WO2007047680A3 - Increasing the activity of radical s-adenosyl methionine (sam) enzymes - Google Patents
Increasing the activity of radical s-adenosyl methionine (sam) enzymes Download PDFInfo
- Publication number
- WO2007047680A3 WO2007047680A3 PCT/US2006/040563 US2006040563W WO2007047680A3 WO 2007047680 A3 WO2007047680 A3 WO 2007047680A3 US 2006040563 W US2006040563 W US 2006040563W WO 2007047680 A3 WO2007047680 A3 WO 2007047680A3
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- WO
- WIPO (PCT)
- Prior art keywords
- radical
- sam
- increasing
- enzymes
- activity
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
- C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/52—Propionic acid; Butyric acids
Abstract
The present disclosure provides methods of increasing the activity of radical S-adenosyl methionine (SAM) enzymes, for example by increasing expression of ferredoxin, flavodoxin, flavodoxin reductase, or combinations thereof in a cell expressing a radical SAM enzyme. Such methods can be used to increase expression of a radical SAM enzyme product, or a downstream organic chemical. Also provided by the present disclosure are cells that have increased expression of ferredoxin, flavodoxin, flavodoxin reductase, or combination thereof. Such cells can be used to practice the disclosed methods.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72692505P | 2005-10-14 | 2005-10-14 | |
US60/726,925 | 2005-10-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007047680A2 WO2007047680A2 (en) | 2007-04-26 |
WO2007047680A3 true WO2007047680A3 (en) | 2007-11-29 |
Family
ID=37963215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/040563 WO2007047680A2 (en) | 2005-10-14 | 2006-10-16 | Increasing the activity of radical s-adenosyl methionine (sam) enzymes |
Country Status (1)
Country | Link |
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WO (1) | WO2007047680A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8652816B2 (en) | 2007-12-04 | 2014-02-18 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
US8883464B2 (en) | 2009-09-27 | 2014-11-11 | Opx Biotechnologies, Inc. | Methods for producing 3-hydroxypropionic acid and other products |
US9512057B2 (en) | 2013-03-15 | 2016-12-06 | Cargill, Incorporated | 3-hydroxypropionic acid compositions |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04006894A (en) | 2002-01-18 | 2004-10-15 | Cargill Inc | Alanine 2,3- aminomutase. |
CA2574280A1 (en) * | 2004-07-30 | 2006-03-02 | Cargill, Incorporated | Alanine 2, 3 aminomutases |
MX2007004980A (en) | 2004-10-25 | 2007-06-14 | Codexis Inc | Improved alanine 2,3-aminomutases and related polynucleotides. |
WO2007047773A2 (en) | 2005-10-14 | 2007-04-26 | Codexis, Inc. | Alanine 2,3-aminomutases and related polynucleotides |
WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
KR20150040359A (en) | 2012-08-10 | 2015-04-14 | 오피엑스 바이오테크놀로지스, 인크. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
US20150057465A1 (en) | 2013-03-15 | 2015-02-26 | Opx Biotechnologies, Inc. | Control of growth-induction-production phases |
JP6603658B2 (en) | 2013-07-19 | 2019-11-06 | カーギル インコーポレイテッド | Microorganisms and methods for the production of fatty acids and fatty acid derivatives |
US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
WO2018127544A1 (en) * | 2017-01-06 | 2018-07-12 | Eth Zurich | USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES |
US11345938B2 (en) | 2017-02-02 | 2022-05-31 | Cargill, Incorporated | Genetically modified cells that produce C6-C10 fatty acid derivatives |
-
2006
- 2006-10-16 WO PCT/US2006/040563 patent/WO2007047680A2/en active Application Filing
Non-Patent Citations (1)
Title |
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JENKINS ET AL.: "Flavoxodin and NADPH-Flavodoxin Reductase from Escherichia coli Support Bovine Cytochrome P450c17 Hydroxylase Activities", J. BIOL. CHEM., vol. 269, no. 44, 4 November 1994 (1994-11-04), pages 27401 - 27408 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8652816B2 (en) | 2007-12-04 | 2014-02-18 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
US8883464B2 (en) | 2009-09-27 | 2014-11-11 | Opx Biotechnologies, Inc. | Methods for producing 3-hydroxypropionic acid and other products |
US9388419B2 (en) | 2009-09-27 | 2016-07-12 | Cargill, Incorporated | Methods for producing 3-hydroxypropionic acid and other products |
US9428778B2 (en) | 2009-09-27 | 2016-08-30 | Cargill, Incorporated | Method for producing 3-hydroxypropionic acid and other products |
US9512057B2 (en) | 2013-03-15 | 2016-12-06 | Cargill, Incorporated | 3-hydroxypropionic acid compositions |
Also Published As
Publication number | Publication date |
---|---|
WO2007047680A2 (en) | 2007-04-26 |
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