WO2005003350A8 - RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER’S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) - Google Patents

RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER’S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)

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Publication number
WO2005003350A8
WO2005003350A8 PCT/US2004/020516 US2004020516W WO2005003350A8 WO 2005003350 A8 WO2005003350 A8 WO 2005003350A8 US 2004020516 W US2004020516 W US 2004020516W WO 2005003350 A8 WO2005003350 A8 WO 2005003350A8
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
short interfering
sina
rna
interfering nucleic
Prior art date
Application number
PCT/US2004/020516
Other languages
French (fr)
Other versions
WO2005003350A2 (en
WO2005003350A3 (en
Inventor
James Mcswiggen
Leonid Beigelman
Original Assignee
Sirna Therapeutics Inc
James Mcswiggen
Leonid Beigelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/607,933 external-priority patent/US20080032942A1/en
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from PCT/US2004/013456 external-priority patent/WO2005041859A2/en
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/en
Priority to US10/562,561 priority Critical patent/US20060247194A1/en
Priority to EP04756160A priority patent/EP1644498A2/en
Priority to CA002528963A priority patent/CA2528963A1/en
Application filed by Sirna Therapeutics Inc, James Mcswiggen, Leonid Beigelman filed Critical Sirna Therapeutics Inc
Publication of WO2005003350A2 publication Critical patent/WO2005003350A2/en
Publication of WO2005003350A8 publication Critical patent/WO2005003350A8/en
Publication of WO2005003350A3 publication Critical patent/WO2005003350A3/en

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Abstract

This invention relates to compounds, compositions, and methods useful for modulating beta-secretase (BACE), amyloid precurson protein (APP), PIN-1, presenillin 1 (PS-1) and/or presenillin 2 (PS-2)gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of BACE, APP, PIN-1, PS-1 and/or PS-2 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double­stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of BACE, APP, PIN-1, PS-1 and/or PS-2 genes.
PCT/US2004/020516 2000-08-30 2004-06-25 RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER’S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) WO2005003350A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002528963A CA2528963A1 (en) 2003-06-27 2004-06-25 Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina)
EP04756160A EP1644498A2 (en) 2003-06-27 2004-06-25 RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
US10/562,561 US20060247194A1 (en) 2000-08-30 2004-06-25 Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US10/607,933 2003-06-27
US10/607,933 US20080032942A1 (en) 2000-08-30 2003-06-27 RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/693,059 2003-10-23
US10/720,448 2003-11-24
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/727,780 2003-12-03
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/757,803 2004-01-14
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/780,447 2004-02-13
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US10/826,966 2004-04-16
PCT/US2004/013456 WO2005041859A2 (en) 2003-04-30 2004-04-30 Conjugates and compositions for cellular delivery.
USPCT/US04/13456 2004-04-30
PCT/US2004/016390 WO2005019453A2 (en) 2001-05-18 2004-05-24 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
USPCT/US04/16390 2004-05-24

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US10/693,059 Continuation-In-Part US20080039414A1 (en) 2000-02-11 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/720,448 Continuation-In-Part US8273866B2 (en) 2000-02-11 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/727,780 Continuation-In-Part US20050233329A1 (en) 2000-02-11 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/757,803 Continuation-In-Part US20050020525A1 (en) 2000-02-11 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/826,966 Continuation-In-Part US20050032733A1 (en) 2000-02-11 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)

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JP2008538500A (en) * 2005-04-22 2008-10-30 アカデミス ツィーケンホイス ライデン Regulation of exon recognition in pre-mRNA by interference with SR protein binding and RNA secondary structure
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