WO2005049071A3 - Epithelium treatment methods and devices for treating the epithelium - Google Patents

Epithelium treatment methods and devices for treating the epithelium Download PDF

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Publication number
WO2005049071A3
WO2005049071A3 PCT/US2004/038186 US2004038186W WO2005049071A3 WO 2005049071 A3 WO2005049071 A3 WO 2005049071A3 US 2004038186 W US2004038186 W US 2004038186W WO 2005049071 A3 WO2005049071 A3 WO 2005049071A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelium
delamination
eye
treatment
devices
Prior art date
Application number
PCT/US2004/038186
Other languages
French (fr)
Other versions
WO2005049071A2 (en
Inventor
Edward Perez
Original Assignee
Edward Perez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edward Perez filed Critical Edward Perez
Priority to MXPA06005434A priority Critical patent/MXPA06005434A/en
Priority to BRPI0416037-1A priority patent/BRPI0416037A/en
Priority to JP2006539983A priority patent/JP2007511293A/en
Priority to AU2004291138A priority patent/AU2004291138A1/en
Priority to EP04811056A priority patent/EP1706080A2/en
Priority to CA002545885A priority patent/CA2545885A1/en
Publication of WO2005049071A2 publication Critical patent/WO2005049071A2/en
Publication of WO2005049071A3 publication Critical patent/WO2005049071A3/en
Priority to IL175579A priority patent/IL175579A0/en
Priority to US11/434,725 priority patent/US20070016292A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
    • A61F9/0133—Knives or scalpels specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Described here are methods and devices for treating an eye, where an epithelial flap has been raised from the eye by epithelial delamination. Some of the treatment methods comprise administering an effective treatment agent to a cornea, epithelium, or eye, before, during, or after the delamination. A number of treatment agents are described. Exemplary treatment agents include adhesion molecules, lubricants, nourishing agents, growth factors, and the like. Other described treatment methods and the devices for such treatment involve cooling the eye, epithelium, or cornea, before, during, or after the delamination. In some variations, the step of cooling comprises cooling a delaminating device to an effective temperature during the delamination. In other variations, the step of cooling comprises introducing a cool fluid to the eye, epithelium, or cornea, before, during, or after the delamination. Other described methods involve the modification of a bandage contact lens, and the introduction of intact epithelial cells to the epithelial flap.
PCT/US2004/038186 2003-11-14 2004-11-15 Epithelium treatment methods and devices for treating the epithelium WO2005049071A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA06005434A MXPA06005434A (en) 2003-11-14 2004-11-15 Epithelium treatment methods and devices for treating the epithelium.
BRPI0416037-1A BRPI0416037A (en) 2003-11-14 2004-11-15 processes and devices for treating epithelium
JP2006539983A JP2007511293A (en) 2003-11-14 2004-11-15 Method of epithelial treatment and device for treating epithelium
AU2004291138A AU2004291138A1 (en) 2003-11-14 2004-11-15 Epithelium treatment methods and devices for treating the epithelium
EP04811056A EP1706080A2 (en) 2003-11-14 2004-11-15 Epithelium treatment methods and devices for treating the epithelium
CA002545885A CA2545885A1 (en) 2003-11-14 2004-11-15 Epithelium treatment methods and devices for treating the epithelium
IL175579A IL175579A0 (en) 2003-11-14 2006-05-11 Epithelium treatment methods and devices for treating the epithelium
US11/434,725 US20070016292A1 (en) 2003-11-14 2006-05-15 Epithelium treatment methods and devices for treating the epithelium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51990303P 2003-11-14 2003-11-14
US60/519,903 2003-11-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/434,725 Continuation-In-Part US20070016292A1 (en) 2003-11-14 2006-05-15 Epithelium treatment methods and devices for treating the epithelium

Publications (2)

Publication Number Publication Date
WO2005049071A2 WO2005049071A2 (en) 2005-06-02
WO2005049071A3 true WO2005049071A3 (en) 2005-11-17

Family

ID=34619393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/038186 WO2005049071A2 (en) 2003-11-14 2004-11-15 Epithelium treatment methods and devices for treating the epithelium

Country Status (10)

Country Link
EP (1) EP1706080A2 (en)
JP (1) JP2007511293A (en)
KR (1) KR20060126971A (en)
CN (1) CN1905847A (en)
AU (1) AU2004291138A1 (en)
BR (1) BRPI0416037A (en)
CA (1) CA2545885A1 (en)
IL (1) IL175579A0 (en)
MX (1) MXPA06005434A (en)
WO (1) WO2005049071A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2498717A1 (en) 2002-09-13 2004-03-25 Ocular Sciences, Inc. Devices and methods for improving vision
TW200803820A (en) * 2006-03-28 2008-01-16 Tissue Engineering Refraction Inc Partially lubricious epithelial delaminator
US7883520B2 (en) 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
GB0620537D0 (en) * 2006-10-17 2006-11-22 Univ Southampton Copolymers suitable for use in corneal bandages
CN101965357B (en) * 2007-08-15 2014-11-05 特拉维夫大学拉莫特有限公司 Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair
WO2017180851A1 (en) 2016-04-13 2017-10-19 Avedro, Inc. Systems and methods for delivering drugs to an eye

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627207A1 (en) * 1992-11-20 1994-12-07 OKAMOTO, Shinseiro Cornea operating method and apparatus
WO2003061518A2 (en) * 2002-01-17 2003-07-31 Edward Perez Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1325891B (en) * 2001-06-22 2004-12-30 Abb Service Srl MINIATURIZED SWITCH POLO

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627207A1 (en) * 1992-11-20 1994-12-07 OKAMOTO, Shinseiro Cornea operating method and apparatus
WO2003061518A2 (en) * 2002-01-17 2003-07-31 Edward Perez Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses

Also Published As

Publication number Publication date
AU2004291138A1 (en) 2005-06-02
CN1905847A (en) 2007-01-31
WO2005049071A2 (en) 2005-06-02
KR20060126971A (en) 2006-12-11
IL175579A0 (en) 2006-09-05
EP1706080A2 (en) 2006-10-04
JP2007511293A (en) 2007-05-10
BRPI0416037A (en) 2007-01-02
MXPA06005434A (en) 2007-01-25
CA2545885A1 (en) 2005-06-02

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