WO2004112848A1 - Solutions ^pur lentilles de contact hydrogel - Google Patents

Solutions ^pur lentilles de contact hydrogel Download PDF

Info

Publication number
WO2004112848A1
WO2004112848A1 PCT/US2004/018377 US2004018377W WO2004112848A1 WO 2004112848 A1 WO2004112848 A1 WO 2004112848A1 US 2004018377 W US2004018377 W US 2004018377W WO 2004112848 A1 WO2004112848 A1 WO 2004112848A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
solution
amount
polyquaternium
disinfecting
Prior art date
Application number
PCT/US2004/018377
Other languages
English (en)
Inventor
Erning Xia
Joseph C. Salamone
Original Assignee
Bausch & Lomb Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb Incorporated filed Critical Bausch & Lomb Incorporated
Publication of WO2004112848A1 publication Critical patent/WO2004112848A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/008—Polymeric surface-active agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • A61L12/145—Polymeric quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/32—Amides; Substituted amides
    • C11D3/323—Amides; Substituted amides urea or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707—Polyethers, e.g. polyalkyleneoxides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3723—Polyamines or polyalkyleneimines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention relates to the development of a gentle multipurpose solution for hydrogel contact lenses. More particularly, the present invention relates to a multi-purpose solution for hydrogel contact lenses that is a gentle, "one bottle” system with “no-rub” disinfecting and passive cleaning for both lipid and protein depositions.
  • contact lenses When contact lenses are removed from the eyes, they often retain on their surface a deposit or proteinaceous, oily and sebaceous matter that, if not removed, greatly reduces wettability properties and optical clarity of the lenses.
  • the lenses In the case of hard contact lenses fabricated from poly(methyl methacrylate), the lenses are of such firmness that they can be treated using mechanical devices to remove deposits of contamination from their surfaces.
  • the selection of cleaning agents is relatively non-critical. In many instances, use of even harsh disinfecting and cleaning agents on hard contact lenses does not create a problem.
  • soft contact lenses because of the hydrophilic properties of soft contact lenses formulated from materials such as poly(2-hydroxyethyl methacrylate), soft contact lenses do absorb more water than hard contact lenses. Consequently, greater care must be exercised in formulating cleansing solutions for soft contact lenses. With soft contact lenses, materials in the solutions can be absorbed and concentrated in the lenses which in-turn can damage the lens and even injure the eyes of the user.
  • solutions intended for hard contact lenses are generally not adaptable for use with soft contact lenses. This may be illustrated, for instance, in the case of hard contact lens solutions containing benzalkonium chloride or chlorobutanol. If these hard contact lens solutions are used on soft contact lenses the solutions' important hydrophilic properties may be lost. Thus, in formulating contact lens care solutions, such as cleaning compositions, a number of factors need to be carefully weighed to assure total compatibility of the system in terms of functional efficaciousness, potential for damage to the lens and possible hazards to the wearer's eyes.
  • Disinfecting agents can cause wearer discomfort. Thus, it would be desirable to provide a safe and effective solution for cleaning soft contact lenses that reduces wearer discomfort while still maintaining efficacy as a disinfectant.
  • This invention provides a multi-purpose solution that requires no digital rubbing, i.e., "no-rub", for disinfecting and cleaning both lipid and protein deposits from a contact lens, and reduces or eliminates wearer discomfort.
  • Solutions of the present invention may likewise be useful as in- eye conditioning solutions, in-eye cleaning solutions or in-eye cleaning and conditioning solutions for contact lens wearers. Solutions of the present invention may also be useful as in-eye drops, which condition the contact lens, and may also clean the contact lens.
  • Such in-eye drops include antimicrobial agents for preservation of the solution, not for disinfection of a contact lens while being worn in an eye.
  • the composition of the present invention preferably comprises about 4.0 to about 5.0 ppm Alexidine.
  • Alexidine has been associated with reduced or eliminated levels, of even non-clinically significant trace levels, of corneal and/or conjunctival staining, which is unexpected since other biguanides may cause such staining.
  • the compositions of the present invention also exhibited greater comfort when compared with other no-rub multi-purpose solutions such as Opti-FreeTM (Alcon Laboratories, Inc., Fort Worth, Texas), which contains Polyquaternium-1 as a disinfecting agent.
  • FIGURE 1 is a graph of mean horizontal decentration vs. decentration for test and control solutions at insertion and 1-hour;
  • FIGURE 2 is a graph of mean movement vs. movement for test and control solutions at insertion and 1-hour
  • FIGURE 3 is a graph of mean inferior overlap vs. overlap for test and control solutions at insertion and 1-hour;
  • FIGURE 4 is a graph of mean comfort vs. analog comfort for test and control solutions at insertion and 1-hour;
  • FIGURE 5 is a graph of mean pre-lens tear film break-up time (TBUT) vs. break-up time (BUT) for test and control solutions at insertion and 1-hour;
  • FIGURE 6 is a graph of mean horizontal decentration vs. decentration for test and control solutions at insertion and 1-hour;
  • FIGURE 7 is a graph of mean movement vs. movement for test and control solutions at insertion and 1-hour;
  • FIGURE 8 is a graph of mean inferior overlap vs. overlap for test and control solutions at insertion and 1-hour;
  • FIGURE 9 is a graph of mean comfort vs. analog comfort for test and control solutions at insertion and 1-hour.
  • FIGURE 10 is a graph of mean pre-lens tear film break-up time (TBUT) vs. break-up time (BUT) for test and control solutions at insertion and 1-hour.
  • the present invention provides no-rub multi-purpose contact lens solutions for disinfecting and cleaning both lipid and protein deposits from a contact lens.
  • the subject solutions provide greater lens comfort to the contact lens wearer.
  • Compositions employed in this invention are aqueous solutions.
  • Compositions of the present invention are preferably used as multi-purpose contact lens solutions to clean and disinfect soft-type contact lenses manufactured from hydrogel biomaterials such as for example but not limited to silicone hydrogel biomaterials.
  • Silicone hydrogel contact lenses include for example but are not limited to contact lenses manufactured from siloxy- containing monomers, siloxy-containing macromolecular monomers, and copolymers with fluoro-containing monomers, alkyl-, cycloalkyl-, arylalkyl- and aryl-containing derivatives of acrylic or methacrylic acid, or itaconic acid, as well as styrenes, butudienes or isoprenes.
  • Such systems could also be copolymerized with hydrophilic monomers such as 2-hydroxyethyl methacrylate, N-vinylpyrrolidone, N,N-dimethylacrylamide and (meth)acrylic acid.
  • compositions of the present invention preferably include one or more polyethers.
  • Polyethers employed in the subject compositions may include for example but are not limited to polyethers based upon poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), i.e., (PEO-PPO-PEO), or poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide), i.e., (PPO- PEO-PPO), or a combination thereof.
  • PEO-PPO-PEO and PPO-PEO-PPO such as for example poloxamers and poloxamines, are commercially available under the trade names PluronicsTM, R-PluronicsTM, TetronicsTM and R-TetronicsTM (BASF Wyandotte Corp., Wyandotte, Michigan).
  • Polyethers in the subject ophthalmic solutions exhibit ready absorption into hydrogel biomaterials such as those used in the manufacture of soft-type contact lenses.
  • Polyethers in the subject ophthalmic solutions after absorption into hydrogel biomaterials to a high concentration, exhibit slow release from the hydrogel biomaterials over a period of time in an aqueous environment.
  • the one or more polyethers release slowly from a worn contact lens into an eye's tear film over a long time period to produce longer lasting wetting performance, improved lubricity, improved end-of-the-day comfort and reduced feeling of dryness from wearing contact lenses.
  • compositions of the present invention provide efficient performance at polyether surfactant concentrations ranging from as little as about 0.01 to about 15 weight percent by volume (w/v). Greater concentrations may be used, but provide no added benefit and only increase the potential for irritating eye tissues. More preferably, the solutions of the subject invention will contain from about 0.1 to about 5 weight percent polyether surfactant.
  • compositions in addition to polyethers likewise include one or more, but at least one, cationic polyelectrolyte that functions to control lens swelling caused by the absorption of high concentrations of polyethers as disclosed in U.S. Patent Application Serial Number 10/392,743, incorporated herein in its entirety by reference. By controlling lens swelling, visual acuity is maintained.
  • Suitable cationic polyelectrolytes include for example but are not limited to polyquaternium 1, polyquaternium 10, polyquatemium 11, polyquaternium 16, polyquaternium 44 and polyquaternium 46, but preferably polyquaternium 10 available under the trade name Polymer JR (BASF Wyandotte Corp.).
  • the ophthalmic solution of the present invention comprises about 0.001 to about 5 weight percent by volume and more preferably from about 0.01 to about 0.5 weight percent of one or more cationic polyelectrolytes for control of lens swelling.
  • compositions of the present invention contain an antimicrobial agent.
  • the use of Alexidine in formulations of the present invention is associated with reduced levels of corneal and/or conjunctival staining. It is unexpected that Alexidine would be associated with reduced or eliminated levels of corneal and/or conjunctival staining since other biguanides may cause such staining. Accordingly, Alexidine, its salts, non-polymeric, non- chloro-containing bis(biguanide)s, or combinations thereof, are the preferred antimicrobial agents, with Alexidine-2HCI being the most preferred.
  • the antimicrobial agent will be used in a disinfecting amount or an amount from about 0.0001 to about 0.5 weight percent by volume.
  • a disinfecting amount of an antimicrobial agent is an amount that will at least partially reduce the microorganism population in the formulations employed.
  • a disinfecting amount is that which will reduce the microbial burden by two log orders in four hours and more preferably by one log order in one hour.
  • a disinfecting amount is an amount which will eliminate the microbial burden on a contact lens when used in the regimen for the recommended soaking time as established by ISO (International Standards for Ophthalmic Optics)/FDA Stand-Alone Procedures for Disinfection Test (ISO/DIS 14729; 2001).
  • such agents are present in concentrations ranging from about 0.00001 to about 0.5 weight percent based on volume (w/v), and more preferably, from about 0.00003 to about 0.05% weight percent.
  • Compositions of the present invention also include one or more but at least one osmolality agent in a concentration sufficient to increase the cleaning efficacy of the solution without adversely affecting the antimicrobial efficacy of the solution.
  • Suitable osmolality agents include for example but are not limited to metal halides such as magnesium, calcium, sodium and potassium chloride, diols and polyols such as propylene glycol and glycerin, mono-, di-, or polysaccharides (saccharides), such as dextrose and trehalose, as well as amino acids such as lysine.
  • Such osmolality agents may be used individually or in combinations in amounts ranging from about 0.01 to about 2.5 weight percent by volume (w/v) and preferably so that the final osmotic value of the solution has an osmolality of more than 200 mOsm/kg, and preferably from 220 to 400 mOsm/kg, and more preferably from 220 to 320 mOsm/kg.
  • buffers may be added to the subject compositions.
  • useful buffering agents include for example, but are not limited to alkali metal salts such as potassium or sodium carbonates, acetates, borates, phosphates, and citrates, and weak acids such as acetic and boric acids.
  • Preferred buffering agents include boric acid, sodium borate, potassium citrate, citric acid, sodium bicarbonate, including combinations of Na 2 PO 4 , NaH 2 PO and KH 2 PO , and aminoalcohols.
  • buffers will be used in amounts ranging from about 0.01 to about 2.5, and preferably, from about 0.1 to about 1.5 percent by weight/volume (w/v).
  • compositions of the present invention are described in still greater detail in the examples provided below. However, it is to be understood that the following examples are for illustrative purposes only and do not purport to be wholly definitive as to conditions and scope of the present invention.
  • Test solution i.e., Solution 1
  • Solution 1 ReNuTM MultiPlus No Rub Formula Multi-Purpose Solution (Bausch & Lomb, Incorporated), hereinafter, "ReNu MultiPlus”, in a clinical performance study.
  • EDTA Ethylenediaminetetraacetic acid
  • PHMB HCI poly(hexamethylene biguanide) DequestTM 2016 (Solutia Inc., St. Louis, Missouri)
  • the objective of this study was to assess the short-term (1-hour) clinical performance of Solution 1 as compared to ReNu MultiPlus when used with PureVisionTM lenses (Bausch & Lomb, Incorporated).
  • the test solution, Solution 1 was prepared in accordance with the present invention.
  • the control solution, ReNu MultiPlus was taken from inventory (lot # GL2029).
  • the lenses used in this study were standard PureVision lenses taken from inventory.
  • Each well of each of the Bausch & Lomb lens cases was pre-treated using a single, 4-hour minimum soak, with either Solution 1 or ReNu MultiPlus.
  • Solution 1 was randomly determined and the fellow well received ReNu MultiPlus.
  • All PureVision lenses were pre-treated using two separate, 4-hour minimum soaks, with either Solution 1 or ReNu MultiPlus, in the pre-treated lens cases, following the same randomization used for the lens case wells.
  • Each subject was fitted with a pre-treated lens pair. Each lens was evaluated for centration, movement, comfort, wetting, deposits and pre-lens tear film break-up time.
  • test solution Solution 1
  • ReNu MultiPlus control solution
  • Test solution i.e., Solution 1
  • Solution 1 Opti-Free ExpressTM No Rub Multipurpose Disinfecting Solution (Alcon Laboratories, Incorporated), hereinafter, "Opti-Free", in a clinical performance study.
  • the objective of this study was to assess the short-term (1-hour) clinical performance of Solution 1 as compared to Opti-Free when used with PureVisionTM lenses (Bausch & Lomb, Incorporated). To this end, twenty- four (24) subjects, all habitual soft spherical contact lens wearers, were enrolled in the study.
  • the test solution, Solution 1 was prepared in accordance with the present invention.
  • the control solution, Opti-Free was taken from inventory (lot # 33813F).
  • the lenses used in this study were standard PureVision lenses taken from inventory.
  • Each well of the Bausch & Lomb lens cases was pre-treated using a single, 4-hour minimum soak, with either Solution 1 or Opti-Free. For each case, the well treated with Solution 1 was randomly determined and the fellow well received Opti-Free. All PureVision lenses were pre-treated using two separate, 4-hour minimum soaks, with either Solution 1 or Opti-Free, in the pre-treated lens cases, following the same randomization used for the lens case wells.
  • Each subject was fitted with a pre-treated lens pair. Each lens was evaluated for centration, movement, comfort, wetting, deposits and pre-lens tear film break-up time. Each subject wore a Solution 1 /PureVision lens and a Opti-Free /PureVision lens on contralateral eyes for approximately 1 hour. The eyes receiving Solution 1/PureVision lenses were randomly assigned. Subjects and the investigator were masked to solution identity. Testing was repeated after 1 hour of lens wear.
  • test solution Solution 1
  • control solution Opti-Free
  • compositions of the present invention may be effectively used as multi-purpose no-rub contact lens solutions for removing and dispersing protein and lipid tear film deposits on both hard and soft-type contact lenses.
  • the subject compositions may be used when the wearer of contact lenses removes the contact lenses from the eyes.
  • the contact lenses may be soaked in solutions of the present compositions at room temperature for a period ranging from about four to twelve hours. The lenses are then removed from the solution and replaced on the eyes.
  • the wearer may optionally rinse the lenses in a preserved saline solution before replacing the lenses on the eyes.
  • the cleaning solution may contain higher concentrations of surfactant, e.g., 3 to 15 weight percent.
  • the rinsing step may be omitted when, for example, the cleaning solution contains up to 1.5 weight percent of surfactant.
  • the solutions disclosed herein are adaptable for use in equipment such as ultrasonic cleaners.
  • the solutions are also stable when heated to temperatures in the range of 80° to 90°C, they are also adaptable for use with high temperature disinfecting methods.
  • lenses are heated to 80° C in a disinfecting unit containing the solution for a time period of at least 10 minutes, removed and rinsed with isotonic saline.
  • compositions for ophthalmic solutions and methods of making and using the same, it will be manifest to those skilled in the art that various modifications may be made without departing from the spirit and scope of the underlying inventive concept.
  • the present invention is likewise not intended to be limited to particular ophthalmic solutions or methods described herein except insofar as indicated by the scope of the appended claims.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eyeglasses (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention porte sur des compositions de nettoyage et de désinfection de lentilles de contact qui réduisent ou éliminent la gêne de l'utilisateur, ces compositions comprenant une quantité désinfectante d'Alexidine. Les solutions sont efficaces pour éliminer les dépôts filmogènes, laissés par les larmes contenant des protéines et des lipides, sur les lentilles de contact dures et souples.
PCT/US2004/018377 2003-06-16 2004-06-10 Solutions ^pur lentilles de contact hydrogel WO2004112848A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46216503A 2003-06-16 2003-06-16
US10/462,165 2003-06-16

Publications (1)

Publication Number Publication Date
WO2004112848A1 true WO2004112848A1 (fr) 2004-12-29

Family

ID=33538982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/018377 WO2004112848A1 (fr) 2003-06-16 2004-06-10 Solutions ^pur lentilles de contact hydrogel

Country Status (1)

Country Link
WO (1) WO2004112848A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090536A1 (fr) * 2004-03-12 2005-09-29 Bausch & Lomb Incorporated Compositions destinees a solubiliser des lipides
WO2006132841A1 (fr) * 2005-06-03 2006-12-14 Bausch & Lomb Incorporated Composition et procede de nettoyage des depots lipidiques sur les lentilles de contact
WO2006132843A1 (fr) * 2005-06-03 2006-12-14 Bausch & Lomb Incorporated Procede de nettoyage de depots lipidiques sur des lentilles de contact en hydrogel de silicone
WO2007002669A1 (fr) * 2005-06-28 2007-01-04 Bausch & Lomb Incorporated Procede intraoculaire de nettoyage et/ou de desinfection de lentilles de contact en hydrogel de silicone
WO2007075691A1 (fr) * 2005-12-21 2007-07-05 Bausch & Lomb Incorporated Procede pour la prevention de croissance de microbes sur des lentilles de contact avec des gouttes ophtalmologiques
WO2007084975A1 (fr) * 2006-01-20 2007-07-26 Bausch & Lomb Incorporated Amélioration de l'efficacité de la désinfection de verres de contact pour des verres de contact rigides perméables aux gaz
WO2007146684A1 (fr) * 2006-06-08 2007-12-21 Bausch & Lomb Incorporated Compositions ophtalmiques contenant un composé de glycérol ramifié et un agent antimicrobien cationique
WO2011139569A1 (fr) * 2010-04-26 2011-11-10 Bausch & Lomb Incorporated Compositions ophtalmiques avec du biguanide et du peg-ester de glycérol

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024542A1 (fr) * 1997-11-12 1999-05-20 Bausch & Lomb Incorporated Desinfection de lentilles de contact au moyen de bis(biguanides) et de biguanides polymeres
US5965088A (en) * 1997-10-23 1999-10-12 Lever; Andrea M. Method for providing rapid disinfection of contact lenses
US6309658B1 (en) * 1997-11-12 2001-10-30 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a carbonate salt for enhanced cleaning
US6369112B1 (en) * 1998-12-15 2002-04-09 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by tyloxapol
US20030096717A1 (en) * 2001-08-17 2003-05-22 Bausch & Lomb Incorporated Composition and method for inhibiting uptake of biguanide antimicrobials by hydrogels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965088A (en) * 1997-10-23 1999-10-12 Lever; Andrea M. Method for providing rapid disinfection of contact lenses
WO1999024542A1 (fr) * 1997-11-12 1999-05-20 Bausch & Lomb Incorporated Desinfection de lentilles de contact au moyen de bis(biguanides) et de biguanides polymeres
US6309658B1 (en) * 1997-11-12 2001-10-30 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a carbonate salt for enhanced cleaning
US6369112B1 (en) * 1998-12-15 2002-04-09 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by tyloxapol
US20030096717A1 (en) * 2001-08-17 2003-05-22 Bausch & Lomb Incorporated Composition and method for inhibiting uptake of biguanide antimicrobials by hydrogels

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090536A1 (fr) * 2004-03-12 2005-09-29 Bausch & Lomb Incorporated Compositions destinees a solubiliser des lipides
WO2006132841A1 (fr) * 2005-06-03 2006-12-14 Bausch & Lomb Incorporated Composition et procede de nettoyage des depots lipidiques sur les lentilles de contact
WO2006132843A1 (fr) * 2005-06-03 2006-12-14 Bausch & Lomb Incorporated Procede de nettoyage de depots lipidiques sur des lentilles de contact en hydrogel de silicone
US7282178B2 (en) 2005-06-03 2007-10-16 Bausch & Lomb Incorporated Composition and method for cleaning lipid deposits on contact lenses
WO2007002669A1 (fr) * 2005-06-28 2007-01-04 Bausch & Lomb Incorporated Procede intraoculaire de nettoyage et/ou de desinfection de lentilles de contact en hydrogel de silicone
WO2007075691A1 (fr) * 2005-12-21 2007-07-05 Bausch & Lomb Incorporated Procede pour la prevention de croissance de microbes sur des lentilles de contact avec des gouttes ophtalmologiques
WO2007084975A1 (fr) * 2006-01-20 2007-07-26 Bausch & Lomb Incorporated Amélioration de l'efficacité de la désinfection de verres de contact pour des verres de contact rigides perméables aux gaz
WO2007146684A1 (fr) * 2006-06-08 2007-12-21 Bausch & Lomb Incorporated Compositions ophtalmiques contenant un composé de glycérol ramifié et un agent antimicrobien cationique
WO2011139569A1 (fr) * 2010-04-26 2011-11-10 Bausch & Lomb Incorporated Compositions ophtalmiques avec du biguanide et du peg-ester de glycérol
US8501200B2 (en) 2010-04-26 2013-08-06 Bausch & Lomb Incorporated Ophthalmic compositions with biguanide and PEG-glycerol esters
EP2664665A1 (fr) * 2010-04-26 2013-11-20 Bausch & Lomb Incorporated Compositions ophthalmiques avec du biguanide et du peg-ester du glycerine
US8889160B2 (en) 2010-04-26 2014-11-18 Bausch & Lomb Incorporated Ophthalmic compositions with biguanide and PEG-glycerol esters

Similar Documents

Publication Publication Date Title
US4820352A (en) Cleaning and conditioning solutions for contact lenses and methods of use
CA2501396C (fr) Composition et procede pour les soins de lentilles
US20060241001A1 (en) Composition for treating contact lenses
JP4907836B2 (ja) コンタクトレンズを清浄するための組成物及び方法
JP2006506192A (ja) プロピレングリコールまたはグリセリンを含有する多目的コンタクトレンズケア組成物
US7282178B2 (en) Composition and method for cleaning lipid deposits on contact lenses
CA2578242A1 (fr) Compositions contenant des tampons a base de n,n,n',n'-tetrakis(hydroxyalkyl)diamine ou de n,n,n',n'-tetrakis(hydroxyalkoxy)diamine
WO2007084975A1 (fr) Amélioration de l'efficacité de la désinfection de verres de contact pour des verres de contact rigides perméables aux gaz
US6790816B2 (en) High osmolyte cleaning and disinfection method and solution for contact lenses
WO2004112848A1 (fr) Solutions ^pur lentilles de contact hydrogel
JP2005513112A (ja) 眼の中でコンタクトレンズを処置するための組成物
US20060276359A1 (en) Composition and method for cleaning lipid deposits on contact lenses
US20070203039A1 (en) Method for cleaning and maintaining contact lenses and related system and kit
JPH09507513A (ja) コンタクトレンズを洗浄および消毒するための炭水化物組成物および方法
CA2626773C (fr) Compositions d'entretien de lentilles ayant une efficacite persistante en termes de nettoyage
CA2547641C (fr) Compositions contenant un tensio-actif non ionique pour le nettoyage des lentilles de contact
EP0115619B1 (fr) Solutions pour le nettoyage et le traitement de verres de contact et procédé pour leur utilisation
TW200528147A (en) Improved disinfection efficacy of lens care regimen
EP0175490A2 (fr) Compositions pour le traitement de lentilles de contact et utilisation de ces compositions
US20060275173A1 (en) Method for cleaning lipid deposits on silicone hydrogel contact lenses
AU721520B2 (en) Carbohydrate composition and method for cleaning and disinfecting contact lenses
JP2000347141A (ja) 含水性コンタクトレンズ用処理液
AU2006202392A1 (en) Composition for treating contact lenses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
122 Ep: pct application non-entry in european phase