bony portions adapted to apply and/or maintain a distraction force between the adjacent bony portions.
- an implant for treating a bony segment includes a body attachable intravertebrally to each of the first and second bony portions and adapted to apply and/or maintain a distraction force between each of the first and second bony portions while allowing motion between each of the first and second bony portions.
- an implant for distracting adjacent bony portions includes a body with a first condition and a second condition. The body extends intravertebrally between the adjacent bony portions for attachment thereto in the second condition.
- a system for distracting adjacent bony portions includes a first anchor and a second anchor engageable to respective ones of the adjacent bony portions.
- An implant body extends intravertebrally of the adjacent bony portions and is attached to the first and second anchors. The body applies a distraction force between the first and second anchors when attached thereto.
- a method for correcting a curved portion of a spinal column segment includes attaching an implant on a concavely curved side of the spinal column segment; and applying a distraction load to the concave side with the implant.
- a method for correcting a curved portion of a spinal column segment includes providing an implant having a first condition wherein the ends of the implant are spaced a first distance, a second condition wherein the ends of the implant are spaced a second distance less than the first distance; attaching the implant to a concave side of the spine in the second condition; and biasing the implant from the second condition to the first condition to apply a distraction load.
- a method for distracting adjacent vertebrae of a spinal column segment includes positioning an implant extradiscally along the adjacent vertebrae; attaching the implant to the adjacent vertebrae; and applying a distraction load to the adjacent vertebrae with the implant.
- Fig. 1 is an elevation view of one embodiment of a distraction implant.
- Fig. 2 is a plan view of the distraction implant of Fig. 1.
- Fig. 3 is a plan view of the distraction implant of Fig. 1 showing a compression force distribution pattern.
- Fig. 4 is a plan view of another embodiment distraction implant.
- Fig. 5 is a plan view of another embodiment distraction implant.
- Fig. 6 is a sectional view through line 6-6 of Fig. 5.
- Fig. 7 is an elevation view looking in the anterior-posterior direction at a concavely curved portion of a spinal column segment with anchors engaged thereto.
- Fig. 1 is an elevation view of one embodiment of a distraction implant.
- Fig. 2 is a plan view of the distraction implant of Fig. 1.
- Fig. 3 is a plan view of the distraction implant of Fig. 1 showing a compression force distribution pattern.
- Fig. 4 is a plan view of another embodiment distraction implant.
- Fig. 5 is
- Fig. 8 is an elevation view looking in the medial-lateral direction toward the concavely curved portion of the spinal column segment of Fig. 7 with distraction implants of Fig. 1 secured thereto.
- Fig. 9 is an anterior-posterior elevation view of the spinal column segment and distraction implants of Fig. 8.
- Fig. 10 is an elevation view of a spinal column segment in the anterior-posterior direction having anchors secured thereto.
- Fig. 11 is the elevation view of the spinal column segment of Fig. 10 with another embodiment distraction implant secured thereto.
- Fig. 12 is a plan view of the spinal column segment and distraction implant of Fig.
- Fig 13 is an elevation view of another embodiment distraction implant.
- Fig 14 is a perspective view of the distraction implant of Fig. 13.
- Fig 15 is an elevation view of another embodiment distraction implant.
- Fig 16 is a perspective view of the distraction implant of Fig. 15.
- Fig 17 is an elevation view of another embodiment distraction implant.
- Fig 18 is a perspective view of the distraction implant of Fig. 17.
- Fig 19 is an elevation view of another embodiment distraction implant.
- Fig 20 is a perspective view of the distraction implant of Fig. 19.
- Fig 21 is an elevation view of another embodiment distraction implant.
- Fig 22 is a perspective view of the distraction implant of Fig. 21.
- Fig 23 is an elevation view of another embodiment distraction implant.
- Fig 24 is a perspective view of the distraction implant of Fig. 23.
- Fig 25 is an elevation view of another embodiment distraction implant.
- Fig, 26 is a perspective view of the distraction implant of Fig. 25.
- Fig 27 is an elevation view of another embodiment distraction implant.
- Fig 28 is a perspective view of the distiaction implant of Fig. 27.
- Fig. 1 there is shown a treatment system 20 that includes a distraction implant 40.
- Distraction implant 40 includes a body 41 with a length extending along a longitudinal axis 49 (Fig. 2) sized to extend between adjacent bony portions for attachment of body 41 thereto.
- Distraction implant 40 can be attached intravertebrally to adjacent bony portions with a first anchor 21 and a second anchor 30 engageable to respective ones of the adjacent bony portions.
- first anchor 21 includes a distal bone engagement portion 22 and a proximal attachment portion 24.
- Second anchor 30 also includes a distal bone engagement portion 32 and a proximal attachment portion 34.
- Body 41 of distraction implant 40 extends between and is attached to attachment portions 24, 34 of anchors 21, 30, respectively.
- distraction implant 40 can be provided with a first hole 42 adjacent a first end 43 of body 41 and a second hole 44 adjacent a second end 45 of body 41.
- First and second holes 42, 44 can be sized to receive proximal attachment portions 24, 34 of anchors 21, 31 therein.
- distraction implant 40 could be configured at each end thereof for attachment to two or more anchors engaged to respective ones of the adjacent bony portions.
- Holes 21, 30 can include a broad and deep configuration to maximize the surface area contact between distraction implant 40 and each of the anchors 21, 30.
- anchors can be positioned by penetrating body 41 with the anchors.
- body 41 can be made from a suitable material that allows body 41 to maintain the desired spatial relationship between the adjacent bony portions.
- Body 41 can continuously maintain and/or exert a distraction force between anchors 21, 30 without rigidly fixing the adjacent bony portions to one another.
- body 41 can include a first condition in which its ends are spaced from one another a first distance.
- Body 41 is fo ⁇ nable to a second condition in which its ends are moved toward one another and spaced a second distance that is less than the first distance.
- Body 41 can be formed by compression, deformation, un-expanding or other transformation to the second condition.
- Body 41 is released, reformed, expanded, or otherwise transformed from the second condition to the first condition to provide a distraction force between the vertebrae to which it is attached.
- body 41 can be attached in its second conditions to anchors 21, 30. After attacliment, body 41 returns toward its first condition to exert and/or maintain a distraction force between anchors 21, 30.
- a distraction force can be applied to anchors 21, 30 with a distraction instrument, and distraction implant 40 can be attached to the distracted anchors 21, 30 to at least partially maintain the distraction force applied thereto. It is further contemplated that a distraction force can be applied between anchors 21, 30 and distiaction implant 40 can in its second condition be attached to the distracted anchors 21, 30, and return toward its first condition after attachment to anchors 21, 30 to maintain or increase the distraction, force between anchors 21, 30.
- body 41 including gels, elastomers, visco- elastic gels or plastics, foams, fabrics, meshes, shape memory alloys, other suitable biocompatible materials, and combinations thereof.
- Anchors 21, 30 can be of the type configured to provide bony incorporation into the bony portion in which the anchor is engaged. Examples of such anchors are provided in U.S. Patent Application Serial No. 10/137,038, filed on May 2, 2002, which is incorporated herein by reference in its entirety. It is also contemplated that anchors 21, 30 could be provided in the form of bone screws, including cannulated bone screws and multi-axial bone screws, staples, suture anchors, spikes, bolts, interbody fusion devices positioned between adjacent bony portions, interbody implants positioned between adjacent bony portions, and other devices suitable for engaging bony structure.
- Body 41 includes a length in the direction of longitudinal axis 49 and a width in the direction of medial axis 51.
- body 41 varies along longitudinal axis 49.
- body 41 includes a base portion 53 extending between first end 43 and second end 45.
- a lower surface 57 of body 41 extends along base portion 53, and is positionable adjacent the bony portions to which distraction implant 40 is to be attached.
- Base portion 53 can be provided with a substantially constant thickness along the length and width of body portion 41.
- a variable stiffness portion of distraction implant 40 in the form of an enlarged mid-portion 48 extends opposite lower surface 57 from base portion 53.
- Medial axis 51 separates body 41 into a first portion 46 and a second portion 47.
- First portion 46 of body 41 includes a first upper surface 48 on one side of longitudinal axis 49, and a second upper surface 54 on the opposite side of longitudinal axis 49.
- second portion 47 of body 41 On the other side of medial axis 51, second portion 47 of body 41 includes a third upper surface 50 along one side of longitudinal axis 49, and a fourth upper surface 52 along the other side of longitudinal axis 49.
- the adjacent upper surfaces 48 and 54 can meet along or adjacent longitudinal axis 49, and the adjacent upper surfaces 50 and 52 can meet along or adjacent longitudinal axis 49.
- the adjacent upper surfaces 48 and 50 can meet along or adjacent medial axis 51, and the adjacent upper surfaces 52 and 54 can meet along or adj cent medial axis 51.
- Each of the surfaces 48, 50, 52, 54 can meet at an apex 55 formed at or adjacent the intersection of longitudinal axis 49 and medial axis 51. It is contemplated apex 55 provides a region or point of maximum thickness for body 41 along mid-portion 48.
- Surfaces 48, 50, 52, 54 of body 41 can taper from apex 55 towards outer edges of body 41.
- surfaces 48, 50, 52, 54 are planar and form a pyramidal shape. Also contemplated are fewer or additional upper surfaces forming other polygonal shapes, and that any one or all of the surfaces 48, 50, 52, 54 can be provided with curvature such that body 41 includes a bulbous or rounded shape. In the embodiment illustrated in Figs.
- the upper surfaces of body 41 provide body 41 with a greatest thickness at or adjacent the intersection of longitudinal axis 49 and medial axis 51. Accordingly, the resistance of body 41 to forces which tend to compressively deform body 41 increases from each of the ends 43, 45 of body 41 toward apex 55.
- Mid-portion 48 can be sized to prevent body 41 from buckling under the expected compressive loads. The amount of compressive deformation of body 41 can be limited under the expected compressive loads to maintain a minimum spacing between ends 43, 45, yet allow ends 43, 45 to move relative to one another so that the adjacent bony portions are not rigidly fixed to one another.
- Fig. 3 shows distraction implant 40 with a compressive force dissipation pattern superimposed thereon as represented by force arrows 56.
- Such compressive forces can be created by static and dynamic compressive loading on distraction implant 40 by the adjacent bony portions.
- the compressive force per unit of cross-sectional area will be highest immediately adjacent holes 42, 44 wherein the material cross-sectional area is the least.
- the width and height of body 41 each increase from ends 43, 45 toward apex 55, providing variable stiffness properties to body 41 along its length.
- the compressive force per unit of cross-sectional area reduces from ends 43, 45 toward apex 55, thus reducing the deformation of body 41 due to compressive forces.
- Body 41 can function as a shock absorbing device that can be compressed to provide a second condition for attachment and sufficiently elastic to return toward its uncompressed, first condition to apply or maintain distraction loading between anchors 21 and 30.
- the flexible body 41 also allows some movement of the adjacent bony portions relative to one another.
- the variable stiffness properties of body 41 limits this movement to maintain stabilization of the adjacent bony portions.
- Specific embodiments of distraction implant 40 are configured for application in the spinal region to maintain and/or provide distraction between adjacent vertebral bodies while preserving, at least partially, segmental motion between the vertebral bodies.
- body 41 can be provided with an overall length in the direction of longitudinal axis 49 in the range from 2 to 4 centimeters between adjacent sides of holes 42 and 44.
- Holes 42, 44 can be provided with a diameter ranging from 1 to 2 centimeters.
- Body 41 can be provided with a maximum width in the direction of medial axis 51 in the range from 2 to 4 centimeters.
- Body 41 can be provided with a maximum height from bottom surface 57 to apex 55 in the range from about 1 to 3 centimeters. It is to be understood that such dimensions can vary and other dimensions are contemplated based on, for example, patient anatomy, the region of the body of the patient in which distraction implant 40 is to be attached, the properties of the material comprising distraction implant 40, and expected loading on the distraction implant 40.
- another embodiment distraction implant 240 includes a body 241 and first and second holes 242, 244 adjacent ends 243, 245, respectively. Body 241 can be provided as discussed above with respect to body 41 of distraction implant 40.
- Body 241 extends along longitudinal axis 249, and medial axis 251 divides body 241 into a first portion 246 and a second portion 247.
- Body 241 can be provided with upper surface portions 248, 250, 252, 254 that are positioned entirely or primarily in respective quadrants formed by the intersection of axes 249, 251.
- Surfaces 248, 250, 252, 254 provide an enlarged mid-portion extending from apex 255 adjacent or at the intersection of the longitudinal and medial axes 249, 251.
- Distraction implant 240 can be provided with one or more reinforcing members in body 241 to assist in maintaining the structural integrity of body 241 and provide variable stiffness properties thereto.
- reinforcing members 258 can be provided around one or more of the anchor holes through body 241, such as shown with respect to hole 242. Reinforcing members 258 can be provided medially of hole 242 to assist body 241 in resisting compressive forces. Reinforcing members 258 can be provided between hole 242 and end 243 to assist body 241 and reinforcing members 258 in resisting tensile forces. Reinforcing members 258 can have a curved shape to extend around the adjacent hole 242 to provide reinforcement in areas of body 241 subject to high stress concentrations applied by the anchor extending through the adjacent hole.
- Medially oriented reinforcing members 260 can be provided, for example, in first portion 246 that extend across longitudinal axis 249 to assist body 241 in resisting compression and tensile forces.
- the ends of reinforcing members 260 can extend from longitudinal axis 249 and away from medial axis 251 toward the end of the implant, such as end 243, to provide longitudinal resistance to compressive and distraction loading.
- the medially extending component of reinforcing members 261 can resist torsional or twisting forces applied to body 241.
- Other embodiments contemplate medially oriented reinforcement members that extend from longitudinal axis 249 toward medial axis 251, that extend parallel to medial axis 251, and combinations thereof.
- First longitudinally oriented reinforcing members 262 extend across medial axis 251 between first portion 246 and second portion 247 of body 241. Reinforcing members 262 extend primarily longitudinally in the direction of longitudinal axis 249. Second longitudinal reinforcing members 264 can be provided that are located in body 241 in one of the first and second portions 246, 247, such as shown in second portion 247. Body 241 can be provided with any one or combination of reinforcing members 258, 260, 262, 264 discussed above. Other embodiments contemplate reinforcing members randomly distributed through body 241 in linear and non-linear arrangements. Various forms for reinforcing members 258, 260, 262, 264 are contemplated.
- the reinforcing members can be in the form of increased material density, or in the form of a material that differs from the material of body 241. Examples include bars, strips, fibers or filaments made from metallic, plastic or other suitable material. Reinforcing members 258, 260, 262, 264 can be embedded in body 241, or extend along one or more of the upper surface portions, or along the lower surface of body 241. Referring to Fig. 5, there is provided another embodiment distraction implant 340 including a body 341 with a first hole 342 adjacent a first end 343 and a second hole 344 adjacent a second end 345. Holes 342, 344 can receive first and second anchors, such as anchors 21, 30 discussed above.
- Body 341 extends along a longitudinal axis 349, and a medial axis 351 divides body 341 into a first portion 346 and a second portion 347.
- Body 341 includes a variable stiffness mid-portion 348 to provide desired load resistance properties to body 341.
- mid-portion 348 includes a bulbous shape with a maximum thiclcness at apex 355 at or adjacent the intersection of longitudinal axis 349 and medial axis 351.
- Mid-portion 348 could also be provided with pyramidal or other enlarged shapes.
- mid-portion 348 includes an upper member 352 extending from and formed at each end with base portion 353 of body 341.
- Upper member 352 can form a chamber 350 with a base portion 353 into which a secondary device 356 can be positioned.
- Secondary device 356 can imbibe fluid or water over time to apply and/or maintain a distraction force to the adjacent bony portions.
- Arrows 354 (Fig. 5) are representative of the outwardly directed pressure applied in chamber 350 by the fluid as compressive forces are applied to body 341.
- the osmotic gradient into secondary device 356 extends in the direction opposite arrows 354, causing secondary device 356 to stiffen and maintain the distraction force over time, or to expand over time to increase the distraction force applied by distiaction implant 340.
- Secondary device 356 can be provided in the form of a sponge, foam, or other suitable osmotic material.
- FIG. 7 there is shown adjacent bony portions for one specific application of the distraction implant which includes a spinal column segment 500.
- Spinal column segment 500 includes a first vertebra 502, a second vertebra 504 and a third vertebra 506.
- a first disc space 508 is located between first vertebra 502 and second vertebra 504, and a second disc space 510 is located between second vertebra 504 and third vertebra 506.
- a first anchor 21 is engaged with first vertebra 502, a second anchor 30 is engaged with second vertebra 504, and a third anchor 430 is engaged with third vertebra 506.
- third anchor 430 can include a distal bone engagement portion 432 engageable to vertebra 506, and a proximal attachment portion 434 extending therefrom for attacliment of a distraction implant.
- spinal column segment 500 is viewed in the anterior-posterior direction, and is deformed with a lateral concave curvature along one side thereof, indicative of scoliosis.
- a distiaction implant system 420 is attachable to anchors 21, 30, and 430 in order to correct the concave curvature of the spinal column segment 500.
- Distraction implant system 420 includes first distraction implant 40 and a second distraction implant 440, which can be identical to first distraction implant 40.
- First implant 40 is attached intravertebrally to first anchor 21 and the second anchor 30.
- Second implant 440 is attached intravertebrally to second anchor 30 and third anchor 430. Attaching implants 40, 440 laterally along the anterior portion of the vertebral bodies avoids the nerves and muscle tissue associated with the posterior vertebral elements, and the vasculature and delicate ligaments along the anterior face of the vertebrae. In addition, the distractive force of the implant is applied directly along the concavely curved side of the vertebral bodies to push the vertebrae into alignment. As distraction implant 40 is attached to anchors 21 and 30, it can be placed in its second condition by, for example, compressing it and attaching it to proximal attachment portions 24, 34 of anchors 21, 30.
- implant 440 can be compressed and attached to proximal attachment portions 34, 434 of anchors 30, 430.
- the attached distraction implants 40, 440 tend to reform from their second condition to their first condition, resulting in distraction forces being applied between respective ones of the anchors attached to the implant, correcting the concave curvature of spinal column 500 toward a normal condition as shown in Fig. 9.
- arrows 512 and 514 indicate distraction forces being applied between anchors 21 and 30, and arrows 516, 518 indicate distiaction forces being applied between anchors 30 and 430.
- Such distraction forces can be applied between the anchors before attaching implants 40, 440 to correct the concave curvature to the spinal column 500.
- Distraction implants 40, 440 can be attached to maintain and/or increase distraction between the adjacent vertebral bodies through the corresponding anchors, correcting the concave curvature of spinal column 500 toward a normal condition as shown in Fig. 9.
- spinal column segment 500 includes first vertebra 502 and second vertebra 504 with the disc space 508 therebetween.
- Disc space 508 is collapsed such that the normal or desired spacing between vertebrae 502, 504 is not provided, as indicated in Fig. 10 by Dl.
- a first anchor 21 is engaged along the anterior portion of vertebra 502, and second and third anchors 521, 621 are engaged laterally or obliquely on opposite sides of vertebra 502.
- vertebra 504 includes a fourth anchor 30 engaged anteriorly thereto, and fifth and sixth anchors 530, 630 are engaged laterally or obliquely on opposite sides of vertebra 504.
- distraction forces 512, 513 and 612 can be applied to anchors 21, 521 and 621, respectively, engaged to vertebra 502.
- Distraction forces 514, 515 and 614 can be applied to anchors 30, 530, and 630, respectively, engaged to vertebra 504.
- Such distraction forces can be applied by attachment of one or more distraction implants, and/or with a distraction instrument prior to attachment of the one or more distraction implants.
- a distraction implant 540 is shown in Fig. 11 that is attachable to anchors 21, 521, 621 and anchors 30, 530, 630.
- distraction implant 540 is provided with a U or horseshoe shape at least along its lower surface 547 extending at least partially around each of the vertebrae 502, 504 and also between vertebrae 502, 504 as shown in Fig. 12.
- the opposite upper surface 552 can be provided with recesses 554 around each of the anchor holes to allow system 520 to maintain a low profile extending from the vertebrae 502, 504.
- Distraction implant 540 can be provided with a body 541 having properties that allow its to be placed in a second condition and return toward a first condition after attachment to exert a distraction load between respective ones of the anchors engaged to vertebrae 502, 504 and restore and maintain the desired disc space height D2 while allowing motion between vertebrae 502, 504.
- body 541 includes an enlarged mid-portion with a bulbous or rounded shape, and is comprised of a flexible material that is compressible to provide implant 540 in a second condition and sufficiently elastic to return toward its first, uncompressed condition to exert a distraction force. Referring to Figs. 13-14, there is shown another embodiment distiaction implant 700.
- Distraction implant 700 includes a body 702 extending from a first end 704 to an opposite second end 706.
- First end 704 includes a hole 710 and second end 706 includes a hole 712 to facilitate intravertebral attachment to a vertebral body with, for example, a first anchor 21 and a second anchor 30 as discussed above with respect to system 20.
- Ends 704, 706 can each be enlarged relative to body 702 to form the respective holes 710, 712 to receive an anchor therethrough. It is also contemplated that either of body 702 or holes 710, 712 and the corresponding anchors can be sized so that ends 704, 706 are not enlarged relative to body 702.
- First hole 710 is spaced a distance 714 from second hole 712 along longitudinal axis 701, and a gap is formed therebetween along longitudinal axis 701 to facilitate movement of first and second ends 704, 706 toward and away from one another in response to compression, expansion, deformation or transformation of body 702.
- Distance 714 can be of sufficient length to extend across at least one spinal disc space so the ends 704, 706 can be attached to respective ones of adjacent vertebral bodies. It is also contemplated that length 714 can be provided such that body 702 extends across one or more vertebrae, and ends 704, 706 can be attached to provide multi-level distraction.
- Implant 700 further includes an overall width 718 between longitudinal axis 701 and an outer wall surface 705 of body 702.
- implant 700 can be positioned along a concavely curved portion of the spine, such as the lateral or antero-lateral portion of a scoliotic spine, and is adapted to exert a distraction force between adjacent anchors to treat the concave curvature.
- Body 702 is curved along a semi-circular path between ends 704, 706, and includes a concave first surface 703 and an opposite convex second, outer surface 705.
- Body 702 includes a first width 708 between first and second surfaces 703, 705.
- Body 702 further includes opposite third and fourth surfaces 707, 709 extending between first surface 703 and second surface 705.
- Third and fourth surface 707, 709 include a second width 711 extending therebetween.
- implant 700 When secured to the spinal column, it is contemplated that one of the third and fourth surfaces 707, 709 will be positioned adjacent the spinal column, and the other of third and fourth surface 707, 709 will face away from the spinal column.
- implant 700 includes a first condition and is formed to a second condition by moving ends 704, 706 toward one another. In the second condition, ends 704, 706 are attached to anchors engaged to vertebrae or other structures along the concavely curved portion of the spine. Distraction implant 700 then refo ⁇ ns toward its first condition to exert a distiaction force between the anchors engaged thereto to correct and/or maintain the concavely curved portion of the spine in the desired alignment.
- Distraction implant 700 can be at least partially formed of a shape-memory material that exhibits pseudoelastic characteristics or behavior at about human body temperature. In one embodiment, the implant 700 is formed of the shape-memory material.
- ends 704, 706 may be at least partially formed of the shape-memory material, with the ends 704, 706 fo ⁇ ned of any suitable biocompatible material, such as, for example, stainless steel or titanium.
- SMAs exhibit a "shape-memory" characteristic or behavior in which a particular component formed of a shape-memory alloy (“SMA") is capable of being deformed from an initial "memorized” shape or configuration to a different shape or configuration, and then reformed back toward its initial shape or configuration.
- SMA shape-memory alloy
- the ability to possess shape- memory is a result of the fact that the SMA undergoes a reversible transformation from an austenitic state to a martensitic state.
- thermoelastic martensitic transformation If this transformation occurs due to a change in temperature, the shape-memory phenomena is commonly referred to as thermoelastic martensitic transformation. If the martensitic transformation occurs due to the imposition of stress, the shape-memory phenomena is commonly referred to as stress-induced martensitic transformation. Both types of transformations are contemplated herein.
- SMAs are known to display a superelastic phenomena or rubber-like behavior in which a strain attained beyond the elastic limit of the SMA material during loading is recovered during unloading. This superelastic phenomena occurs when stress is applied to an SMA article at a temperature slightly higher than the temperature at which the SMA begins to transform into austenite (sometimes referred to as the transformation temperature).
- the article When stressed, the article first deforms elastically up to the yield point of the SMA material (sometimes referred to as the critical stress). However, upon the further imposition of stress, the SMA material begins to transform into stress-induced martensite or "SIM". This transformation takes place at essentially constant stress, up to the point where the SMA material is completely transformed into martensite. When the stress is removed, the SMA material will reform back into austenite and the article will return to its original, pre-programmed or memorized shape. This phenomena is sometimes referred to as superelasticity or pseudoelasticity. It should be understood that this phenomena can occur without a corresponding change in temperature of the SMA material. Shape-memory materials can also be pliable and can typically be readily reshaped at temperatures below their transformation temperature range.
- Such articles can be trained to have a pre-programmed shape (commonly referred to as a "memorized shape") which the article will form into when the shape-memory material reaches a temperature above its transformation temperature range. After reaching such a temperature, the article will attempt to form to its pre-programmed, memorized shape. In so doing, the article converts heat energy into mechanical work.
- shape-memory materials suitable for use with the distraction implants, including shape-memory metal alloys (e.g., alloys of known metals, such as, for example, copper and zinc, nickel and titanium, and silver and cadmium) and shape-memory polymers.
- Nitinol a bio-compatible SMA formed of nickel and titanium.
- Nitinol is well suited for the particular application of the distraction implants because it can be programmed to undergo a stress-induced martensitic transformation or the ⁇ noelastic martensitic tiansformation at about normal human body temperature (i.e., at about 35-40 degrees Celsius).
- nitinol has a very low corrosion rate and excellent wear resistance, thereby providing an advantage when used as a support structure within the human body.
- implant studies in animals have shown minimal elevations of nickel in the tissues in contact with the nitinol material. It should be understood, however, that other SMA materials that exhibit superelastic characteristics are contemplated as being within the scope of the invention. Techniques are contemplated that are suited for distraction implant 700 made from shape memory material. It should be understood that such techniques are also applicable to the other distiaction implant embodiments discussed herein.
- the distraction implant ends, such as ends 704, 706 of implant 700 are moved toward one another to bend body 702 and place shape memory material comprising at least a portion of body 702 in a SIM condition.
- Body 702 is maintained in this SIM condition, and the ends 704, 706 of implant 700 are attached to vertebrae or other structures along the concavely curved portion of the spine with anchors.
- the stress on body 702 is then removed, and the engaged distraction implant 700 reforms back into an austenitic state toward its original shape, exerting a distraction force between the anchors engaged thereto to correct and/or maintain the concavely curved portion of the spine in the desired alignment.
- the gap between ends 704, 706 formed by laterally offsetting body 702 relative to longitudinal axis 701 facilitates movement of ends 704, 706 toward one another to obtain the SIM state or condition, and facilitates flexing of body 702 in the austenetic state to permit a limited range of motion for the vertebral level(s) to which implant 700 is engaged.
- multiple distraction implants 700 can be stacked one upon the other, and engaged to the concavely curved portion of the spinal column with the same bone anchor at each end.
- the bodies 702 of the stacked implants 700 can be arranged to be laterally offset to the same side of longitudinal axis 701, or arranged to be laterally offset to opposite sides of longitudinal axis 701.
- Multiple distraction implants 700 can also be spaced longitudinally and engaged along the spinal column in order to provide distraction at multiple levels. Different levels of the spinal column can be distracted with one implant 700 or differing numbers of stacked implants 700 to provide differing distraction forces and stiffness properties for the implant system along the spinal column.
- One or both of the ends 704, 706 of implant 700 can be rigidly secured to the adjacent bone anchor, or allowed to rotate relative thereto. By allowing the ends 704, 706 to rotate, the distraction force will be directed primarily in the direction of movement of ends 704, 706 away from one another as body 702 reforms to the firs condition. If one or both of the ends 704, 706 is fixed to the bone anchor, compound forces on the anchor are generated.
- the compound forces will include a component extending transversely to the central axis of the spinal column, and can be employed to align or maintain alignment of adjacent vertebrae in a direction transverse to the central axis of the spinal column in the anterior-posterior direction, such as would be desirable to correct spondylolisthesis.
- Other shapes for distraction implant 700 are also contemplated.
- Figs. 15 and 16 show a distraction implant 720 similar to distraction implant 700.
- Distraction implant 720 includes a body 722 extending between a first end 724 and an opposite second end 726. Body 722 includes a semi-oval shape between first and second ends 724, 726.
- the semi-oval shape for body 722 provides, for implants of identical lengths 714, 734, a reduced overall width 738 for distraction implant 720 as compared to semi-circular distraction implant 700 having the same overall length.
- the distraction implant include a second body portion extending between the opposite ends to provide additional support to maintain a distraction force.
- distraction implant 760 including a body 761 with a first body portion 762 and a second body portion
- Body portions 762, 763 each extend between opposite ends 764, 766, where holes can be provided along longitudinal axis 769 to facilitate attachment to vertebrae.
- Body 761 forms a circular shape with an opening 768 therethrough, allowing ends
- FIGS. 19 and 20 show a distraction implant 780 including a body 781 with a first body portion 782 and a second body portion 783. Body portions
- Body 781 forms an oval shape with an opening 788 therethrough, allowing ends 784, 786 to flex or be moved toward one another or away from one another in response to a deformation or change in shape in body portions 782,
- Body portions 782, 783 are integrally formed with one another at each of the first and second ends 784, 786 to provide a continuous body structure about opening 768.
- the oval shape of body 781 of distraction implant 780 includes an overall width 790 between the outer surfaces of body portions 782, 783.
- Body 781 includes a length 792 between ends 784, 786.
- distiaction implant 760 includes a width 770 for its circular shaped body and a length 772 along axis 769 that is substantially the same as width 770.
- width 790 is less than width 770 of distraction implant 760 for implants having the same lengths 772, 792. Accordingly, distraction implant 780 can be employed if a greater length to width ratio is desired. Figs.
- Distraction implant 800 includes a body 801 with a first body portion 802 and a second body portion 803. Body portions 802, 803 each extend between opposite ends 804, 806, where holes can be provided to facilitate attachment to vertebrae. Body 801 forms an oval shape with an opening 808 therethrough, allowing ends 804, 806 to flex or be moved toward one another or away from one another in response to a deformation or change in shape in body portions 802, 803.
- distiaction implant 800 includes a hinged connection at one or both of the ends 804, 806 to allow body portions 802, 803 to move independently relative to one another.
- Figs. 23-24 show a distraction implant 820 including a body 822 extending between a first end 824 and an opposite second end 826. Body 822 is offset laterally from ends 824, 826 to facilitate movement of ends 824, 826 toward and away from one another in response to compression, deformation or transformation of body 822.
- Body 822 includes a linear portion 828 and a pair of angled portions 830, 832 at opposite ends of linear portion 828. Angled portions 830, 832 extend from linear portion 828 to respective ones of the ends 824, 826 to offset linear portion 828 therefrom. Other embodiments contemplated that body 822 can include multiple linear segments interconnected by angled portions, multiple angled portions interconnected with one another, and combinations of linear, angled and arcuate or curved portions between ends 824, 826. In Figs. 25- 26 there is shown distraction implant 840 including a body 842 extending between opposite ends 844, 846.
- Body 842 includes a first body portion 850 and a second body portion 856 extending along opposite sides of opening 848 and offset laterally from the longitudinal axis of implant 840.
- Body portion 850 includes a first angled portion 852 extending from first end 844 to a second angled portion 854, which extends from first angled portion 852 to second end 846.
- second body portion 856 includes a first angled portion 858 extending from first end 844 to a second angled portion 860, which extends from first angled portion 858 to second end 846.
- the junction of angled portions 852, 854 and angled portions 858, 860 are offset laterally from ends 844, 846, providing body 842 with a diamond shape about opening 848.
- distraction implant 870 including a body 872 extending between opposite ends 874, 876.
- Body 872 includes a multiple body portions 878, 880 linked with one another along the length of body 872 and between ends 874, 876 to form a chain shape.
- body portions 878, 880 are diamond shaped so that the at least a portion of each body portion is offset laterally from longitudinal axis 871.
- Body portions 878, 880 can also be provided with other shapes, such as circular, oval, square, rectangular or other shapes discussed herein. Furthermore, body portions 878, 880 need not be symmetrical along longitudinal axis 871 of distraction. For example, body portions 878, 880 can be open along or adjacent longitudinal axis 871 to form a zigzag or corrugated shape along longitudinal axis 871. It is contemplated the implants described herein can be used for the correction of spinal defo ⁇ nities, such as by distracting a concavely curved portion of the spinal column.
- the distiaction implants can be positioned along surfaces of the spinal column segment coinprising the concavely curved portion of the spinal column segment to directly counteract the concave curvature with distraction forces.
- the distraction implants can be employed in fusionless treatment of scoliosis either alone or as an adjunct to a convexly applied fusionless scoliosis treatment system. It is further contemplated the implants described herein can be used for intravertebral distraction of adjacent vertebrae across a disc space in which the disc space is collapsed, or the relationship or spacing between the vertebra is desired to be altered or maintained.
- the distraction implants can stabilize the spinal column segment while allowing segmental motion.
- one or more distraction implants can be attached to any bony portion in which distiaction and motion between adjacent bony portions is desired. While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, and that all changes and modifications that come within the spirit of the invention are desired to be protected.
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- Orthopedic Medicine & Surgery (AREA)
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- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006551216A JP2007519478A (en) | 2004-01-30 | 2005-01-21 | Orthopedic distraction implants and techniques |
EP05711621A EP1720471A1 (en) | 2004-01-30 | 2005-01-21 | Orthopedic distraction implants and techniques |
CA002554638A CA2554638A1 (en) | 2004-01-30 | 2005-01-21 | Orthopedic distraction implants and techniques |
AU2005211321A AU2005211321A1 (en) | 2004-01-30 | 2005-01-21 | Orthopedic distraction implants and techniques |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/768,797 | 2004-01-30 | ||
US10/768,797 US7297146B2 (en) | 2004-01-30 | 2004-01-30 | Orthopedic distraction implants and techniques |
Publications (1)
Publication Number | Publication Date |
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WO2005074825A1 true WO2005074825A1 (en) | 2005-08-18 |
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PCT/US2005/001612 WO2005074825A1 (en) | 2004-01-30 | 2005-01-21 | Orthopedic distraction implants and techniques |
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US (2) | US7297146B2 (en) |
EP (1) | EP1720471A1 (en) |
JP (1) | JP2007519478A (en) |
CN (1) | CN1929792A (en) |
AU (1) | AU2005211321A1 (en) |
CA (1) | CA2554638A1 (en) |
WO (1) | WO2005074825A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009523045A (en) * | 2006-01-13 | 2009-06-18 | スピネアルト・エス・アー | System with plate and pedicle screw and its application |
US7909857B2 (en) | 2008-03-26 | 2011-03-22 | Warsaw Orthopedic, Inc. | Devices and methods for correcting spinal deformities |
WO2011116773A1 (en) | 2010-03-24 | 2011-09-29 | Aarhus Universitet | Implant for treatment of skeletal deformities |
US9017388B2 (en) | 2006-09-14 | 2015-04-28 | Warsaw Orthopedic, Inc. | Methods for correcting spinal deformities |
WO2015162496A3 (en) * | 2014-04-25 | 2016-01-21 | Kyon Ag | Flexible implant for distraction |
Families Citing this family (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7972337B2 (en) | 2005-12-28 | 2011-07-05 | Intrinsic Therapeutics, Inc. | Devices and methods for bone anchoring |
CA2425951C (en) * | 1999-08-18 | 2008-09-16 | Intrinsic Therapeutics, Inc. | Devices and method for nucleus pulposus augmentation and retention |
US7717961B2 (en) | 1999-08-18 | 2010-05-18 | Intrinsic Therapeutics, Inc. | Apparatus delivery in an intervertebral disc |
US7998213B2 (en) | 1999-08-18 | 2011-08-16 | Intrinsic Therapeutics, Inc. | Intervertebral disc herniation repair |
US8323341B2 (en) | 2007-09-07 | 2012-12-04 | Intrinsic Therapeutics, Inc. | Impaction grafting for vertebral fusion |
WO2009033100A1 (en) | 2007-09-07 | 2009-03-12 | Intrinsic Therapeutics, Inc. | Bone anchoring systems |
WO2004100841A1 (en) | 1999-08-18 | 2004-11-25 | Intrinsic Therapeutics, Inc. | Devices and method for augmenting a vertebral disc nucleus |
US7094258B2 (en) | 1999-08-18 | 2006-08-22 | Intrinsic Therapeutics, Inc. | Methods of reinforcing an annulus fibrosis |
US6969610B2 (en) * | 2001-01-12 | 2005-11-29 | University Of Rochester | Methods of modifying cell structure and remodeling tissue |
GB0107708D0 (en) | 2001-03-28 | 2001-05-16 | Imp College Innovations Ltd | Bone fixated,articulated joint load control device |
US7285121B2 (en) * | 2001-11-05 | 2007-10-23 | Warsaw Orthopedic, Inc. | Devices and methods for the correction and treatment of spinal deformities |
US7618441B2 (en) * | 2002-01-22 | 2009-11-17 | Jorge Abel Groiso | Bone staple and methods for correcting spine disorders |
US7052497B2 (en) | 2002-08-14 | 2006-05-30 | Sdgi Holdings, Inc. | Techniques for spinal surgery and attaching constructs to vertebral elements |
DE602004018903D1 (en) | 2003-02-14 | 2009-02-26 | Depuy Spine Inc | IN-SITU MANUFACTURED INTERVERTEBRALE FUSION DEVICE |
JP4542034B2 (en) * | 2003-06-26 | 2010-09-08 | ジンテーズ ゲゼルシャフト ミト ベシュレンクテル ハフツング | Double clamping part elastically tightened to the outer fixing |
US7815665B2 (en) | 2003-09-24 | 2010-10-19 | N Spine, Inc. | Adjustable spinal stabilization system |
US7763052B2 (en) | 2003-12-05 | 2010-07-27 | N Spine, Inc. | Method and apparatus for flexible fixation of a spine |
US20050203513A1 (en) * | 2003-09-24 | 2005-09-15 | Tae-Ahn Jahng | Spinal stabilization device |
US8979900B2 (en) | 2003-09-24 | 2015-03-17 | DePuy Synthes Products, LLC | Spinal stabilization device |
US20050065516A1 (en) | 2003-09-24 | 2005-03-24 | Tae-Ahn Jahng | Method and apparatus for flexible fixation of a spine |
BR0318485A (en) * | 2003-09-29 | 2006-09-12 | Synthes Gmbh | dynamic damping element for two bones |
US20060058796A1 (en) * | 2004-09-14 | 2006-03-16 | Hartdegen Vernon R | Compression brace |
FR2875398B1 (en) * | 2004-09-21 | 2007-07-06 | Newdeal Sa Sa | JOINT IMPLANT OF INTERPOSITION |
WO2006042206A2 (en) * | 2004-10-06 | 2006-04-20 | Nuvasive, Inc. | Systems and methods for direct restoration of foraminal volume |
DE102004048938B4 (en) * | 2004-10-07 | 2015-04-02 | Synthes Gmbh | Device for the dynamic stabilization of vertebral bodies |
WO2006049993A2 (en) * | 2004-10-28 | 2006-05-11 | Axial Biotech, Inc. | Apparatus and method for concave scoliosis expansion |
US7931680B2 (en) * | 2005-03-31 | 2011-04-26 | Depuy Products, Inc. | Plate for lengthening the lateral column of the foot |
US7967844B2 (en) * | 2005-06-10 | 2011-06-28 | Depuy Spine, Inc. | Multi-level posterior dynamic stabilization systems and methods |
US7766943B1 (en) * | 2005-08-11 | 2010-08-03 | Medicine Lodge Inc. | Modular percutaneous spinal fusion system and method |
US8366773B2 (en) | 2005-08-16 | 2013-02-05 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
US7670374B2 (en) | 2005-08-16 | 2010-03-02 | Benvenue Medical, Inc. | Methods of distracting tissue layers of the human spine |
WO2008103781A2 (en) | 2007-02-21 | 2008-08-28 | Benvenue Medical, Inc. | Devices for treating the spine |
US20070049941A1 (en) * | 2005-08-25 | 2007-03-01 | Lanx, Llc | Plate with stabilization |
GB0521582D0 (en) * | 2005-10-22 | 2005-11-30 | Depuy Int Ltd | An implant for supporting a spinal column |
GB0521585D0 (en) * | 2005-10-22 | 2005-11-30 | Depuy Int Ltd | A spinal support rod |
US8357181B2 (en) | 2005-10-27 | 2013-01-22 | Warsaw Orthopedic, Inc. | Intervertebral prosthetic device for spinal stabilization and method of implanting same |
EP1800614B1 (en) * | 2005-12-23 | 2009-02-25 | BIEDERMANN MOTECH GmbH | Dynamic stabilization device for bones or vertebrae |
GB0600662D0 (en) * | 2006-01-13 | 2006-02-22 | Depuy Int Ltd | Spinal support rod kit |
US7901409B2 (en) * | 2006-01-20 | 2011-03-08 | Canaveral Villegas Living Trust | Intramedullar devices and methods to reduce and/or fix damaged bone |
US8348952B2 (en) * | 2006-01-26 | 2013-01-08 | Depuy International Ltd. | System and method for cooling a spinal correction device comprising a shape memory material for corrective spinal surgery |
US7815663B2 (en) | 2006-01-27 | 2010-10-19 | Warsaw Orthopedic, Inc. | Vertebral rods and methods of use |
US20070270821A1 (en) * | 2006-04-28 | 2007-11-22 | Sdgi Holdings, Inc. | Vertebral stabilizer |
US8012179B2 (en) * | 2006-05-08 | 2011-09-06 | Warsaw Orthopedic, Inc. | Dynamic spinal stabilization members and methods |
US8449576B2 (en) * | 2006-06-28 | 2013-05-28 | DePuy Synthes Products, LLC | Dynamic fixation system |
US7766942B2 (en) * | 2006-08-31 | 2010-08-03 | Warsaw Orthopedic, Inc. | Polymer rods for spinal applications |
US8308770B2 (en) * | 2006-09-22 | 2012-11-13 | Depuy Spine, Inc. | Dynamic stabilization system |
US8317841B2 (en) * | 2006-09-26 | 2012-11-27 | Bray Jr Robert S | Cervical dynamic stabilization system |
US8114080B2 (en) * | 2006-09-27 | 2012-02-14 | Depuy Products, Inc. | Flexible bone fixation device |
WO2008070863A2 (en) | 2006-12-07 | 2008-06-12 | Interventional Spine, Inc. | Intervertebral implant |
US20080154310A1 (en) * | 2006-12-21 | 2008-06-26 | Warsaw Orthopedic, Inc. | Reinforced orthopedic plate |
US7875059B2 (en) * | 2007-01-18 | 2011-01-25 | Warsaw Orthopedic, Inc. | Variable stiffness support members |
US7931676B2 (en) * | 2007-01-18 | 2011-04-26 | Warsaw Orthopedic, Inc. | Vertebral stabilizer |
ES2757819T3 (en) | 2007-02-21 | 2020-04-30 | Benvenue Medical Inc | Devices to treat the spine |
US8740944B2 (en) * | 2007-02-28 | 2014-06-03 | Warsaw Orthopedic, Inc. | Vertebral stabilizer |
US20080255615A1 (en) * | 2007-03-27 | 2008-10-16 | Warsaw Orthopedic, Inc. | Treatments for Correcting Spinal Deformities |
US20080269805A1 (en) | 2007-04-25 | 2008-10-30 | Warsaw Orthopedic, Inc. | Methods for correcting spinal deformities |
US20080275567A1 (en) * | 2007-05-01 | 2008-11-06 | Exploramed Nc4, Inc. | Extra-Articular Implantable Mechanical Energy Absorbing Systems |
US8709090B2 (en) | 2007-05-01 | 2014-04-29 | Moximed, Inc. | Adjustable absorber designs for implantable device |
US8123805B2 (en) | 2007-05-01 | 2012-02-28 | Moximed, Inc. | Adjustable absorber designs for implantable device |
US20080275552A1 (en) * | 2007-05-01 | 2008-11-06 | Exploramed Nc4, Inc. | Adjustable absorber designs for implantable device |
US9655648B2 (en) | 2007-05-01 | 2017-05-23 | Moximed, Inc. | Femoral and tibial base components |
US20110245928A1 (en) | 2010-04-06 | 2011-10-06 | Moximed, Inc. | Femoral and Tibial Bases |
US20100137996A1 (en) | 2007-05-01 | 2010-06-03 | Moximed, Inc. | Femoral and tibial base components |
US9907645B2 (en) | 2007-05-01 | 2018-03-06 | Moximed, Inc. | Adjustable absorber designs for implantable device |
US8894714B2 (en) | 2007-05-01 | 2014-11-25 | Moximed, Inc. | Unlinked implantable knee unloading device |
US7655041B2 (en) | 2007-05-01 | 2010-02-02 | Moximed, Inc. | Extra-articular implantable mechanical energy absorbing systems and implantation method |
US8900307B2 (en) | 2007-06-26 | 2014-12-02 | DePuy Synthes Products, LLC | Highly lordosed fusion cage |
US8425616B2 (en) * | 2007-07-09 | 2013-04-23 | Moximed, Inc. | Surgical implantation method and devices for an extra-articular mechanical energy absorbing apparatus |
US20090018665A1 (en) * | 2007-07-09 | 2009-01-15 | Exploramed Nc4, Inc. | Surgical implantation method and devices for an extra-articular mechanical energy absorbing apparatus |
US7846211B2 (en) * | 2007-07-09 | 2010-12-07 | Moximed, Inc. | Surgical implantation method and devices for an extra-articular mechanical energy absorbing apparatus |
US7632310B2 (en) * | 2007-07-09 | 2009-12-15 | Moximed, Inc. | Surgical implantation method and devices for an extra-articular mechanical energy absorbing apparatus |
US8790380B2 (en) * | 2007-07-26 | 2014-07-29 | Dynamic Spine, Llc | Segmental orthopaedic device for spinal elongation and for treatment of scoliosis |
US9204908B2 (en) | 2007-07-26 | 2015-12-08 | Dynamic Spine, Llc | Segmental orthopedic device for spinal elongation and for treatment of scoliosis |
BRPI0814831A2 (en) * | 2007-08-07 | 2015-03-31 | Synthes Gmbh | Dynamic cable system, and dynamic clamping system. |
US20090088803A1 (en) * | 2007-10-01 | 2009-04-02 | Warsaw Orthopedic, Inc. | Flexible members for correcting spinal deformities |
GB0720762D0 (en) * | 2007-10-24 | 2007-12-05 | Depuy Spine Sorl | Assembly for orthopaedic surgery |
BRPI0906516A2 (en) | 2008-01-17 | 2019-09-24 | Synthes Gmbh | expandable intervertebral implant and associated method for its manufacture. |
US20140018804A1 (en) * | 2008-03-18 | 2014-01-16 | Dallen Medical, Inc. | Dynamic tissue holding device with low profile spring |
CA2720580A1 (en) | 2008-04-05 | 2009-10-08 | Synthes Usa, Llc | Expandable intervertebral implant |
US9808345B2 (en) | 2008-07-24 | 2017-11-07 | Iorthopedics, Inc. | Resilient arthroplasty device |
US20100057114A1 (en) * | 2008-09-02 | 2010-03-04 | Butler Michael S | PEEK Spinal Mesh and PEEK Spinal Mesh Applicator |
EP2373236B1 (en) | 2008-12-17 | 2014-05-21 | Synthes GmbH | Posterior spine dynamic stabilizer |
US8118840B2 (en) | 2009-02-27 | 2012-02-21 | Warsaw Orthopedic, Inc. | Vertebral rod and related method of manufacture |
US8535327B2 (en) | 2009-03-17 | 2013-09-17 | Benvenue Medical, Inc. | Delivery apparatus for use with implantable medical devices |
US8147528B2 (en) * | 2009-03-18 | 2012-04-03 | Depuy Spine, Inc. | Laminoplasty methods and devices |
US8435265B2 (en) * | 2009-03-18 | 2013-05-07 | Depuy Spine, Inc. | Laminoplasty methods using hinge device |
US9526620B2 (en) | 2009-03-30 | 2016-12-27 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
CA2765526A1 (en) | 2009-06-17 | 2010-12-23 | Trinity Orthopedics, Llc | Expanding intervertebral device and methods of use |
US8282636B2 (en) * | 2009-08-10 | 2012-10-09 | Imds Corporation | Orthopedic external fixator and method of use |
US9066757B2 (en) * | 2009-08-10 | 2015-06-30 | Virak Orthopedic Research Llc | Orthopedic external fixator and method of use |
US9278004B2 (en) | 2009-08-27 | 2016-03-08 | Cotera, Inc. | Method and apparatus for altering biomechanics of the articular joints |
US9668868B2 (en) | 2009-08-27 | 2017-06-06 | Cotera, Inc. | Apparatus and methods for treatment of patellofemoral conditions |
US10349980B2 (en) | 2009-08-27 | 2019-07-16 | The Foundry, Llc | Method and apparatus for altering biomechanics of the shoulder |
JP5671539B2 (en) | 2009-08-27 | 2015-02-18 | コテラ, インコーポレイテッド | Method and apparatus for force redistribution in articulating joints |
US9861408B2 (en) | 2009-08-27 | 2018-01-09 | The Foundry, Llc | Method and apparatus for treating canine cruciate ligament disease |
US9011494B2 (en) | 2009-09-24 | 2015-04-21 | Warsaw Orthopedic, Inc. | Composite vertebral rod system and methods of use |
EP2506787B1 (en) | 2009-12-01 | 2015-02-25 | Synthes GmbH | Non-fusion scoliosis expandable spinal rod |
GB2476124A (en) * | 2009-12-08 | 2011-06-15 | R Thomas Grotz | Inflatable arthroplasty implant |
US9393129B2 (en) | 2009-12-10 | 2016-07-19 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
US10307257B2 (en) | 2010-01-22 | 2019-06-04 | Iorthopedics, Inc. | Resilient knee implant and methods |
CN102834073B (en) | 2010-01-22 | 2016-01-13 | R·托马斯·哥罗兹 | Elasticity knee implants and method |
US20110218572A1 (en) * | 2010-03-04 | 2011-09-08 | Beat Lechmann | Expandable lamina spinal fusion implant |
EP2579795B1 (en) | 2010-06-10 | 2018-10-31 | Globus Medical, Inc. | Low-profile, uniplanar bone screw |
US9592063B2 (en) | 2010-06-24 | 2017-03-14 | DePuy Synthes Products, Inc. | Universal trial for lateral cages |
US8979860B2 (en) | 2010-06-24 | 2015-03-17 | DePuy Synthes Products. LLC | Enhanced cage insertion device |
WO2012003175A1 (en) | 2010-06-29 | 2012-01-05 | Synthes Usa, Llc | Distractible intervertebral implant |
US9402732B2 (en) | 2010-10-11 | 2016-08-02 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
RU2453289C1 (en) * | 2010-11-12 | 2012-06-20 | Общество с ограниченной ответственностью "ИЛЬКОМ" | Device for spinous process distraction |
WO2012071373A1 (en) | 2010-11-22 | 2012-05-31 | Synthes Usa, Llc | Non-fusion scoliosis expandable spinal rod |
USD833613S1 (en) | 2011-01-19 | 2018-11-13 | Iorthopedics, Inc. | Resilient knee implant |
US9757241B2 (en) | 2011-09-01 | 2017-09-12 | R. Thomas Grotz | Resilient interpositional arthroplasty device |
CA2825198C (en) | 2011-01-25 | 2020-01-14 | DePuy Synthes Products, LLC | Expandable bone fixation implant |
US20120209338A1 (en) * | 2011-02-10 | 2012-08-16 | Jorge Groiso | Device for correction of bone and soft tissue disorders |
US9044270B2 (en) | 2011-03-29 | 2015-06-02 | Moximed, Inc. | Apparatus for controlling a load on a hip joint |
US8870929B2 (en) | 2011-04-13 | 2014-10-28 | Polyvalor, Limited Partnership Valorisation HSJ, Limited Partnership | Surgical devices for the correction of spinal deformities |
US9345493B2 (en) * | 2011-05-10 | 2016-05-24 | Peter Nakaji | Cranial plating and bur hole cover system and methods of use |
US8814873B2 (en) | 2011-06-24 | 2014-08-26 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
DE102012105123B3 (en) * | 2012-06-13 | 2013-09-12 | Hipp Medical Ag | Fixation device for fixing fractured ends of bones of a bone fracture |
DE102012105125B3 (en) * | 2012-06-13 | 2013-08-14 | Hipp Medical Ag | Clamping element for fixing fractured ends of bone of a bone fracture |
US9468466B1 (en) | 2012-08-24 | 2016-10-18 | Cotera, Inc. | Method and apparatus for altering biomechanics of the spine |
RU2514121C1 (en) * | 2013-02-01 | 2014-04-27 | Закрытое Акционерное Общество "КИМПФ" | Retainer for spinal ligament and bone structure prosthetic repair accompanying laminoplasty |
US9717601B2 (en) | 2013-02-28 | 2017-08-01 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
US9522070B2 (en) | 2013-03-07 | 2016-12-20 | Interventional Spine, Inc. | Intervertebral implant |
US10085783B2 (en) | 2013-03-14 | 2018-10-02 | Izi Medical Products, Llc | Devices and methods for treating bone tissue |
JP6650395B2 (en) | 2013-11-11 | 2020-02-19 | アースレックス インコーポレイテッド | Screw to generate and apply compression in the body |
US10016198B2 (en) | 2014-11-13 | 2018-07-10 | Arthrex, Inc. | Staples for generating and applying compression within a body |
EP3563776A3 (en) | 2013-11-13 | 2020-08-05 | Arthrex, Inc | Staples for generating and applying compression within a body |
US9980715B2 (en) | 2014-02-05 | 2018-05-29 | Trinity Orthopedics, Llc | Anchor devices and methods of use |
US9408647B2 (en) * | 2014-02-27 | 2016-08-09 | Biomedical Enterprises, Inc. | Method and apparatus for use of a compressing plate |
WO2015138995A1 (en) | 2014-03-13 | 2015-09-17 | Mx Orthopedics, Copr | Plates for generating, applying and maintaining compression within a body |
AU2016211398B2 (en) | 2015-01-28 | 2020-03-12 | Arthrex, Inc. | Self-compressing screws for generating and applying compression within a body |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
KR101666527B1 (en) | 2015-12-14 | 2016-10-24 | 권용원 | implant apparatus for promote bone growth |
AU2017286831B2 (en) | 2016-06-28 | 2022-06-09 | Eit Emerging Implant Technologies Gmbh | Expandable and angularly adjustable articulating intervertebral cages |
WO2018002711A2 (en) | 2016-06-28 | 2018-01-04 | Eit Emerging Implant Technologies Gmbh | Expandable, angularly adjustable intervertebral cages |
CA3039081A1 (en) * | 2016-10-06 | 2018-04-12 | Ao Technology Ag | Device for correcting unbalanced growth plate activity and for orthodontic applications |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
US10398563B2 (en) | 2017-05-08 | 2019-09-03 | Medos International Sarl | Expandable cage |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
US11648000B2 (en) | 2018-07-30 | 2023-05-16 | Braunvest Llc | Vertebral probes and related surgical methods |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11246636B2 (en) | 2019-04-26 | 2022-02-15 | Braunvest Llc | Systems, methods, and apparatus for spinal deformity correction |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6402750B1 (en) * | 2000-04-04 | 2002-06-11 | Spinlabs, Llc | Devices and methods for the treatment of spinal disorders |
WO2002102259A2 (en) * | 2001-06-16 | 2002-12-27 | Dilip Kumar Sengupta | An assembly for the stabilisation of vertebral bodies of the spine |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2580821A (en) * | 1950-10-21 | 1952-01-01 | Nicola Toufick | Spring impactor bone plate |
GB1241292A (en) | 1967-09-29 | 1971-08-04 | Nat Res Dev | Devices for correcting scoliotic curves |
NL7306853A (en) | 1973-05-16 | 1974-11-19 | ||
US3977397A (en) | 1974-11-27 | 1976-08-31 | Kalnberz Viktor Konstantinovic | Surgical compression-distraction instrument |
FI53062C (en) | 1975-05-30 | 1978-02-10 | Erkki Einari Nissinen | |
FR2416683A1 (en) * | 1978-02-10 | 1979-09-07 | Judet Robert | IMPROVEMENTS TO OSTEO-SYNTHESIS DEVICES |
CH628803A5 (en) | 1978-05-12 | 1982-03-31 | Sulzer Ag | Implant insertable between adjacent vertebrae |
PL127121B1 (en) | 1980-07-30 | 1983-09-30 | Wyzsza Szkola Inzynierska | Surgical strut for treating spinal affections |
US4386603A (en) | 1981-03-23 | 1983-06-07 | Mayfield Jack K | Distraction device for spinal distraction systems |
US4743260A (en) | 1985-06-10 | 1988-05-10 | Burton Charles V | Method for a flexible stabilization system for a vertebral column |
FR2658413B1 (en) | 1990-02-19 | 1997-01-03 | Sofamor | OSTEOSYNTHESIS DEVICE FOR THE CORRECTION OF SPINAL DEVIATIONS. |
FR2668361A1 (en) * | 1990-10-30 | 1992-04-30 | Mai Christian | OSTEOSYNTHESIS CLIP AND PLATE WITH SELF-RETENTIVE DYNAMIC COMPRESSION. |
FR2676911B1 (en) | 1991-05-30 | 1998-03-06 | Psi Ste Civile Particuliere | INTERVERTEBRAL STABILIZATION DEVICE WITH SHOCK ABSORBERS. |
FR2693364B1 (en) | 1992-07-07 | 1995-06-30 | Erpios Snc | INTERVERTEBRAL PROSTHESIS FOR STABILIZING ROTATORY AND FLEXIBLE-EXTENSION CONSTRAINTS. |
US5702395A (en) | 1992-11-10 | 1997-12-30 | Sofamor S.N.C. | Spine osteosynthesis instrumentation for an anterior approach |
FR2700464B1 (en) * | 1992-11-13 | 1995-04-14 | Maurice Bertholet | Connecting piece for bone elements. |
US5415661A (en) * | 1993-03-24 | 1995-05-16 | University Of Miami | Implantable spinal assist device |
FR2709246B1 (en) | 1993-08-27 | 1995-09-29 | Martin Jean Raymond | Dynamic implanted spinal orthosis. |
NL9400210A (en) | 1994-02-10 | 1995-09-01 | Acromed Bv | Implantation device for limiting movements between two vertebrae. |
DE9402839U1 (en) | 1994-02-22 | 1994-04-14 | Howmedica GmbH, 24232 Schönkirchen | Device for setting up a spine with damaged vertebrae |
EP0669109B1 (en) | 1994-02-28 | 1999-05-26 | Sulzer Orthopädie AG | Stabilizer for adjacent vertebrae |
AU4089697A (en) | 1994-05-25 | 1998-03-19 | Roger P Jackson | Apparatus and method for spinal fixation and correction of spinal deformities |
GB9413855D0 (en) | 1994-07-08 | 1994-08-24 | Smith & Nephew | Prosthetic devices |
DE29501880U1 (en) * | 1995-02-06 | 1995-05-24 | Karl Leibinger Medizintechnik GmbH & Co. KG, 78570 Mühlheim | Bone extension device |
US5634926A (en) * | 1995-04-25 | 1997-06-03 | Jobe; Richard P. | Surgical bone fixation apparatus |
DE29600879U1 (en) | 1996-01-19 | 1996-03-28 | Howmedica GmbH, 24232 Schönkirchen | Spinal implant |
AU2655397A (en) | 1996-04-18 | 1997-11-07 | Jan-Erik Nilsson | Device and method for correcting and stabilising a deviating curvature of a spinal column |
FR2751864B1 (en) | 1996-08-01 | 1999-04-30 | Graf Henry | DEVICE FOR MECHANICALLY CONNECTING AND ASSISTING VERTEBRES BETWEEN THEM |
US6019793A (en) * | 1996-10-21 | 2000-02-01 | Synthes | Surgical prosthetic device |
US5947999A (en) | 1996-12-03 | 1999-09-07 | Groiso; Jorge A. | Surgical clip and method |
US6224596B1 (en) | 1997-01-06 | 2001-05-01 | Roger P. Jackson | Set screw for use with osteosynthesis apparatus |
US6287308B1 (en) | 1997-07-14 | 2001-09-11 | Sdgi Holdings, Inc. | Methods and apparatus for fusionless treatment of spinal deformities |
EP0999795A1 (en) | 1997-07-31 | 2000-05-17 | Plus Endoprothetik Ag | Device for stiffening and/or correcting a vertebral column or such like |
FR2774581B1 (en) * | 1998-02-10 | 2000-08-11 | Dimso Sa | INTEREPINOUS STABILIZER TO BE ATTACHED TO SPINOUS APOPHYSIS OF TWO VERTEBRES |
US6241746B1 (en) * | 1998-06-29 | 2001-06-05 | Cordis Corporation | Vascular filter convertible to a stent and method |
US6299613B1 (en) | 1999-04-23 | 2001-10-09 | Sdgi Holdings, Inc. | Method for the correction of spinal deformities through vertebral body tethering without fusion |
US6325805B1 (en) | 1999-04-23 | 2001-12-04 | Sdgi Holdings, Inc. | Shape memory alloy staple |
US6059787A (en) * | 1999-04-26 | 2000-05-09 | Allen; Drew | Compression bone staple apparatus and method |
US6224599B1 (en) * | 1999-05-19 | 2001-05-01 | Matthew G. Baynham | Viewable wedge distractor device |
US6277149B1 (en) * | 1999-06-08 | 2001-08-21 | Osteotech, Inc. | Ramp-shaped intervertebral implant |
US6530929B1 (en) | 1999-10-20 | 2003-03-11 | Sdgi Holdings, Inc. | Instruments for stabilization of bony structures |
US6293949B1 (en) | 2000-03-01 | 2001-09-25 | Sdgi Holdings, Inc. | Superelastic spinal stabilization system and method |
US6565605B2 (en) * | 2000-12-13 | 2003-05-20 | Medicinelodge, Inc. | Multiple facet joint replacement |
US6743257B2 (en) * | 2000-12-19 | 2004-06-01 | Cortek, Inc. | Dynamic implanted intervertebral spacer |
US20040172040A1 (en) * | 2001-10-19 | 2004-09-02 | Heggeness Michael H. | Bone compression devices and systems and methods of contouring and using same |
US6783527B2 (en) | 2001-10-30 | 2004-08-31 | Sdgi Holdings, Inc. | Flexible spinal stabilization system and method |
US6966911B2 (en) | 2002-01-22 | 2005-11-22 | Jorge Abel Groiso | Bone staple and methods for correcting bone deficiencies by controllably suppressing and/or inducing the growth of the epiphyseal plate |
US6966910B2 (en) * | 2002-04-05 | 2005-11-22 | Stephen Ritland | Dynamic fixation device and method of use |
ATE552789T1 (en) * | 2002-05-08 | 2012-04-15 | Stephen Ritland | DYNAMIC FIXATION DEVICE |
US7635367B2 (en) | 2003-08-05 | 2009-12-22 | Medicrea International | Osteosynthesis clip and insertion tool for use with bone tissue fragments |
-
2004
- 2004-01-30 US US10/768,797 patent/US7297146B2/en not_active Expired - Fee Related
-
2005
- 2005-01-21 JP JP2006551216A patent/JP2007519478A/en active Pending
- 2005-01-21 CN CNA2005800069576A patent/CN1929792A/en active Pending
- 2005-01-21 CA CA002554638A patent/CA2554638A1/en not_active Abandoned
- 2005-01-21 AU AU2005211321A patent/AU2005211321A1/en not_active Abandoned
- 2005-01-21 EP EP05711621A patent/EP1720471A1/en not_active Withdrawn
- 2005-01-21 WO PCT/US2005/001612 patent/WO2005074825A1/en active Application Filing
-
2007
- 2007-11-13 US US11/983,911 patent/US8142476B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6402750B1 (en) * | 2000-04-04 | 2002-06-11 | Spinlabs, Llc | Devices and methods for the treatment of spinal disorders |
WO2002102259A2 (en) * | 2001-06-16 | 2002-12-27 | Dilip Kumar Sengupta | An assembly for the stabilisation of vertebral bodies of the spine |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009523045A (en) * | 2006-01-13 | 2009-06-18 | スピネアルト・エス・アー | System with plate and pedicle screw and its application |
US9017388B2 (en) | 2006-09-14 | 2015-04-28 | Warsaw Orthopedic, Inc. | Methods for correcting spinal deformities |
US7909857B2 (en) | 2008-03-26 | 2011-03-22 | Warsaw Orthopedic, Inc. | Devices and methods for correcting spinal deformities |
US9011498B2 (en) | 2008-03-26 | 2015-04-21 | Warsaw Orthopedic, Inc. | Devices and methods for correcting spinal deformities |
WO2011116773A1 (en) | 2010-03-24 | 2011-09-29 | Aarhus Universitet | Implant for treatment of skeletal deformities |
WO2015162496A3 (en) * | 2014-04-25 | 2016-01-21 | Kyon Ag | Flexible implant for distraction |
US10448974B2 (en) | 2014-04-25 | 2019-10-22 | Kyon Ag | Flexible implant for distraction |
Also Published As
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CA2554638A1 (en) | 2005-08-18 |
AU2005211321A1 (en) | 2005-08-18 |
JP2007519478A (en) | 2007-07-19 |
US8142476B2 (en) | 2012-03-27 |
EP1720471A1 (en) | 2006-11-15 |
US20080071373A1 (en) | 2008-03-20 |
US20050171539A1 (en) | 2005-08-04 |
US7297146B2 (en) | 2007-11-20 |
CN1929792A (en) | 2007-03-14 |
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