WO2004097020A3 - Rna interference mediated inhibition of map kinase gene expression - Google Patents

Rna interference mediated inhibition of map kinase gene expression Download PDF

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Publication number
WO2004097020A3
WO2004097020A3 PCT/US2004/012517 US2004012517W WO2004097020A3 WO 2004097020 A3 WO2004097020 A3 WO 2004097020A3 US 2004012517 W US2004012517 W US 2004012517W WO 2004097020 A3 WO2004097020 A3 WO 2004097020A3
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WO
WIPO (PCT)
Prior art keywords
map kinase
rna
nucleic acid
gene expression
molecules
Prior art date
Application number
PCT/US2004/012517
Other languages
French (fr)
Other versions
WO2004097020A2 (en
Inventor
James Mcswiggen
Leonid Beigelman
Nassim Usman
Peter Haeberli
Bharat Chowrira
Barry Polisky
Original Assignee
Sirna Therapeutics Inc
James Mcswiggen
Leonid Beigelman
Nassim Usman
Peter Haeberli
Bharat Chowrira
Barry Polisky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/424,339 external-priority patent/US20060127891A1/en
Priority claimed from US10/427,160 external-priority patent/US7833992B2/en
Priority claimed from US10/444,853 external-priority patent/US8202979B2/en
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Application filed by Sirna Therapeutics Inc, James Mcswiggen, Leonid Beigelman, Nassim Usman, Peter Haeberli, Bharat Chowrira, Barry Polisky filed Critical Sirna Therapeutics Inc
Priority to US10/923,379 priority Critical patent/US20050239731A1/en
Publication of WO2004097020A2 publication Critical patent/WO2004097020A2/en
Publication of WO2004097020A3 publication Critical patent/WO2004097020A3/en
Priority to US12/334,146 priority patent/US20090306182A1/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11024—Mitogen-activated protein kinase (2.7.11.24), i.e. MAPK or MAPK2 or c-Jun N-terminal kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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Abstract

This invention relates to compounds, compositions, and methods useful for modulating mitogen activated protein kinase (MAP kinase ) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of MAP kinase and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of mitogen activated protein kinase (MAP kinase ) genes such as c-JUN, JNK1, JNK2, p38, ERK1, or ERK2.
PCT/US2004/012517 2001-05-18 2004-04-23 Rna interference mediated inhibition of map kinase gene expression WO2004097020A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/923,379 US20050239731A1 (en) 2001-05-18 2004-08-20 RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
US12/334,146 US20090306182A1 (en) 2002-02-20 2008-12-12 RNA INTERFERENCE MEDIATED INHIBITION OF MAP KINASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US10/424,339 US20060127891A1 (en) 2002-02-20 2003-04-25 RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA)
US10/424,339 2003-04-25
US10/427,160 2003-04-30
US10/427,160 US7833992B2 (en) 2001-05-18 2003-04-30 Conjugates and compositions for cellular delivery
US10/444,853 US8202979B2 (en) 2002-02-20 2003-05-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US10/444,853 2003-05-23
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/693,059 2003-10-23
US10/720,448 2003-11-24
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/757,803 2004-01-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/424,339 Continuation-In-Part US20060127891A1 (en) 2001-05-18 2003-04-25 RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/923,379 Continuation-In-Part US20050239731A1 (en) 2001-05-18 2004-08-20 RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)

Publications (2)

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WO2004097020A2 WO2004097020A2 (en) 2004-11-11
WO2004097020A3 true WO2004097020A3 (en) 2006-01-05

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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7902167B2 (en) 2006-10-02 2011-03-08 Aprea Ab Compounds and methods for down-regulating Wrap53 protein by RNA interference
WO2008109369A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tnf gene expression and uses thereof
WO2008109358A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting mapk1 gene expression and uses thereof
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
EP2310503A2 (en) * 2008-06-19 2011-04-20 Santaris Pharma A/S Rna antagonists targeting hsp70-2
WO2012027206A1 (en) 2010-08-24 2012-03-01 Merck Sharp & Dohme Corp. SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
EP2891648B1 (en) 2012-08-31 2022-02-16 Idemitsu Kosan Co., Ltd Aromatic amine derivative, and organic electroluminescent element using the same
JP6677648B2 (en) 2014-04-07 2020-04-08 メモリアル スローン ケタリング キャンサー センター Regulation of cell proliferation and pluripotency
EP3548005A4 (en) 2016-11-29 2020-06-17 Puretech Health LLC Exosomes for delivery of therapeutic agents

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1991015580A1 (en) * 1990-04-10 1991-10-17 Research Development Foundation Gene therapy for cell proliferative diseases
WO2000044895A1 (en) * 1999-01-30 2000-08-03 Roland Kreutzer Method and medicament for inhibiting the expression of a defined gene
WO2003072590A1 (en) * 2002-02-20 2003-09-04 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015580A1 (en) * 1990-04-10 1991-10-17 Research Development Foundation Gene therapy for cell proliferative diseases
WO2000044895A1 (en) * 1999-01-30 2000-08-03 Roland Kreutzer Method and medicament for inhibiting the expression of a defined gene
WO2003072590A1 (en) * 2002-02-20 2003-09-04 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ELBASHIR SAYDA M ET AL: "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 20, no. 23, 3 December 2001 (2001-12-03), pages 6877 - 6888, XP002225998, ISSN: 0261-4189 *
KAWASAKI H ET AL: "siRNAs generated by recombinant human dicer induce specific and significant but target site-independent gene silencing in human cells", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 31, no. 3, 1 February 2003 (2003-02-01), pages 981 - 987, XP002971836, ISSN: 0305-1048 *
PARRISH SUSAN ET AL: "Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference", MOLECULAR CELL, vol. 6, no. 5, November 2000 (2000-11-01), pages 1077 - 1087, XP002226298, ISSN: 1097-2765 *

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