WO2005063966A3 - Verfahren zur in vitro differenzierung neuronaler stammzellen oder von neuronalen stammzellen abgeleiteter zellen - Google Patents

Verfahren zur in vitro differenzierung neuronaler stammzellen oder von neuronalen stammzellen abgeleiteter zellen Download PDF

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Publication number
WO2005063966A3
WO2005063966A3 PCT/EP2004/014673 EP2004014673W WO2005063966A3 WO 2005063966 A3 WO2005063966 A3 WO 2005063966A3 EP 2004014673 W EP2004014673 W EP 2004014673W WO 2005063966 A3 WO2005063966 A3 WO 2005063966A3
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Prior art keywords
cells
neuronal stem
stem cells
vitro differentiation
derived
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PCT/EP2004/014673
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English (en)
French (fr)
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WO2005063966A2 (de
Inventor
Martin H Maurer
Robert E Feldmann
Wolfgang Kuschinsky
Armin Schneider
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Axaron Bioscience Ag
Martin H Maurer
Robert E Feldmann
Wolfgang Kuschinsky
Armin Schneider
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Application filed by Axaron Bioscience Ag, Martin H Maurer, Robert E Feldmann, Wolfgang Kuschinsky, Armin Schneider filed Critical Axaron Bioscience Ag
Priority to AU2004309070A priority Critical patent/AU2004309070A1/en
Priority to US10/584,341 priority patent/US20090081189A1/en
Priority to CA002551259A priority patent/CA2551259A1/en
Priority to EP04804267A priority patent/EP1697501A2/de
Publication of WO2005063966A2 publication Critical patent/WO2005063966A2/de
Publication of WO2005063966A3 publication Critical patent/WO2005063966A3/de

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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Immunology (AREA)
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Abstract

Das Verfahren zur in vitro Differenzierung von neuronalen Stammzellen umfasst das in Kontakt bringen der Zellen mit einer Substanz, die eine Reaktion des Wnt­Signaltransduktionswegs inhibiert, und das Kultivieren dieser Zellen unter Bedingungen, die eine Vermehrung und/oder Differenzierung der Zellen ermöglichen. In einer bevorzugten Ausführungsform des Verfahrens differenzieren die neuronalen Stammzellen zu gehirnzellenähnlichen Zellen.
PCT/EP2004/014673 2003-12-23 2004-12-23 Verfahren zur in vitro differenzierung neuronaler stammzellen oder von neuronalen stammzellen abgeleiteter zellen WO2005063966A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2004309070A AU2004309070A1 (en) 2003-12-23 2004-12-23 Method for in vitro differentiation of neuronal stem cells or cells derived from neuronal stem cells
US10/584,341 US20090081189A1 (en) 2003-12-23 2004-12-23 Process for in vitro differentiation of neuronal stem cells or of cells derived from neuronal stem cells
CA002551259A CA2551259A1 (en) 2003-12-23 2004-12-23 A process for in vitro differentiation of neuronal stem cells or of cells derived from neuronal stem cells
EP04804267A EP1697501A2 (de) 2003-12-23 2004-12-23 Verfahren zur in vitro differenzierung neuronaler stammzellen oder von neuronalen stammzellen abgeleiteter zellen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10361444.3 2003-12-23
DE10361444A DE10361444A1 (de) 2003-12-23 2003-12-23 Verfahren zur in vitro Differenzierung neuronaler Stammzellen oder von neuronalen Stammzellen abgeleiteter Zellen

Publications (2)

Publication Number Publication Date
WO2005063966A2 WO2005063966A2 (de) 2005-07-14
WO2005063966A3 true WO2005063966A3 (de) 2005-10-27

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PCT/EP2004/014673 WO2005063966A2 (de) 2003-12-23 2004-12-23 Verfahren zur in vitro differenzierung neuronaler stammzellen oder von neuronalen stammzellen abgeleiteter zellen

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US (1) US20090081189A1 (de)
EP (1) EP1697501A2 (de)
AU (1) AU2004309070A1 (de)
CA (1) CA2551259A1 (de)
DE (1) DE10361444A1 (de)
WO (1) WO2005063966A2 (de)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
WO2006024947A2 (en) * 2004-09-02 2006-03-09 Neuro Therapeutics Ab Methods and materials relating to enhanced production of dopamine neurons
WO2007016485A2 (en) * 2005-07-29 2007-02-08 Athersys, Inc. Use of a gsk-3 inhibitor to maintain potency of cultured cells
WO2010014622A2 (en) * 2008-07-28 2010-02-04 Fondazione Istituto Firc Di Oncologica Molecolare (Ifom) In vitro model for modulating the blood brain barrier and methods of screening
EP2346902A1 (de) * 2008-11-04 2011-07-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Modulieren der neuronalen plastizität und behandlung des verlusts von nervenzellen durch modulieren von wnt7a oder wnt7b-modulation
CN111690612B (zh) * 2019-02-28 2023-07-25 同济大学 通过调控Wnt信号和/或Notch信号扩增人神经前体细胞的方法
CN114292815A (zh) * 2022-01-08 2022-04-08 广东省疾病预防控制中心 一种人神经祖细胞分化方法及其在毒性测试中的应用

Citations (2)

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WO1999057248A1 (en) * 1998-04-30 1999-11-11 President And Fellows Of Harvard College Induction of neuronal regeneration
US6686198B1 (en) * 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells

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Also Published As

Publication number Publication date
WO2005063966A2 (de) 2005-07-14
US20090081189A1 (en) 2009-03-26
DE10361444A1 (de) 2005-07-21
CA2551259A1 (en) 2005-07-14
AU2004309070A1 (en) 2005-07-14
EP1697501A2 (de) 2006-09-06

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