DE60318716D1 - THIENO-PYRROLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONIC RECEPTORS - Google Patents

THIENO-PYRROLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONIC RECEPTORS

Info

Publication number
DE60318716D1
DE60318716D1 DE60318716T DE60318716T DE60318716D1 DE 60318716 D1 DE60318716 D1 DE 60318716D1 DE 60318716 T DE60318716 T DE 60318716T DE 60318716 T DE60318716 T DE 60318716T DE 60318716 D1 DE60318716 D1 DE 60318716D1
Authority
DE
Germany
Prior art keywords
sup
thieno
antagonists
hormonic
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60318716T
Other languages
German (de)
Other versions
DE60318716T2 (en
Inventor
Jean Claude Arnould
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60318716D1 publication Critical patent/DE60318716D1/en
Application granted granted Critical
Publication of DE60318716T2 publication Critical patent/DE60318716T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>6a</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, A and B are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
DE60318716T 2002-08-21 2003-08-18 THIENO-PYRROLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONIC RECEPTORS Expired - Fee Related DE60318716T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02292076 2002-08-21
EP02292076 2002-08-21
PCT/GB2003/003603 WO2004018479A1 (en) 2002-08-21 2003-08-18 Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number Publication Date
DE60318716D1 true DE60318716D1 (en) 2008-03-06
DE60318716T2 DE60318716T2 (en) 2009-01-08

Family

ID=31896981

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318716T Expired - Fee Related DE60318716T2 (en) 2002-08-21 2003-08-18 THIENO-PYRROLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONIC RECEPTORS

Country Status (8)

Country Link
US (1) US7317010B2 (en)
EP (1) EP1532154B1 (en)
JP (1) JP2006508050A (en)
AT (1) ATE384066T1 (en)
AU (1) AU2003267551A1 (en)
DE (1) DE60318716T2 (en)
ES (1) ES2298545T3 (en)
WO (1) WO2004018479A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279493B2 (en) * 2002-06-28 2007-10-09 Euro-Celtique S.A. Therapeutic agents useful for treating pain
TW200407127A (en) * 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
DE602004008474T2 (en) * 2003-07-31 2008-05-15 Wyeth N-SULFONYLHETEROCYCLOPYRROLYL ALKYLAMINE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6-LIGANDS.
CN1942479A (en) * 2004-02-20 2007-04-04 阿斯利康(瑞典)有限公司 Thienopyrroles as antagonists of GnRH
GB0403781D0 (en) * 2004-02-20 2004-03-24 Astrazeneca Ab Chemical compounds
WO2005079805A1 (en) * 2004-02-20 2005-09-01 Astrazeneca Ab Pyrrole derivatives as gonadotropin releasing hormone (gnrh) antagonists
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
MXPA06014574A (en) 2004-06-24 2007-03-12 Incyte Corp N-substituted piperidines and their use as pharmaceuticals.
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
JP2014518223A (en) * 2011-06-20 2014-07-28 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド Compounds and their therapeutic uses

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JPH04356029A (en) 1990-07-02 1992-12-09 Japan Synthetic Rubber Co Ltd Nonlinear optical element
JPH04179949A (en) 1990-11-15 1992-06-26 Fuji Photo Film Co Ltd New dye forming coupler and silver halide color photographic sensitive material using the same
NZ325060A (en) 1995-12-14 2000-02-28 Merck & Co Inc Non peptide indole derivative and their use as antagonists of gonadotropin releasing hormone
JP3092947B2 (en) 1995-12-14 2000-09-25 メルク エンド カンパニー インコーポレーテッド Gonadotropin-releasing hormone antagonist
SK77598A3 (en) 1995-12-14 1999-01-11 Merck & Co Inc Nonpeptide derivatives, pharmaceutical composition containing them and their use
IL124459A0 (en) 1995-12-14 1998-12-06 Merck & Co Inc Antagonists of gonadotropin releasing hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2291829A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2292605A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002502427A (en) 1997-06-05 2002-01-22 メルク エンド カンパニー インコーポレーテッド Gonadotropin-releasing hormone antagonist
WO1998055123A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6156772A (en) 1997-06-05 2000-12-05 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU729663B2 (en) 1997-06-05 2001-02-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU1197299A (en) 1997-10-28 1999-05-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1027046A4 (en) 1997-10-28 2002-04-03 Merck & Co Inc Antagonists of gonadotropin releasing hormone
EP1068195A1 (en) * 1998-02-11 2001-01-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU2597899A (en) 1998-02-11 1999-08-30 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU3367999A (en) 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1071423A1 (en) 1998-04-02 2001-01-31 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2326185A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU3118399A (en) 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002510628A (en) 1998-04-02 2002-04-09 メルク エンド カムパニー インコーポレーテッド Gonadotropin-releasing hormone antagonist
WO1999051595A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6025366A (en) * 1998-04-02 2000-02-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002538208A (en) * 1999-03-10 2002-11-12 メルク エンド カムパニー インコーポレーテッド 6-azaindole compounds as gonadotropin-releasing hormone antagonists
AU3396000A (en) 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
JP2002538204A (en) 1999-03-10 2002-11-12 メルク エンド カムパニー インコーポレーテッド 6-azaindole compounds as gonadotropin-releasing hormone antagonists
CA2366615A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
JP2003526618A (en) 1999-03-10 2003-09-09 メルク エンド カムパニー インコーポレーテッド 6-azaindole compounds as gonadotropin-releasing hormone antagonists
CA2367121A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
AU4738101A (en) * 2000-03-17 2001-10-03 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
SE0100566D0 (en) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (en) * 2001-05-14 2001-05-14 Astrazeneca Ab Compounds

Also Published As

Publication number Publication date
US20060004053A1 (en) 2006-01-05
ATE384066T1 (en) 2008-02-15
DE60318716T2 (en) 2009-01-08
AU2003267551A1 (en) 2004-03-11
EP1532154A1 (en) 2005-05-25
JP2006508050A (en) 2006-03-09
ES2298545T3 (en) 2008-05-16
WO2004018479A1 (en) 2004-03-04
US7317010B2 (en) 2008-01-08
EP1532154B1 (en) 2008-01-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee