WO2005033711A3 - Clot-lyse-assay - Google Patents

Clot-lyse-assay Download PDF

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Publication number
WO2005033711A3
WO2005033711A3 PCT/DE2004/002224 DE2004002224W WO2005033711A3 WO 2005033711 A3 WO2005033711 A3 WO 2005033711A3 DE 2004002224 W DE2004002224 W DE 2004002224W WO 2005033711 A3 WO2005033711 A3 WO 2005033711A3
Authority
WO
WIPO (PCT)
Prior art keywords
clot lysis
lysis assay
streptokinase
assay
psac
Prior art date
Application number
PCT/DE2004/002224
Other languages
English (en)
French (fr)
Other versions
WO2005033711A2 (de
Inventor
Thomas Stief
Harald Renz
Original Assignee
Transmit Technologietransfer
Thomas Stief
Harald Renz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transmit Technologietransfer, Thomas Stief, Harald Renz filed Critical Transmit Technologietransfer
Publication of WO2005033711A2 publication Critical patent/WO2005033711A2/de
Publication of WO2005033711A3 publication Critical patent/WO2005033711A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung bezieht sich auf eine neue Methode eines Clot-Lyse-Assays, der zur Untersuchung der Thrombolyse, insbesondere durch Urokinase (u-PA), t-PA, Streptokinase (SK), Plasminogen-Streptokinase-Aktivator-Komplex (PSAC), Reteplase (RP) oder Tenecteplase (TP), verwendet werden kann.
PCT/DE2004/002224 2003-10-06 2004-10-05 Clot-lyse-assay WO2005033711A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10346751.3 2003-10-06
DE2003146751 DE10346751A1 (de) 2003-10-06 2003-10-06 Clot-Lysis-Assay

Publications (2)

Publication Number Publication Date
WO2005033711A2 WO2005033711A2 (de) 2005-04-14
WO2005033711A3 true WO2005033711A3 (de) 2005-06-02

Family

ID=34353347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/002224 WO2005033711A2 (de) 2003-10-06 2004-10-05 Clot-lyse-assay

Country Status (2)

Country Link
DE (1) DE10346751A1 (de)
WO (1) WO2005033711A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3838529A1 (de) * 1988-11-14 1990-05-17 Behringwerke Ag Globaltest zur erfassung der hauptkomponenten des fibrinolysesystems
DE3917949A1 (de) * 1989-05-30 1991-01-24 Schering Ag Neues thrombolytikum
DE19903693A1 (de) * 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease zur Aktivierung des Gerinnungsfaktors VII
EP0937146A2 (de) * 1996-09-20 1999-08-25 The General Hospital Corporation Zusammensetzung und verfahren zur verstärkung von fibrinolyse unter verwendung von antikörpern gegen alpha2-antiplasmin
DE19756773A1 (de) * 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Neues Verfahren und Diagnosemittel zur Hämostase-Diagnostik

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1989, BERRETTINI M ET AL: "INTERACTION OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR WITH THE ENZYMES OF THE CONTACT ACTIVATION SYSTEM", XP002318600, Database accession no. PREV198988071035 *
JONES A J ET AL: "A precise and rapid microtitre plate clot lysis assay: methodology, kinetic modeling and measurement of catalytic constants for plasminogen activation during fibrinolysis.", THROMBOSIS AND HAEMOSTASIS. 30 NOV 1990, vol. 64, no. 3, 30 November 1990 (1990-11-30), pages 455 - 463, XP009044274, ISSN: 0340-6245 *
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, no. 20, 1989, pages 11738 - 11743, ISSN: 0021-9258 *
MISCHKE R: "Sensitivity of the reaction time of the resonance thrombogram for factor VIII:C and factor IX deficiencies in the blood of dogs with haemophilia A or B.", HAEMOPHILIA : THE OFFICIAL JOURNAL OF THE WORLD FEDERATION OF HEMOPHILIA. SEP 2000, vol. 6, no. 5, September 2000 (2000-09-01), pages 575 - 580, XP002318599, ISSN: 1351-8216 *
SWANK P R ET AL: "A computer program for microplate reader interface and analysis of kinetic, microclot lysis assays.", THROMBOSIS RESEARCH. 15 OCT 1991, vol. 64, no. 2, 15 October 1991 (1991-10-15), pages 235 - 242, XP002318597, ISSN: 0049-3848 *
TORBET J: "The thrombin activation pathway modulates the assembly, structure and lysis of human plasma clots in vitro.", THROMBOSIS AND HAEMOSTASIS. MAY 1995, vol. 73, no. 5, May 1995 (1995-05-01), pages 785 - 792, XP001076643, ISSN: 0340-6245 *
VON DEM BORNE P A ET AL: "Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis.", BLOOD. 15 OCT 1995, vol. 86, no. 8, 15 October 1995 (1995-10-15), pages 3035 - 3042, XP002318596, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2005033711A2 (de) 2005-04-14
DE10346751A1 (de) 2005-04-21

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