WO2005005477A3 - Stabilised insulin compositions - Google Patents

Stabilised insulin compositions Download PDF

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Publication number
WO2005005477A3
WO2005005477A3 PCT/DK2004/000481 DK2004000481W WO2005005477A3 WO 2005005477 A3 WO2005005477 A3 WO 2005005477A3 DK 2004000481 W DK2004000481 W DK 2004000481W WO 2005005477 A3 WO2005005477 A3 WO 2005005477A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
insulin
insulin compositions
stabilised insulin
compositions
Prior art date
Application number
PCT/DK2004/000481
Other languages
French (fr)
Other versions
WO2005005477A2 (en
Inventor
Ib Jonassen
Sven Havelund
Thomas Boerglund Kjeldsen
Ulla Ribel-Madsen
Original Assignee
Novo Nordisk As
Ib Jonassen
Sven Havelund
Thomas Boerglund Kjeldsen
Ulla Ribel-Madsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Ib Jonassen, Sven Havelund, Thomas Boerglund Kjeldsen, Ulla Ribel-Madsen filed Critical Novo Nordisk As
Priority to EP04738978A priority Critical patent/EP1644411A2/en
Publication of WO2005005477A2 publication Critical patent/WO2005005477A2/en
Publication of WO2005005477A3 publication Critical patent/WO2005005477A3/en
Priority to US11/328,606 priority patent/US20060183667A1/en
Priority to US12/476,712 priority patent/US20090239784A1/en
Priority to US13/080,162 priority patent/US20110245163A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to human insulin analogues having a fast onset of action. These analogues may have amino acid in position B26 is substituted with Phe, or be Des(B30) analogues of human insulin. The invention also relates to compositions comprising such insulin analogues, and to compositions comprising a mixture of an insulin analogue having a fast onset of action and insulin having a protracted action.
PCT/DK2004/000481 2003-07-11 2004-07-05 Stabilised insulin compositions WO2005005477A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04738978A EP1644411A2 (en) 2003-07-11 2004-07-05 Stabilised insulin compositions
US11/328,606 US20060183667A1 (en) 2003-07-11 2006-01-10 Stabilised insulin compositions
US12/476,712 US20090239784A1 (en) 2003-07-11 2009-06-02 Stablised Insulin Compositions
US13/080,162 US20110245163A1 (en) 2003-07-11 2011-04-05 Stabilised Insulin Compositions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200301065 2003-07-11
DKPA200301065 2003-07-11
US48768303P 2003-07-16 2003-07-16
US60/487,683 2003-07-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/328,606 Continuation US20060183667A1 (en) 2003-07-11 2006-01-10 Stabilised insulin compositions

Publications (2)

Publication Number Publication Date
WO2005005477A2 WO2005005477A2 (en) 2005-01-20
WO2005005477A3 true WO2005005477A3 (en) 2005-03-24

Family

ID=34066438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2004/000481 WO2005005477A2 (en) 2003-07-11 2004-07-05 Stabilised insulin compositions

Country Status (2)

Country Link
EP (1) EP1644411A2 (en)
WO (1) WO2005005477A2 (en)

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JP4933455B2 (en) 2005-02-02 2012-05-16 ノヴォ ノルディスク アー／エス New insulin derivatives
ES2371361T3 (en) 2005-12-28 2011-12-30 Novo Nordisk A/S COMPOSITIONS THAT INCLUDE AN INSULIN ACILADA AND ZINC AND METHOD OF PRODUCTION OF SUCH COMPOSITIONS.
US8722620B2 (en) 2006-02-27 2014-05-13 Novo Nordisk A/S Insulin derivatives
RU2451029C2 (en) 2006-05-09 2012-05-20 Ново Нордиск А/С Insulin derivative
US8796205B2 (en) 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
DE102006031962A1 (en) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidated insulin glargine
WO2008017381A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
HUE029512T2 (en) 2006-09-22 2017-03-28 Novo Nordisk As Protease resistant insulin analogues
DE102007005045B4 (en) 2007-01-26 2008-12-18 Sanofi-Aventis Phenothiazine derivatives, process for their preparation and their use as medicines
JP5496082B2 (en) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス Method for drying protein composition, dry protein composition, and pharmaceutical composition containing dry protein
WO2008152106A1 (en) 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
CN101932601B (en) 2007-11-08 2016-08-03 诺沃-诺迪斯克有限公司 Insulin derivates
DE102007054497B3 (en) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh New crystalline hydrate form of dodecanedioic acid 4-((2S,3R)-3-((S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl)-benzylamide ((2S,3R,4R,5R)-pentahydroxy-hexyl)-amide useful e.g. to treat hyperlipidemia
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
EP2310372B1 (en) 2008-07-09 2012-05-23 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
MX2011004357A (en) 2008-10-30 2011-05-23 Novo Nordisk As Treating diabetes melitus using insulin injections with less than daily injection frequency.
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
EP2470552B1 (en) 2009-08-26 2013-11-13 Sanofi Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
DE102010015123A1 (en) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh New benzylamidic diphenylazetidinone compounds, useful for treating lipid disorders, hyperlipidemia, atherosclerotic manifestations or insulin resistance, and for reducing serum cholesterol levels
EP2582709B1 (en) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
DK2632478T3 (en) 2010-10-27 2019-10-07 Novo Nordisk As TREATMENT OF DIABETES MELITUS USING INSULIN INJECTIONS SUBMITTED AT VARIOUS INJECTION INTERVALS
EP2683702B1 (en) 2011-03-08 2014-12-24 Sanofi New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (en) 2011-03-08 2016-06-01 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
US8846666B2 (en) 2011-03-08 2014-09-30 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120057A1 (en) 2011-03-08 2012-09-13 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
JP2016519127A (en) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス New dosing regimen
WO2015052088A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (en) 2014-02-28 2016-08-03 Novo Nordisk As INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE
HRP20221324T1 (en) 2016-12-16 2022-12-23 Novo Nordisk A/S Insulin containing pharmaceutical compositions
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

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WO2000069901A2 (en) * 1999-05-19 2000-11-23 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes

Patent Citations (2)

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US5618913A (en) * 1985-08-30 1997-04-08 Novo Nordisk A/S Insulin analogues
WO2000069901A2 (en) * 1999-05-19 2000-11-23 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes

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HU SHI-QUAN ET AL: "Contribution of the B16 and B26 tyrosine residues to the biological activity of insulin", JOURNAL OF PROTEIN CHEMISTRY, vol. 12, no. 6, 1993, pages 741 - 747, XP008041533, ISSN: 0277-8033 *
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Also Published As

Publication number Publication date
EP1644411A2 (en) 2006-04-12
WO2005005477A2 (en) 2005-01-20

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