WO2004109296A1 - Procede et dispositif de mise en place d’un recipient dans un dispositif de prelevement de liquide - Google Patents
Procede et dispositif de mise en place d’un recipient dans un dispositif de prelevement de liquide Download PDFInfo
- Publication number
- WO2004109296A1 WO2004109296A1 PCT/FR2004/050203 FR2004050203W WO2004109296A1 WO 2004109296 A1 WO2004109296 A1 WO 2004109296A1 FR 2004050203 W FR2004050203 W FR 2004050203W WO 2004109296 A1 WO2004109296 A1 WO 2004109296A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- needle
- sampling
- movement
- liquid
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/08—Ergonomic or safety aspects of handling devices
- B01L2200/082—Handling hazardous material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/141—Preventing contamination, tampering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
Definitions
- the present invention relates to a method of placing a container, such as a bottle containing a liquid of interest, in a device for withdrawing the liquid. It also relates to a sampling device allowing the implementation of the implementation process.
- This invention is particularly advantageous for containers containing liquid samples which may be dangerous, such as: • biological substances,
- Such containers are moreover generally used in automatic in vitro diagnostic machines allowing the analysis of different parameters or biological substances which are essentially dangerous for the user, and can consist of all or part:
- viruses hepatitis B, hepatitis C, AIDS, etc.
- pathogenic bacteria Staphylococcus aureus, Streptococcus pneumoniae, etc.
- nucleic acid sequences mainly RNA, DNA
- the stall of the technique is therefore generally made up of containers in the form of bottles. These bottles are placed vertically, so that it is difficult for the sampling means to recover all of the liquid of interest contained in each bottle. This quantity of liquid, which remains present in the bottle, is therefore a source of potential contamination for the user of the diagnostic machine thus equipped.
- said user is obliged to set up each container until the sampling means, which are associated with it, are well positioned, which generally involves a snap-fastening or a screwing of said bottle. relative to the device, this removal of said liquid of interest, which can generate splashes, which are also a source of contamination.
- the present invention proposes to respond to the drawbacks of the prior art developed above, by proposing an installation method and a device for implementing this method which are simple and which can easily be automated, but which, when said device is manual, considerably reducing the risk of contamination for the user.
- the invention therefore relates to a method of placing a container, such as a bottle comprising an opening and containing a liquid of interest, in a device for collecting the liquid, a collecting device essentially consisting of a collecting needle.
- the method consisting of a linear movement of the container and a concomitant pivoting movement of the needle, movements during which the free end of said needle is moved between an extreme outer position and an extreme position inside said container, the axis longitudinal of the needle and the perpendicular plane of the opening forming a substantially constant intersection during the positioning of the container.
- perpendicular plane of the opening is meant the plane perpendicular to the longitudinal axis of the container positioned at the level of the opening of the container.
- substantially constant intersection it should be understood that the intersection between the perpendicular plane of the opening and the longitudinal axis of the needle is always located between the walls of the container which form the opening of the latter without, however, squint said walls.
- the pivoting of the needle takes place in a plane containing the linear axis of movement of the container.
- the general movement of the container is a movement from the bottom upwards, while the general movement of the free end of the needle is a movement from the top to the bottom.
- the free end of said needle in the extreme inner position of the needle, is located substantially in the lowest point of the container, depending on the earth's gravity.
- the device comprises transmission means which are present between the sliding means and the pivoting support, in order to make the linear and pivoting movements concomitant.
- the transmission means comprise at least one tongue cooperating with guide and articulation axes, a chain, a belt and / or a cascade of pinions.
- the sliding means comprise at least two rods which are parallel to each other and to the movement of the tank when it is put in place.
- FIG. 1 represents a schematic view of the kinematics of the positioning method, according to the invention, before the free end of the sampling needle enters the container through its opening, as is the case in the extreme outside position.
- FIG. 2 represents a schematic view of the kinematics of the positioning method, according to the invention, when the free end of the sampling needle is located at the level of the container by its opening.
- Figures 3 to 8 show schematic views of the kinematics of the positioning method according to the invention when the free end of the sampling needle is located within the container.
- FIG. 9 represents a schematic view of the kinematics of the positioning method, according to the invention, when the free end of the sampling needle is located substantially in the lowest point of the container, according to the earth's gravity, as is the case in the extreme interior position.
- FIG. 10 represents a side view of the sampling device in the presence of the container, in the position preceding the introduction of the sampling needle, showing the means for transmitting movements between the sliding carriage and the pivoting support.
- FIG. 11 shows a side view of the sampling device in the presence of the container, in the position after the introduction of the sampling needle, also showing the means for transmitting movements between the sliding carriage and the pivoting support.
- FIG. 12 represents a view in longitudinal section of the sampling device of FIG. 10 of the sampling device in the presence of the container, before the free end of the sampling needle enters the container through its opening, such that c 'is the case in the extreme external position.
- FIG. 13 represents a view in longitudinal section of the sampling device of FIG. 11, that is to say when the free end of the sampling needle is located substantially in the lowest point of the container, according to terrestrial gravity, as is the case in the extreme interior position.
- the present invention relates to a method of placing a container 1, which method is well represented in all of FIGS. 1 to 9 of this patent application.
- a sampling device 4 represented here by a rigid sampling needle
- This method essentially consists in allowing the introduction of the free end 5 of the needle 4 through the opening 2 of the container 1, without the assembly of the needle 4 touching the inner and, of course, outer edges. of said container 1, either at the opening 2 or the rest of the container 1.
- this container 1 is constituted by a bottle 1. The only access to the interior of this bottle 1 is in the upper position at the opening 2, when the bottle 1 is placed on its cuL
- the needle 4 is not yet introduced into the interior of the bottle 1.
- FIGS. 5, 6, 7 and 8 are intermediate figures which, chronologically, show the pivoting of the needle 4 and the approximation of the carrying carriage 7 with respect to the pivoting support 6.
- FIG. 9 The last position is that shown in FIG. 9 where the free end 5 is in the lowest position of the container 1, so that it is possible to withdraw almost all or even all of the liquid of interest 3 contained in said bottle 1.
- This liquid 3 has only been shown in this FIG. 9 in order to facilitate the reading of all of FIGS. 1 to 8. This facilitates the handling of the empty bottle 1 while preserving the user of any possible contamination by said liquid of interest
- FIG. 10 and 11 there is a side view of the carriage 7 carrying the container 1 and a frame 18 supporting the sampling means 4 and highlighting the means of transmission 9 of the movements present between the pivoting support 6, according F2 of FIG. 11, carrying the sampling needle 4 and the sliding carriage 7 carrying the container 1.
- Said transmission means 9 consist of:
- a tongue which has, on the one hand, a hinge pin 16, and on the other hand, a guide groove 11, and A guide pin 17 carried by the lateral support 14, present at the opening 2.
- This guide pin 17 is in fact constituted by a stud which is present and cooperates with the groove 11. In a first extreme position, fcdit axis 17 is placed at one end of the groove 11 as shown in Figure 10, while in a second extreme position, the axis 17 is placed at the other end of the groove 11, like this is shown in Figure 11.
- the user opens the cap of the bottle 1 and positions said bottle 1 in its carriage 7, as shown in FIG. 10. Then, in order to bring the bottle 1 closer to the needle 4, it performs a sliding movement according to FI, by actuating the handle 12 of the carriage 7, parallel to the longitudinal axis of the coating means 8, so that said means slide within the guides 19 integral with the chassis 18, as shown in Figures 12 and 13.
- This approximation causes the sliding of the guide axis 17 within the groove 11, so that the transmission means 9 tilt according to F2 to allow the introduction of the needle 4 into the bottle 1.
- the chassis 18 is fixed to the frame of the measuring instrument, not shown in the figures, by a support 10 which may contain a sensor for detecting the mass of the entire sampling device 4, of the carriage 7 and from bottle 1a with its content 3.
- a sensor for detecting the mass of the entire sampling device 4, of the carriage 7 and from bottle 1a with its content 3.
- a sensor is well known to those skilled in the art.
- This also allows automation of the filling control, automation which can be pushed to allow sliding according to FI, such automation is also well known to those skilled in the art.
- FIGS. 12 and 13 show more precisely, the whole of the sampling device 4 and of the container 1 in the extreme position, that is to say on the one hand, before the needle 4 enters the inside of the bottle 1, this is what is shown in FIG. 12, on the other hand, when the needle 4 is in the position for withdrawing the liquid 3 contained in said bottle 1, this is what is shown on Figure 13.
- the carriage 7 comprises a handle 12 for handling said carriage 7.
- This handle 12 comprises, among other things, a recess 13 allowing the positioning of the bottom of the container 1.
- the bottle 1 is well maintained in position, all the more so since there is also the presence of a lateral support 14 which laterally supports said bottle 1.
- the sampling device 4 is associated with the pivoting support 6 including : The hinge pin 16 which also serves for the pivoting of the transmission means 9, and
- Container such as a bottle
- Sampling device such as a sampling needle
- Support articulation axis 6, transmission means 9 and protective casing 15 17.
- Chassis supporting the sampling means 4 are 18. Chassis supporting the sampling means 4
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006530444A JP4399461B2 (ja) | 2003-05-28 | 2004-05-19 | 液体を含む容器を液体サンプリング用装置内に配置する方法及び当該方法を実施するためのサンプリング装置 |
AU2004245730A AU2004245730B2 (en) | 2003-05-28 | 2004-05-19 | Method and device for placement of a recipient in a device for sampling liquid |
CN2004800147180A CN1795390B (zh) | 2003-05-28 | 2004-05-19 | 用来把包含液体的容器放置在用来取样液体的装置中的方法和用来应用该方法的取样装置 |
US10/557,176 US7497135B2 (en) | 2003-05-28 | 2004-05-19 | Method for placing a receptacle containing a liquid in a device for sampling the liquid and sampling device for applying the method |
EP04767830A EP1627234A1 (fr) | 2003-05-28 | 2004-05-19 | Procede et dispositif de mise en place d'un recipient dans un dispositif de prelevement de liquide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0306474 | 2003-05-28 | ||
FR0306474A FR2855612B1 (fr) | 2003-05-28 | 2003-05-28 | Procede de mise en place d'un recipient contenant un liquide dans un dispositif de prelevement du liquide et dispositif de prelevement pour la mise en oeuvre du procede |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004109296A1 true WO2004109296A1 (fr) | 2004-12-16 |
Family
ID=33427508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2004/050203 WO2004109296A1 (fr) | 2003-05-28 | 2004-05-19 | Procede et dispositif de mise en place d’un recipient dans un dispositif de prelevement de liquide |
Country Status (7)
Country | Link |
---|---|
US (1) | US7497135B2 (fr) |
EP (1) | EP1627234A1 (fr) |
JP (1) | JP4399461B2 (fr) |
CN (1) | CN1795390B (fr) |
AU (1) | AU2004245730B2 (fr) |
FR (1) | FR2855612B1 (fr) |
WO (1) | WO2004109296A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006075201A1 (fr) * | 2004-09-08 | 2006-07-20 | Pfizer Products Inc. | Systeme automatique pour manipuler et peser des quantites analytiques de substances a particules |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2891850T3 (es) | 2015-11-25 | 2022-01-31 | Siemens Healthcare Diagnostics Products Gmbh | Procedimiento para la transferencia de un volumen de líquido en un dispositivo de análisis |
CN108444769B (zh) * | 2018-06-26 | 2019-06-25 | 李荣旭 | 一种海体污染船舶用采集取样装置 |
DE102022103659A1 (de) * | 2022-02-16 | 2023-08-17 | Agilent Technologies, Inc. | Rotierbar gelagerte Probennadel für Analysegerät |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4478095A (en) * | 1981-03-09 | 1984-10-23 | Spectra-Physics, Inc. | Autosampler mechanism |
US4570495A (en) * | 1983-06-04 | 1986-02-18 | Horiba, Ltd. | Apparatus for drawing liquid samples into a liquid testing machine |
JPH03202772A (ja) * | 1989-12-29 | 1991-09-04 | Otsuka Denshi Kk | 反応容器の洗浄装置 |
US5084242A (en) * | 1987-08-14 | 1992-01-28 | Kabushiki Kaisha Toshiba | Distribution nozzle apparatus for automatic chemical analyzer |
WO1993021534A1 (fr) * | 1992-04-16 | 1993-10-28 | Amersham International Plc | Dispositif pour prelever des liquides |
WO1996007918A1 (fr) * | 1994-09-08 | 1996-03-14 | S.E.A.C. S.R.L. | Appareil automatique servant a effectuer des analyses immunologiques |
US5744729A (en) * | 1995-12-19 | 1998-04-28 | Toa Medical Electronics Co., Ltd. | Sample sucking device |
US5913237A (en) * | 1995-08-23 | 1999-06-15 | Elpatronic Ag | Apparatus for providing a fluid connection between a fixed fluid coupling and a moving container |
WO2003059515A2 (fr) * | 2002-01-18 | 2003-07-24 | Evotec Oai Ag | Dispositif de transport de fluides et procede d'alimentation et d'evacuation de fluides |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3230776A (en) * | 1963-05-31 | 1966-01-25 | Technicon Instr | Liquid sample supply apparatus |
US3282651A (en) * | 1963-07-12 | 1966-11-01 | Technicon Instr | Sample and reagent and/or wash liquid supply apparatus |
GB1051956A (fr) * | 1964-04-01 | |||
FR1514348A (fr) * | 1967-01-12 | 1968-02-23 | Ministere De L Agriculture Ser | Machine pour l'exécution d'analyses de laboratoire |
US3529475A (en) * | 1969-02-26 | 1970-09-22 | Hewlett Packard Co | Automatic fluid sampling system |
US3858450A (en) * | 1971-10-21 | 1975-01-07 | Coulter Electronics | Sample mixing and metering apparatus |
US3853008A (en) * | 1972-02-24 | 1974-12-10 | Beckman Instruments Inc | Liquid sample supply apparatus |
US3949615A (en) * | 1974-05-13 | 1976-04-13 | Instrumentation Laboratory, Inc. | Analysis apparatus |
IT1130926B (it) * | 1980-03-07 | 1986-06-18 | Erba Strumentazione | Dispositivo per il prelievo di campioni da analizzare,specialmente in capionatori automatici |
CH673894A5 (fr) * | 1987-10-15 | 1990-04-12 | Nivarox Sa | |
US5171527A (en) * | 1990-01-26 | 1992-12-15 | Cryo-Cell International, Inc. | Apparatus for removing fluid from an umbilical cord |
FR2754599B1 (fr) | 1996-10-15 | 1998-12-04 | Merck Clevenot Laboratoires | Appareil automatique de dosage immunologique |
FR2783321B1 (fr) | 1998-09-11 | 2000-11-24 | Biotrol Diagnostic | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
-
2003
- 2003-05-28 FR FR0306474A patent/FR2855612B1/fr not_active Expired - Fee Related
-
2004
- 2004-05-19 AU AU2004245730A patent/AU2004245730B2/en not_active Ceased
- 2004-05-19 US US10/557,176 patent/US7497135B2/en not_active Expired - Fee Related
- 2004-05-19 CN CN2004800147180A patent/CN1795390B/zh not_active Expired - Fee Related
- 2004-05-19 EP EP04767830A patent/EP1627234A1/fr not_active Withdrawn
- 2004-05-19 JP JP2006530444A patent/JP4399461B2/ja not_active Expired - Fee Related
- 2004-05-19 WO PCT/FR2004/050203 patent/WO2004109296A1/fr active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4478095A (en) * | 1981-03-09 | 1984-10-23 | Spectra-Physics, Inc. | Autosampler mechanism |
US4570495A (en) * | 1983-06-04 | 1986-02-18 | Horiba, Ltd. | Apparatus for drawing liquid samples into a liquid testing machine |
US5084242A (en) * | 1987-08-14 | 1992-01-28 | Kabushiki Kaisha Toshiba | Distribution nozzle apparatus for automatic chemical analyzer |
JPH03202772A (ja) * | 1989-12-29 | 1991-09-04 | Otsuka Denshi Kk | 反応容器の洗浄装置 |
WO1993021534A1 (fr) * | 1992-04-16 | 1993-10-28 | Amersham International Plc | Dispositif pour prelever des liquides |
WO1996007918A1 (fr) * | 1994-09-08 | 1996-03-14 | S.E.A.C. S.R.L. | Appareil automatique servant a effectuer des analyses immunologiques |
US5913237A (en) * | 1995-08-23 | 1999-06-15 | Elpatronic Ag | Apparatus for providing a fluid connection between a fixed fluid coupling and a moving container |
US5744729A (en) * | 1995-12-19 | 1998-04-28 | Toa Medical Electronics Co., Ltd. | Sample sucking device |
WO2003059515A2 (fr) * | 2002-01-18 | 2003-07-24 | Evotec Oai Ag | Dispositif de transport de fluides et procede d'alimentation et d'evacuation de fluides |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 015, no. 471 (P - 1282) 28 November 1991 (1991-11-28) * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006075201A1 (fr) * | 2004-09-08 | 2006-07-20 | Pfizer Products Inc. | Systeme automatique pour manipuler et peser des quantites analytiques de substances a particules |
Also Published As
Publication number | Publication date |
---|---|
AU2004245730B2 (en) | 2009-09-10 |
JP4399461B2 (ja) | 2010-01-13 |
US20060254370A1 (en) | 2006-11-16 |
CN1795390B (zh) | 2011-06-08 |
FR2855612B1 (fr) | 2006-02-24 |
EP1627234A1 (fr) | 2006-02-22 |
JP2007500355A (ja) | 2007-01-11 |
CN1795390A (zh) | 2006-06-28 |
AU2004245730A1 (en) | 2004-12-16 |
US7497135B2 (en) | 2009-03-03 |
FR2855612A1 (fr) | 2004-12-03 |
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