WO2004096265A1

WO2004096265A1 - Nutrient liquid containing human growth hormone and the preparation method thereof

Info

Publication number: WO2004096265A1
Application number: PCT/CN2003/000698
Authority: WO
Inventors: Shenggang Fan; Longjiang Huo; Ping Ju; Ningbo Feng
Original assignee: Yantai Apollo Biotechnology, Co., Ltd.
Priority date: 2003-04-30
Filing date: 2003-08-20
Publication date: 2004-11-11
Also published as: AU2003261569A1; CN1449819A

Abstract

The present invention disclosed a nutrient liquid that could regulate immunity, delay senility. It composed of human growth hormone, amino acid, heme iron, sodium selenite, magnesium lactate and zinc gluconate. Each component of the nutrient liquid is treating with ozone and comminuting mechanically into nanometer powder.

Description

Vitality oral fluid and preparation method thereof

The invention relates to the field of biotechnology, in particular to an oral solution capable of delaying or even reversing senescence and enhancing immune function, and a preparation method thereof.

Background technique

With the acceleration of people's pace of life, mental stress and day-by-day increase, and irregular lifestyles have become a causative factor for high-income people in China, making them more aging. Especially for mental workers, the body is in a state called "sub-health" by the medical community, which causes the functional age and biological age to be significantly higher than the natural age. Coming younger and younger. While modern society is developing rapidly, people ’s demand is also increasing, and people are paying more and more attention to the quality of life. At present, such products on the market have just started, and various related products are uneven in quality and efficacy. Although it has more or less effects, at present, it has encountered relatively great difficulties in delaying aging, in particular reversing aging, and enhancing immune function of various products, which are specifically reflected in: 1. Large dosage and large side effects. For example, some injection products are more effective. However, its amount is too large, the host protein produces an antigen response in the human body, and even causes metabolic disorders of sugars, fats, and proteins; 2. The physiological activities of the active factors of the existing products are difficult to maintain at room temperature for a long time, and they are not quite active , The effect will be greatly reduced; 3. The bioavailability of the active ingredient is very low. Generally speaking, the active ingredient does not work until it enters the cell through the blood. Such products on the market are almost drinkable orally, which leads to this active ingredient It is mostly decomposed and loses vitality in the gastrointestinal tract; 4. The cost is too high, which is unbearable for ordinary consumers.

Therefore, a kind of Weishengli oral liquid with less dosage, small side effects, low cost, long storage time of active factors, and high utilization rate of active ingredients has never been seen.

Summary of the Invention

The purpose of the present invention is to overcome the shortcomings of the prior art mentioned above and provide a vitality oral solution capable of delaying aging and enhancing immune function. It mainly solves the problems of large amount of existing products, large side effects, high cost, short storage time of active factors, and low utilization of active ingredients.

Another object of the present invention is to provide a method for preparing a vitality liquid. In order to achieve the above object, the present invention is achieved as follows: Weishengli oral liquid, which is composed of the following components by weight parts, active peptides 0. 15-0. 50, amino acids 50- 100, heme iron 20-80 , Sodium selenite 0.30-0. 80, magnesium lactate 0.18-0. 30, zinc gluconate 0.25-0. 50.

In order to further achieve the above objective, a preferred embodiment of the present invention is that the weight ratio of each component is: active peptide 0.18-0. 40, amino acid 55-80, heme iron 30-60, sodium selenite 0. 35-0. 60, magnesium lactate 0. 19-0. 25, zinc gluconate 0. 28-0. 40.

In order to further achieve the above-mentioned object, a best embodiment of the present invention is that the weight ratio of each component is: active peptide 0.20, amino acid 58, heme iron 35, sodium selenite G. 40, magnesium lactate 0. 20, zinc gluconate 0.30.

The method for preparing the Weishengli oral liquid according to the present invention comprises the following process steps: The first step is ozone treatment. Weigh each component and treat it with ozone;

The second step is to prepare nano powder. Put amino acid and heme iron into compound high-shear crushing disperser to prepare nano powder;

The third step is ultrasonic mixing. Transfer the nano-powder into the ultrasonic mixer, add active peptides after 30 minutes, continue mixing for 60 minutes, and freeze to -18 ° C;

The fourth step is mixing. Blend each component at 2 ° C, mix well;

The fifth step is packaging.釆 Use sterile cans to make finished products.

The active peptide HGH of the present invention is an abbreviation of Human Growth Hormone, and is also called human growth hormone. It is a physiologically active substance secreted by the endocrine glands. The body's most important hormone (protein peptide), which is composed of 191 amino acid molecules, is the commander of all other hormones.

In general, when a person reaches 30 years of age, the secretion of active peptides gradually decreases. Because it participates in almost all life activities of the human body, it controls the growth and development, immune regulation, and metabolism of the human body. The amount of its secretion directly affects the growth and development of human cells, bones, cartilage, muscles, skin, liver, and kidneys.

The Weishengli oral liquid of the present invention is based on the traditional knowledge of traditional Chinese medicine for thousands of years, combined with the achievements of modern pharmacological research and the latest cutting-edge bioengineering technology. Human free radicals have significant functions all the way to thinking and emotion. It can fight diseases, activate the immune system, make people less sick, increase physical strength, Energizing, working long hours without feeling tired. Reveals a person's mental outlook, full of confidence, and high emotions. Revitalizes skin and bones. And it is an effective weight-loss medicine to reshape the body, selectively reduce deep fat in the waist, abdomen and thigh, and increase muscle. Regenerate organs such as liver, lungs, and kidneys, and restore organs and tissues to a younger level.

Modern medical research proves that the reason why people age is because of "telomeres,"

(Tel omero) decreases with cell division. At a certain level, "telomeres" disappear, cells stop dividing, and people will age and die.

However, this "telomere" is controlled by the "telomerase" in the nucleus. Normally, "telomerase" is in the "off" state, and active peptides (such as HGH, IFG-1) enter the cell through the blood, and it acts on the DNA of "telomerase", activates telomerase, and makes It is in an "open" state and increases the length of telomeres, thereby delaying aging.

In fact, the human immune system has declined sharply in middle-aged and elderly people, opening the door to various infectious diseases and cancers. The Weishengli oral liquid of the present invention can promote the increase of immune factors in the human body (including: Cytokines, interleukins 1 and 2, immunoglobulin G, tumor necrosis factor), thereby enhancing the immune function.

The Weishengli oral liquid provided by the invention provides important active peptides of the human body and promotes the secretion of glands, thereby enabling healthy development of human cells, bones, cartilage, muscles, skin, liver and kidneys, and delaying aging. After inspection, it contains a variety of amino acids and trace elements required by the human body, and various indicators are far higher than the standards of health foods, and the detection indicators of their fungi are far lower than the standards of health foods.

The Weishengli oral liquid of the present invention has obvious effects after taking it, and the majority of users take deep sleep on the second day after taking it; on the third day, the user's physical strength increases, fatigue is weakened, and his complexion becomes ruddy; one week later, Wet skin, reduced hair loss, increased energy, fast wound healing, reduced local edema, lightened scars, improved vision (presbyopia), reduced fat, increased appetite, improved sexual function, reduced female dryness; after one month, memory significantly increased, Decreased white hair, faded spots, disappeared small facial wrinkles, lightened dark circles, lightened age spots, decreased waist fat, female menopause may resume menstruation, increased immunity, increased endurance, energetic, refractory migraine, high blood pressure The symptoms of vertigo disappeared, and old diseases such as joint pain, rheumatism, and lumbar muscle strain improved significantly; two months, muscle strength increased, fat was further reduced, weight adjustment tended to be normal, fingers, toes Nail growth is improved, sexual function is enhanced, strength is increased, skin is moisturized, vision and night vision are improved, fatty liver disappears; three months, menstrual symptoms are reduced, body flexibility is increased, wounds heal quickly, muscle pain quickly disappears, muscle size increases The functions of various organs continued to improve; four months, the same effect as above, generally speaking, the effects increased and gradually became consistent; five months, significant weight loss and reduction in measurements, muscle strength due to reduced fat Increased skin thickness, elasticity and toughness, improved texture and appearance, increased hair density and healthy and shiny; six months, the effect is the same as above, but the effect is better and more stable, fat spheres are greatly reduced, emotional stability, vision It has been greatly improved. The old wound is healed or is being healed, the gray hair is turned to the original natural luster, the body shape is improved, the energy is vigorous, and the sports endurance is significantly enhanced.

An effect survey conducted in 2001 included 800 people, including entrepreneurs, senior executives, and most doctors, accounting for 20 °. . The data of 202 subjects were randomly selected for analysis. The 202 people ranged from 36 to 74 years old, and women accounted for 19%. The average treatment time of 202 people was 180 days, with a minimum of 1 month and a maximum of 2 years.

The results are as follows: 89% of pathological solutions, 84% of increased cardiac contractility, 85% of reduced cholesterol, 81% of increased muscle, 72% of reduced fat, and 81% of improved endurance, 68% increase in skin thickness, 71% increase in skin elasticity, 61% disappearance of wrinkles, 57% increase in wound healing ability, 58% decrease in hot flashes, and 39% regular menstruation. 78% increase confidence in life, 70% skin thinning and whitening, 89% increase in energy, 73% mood stabilization, 70% resistance to common diseases, 60% increase in memory, old 55% of wounds healed, and 36% were new hair.

Investigation results: The therapeutic effect reaches 100%, so the Weishengli oral liquid of the present invention has a very good effect in delaying and reversing aging and enhancing immune function.

Compared with the prior art, the Weishengli oral liquid according to the present invention has prominent substantive characteristics and significant progress:

1. Because the present invention adopts nano-embedding technology, the physiological activity of the active factor can be kept at room temperature for two years;

2. As the present invention adopts the form of oral spray instead of oral administration, it can be directly absorbed from the oral mucosa under the tongue and enter the blood microcirculation, thereby avoiding the active ingredient being largely decomposed and inactivated in the gastrointestinal tract. Force

3. Easy to use, less dosage, efficient and safe, and obvious effect;

4. Low cost.

detailed description:

In order to better understand and implement, the Weishengli oral liquid of the present invention and the preparation method thereof will be described in detail below with reference to the examples.

Example 1. Weigh 0.20g of active peptide, 58g of amino acid, 35g of heme iron, 0.40g of sodium selenite, 0.20g of magnesium lactate, 0.30g of zinc gluconate, and treat with ozone.

The amino acid and heme iron were put into a compound high-shear crushing and dispersing machine to prepare nano powder. Transfer the nanopowder into the ultrasonic mixer, add the active peptide after 30 minutes and continue mixing for 60 minutes, then freeze to -18 ° C. Formulated at 2 ° C according to the distribution ratio of each group, mixed, and then sterilized canned to prepare the vitality oral solution of the present invention.

Example 2. Weigh 0.30 g of active peptide, 80 g of amino acid, 40 g of heme iron, 0.46 g of sodium selenite, 0.18 g of magnesium lactate, and 0.35 g of gluconate, respectively, and treat with ozone.

The amino acid and heme hydrazone were put into a compound high-shear crushing disperser to prepare a nano powder. Transfer the nanopowder into the ultrasonic mixer, add the active peptide after 30 minutes and continue mixing for 60 minutes, then freeze to -18 ° C. Formulated at 2 ° C according to the distribution ratio of each group, mixed, and then sterilized canned to prepare the vitality oral solution of the present invention.

In Example 3, 0.18 g of active peptide, 55 g of amino acid, 30 g of heme iron, 0.35 g of sodium selenite, 0.19 g of magnesium lactate, and 0.28 g of zinc gluconate were weighed, respectively, and treated with ozone.

The amino acid and heme iron are put into a compound high-shear crushing and dispersing machine to prepare a nano powder. Transfer the nanopowder into the ultrasonic mixer, add the active peptide after 30 minutes and continue mixing for 60 minutes, then freeze to -18 ° C. Formulated at 2 ° C according to the distribution ratio of each group, mixed with hooks, and then sterilized canned to prepare the vitality oral solution of the present invention.

Example 4. Weigh 0.40 g of active peptide, 80 g of amino acid, 60 g of heme iron, 0.60 g of sodium selenite, 0.25 g of magnesium lactate, and 0.40 g of zinc gluconate, respectively, and treat with ozone.

The amino acid and heme iron are put into a compound high-shear crushing and dispersing machine to prepare a nano powder. Transfer the nano powder to the ultrasonic mixer, add active peptide after 30 minutes and continue mixing for 60 minutes Minutes, then frozen to -18 ° C. Formulated according to the distribution ratio of each group at 2 ° C, mixed, and then aseptically canned to prepare the vitality oral solution of the present invention.

Example 5, 0.15 g of active peptide, 50 g of amino acid, 20 g of heme iron, 0.30 g of sodium selenite, 0.18 g of magnesium lactate, and 0.25 g of zinc gluconate were weighed, respectively, and treated with ozone.

The amino acid and heme iron are put into a compound high-shear crushing and dispersing machine to prepare a nano powder. Transfer the nanopowder into the ultrasonic mixer, add the active peptide after 30 minutes and continue mixing for 60 minutes, then freeze to -18 ° C. Formulated at 2 ° C according to the distribution ratio of each group, mixed, and then sterilized canned to prepare the vitality oral solution of the present invention.

In Example 6, 0.50 g of active peptide, 100 g of amino acid, 80 g of heme iron, 0.80 g of sodium selenite, 0.30 g of magnesium lactate, and 0.50 g of zinc gluconate were weighed and treated with ozone.

Claims

Claim

1. A Weishengli oral liquid, characterized in that it is composed of the following components in parts by weight, active peptide 0. 15-0. 50, amino acid 50-100, heme iron 20-80, selenite Sodium 0. 30-0. 80, magnesium lactate 0. 18-0. 30, zinc gluconate 0. 25-0. 50.

2. The Weishengli oral liquid according to claim 1, characterized in that: the weight ratio of each component is, active peptide 0.18-0. 40, amino acid 55-80, heme iron 30- 60. Sodium selenite 0.35-0. 60, magnesium lactate 0.19-0. 25, zinc gluconate 0. 28-0. 40.

3. The Weishengli oral liquid according to claim 2, characterized in that: the weight ratio of each component is: active peptide 0.20, amino acid 58, heme iron 35, sodium selenite 0. 40, magnesium lactate 0.20, zinc gluconate 0.30.

4. The method for preparing any of the Weishengli oral liquids according to claims 1-3, characterized in that it comprises the following process steps:

The first step is ozone treatment, each component is weighed and treated with ozone;

In the second step, a nano powder is prepared, and the amino acid and heme iron are placed in a compound high-shear crushing disperser to prepare a nano powder.

The third step is ultrasonic mixing. The nanopowder is transferred into an ultrasonic mixer. After 30 minutes, the active peptide is added and mixing is continued for 60 minutes, and frozen to -18 ° C;

The fourth step is mixing, and the components are blended at 2 ° C to mix evenly;

The fifth step is packaging, using aseptic canning, to make the finished product.