WO2005033121A3 - Synthese de 2-aralkyloxyadenosines, 2-alkoxyadenosines, et leurs analogues - Google Patents

Synthese de 2-aralkyloxyadenosines, 2-alkoxyadenosines, et leurs analogues Download PDF

Info

Publication number
WO2005033121A3
WO2005033121A3 PCT/US2004/032762 US2004032762W WO2005033121A3 WO 2005033121 A3 WO2005033121 A3 WO 2005033121A3 US 2004032762 W US2004032762 W US 2004032762W WO 2005033121 A3 WO2005033121 A3 WO 2005033121A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkoxyadenosines
aralkyloxyadenosines
analogs
synthesis
haloadenosineis
Prior art date
Application number
PCT/US2004/032762
Other languages
English (en)
Other versions
WO2005033121A2 (fr
Inventor
Allan R Moorman
Michael Scannell
Thiagarajan Balasubramanian
Russell Outcalt
Original Assignee
King Pharmaceuticals Res & Dev
Allan R Moorman
Michael Scannell
Thiagarajan Balasubramanian
Russell Outcalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King Pharmaceuticals Res & Dev, Allan R Moorman, Michael Scannell, Thiagarajan Balasubramanian, Russell Outcalt filed Critical King Pharmaceuticals Res & Dev
Publication of WO2005033121A2 publication Critical patent/WO2005033121A2/fr
Publication of WO2005033121A3 publication Critical patent/WO2005033121A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé pratique qui permet de résoudre plusieurs des problèmes des procédés de la technique antérieure dans la synthèse de 2-[2-(4-chlorophényl)éthoxy]adénosine et de ses analogues. Ledit procédé présente des avantages au niveau du coût, de l'efficacité et de la pureté du produit final. Pour bénéficier desdits avantages, la réaction n'est pas extrêmement variable et dépend de la quantité d'alkoxyde utilisée, selon qu'elle est réalisée de manière nette ou dans divers solvants. Cette invention a aussi pour objet des avantages au niveau de l'extensibilité et du coût, tandis qu'est obtenu un produit final de pureté élevée.
PCT/US2004/032762 2003-10-03 2004-10-04 Synthese de 2-aralkyloxyadenosines, 2-alkoxyadenosines, et leurs analogues WO2005033121A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50880403P 2003-10-03 2003-10-03
US60/508,804 2003-10-03

Publications (2)

Publication Number Publication Date
WO2005033121A2 WO2005033121A2 (fr) 2005-04-14
WO2005033121A3 true WO2005033121A3 (fr) 2005-07-28

Family

ID=34421789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/032762 WO2005033121A2 (fr) 2003-10-03 2004-10-04 Synthese de 2-aralkyloxyadenosines, 2-alkoxyadenosines, et leurs analogues

Country Status (1)

Country Link
WO (1) WO2005033121A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
BRPI0614290A2 (pt) 2005-08-08 2011-03-22 Argenta Discovery Ltd derivados de biciclo [ 2.2.1 ] hept-7-ilamina e seus usos
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
KR101461263B1 (ko) 2005-10-21 2014-11-17 노파르티스 아게 Ｉｌ-13에 대항한 인간 항체 및 치료적 용도
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2007121920A2 (fr) 2006-04-21 2007-11-01 Novartis Ag Composés organiques
JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
PT2379507E (pt) 2008-12-30 2014-01-21 Pulmagen Therapeutics Inflammation Ltd Compostos de sulfonamida para o tratamento de desordens respiratórias
WO2010150014A1 (fr) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited Glitazones 5r-5–deutérés pour le traitement de maladies respiratoires
ME01528B (me) * 2009-09-21 2014-04-20 Gilead Sciences Inc POSTUPCI l INTERMEDIJERI ZA PROIZVODNJU 1'-CIJANOKARBANUKLEOZIDIH ANALOGA
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
WO2011098746A1 (fr) 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Sels d'addition acide cristallins de l'énantiomère (5r) de la pioglitazone
GB201002243D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
GB201002224D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
WO2012034095A1 (fr) 2010-09-09 2012-03-15 Irm Llc Composés et compositions comme inhibiteurs de trk
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
MA34969B1 (fr) 2011-02-25 2014-03-01 Irm Llc Composes et compositions en tant qu inibiteurs de trk

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430027A (en) * 1992-05-14 1995-07-04 Novo Nordisk A/S 2-chloro-N6 -substituted adenosines, their pharmaceutical compositions, and activity in treating ischemias
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
US5484774A (en) * 1992-12-23 1996-01-16 Novo Nordisk A/S 2, N6 -disubstituted adenosines, tri-O-ester derivatives and their pharmaceutical compositions to treat ischemias
US5654285A (en) * 1991-04-06 1997-08-05 Astra Pharmaceuticals Limited ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation
WO1997033591A1 (fr) * 1996-03-13 1997-09-18 Novo Nordisk A/S Procede de traitement d'affections associees aux cytokines chez les mammiferes
US5683989A (en) * 1993-12-17 1997-11-04 Novo Nordisk A/S Treatment of ischemias by administration of 2,N6 -substituted adenosines

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654285A (en) * 1991-04-06 1997-08-05 Astra Pharmaceuticals Limited ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
US5578582A (en) * 1991-10-24 1996-11-26 Novo Nordisk A/S Methods of treating ischemia with C2, N6 -disubstituted adenosine derivatives
US5430027A (en) * 1992-05-14 1995-07-04 Novo Nordisk A/S 2-chloro-N6 -substituted adenosines, their pharmaceutical compositions, and activity in treating ischemias
US5484774A (en) * 1992-12-23 1996-01-16 Novo Nordisk A/S 2, N6 -disubstituted adenosines, tri-O-ester derivatives and their pharmaceutical compositions to treat ischemias
US5683989A (en) * 1993-12-17 1997-11-04 Novo Nordisk A/S Treatment of ischemias by administration of 2,N6 -substituted adenosines
WO1997033591A1 (fr) * 1996-03-13 1997-09-18 Novo Nordisk A/S Procede de traitement d'affections associees aux cytokines chez les mammiferes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HALBFINGER ET AL: "Molecular Recognition of modified Adenine Nucleotides by the P2y(1)-Receptor. 1.A Synthetic Biochemical, and NMR Approach", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 26, December 1999 (1999-12-01), pages 5325 - 5337, XP002987238 *
KOCHETKOV ET AL: "Organic Chemistry of Nucleic Acids, Part B", 1972, PLENUM PRESS, NEW YORK, pages: 453 *
MARUMOTO ET AL: "Synthesis and Coronary Vasodilating Activity of 2-Substituted Adenosines", CHEMICAL & PHARMACEUTICAL BULLETIN (JAPAN), vol. 23, no. 4, 1975, pages 759 - 774, XP002154408 *
MARUMOTO ET AL: "Synthesis and Enzymatic Activity of Adenosine 3',5'-Cyclic Phosphate Analogs", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 27, no. 4, April 1979 (1979-04-01), pages 990 - 1003, XP001094185 *
ROBINS ET AL: "Nucleic Acid Related Compounds. 114. Synthesis of 2,6-(Disubstituted)purine 2',3'-Dinucleosides and Selected Cytotoxic, Anti-Hepatitis B, and Adenosine Deaminase Substrate Activities", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 38, no. 6, November 2001 (2001-11-01) - December 2001 (2001-12-01), pages 1297 - 1306, XP002952782 *
SMITH ET AL: "March's Advanced Organic Chemistry - Reactions, Mechanisms, and Structure", 2001, JOHN WILEY & SONS, NEW YORK, pages: 486 - 487 *
WANNER ET AL: "2-Nitro Analogues of Adenosine and 1-Deazaadenosine: Synthesis and Binding Studies at the Adenosine A1, A2A and A3 Receptor Subtypes", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 18, 18 September 2000 (2000-09-18), pages 2141 - 2144, XP004208330 *

Also Published As

Publication number Publication date
WO2005033121A2 (fr) 2005-04-14

Similar Documents

Publication Publication Date Title
WO2005033121A3 (fr) Synthese de 2-aralkyloxyadenosines, 2-alkoxyadenosines, et leurs analogues
MX270158B (es) Produccion de un producto de fermentacion.
ZA200307450B (en) Process for the production of synthesis gas.
HUE037560T2 (hu) Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására
WO2003089445A3 (fr) Processus de reaction et separation pour la fabrication d'alcools de sucres dianhydro
GB0218010D0 (en) Production of a fermentation product
WO2002030870A3 (fr) Derives de c-cyclohexylmethylamine substitues
AU2003301287A1 (en) Process for the preparation of a coffee product
MX272734B (es) Procedimiento para la produccion de un producto alimenticio congelado.
AU2003229726A1 (en) Method for producing alkoxylated products at optimized reaction pressures
AU2003258667A1 (en) Method for the production by fermentation of sulphur-containing fine chemicals (metf)
WO2008062325A3 (fr) Procédé et appareil de production de produit au moyen d'une coquille de moule incurvable
WO2005063731A3 (fr) Production de dihydronepetalactone par reduction de l'acide nepetalique
WO2004014337A3 (fr) Procede de preparation d'un comprime dispersible de cephalexine
AU2003300727A1 (en) Process for synthesis of alpha-substituted acroleins
AU2003290401A1 (en) A process for industrially viable preparation of (s,s,s) phenylmethyl-2-azabicyclo-(3.3.0)-octane-3-carboxylate tosylate
ZA200500606B (en) Method for the continuous intermediate seperation of an oxirane produced by the oxirane synthesis with no coupling product by means of a partition-wall column
AU4291901A (en) Process for the production of 2-hydroxyethylmaleimide and the product obtained by the process
MXPA03002694A (es) Compuestos de 5-fenilbencilamina, procedimiento para su produccion e intermediarios para su sintesis.
WO2004034983A3 (fr) Preparation de composes triazospiro
WO2003080567A3 (fr) Produits intermediaires destines a la synthese de la discodermolide et de ses analogues, et leurs procedes de preparation
ES2183718A1 (es) Nuevo procedimiento para la preparacion de hidroxiarilglicinas, alcoxiarilglicinas y sus glicinatos.
CA2510174A1 (fr) Procede de preparation d'(-)-epicatechine a partir d'une nouvelle source naturelle, dichrostachys cinerea
AU2003292637A1 (en) Process for producing chocolate
AU2001266323A1 (en) Process for the production of calcium pantothenate

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
122 Ep: pct application non-entry in european phase