WO2005035058A1 - Dispositif mobile pour des diagnostics, des therapies et des procedes photodynamiques - Google Patents

Dispositif mobile pour des diagnostics, des therapies et des procedes photodynamiques Download PDF

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Publication number
WO2005035058A1
WO2005035058A1 PCT/HR2004/000035 HR2004000035W WO2005035058A1 WO 2005035058 A1 WO2005035058 A1 WO 2005035058A1 HR 2004000035 W HR2004000035 W HR 2004000035W WO 2005035058 A1 WO2005035058 A1 WO 2005035058A1
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WO
WIPO (PCT)
Prior art keywords
therapy
light
cluster
photodynamic
fitted
Prior art date
Application number
PCT/HR2004/000035
Other languages
English (en)
Inventor
Antun Persin
Kreso Tisaj
Hrvoje Zorc
Vitomir Stanisic
Roudnicky Dunja Soldo
Nenad Agatic
Martin Loncaric
Anton Radman
Original Assignee
Rudjer Boskovic Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rudjer Boskovic Institute filed Critical Rudjer Boskovic Institute
Publication of WO2005035058A1 publication Critical patent/WO2005035058A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes

Definitions

  • the invention concerns a mobile device for external photodynamic diagnostics and therapy and methods.
  • External photodynamic therapy is a method of medical treatment for pathological skin changes which utilizes photo-sensitizers and lights.
  • Photo-sensitizers are mostly derivatives of porp yrine, while light sources used for photodynamic therapy are bulbs, lasers, arc lamps, fluorescent tubes and light-emitting diodes.
  • Today, the most frequently used photo-sensitizer is the 5-aminolevulinic acid (abbr.
  • 5-ALA the abbreviation ALA-PDT is already accepted worldwide for photodynamic therapy which uses 5-aminolevulinic acid as photo-sensitizers.
  • 5-ALA the abbreviation of 5-ALA in photodynamic therapy is the simplicity of its application.
  • PpIX proto-porphyrine IX
  • the maximum degree of absorption occurs at a wave length of about 407 nm, followed by gradually decreasing maximums at wave lengths of about 504 nm, 538 nm, 575 nm, and the lowest degree at about 635 nm. Diagnostics utilizes the highest maximum at about 407 nm.
  • fluorescence of PpIX occurs in the red section of the spectrum, with a maximum level being reached at about 635 nm. Since the accumulation of PpIX in skin affected by pathological changes is considerably higher than is the case in healthy skin, the intensity of fluorescent light of pathological changes of skin is going to be several times stronger than the intensity of fluorescence of healthy skin.
  • the existing devices target two maximums: a short wave absorption maximum of about 407 nm for shallow tumours such as keratosis, or a long wave absorption maximum of about 635 nm for deeper tumours.
  • Illuminators based on discreet light-emitting diodes are effective in the transformation of electric energy into light energy, but they are used for stationary illuminators since a number of light-emitting diodes are required if the intensity required for phototherapy is to be achieved (for instance, illumination lamps based on discreet light-emitting diodes produced by PHOTOCURE).
  • a discreet light-emitting diode is a miniature lamp, 3 mm or 5 mm in diameter, whose light source is a small crystal of a light-emitting diode, its most common dimension being 0.3 mm x 0.3mm.
  • the invention is a portable device for external photodynamic diagnostics and therapy which is fully computer controlled, which has a camera for storage of photographs of a lesion prior to therapy, during diagnostic process, during therapy and after therapy, and which uses a new type of lamp comprising a considerable number of light-emitting diode crystals, evenly and closely spaced in two dimensions on a base which conducts thenrial energy and insulates electric energy - as a light source.
  • the crystals are encased in transparent optical material such as silicon or epoxy, or are hermetically sealed in a capsule with a glass window.
  • This new source of light consisting of a considerable number of small crystals of light-emitting diodes, was named "Cluster LED" (Light Emitting Diode).
  • the cluster Since the light-emitting diodes emit light as a Lambert source - into the hemisphere, the cluster is fitted into a reflector of a suitable shape - most usually paraboloidal, which considerably reduces the divergence of radiated light. Further divergence reduction is achieved by placing an appropriately shaped dioptre in front of the reflector.
  • This 95 combination of a cluster, reflector and dioptre creates a new type of lamp based on light- emitting diodes - a "cluster-lamp" of light-emitting diodes, or cluster LED lamp.
  • This invention employs the "cluster LED lamp” as a light source for photodynamic therapy, since it is inexpensive, light and effective. Available on the market are highly efficient clusters which emit light in the violet segment of the spectrum, with a maximum emission
  • this invention can also be used for photodynamic therapy with those photo-sensitizers.
  • the invention comprises a string of such clusters of light-emitting diodes together
  • the light-emitting diode cluster (1) consists of a considerable number of small crystals of light-emitting diodes (2), which are arranged bi-dimensionally on a base that is electrically insulated and able to conduct thermal energy (3), and is itself fixed to a metal base (4).
  • diodes (2) are encased in transparent optic material (5), silicon or epoxy, but they can also be hermetically sealed in a capsule with a glass window. Electric energy supply for the light-emitting diode cluster (1) is fed via the contact (6) to which the light-emitting diode crystals are connected (2). The light-emitting diode cluster (1) is secured with screws to an appropriate cooler (7). A light-emitting diode cluster (1) is available on the market as a
  • the existing light-emitting diode clusters (1) emitting in the visible spectrum have maximums distributed along the entire spectrum - depending on the producer. At this point in time the market offers clusters with maximums in the visible spectrum at, for example, 405 nm, 430 nm, 450 nm, 467 nm, 505 nm, 520
  • Fig. 2 presents the light-emitting diode cluster lamp (10) comprising a light-emitting diode cluster (1), reflector (8) and dioptre (9).
  • the reflector (8) can be made of metal or plastic with a steam-bonded reflective layer on the inside. The aim is to collect as much light emitted by the light-emitting diode crystals into the hemisphere as possible, and to
  • Dioptre (9) serves to further reduce divergence and increase the homogeneity of the beam.
  • Dioptre can be a lens, a spherical or a spherical plane, the Fresnel lens, axicon or a window. Almost all combinations of a
  • Fig. 3 Presents the head (32) of the mobile device for photodynamic diagnostic and therapy and methods, where a CCD camera (12) is fitted to the cooler (11), where the cluster-lamps (13) designed to provoke fluorescence in photo-sensitizers are positioned
  • cooling ventilators 21
  • necessary electronics (25) for supplying the cluster- lamps for diagnostics; (26) for supplying the cluster lamps for therapy; (27) supplying the cluster-lamps for illumination; (28) for supplying the pointers (19); (29) for supplying the ventilator (21).
  • the electronic elements are linked to the control electronics (31),
  • FIG. 4 presents an overview of the whole mobile device for photodynamic diagnostics and therapy and methods, where the head (32) is fitted to a mechanical arm (33) which can be translated into a wheeled casing (34), within which lie the control electronics (31) and the source of power supply (35), which are mutually interlinked as
  • the outside computer is linked to the CCD camera (12), and with the control electronics (31), by way of which the entire device for photodynamic diagnostics and therapy and methods is controlled (36).
  • Method of industrial or other application of the invention The method of industrial or other application of the invention is visible from the description of the invention.

Abstract

L'invention porte sur un dispositif mobile pour des diagnostics, des thérapies et des procédés photodynamiques, qui est entièrement contrôlé par ordinateur, qui est doté d'une caméra afin de stocker des photographies de lésions avant la thérapie, au cours du diagnostic, pendant la thérapie et après la thérapie, et qui utilise une source de lumière sous la forme d'un nouveau type de lampe en grappe faite d'un nombre élevé de petits cristaux pour diodes électroluminescentes, un réflecteur et un dioptre.
PCT/HR2004/000035 2003-10-10 2004-10-07 Dispositif mobile pour des diagnostics, des therapies et des procedes photodynamiques WO2005035058A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HRP20030817A 2003-10-10
HR20030817A HRP20030817A2 (hr) 2003-10-10 2003-10-10 Mobilni uređaj za fotodinamičku dijagnostiku i terapiju i metode

Publications (1)

Publication Number Publication Date
WO2005035058A1 true WO2005035058A1 (fr) 2005-04-21

Family

ID=34430651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HR2004/000035 WO2005035058A1 (fr) 2003-10-10 2004-10-07 Dispositif mobile pour des diagnostics, des therapies et des procedes photodynamiques

Country Status (2)

Country Link
HR (1) HRP20030817A2 (fr)
WO (1) WO2005035058A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119084A1 (fr) * 2006-04-19 2007-10-25 Ruder Boskovic Institute Dispositif d'iirradiation séquentielle intelligent
WO2010142430A1 (fr) 2009-06-09 2010-12-16 Helbo Photodynamic Systems Gmbh & Co. Kg Dispositif et procédé de photochimiothérapie
CZ305993B6 (cs) * 2015-05-18 2016-06-08 Univerzita PalackĂ©ho Plošný zdroj záření, zejména k navození a monitorování fotodynamického jevu in vitro

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9112188U1 (fr) * 1991-09-30 1991-12-19 Steiger, Erwin, Dipl.-Phys., 8038 Groebenzell, De
WO1998025528A1 (fr) * 1996-12-10 1998-06-18 Asah Medico A/S Dispositif servant a effectuer le traitement esthetique d'un tissu
US20010023363A1 (en) * 1998-07-09 2001-09-20 Yoram Harth Apparatus and method for high energy photodynamic therapy of acne vulgaris and seborrhea
EP1281370A2 (fr) * 2001-08-03 2003-02-05 Susann Edel Dispositif d'irradiation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9112188U1 (fr) * 1991-09-30 1991-12-19 Steiger, Erwin, Dipl.-Phys., 8038 Groebenzell, De
WO1998025528A1 (fr) * 1996-12-10 1998-06-18 Asah Medico A/S Dispositif servant a effectuer le traitement esthetique d'un tissu
US20010023363A1 (en) * 1998-07-09 2001-09-20 Yoram Harth Apparatus and method for high energy photodynamic therapy of acne vulgaris and seborrhea
EP1281370A2 (fr) * 2001-08-03 2003-02-05 Susann Edel Dispositif d'irradiation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119084A1 (fr) * 2006-04-19 2007-10-25 Ruder Boskovic Institute Dispositif d'iirradiation séquentielle intelligent
HRP20060149B1 (en) * 2006-04-19 2008-11-30 Institut "Ruđer Bošković" Intelligent sequential illuminator photodynamic therapy
WO2010142430A1 (fr) 2009-06-09 2010-12-16 Helbo Photodynamic Systems Gmbh & Co. Kg Dispositif et procédé de photochimiothérapie
DE102010023258A1 (de) 2009-06-09 2011-04-07 Helbo Photodynamic Systems Gmbh & Co. Kg Vorrichtung und Verfahren für die photodynamische Therapie
CZ305993B6 (cs) * 2015-05-18 2016-06-08 Univerzita PalackĂ©ho Plošný zdroj záření, zejména k navození a monitorování fotodynamického jevu in vitro
WO2016184441A1 (fr) 2015-05-18 2016-11-24 Univerzita Palackého v Olomouci Source d'irradiation plane spécialement conçue pour l'induction et la surveillance in vitro d'effet photodynamique

Also Published As

Publication number Publication date
HRP20030817A2 (hr) 2006-04-30

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