WO2005010202A3 - PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS - Google Patents

PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS Download PDF

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Publication number
WO2005010202A3
WO2005010202A3 PCT/US2004/023010 US2004023010W WO2005010202A3 WO 2005010202 A3 WO2005010202 A3 WO 2005010202A3 US 2004023010 W US2004023010 W US 2004023010W WO 2005010202 A3 WO2005010202 A3 WO 2005010202A3
Authority
WO
WIPO (PCT)
Prior art keywords
hnf
nuclear factor
acetic acid
acid derivatives
hepatocyte nuclear
Prior art date
Application number
PCT/US2004/023010
Other languages
French (fr)
Other versions
WO2005010202A2 (en
Inventor
Christopher Mapes
Jyun-Hung Chen
Pierre Michellys
Original Assignee
Ligand Pharmacueticals Inc
Christopher Mapes
Jyun-Hung Chen
Pierre Michellys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmacueticals Inc, Christopher Mapes, Jyun-Hung Chen, Pierre Michellys filed Critical Ligand Pharmacueticals Inc
Publication of WO2005010202A2 publication Critical patent/WO2005010202A2/en
Publication of WO2005010202A3 publication Critical patent/WO2005010202A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is directed to hepatocyte nuclear factor 4 α (HNF-4 α) receptor modulator compounds. This invention is also directed to pharmaceutical agents comprising such compounds as well as methods of using such compounds and pharmaceutical agents for modulating HNF-4 α receptors as well as processes mediated by HNF-4 α receptors. Also provided are methods of making such compounds and pharmaceutical agents, as well as intermediates used in their synthesis.
PCT/US2004/023010 2003-07-16 2004-07-16 PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS WO2005010202A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48805703P 2003-07-16 2003-07-16
US60/488,057 2003-07-16

Publications (2)

Publication Number Publication Date
WO2005010202A2 WO2005010202A2 (en) 2005-02-03
WO2005010202A3 true WO2005010202A3 (en) 2005-04-21

Family

ID=34102740

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023010 WO2005010202A2 (en) 2003-07-16 2004-07-16 PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS

Country Status (1)

Country Link
WO (1) WO2005010202A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505509D0 (en) * 2005-03-17 2005-04-27 Ic Innovations Ltd Compounds
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
PT2427417E (en) * 2009-05-04 2014-01-13 Prometic Biosciences Inc Salts of 3-pentylphenylacetic acid and pharmaceutical uses thereof
MY162420A (en) * 2010-10-27 2017-06-15 Prometic Pharma Smt Ltd Compounds and compositions for the treatment of cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847008A (en) * 1996-02-02 1998-12-08 Merck & Co., Inc. Method of treating diabetes and related disease states
US5859051A (en) * 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847008A (en) * 1996-02-02 1998-12-08 Merck & Co., Inc. Method of treating diabetes and related disease states
US5859051A (en) * 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents

Also Published As

Publication number Publication date
WO2005010202A2 (en) 2005-02-03

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