WO2005007675A3 - Acides amino triazole-$g(e) - Google Patents

Acides amino triazole-$g(e) Download PDF

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Publication number
WO2005007675A3
WO2005007675A3 PCT/US2004/022081 US2004022081W WO2005007675A3 WO 2005007675 A3 WO2005007675 A3 WO 2005007675A3 US 2004022081 W US2004022081 W US 2004022081W WO 2005007675 A3 WO2005007675 A3 WO 2005007675A3
Authority
WO
WIPO (PCT)
Prior art keywords
epsiv
triazole
amino acids
peptides
small molecule
Prior art date
Application number
PCT/US2004/022081
Other languages
English (en)
Other versions
WO2005007675A2 (fr
Inventor
M Reza Ghadiri
William S Horne
Original Assignee
Scripps Research Inst
M Reza Ghadiri
William S Horne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, M Reza Ghadiri, William S Horne filed Critical Scripps Research Inst
Publication of WO2005007675A2 publication Critical patent/WO2005007675A2/fr
Publication of WO2005007675A3 publication Critical patent/WO2005007675A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur des acides amino-1,2,3-triazole-e et sur des peptides et polypeptides en comportant au moins trois, lesdits peptides pouvant être linéaires ou cycliques. Dans certaines exécutions les peptides cycliques peuvent s'assembler pour former des structures supramoléculaires à usage thérapeutique ou pouvant servir au transport de petites molécules, ou à moduler le transport de petites molécules à l'intérieur de cellules ou entre des cellules.
PCT/US2004/022081 2003-07-09 2004-07-09 Acides amino triazole-$g(e) WO2005007675A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48596103P 2003-07-09 2003-07-09
US60/485,961 2003-07-09

Publications (2)

Publication Number Publication Date
WO2005007675A2 WO2005007675A2 (fr) 2005-01-27
WO2005007675A3 true WO2005007675A3 (fr) 2005-07-14

Family

ID=34079174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022081 WO2005007675A2 (fr) 2003-07-09 2004-07-09 Acides amino triazole-$g(e)

Country Status (1)

Country Link
WO (1) WO2005007675A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9175056B2 (en) 2006-12-14 2015-11-03 Alleron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US9493509B2 (en) 2007-02-23 2016-11-15 Aileron Therapeutics, Inc. Triazole macrocycle systems
US9527896B2 (en) 2007-01-31 2016-12-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955738B2 (en) 2004-03-05 2011-06-07 Honeywell International, Inc. Polymer ionic electrolytes
US7834038B2 (en) * 2005-11-09 2010-11-16 New York University Methods for preparing nonpeptidic oligomers from amino acids
US7981998B2 (en) 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
US20130072439A1 (en) 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
CN108570097A (zh) 2010-08-13 2018-09-25 爱勒让治疗公司 拟肽大环化合物
SG11201404648PA (en) 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
EP2914256B1 (fr) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
CN112972378A (zh) 2014-09-24 2021-06-18 艾瑞朗医疗公司 拟肽大环化合物及其制剂
JP2017533889A (ja) 2014-09-24 2017-11-16 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
EP3294318A4 (fr) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RANGANATHAN ET AL.: "Double-helical cyclic peptides: design, synthesis, and crystal structure of figure-eight mirror-iamge conformers of adamantane-constrained cystine-containing peptide cyclo(adm-Cyst)3", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, June 2000 (2000-06-01), pages 4415 - 4422 *
RANGANATHAN ET AL.: "Norborene constrained cyclic peptides with haipin architecture: design, synthesis, conformation, and membrane ion transport", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, June 2000 (2000-06-01), pages 365 - 374 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9175056B2 (en) 2006-12-14 2015-11-03 Alleron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US9527896B2 (en) 2007-01-31 2016-12-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9493509B2 (en) 2007-02-23 2016-11-15 Aileron Therapeutics, Inc. Triazole macrocycle systems
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9522947B2 (en) 2011-10-18 2016-12-20 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

Also Published As

Publication number Publication date
WO2005007675A2 (fr) 2005-01-27

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