WO2005016936A3 - Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables - Google Patents

Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables Download PDF

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Publication number
WO2005016936A3
WO2005016936A3 PCT/IB2004/002648 IB2004002648W WO2005016936A3 WO 2005016936 A3 WO2005016936 A3 WO 2005016936A3 IB 2004002648 W IB2004002648 W IB 2004002648W WO 2005016936 A3 WO2005016936 A3 WO 2005016936A3
Authority
WO
WIPO (PCT)
Prior art keywords
cefditoren
isomer
esters
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IB2004/002648
Other languages
English (en)
Other versions
WO2005016936A2 (fr
Inventor
Yatendra Kumar
Mohan Prasad
Kaptan Singh
Ashok Prasad
Santosh Richhariya
Original Assignee
Ranbaxy Lab Ltd
Yatendra Kumar
Mohan Prasad
Kaptan Singh
Ashok Prasad
Santosh Richhariya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Yatendra Kumar, Mohan Prasad, Kaptan Singh, Ashok Prasad, Santosh Richhariya filed Critical Ranbaxy Lab Ltd
Priority to EP04744275A priority Critical patent/EP1660505A2/fr
Publication of WO2005016936A2 publication Critical patent/WO2005016936A2/fr
Publication of WO2005016936A3 publication Critical patent/WO2005016936A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

L'invention concerne un procédé sélectif de préparation de l'isomère Z de cefditorène de formule I et de ses sels et esters pharmaceutiquement acceptables. Le cefditorène possède un large spectre d'activité anti-bactérienne contre les bactéries gram positif et gram négatif.
PCT/IB2004/002648 2003-08-14 2004-08-13 Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables WO2005016936A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04744275A EP1660505A2 (fr) 2003-08-14 2004-08-13 Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1004/DEL/2003 2003-08-14
IN1004DE2003 2003-08-14

Publications (2)

Publication Number Publication Date
WO2005016936A2 WO2005016936A2 (fr) 2005-02-24
WO2005016936A3 true WO2005016936A3 (fr) 2005-08-11

Family

ID=34179269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002648 WO2005016936A2 (fr) 2003-08-14 2004-08-13 Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables

Country Status (2)

Country Link
EP (1) EP1660505A2 (fr)
WO (1) WO2005016936A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003141A2 (fr) 2003-07-04 2005-01-13 Orchid Chemicals & Pharmaceuticals Ltd Procede perfectionne pour la preparation de cefditoren
WO2005100369A1 (fr) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Depletion d'e-isomeres dans la preparation de cephalosporines (vinyle susbstitue en 2)-3 enrichies en z
JP4064948B2 (ja) * 2004-06-04 2008-03-19 明治製菓株式会社 ３−アルケニルセフェム化合物及び製造方法
WO2011093294A1 (fr) * 2010-01-27 2011-08-04 日本化学工業株式会社 Procédé de préparation d'un dérivé de céphalosporine
CN104513256B (zh) * 2013-10-07 2018-07-31 鲁南贝特制药有限公司 一种头孢妥仑匹酯的制备方法
CN103665002B (zh) * 2013-12-18 2016-02-03 成都医路康医学技术服务有限公司 一种头孢妥仑匹酯的制备方法
CN104788471B (zh) * 2015-03-23 2017-06-27 浙江华方药业股份有限公司 一种头孢妥仑匹酯母核的合成方法
CN105175432B (zh) * 2015-09-09 2017-05-24 山东罗欣药业集团股份有限公司 一种头孢妥仑匹酯的制备方法
CN106366097A (zh) * 2016-08-19 2017-02-01 陕西思尔生物科技有限公司 一种头孢妥仑匹脂的制备方法
CN108997377B (zh) * 2018-07-27 2020-04-28 湖北凌晟药业有限公司 一种e型7-atca的制备方法
CN110655527A (zh) * 2019-09-20 2020-01-07 北京济美堂医药研究有限公司 一种高纯度头孢妥仑匹酯制备方法
CN113788844A (zh) * 2021-09-08 2021-12-14 湖北凌晟药业有限公司 一种e型头孢妥仑钠的制备方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839350A (en) * 1984-09-07 1989-06-13 Meiji Seika Kaisha, Ltd. Cephalosporin compounds and the production thereof
US4918068A (en) * 1986-03-03 1990-04-17 Meiji Seika Kaisha, Ltd. Cephem compounds
US5233035A (en) * 1989-09-26 1993-08-03 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0597429A2 (fr) * 1992-11-10 1994-05-18 Biochemie Gesellschaft M.B.H. Procédé pour la préparation de 3-vinylcéphalosporines
EP0658558A1 (fr) * 1993-11-17 1995-06-21 Biochemie Gesellschaft M.B.H. Séparation d'isomères d'un dérivé de la céphalosporin
EP0723965A1 (fr) * 1993-09-29 1996-07-31 Meiji Seika Kaisha Ltd. Nouveau derive de cephalosporine
EP1016665A1 (fr) * 1997-06-24 2000-07-05 Meiji Seika Kaisha, Ltd. Procede pour l'elaboration selective de z-isomeres de 3-(vinyl substitue en 2) cephalosporines
US20020002279A1 (en) * 1996-09-20 2002-01-03 Kiyoshi Yasui Crystalline substance of cefditoren pivoxyl and the production of the same
WO2003091230A1 (fr) * 2002-04-26 2003-11-06 Orchid Chemicals & Pharmaceuticals Limited Procede de preparation du produit intermediaire 4-methylthiazol-5-carbaldehyde

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839350A (en) * 1984-09-07 1989-06-13 Meiji Seika Kaisha, Ltd. Cephalosporin compounds and the production thereof
US4918068A (en) * 1986-03-03 1990-04-17 Meiji Seika Kaisha, Ltd. Cephem compounds
US5233035A (en) * 1989-09-26 1993-08-03 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0597429A2 (fr) * 1992-11-10 1994-05-18 Biochemie Gesellschaft M.B.H. Procédé pour la préparation de 3-vinylcéphalosporines
EP0723965A1 (fr) * 1993-09-29 1996-07-31 Meiji Seika Kaisha Ltd. Nouveau derive de cephalosporine
EP0658558A1 (fr) * 1993-11-17 1995-06-21 Biochemie Gesellschaft M.B.H. Séparation d'isomères d'un dérivé de la céphalosporin
US20020002279A1 (en) * 1996-09-20 2002-01-03 Kiyoshi Yasui Crystalline substance of cefditoren pivoxyl and the production of the same
EP1016665A1 (fr) * 1997-06-24 2000-07-05 Meiji Seika Kaisha, Ltd. Procede pour l'elaboration selective de z-isomeres de 3-(vinyl substitue en 2) cephalosporines
WO2003091230A1 (fr) * 2002-04-26 2003-11-06 Orchid Chemicals & Pharmaceuticals Limited Procede de preparation du produit intermediaire 4-methylthiazol-5-carbaldehyde

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KENJI SAKAGAMI ET AL.: "Synthesis and Oral Activity of ME1207, a New Orally Active Cephalosporin", THE JOURNAL OF ANTIBIOTICS, vol. XLIII, no. 8, 1990, pages 1047 - 1050, XP009049100 *
SAKAGAMI K ET AL: "SYNTHESIS AND ORAL ACTIVITY OF PIVALOYLOCYMETHYL7-Ä(Z)-2-(2-AMINOTHIA ZOL-4-YL)-2-METHOXYIMINOACETAMIDOÜ-3-(Z)-(4-METHYLTHIAZOL-5-YL)VINYL- 3-CEPHEM-4-CARBOXYLATE (ME1207) AND ITS RELATED COMPOUND", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 39, no. 9, September 1991 (1991-09-01), pages 2433 - 2436, XP009042230, ISSN: 0009-2363 *

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Publication number Publication date
WO2005016936A2 (fr) 2005-02-24
EP1660505A2 (fr) 2006-05-31

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