WO2005005608A3 - Compositions and methods for differentiating adipose stromal cells into pancratic beta cells - Google Patents

Compositions and methods for differentiating adipose stromal cells into pancratic beta cells Download PDF

Info

Publication number
WO2005005608A3
WO2005005608A3 PCT/US2004/020980 US2004020980W WO2005005608A3 WO 2005005608 A3 WO2005005608 A3 WO 2005005608A3 US 2004020980 W US2004020980 W US 2004020980W WO 2005005608 A3 WO2005005608 A3 WO 2005005608A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
methods
compositions
pancratic
adipose stromal
Prior art date
Application number
PCT/US2004/020980
Other languages
French (fr)
Other versions
WO2005005608A2 (en
Inventor
Alireza Rezania
Original Assignee
Lifescan Inc
Alireza Rezania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifescan Inc, Alireza Rezania filed Critical Lifescan Inc
Publication of WO2005005608A2 publication Critical patent/WO2005005608A2/en
Publication of WO2005005608A3 publication Critical patent/WO2005005608A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates generally to methods and compositions for the production of cells characteristic of pancreatic beta cell lineage. In particular, the present invention relates to methods and compositions for differentiating adipose stromal cells into cells having at least one marker, preferably two or more markers, characteristic of pancreatic beta cell lineage. The present invention also relates to the cells produced in accordance with the present methods and the use of these cells in the treatment of diseases.
PCT/US2004/020980 2003-06-30 2004-06-29 Compositions and methods for differentiating adipose stromal cells into pancratic beta cells WO2005005608A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48380203P 2003-06-30 2003-06-30
US60/483,802 2003-06-30

Publications (2)

Publication Number Publication Date
WO2005005608A2 WO2005005608A2 (en) 2005-01-20
WO2005005608A3 true WO2005005608A3 (en) 2005-06-23

Family

ID=34061989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/020980 WO2005005608A2 (en) 2003-06-30 2004-06-29 Compositions and methods for differentiating adipose stromal cells into pancratic beta cells

Country Status (1)

Country Link
WO (1) WO2005005608A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150174202A1 (en) * 2011-09-28 2015-06-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and Compositions for Modulating Beta Cell Proliferation
EP2893000B1 (en) 2012-09-03 2019-04-10 Novo Nordisk A/S Generation of pancreatic endoderm from pluripotent stem cells using small molecules
JP2013063088A (en) * 2012-12-14 2013-04-11 Nippon Institute For Biological Science Method for inducing differentiation to neurocyte from adipose tissue stromal cells
EP3294303B1 (en) * 2015-05-11 2022-02-16 Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California Pancreatic stromal progenitor cells
WO2021048250A1 (en) * 2019-09-10 2021-03-18 Fundació Institut De Bioenginyeria De Catalunya Multi-layered cell capsules and uses thereof
CN113736725B (en) * 2020-05-29 2024-04-16 国玺干细胞应用技术股份有限公司 Cell differentiation medium composition, high secretion amount insulin producing cell and preparation thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US6617161B2 (en) * 1997-06-25 2003-09-09 The United States Of America As Represented By The Department Of Health And Human Services Serum-free cell growth medium
US6670180B2 (en) * 1996-03-18 2003-12-30 University Of Pittsburgh Cell culture media for mammalian cells
US6815203B1 (en) * 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US6670180B2 (en) * 1996-03-18 2003-12-30 University Of Pittsburgh Cell culture media for mammalian cells
US6617161B2 (en) * 1997-06-25 2003-09-09 The United States Of America As Represented By The Department Of Health And Human Services Serum-free cell growth medium
US6815203B1 (en) * 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types

Also Published As

Publication number Publication date
WO2005005608A2 (en) 2005-01-20

Similar Documents

Publication Publication Date Title
EP1497435A4 (en) Placental derived stem cells and uses thereof
WO2006017134A3 (en) Preprimitive streak and mesendoderm cells
WO2006018836A3 (en) Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
WO2005005601A8 (en) Compositions and methods for treating and diagnosing cancer
WO2005042703A3 (en) Placental stem cells and uses thereof
WO2006050330A3 (en) Platelets from stem cells
WO2005116073A3 (en) Pdx1 expressing endoderm
SG146682A1 (en) Modulation of eif4e expression
WO2006134494A3 (en) Anti-connexin compounds and therapeutic uses thereof
WO2005003320A3 (en) Neuronal differentiation of stem cells
WO2008085221A3 (en) Therapeutic use of cd31 expressing cells
WO2001021766A3 (en) Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells
EP1709195A4 (en) Cell transfecting formulations of small interfering rna, related compositions and methods of making and use
MX2007004551A (en) Thiadiazole compounds and methods of use.
WO2005063971A3 (en) Definitive endoderm
WO2007051038A3 (en) Pdx1-expressing dorsal and ventral foregut endoderm
WO2006124892A3 (en) Modulators of alpha-synuclein toxicity
TW200621256A (en) Formulations
WO2006083394A3 (en) Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006133271A3 (en) Compositions and methods relating to target-specific photodynamic therapy
WO2006073890A3 (en) Use of glp-1 and agonists thereof to prevent cardiac myocyte apoptosis
WO2005095652A3 (en) Pnmt as a novel marker for progenitor cells
EA015670B9 (en) Antisense compounds targeted to connexins and methods of use thereof
WO2006105152A3 (en) Amnion-derived cell compositions, methods of making and uses thereof
WO2004113513A3 (en) Methods and compositions for modulating stem cell growth and differentiation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase