WO2004089551A2 - Systeme de buse pour dispositif de distribution de liquide comportant une buse et une fixation de buse et/ou une collerette de fixation - Google Patents

Systeme de buse pour dispositif de distribution de liquide comportant une buse et une fixation de buse et/ou une collerette de fixation Download PDF

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Publication number
WO2004089551A2
WO2004089551A2 PCT/EP2004/000082 EP2004000082W WO2004089551A2 WO 2004089551 A2 WO2004089551 A2 WO 2004089551A2 EP 2004000082 W EP2004000082 W EP 2004000082W WO 2004089551 A2 WO2004089551 A2 WO 2004089551A2
Authority
WO
WIPO (PCT)
Prior art keywords
nozzle
liquid
micro
bore
holder
Prior art date
Application number
PCT/EP2004/000082
Other languages
German (de)
English (en)
Other versions
WO2004089551A3 (fr
Inventor
Heinrich Kladders
Herbert Wachtel
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Priority to CA002513167A priority Critical patent/CA2513167A1/fr
Priority to EP04739056A priority patent/EP1587629A2/fr
Priority to JP2006504383A priority patent/JP2007517529A/ja
Publication of WO2004089551A2 publication Critical patent/WO2004089551A2/fr
Publication of WO2004089551A3 publication Critical patent/WO2004089551A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released

Definitions

  • Nozzle system for an application device for liquids consisting of nozzle and nozzle holder and / or union nut
  • the invention relates to a nozzle system for a dispensing device for liquids, which includes a nozzle and a device that fixes the nozzle in the dispensing device.
  • the device has a liquid reservoir, from which a liquid is pressed under pressure through a nozzle for dispensing the liquid.
  • the nozzle is fixed to the delivery device by a holder.
  • This bracket can itself from a second bracket, e.g. be held in the form of a union nut or the union nut itself is the holder.
  • at least part of the outer surface of the holding device is micro- or nanostructured.
  • the present invention is preferably part of a propellant-free device for atomizing pharmaceutical liquids.
  • a nebulizer according to the invention is used, for example, to provide an aerosol of droplets for inhalation through the mouth and throat area into a patient's lungs, for nasal absorption or for spraying the surface of the eye.
  • WO 91/14468 discloses a device for the propellant-free administration of a metered amount of a liquid medicament for inhalation use.
  • a further development of the device is described in detail in WO 97/12687.
  • Reference is made to the cited references are expressly incorporated herein and the technology described therein is referred to as Respimat ® technology in the context of the present invention. This term is understood in particular to mean the technology on which a device according to FIGS. 6a and 6b of WO 97/12687 and the associated description is based.
  • liquid drug formulations are stored in a reservoir. From there, they are transported via a riser pipe into a pressure chamber, in order to then be pressed further through a nozzle.
  • the nozzle has a liquid inlet side and a liquid outlet side. There is an opening on the liquid inlet side through which a liquid coming from the pressure chamber can enter the nozzle. On the opposite side, the end face of the nozzle, the liquid then exits through two nozzle openings which are aligned in such a way that the liquid jets emerging from the openings collide with one another and are thereby atomized.
  • the nozzle openings are located in the inhaler so that they are in direct contact with the outside environment.
  • inhalers usually deliver formulations based on water or water-ethanol mixtures. They can nebulize a small amount of a liquid formulation in the therapeutically necessary dosage within a few seconds into an aerosol suitable for therapeutic inhalation.
  • the device can be used to atomize quantities of less than 100 microliters with, for example, one stroke to an aerosol with an average particle size of less than 20 micrometers so that the inhalable portion of the aerosol already corresponds to the therapeutically effective amount.
  • nebulisers with Respimat ® technology a drug solution is converted into a respirable low-speed aerosol cloud by means of a high pressure of up to 500 bar, which can then be inhaled by the patient.
  • a small part of the liquid can be deposited as a film or as small droplets from the outside onto the face of the nozzle or the face of the holder system of the nozzle or the inside of the mouthpiece.
  • This portion of the liquid is also referred to as the mouthpiece portion in the context of this description of the invention.
  • the proportion of precipitated liquid does not have to be constant with every stroke, but can be due to several factors such as the orientation of the device in space during the
  • the deposited liquid can also contaminate the outer surface of the nozzle system or the mouthpiece, which in turn can affect the pharmaceutical quality of a next aerosol cloud.
  • the two effects are rather small with Respimat technology devices, it is important for quality assurance reasons to minimize such effects.
  • Another task is to optimize the quality with which atomizers of the Respimat ® technology apply a liquid.
  • the present invention relates to a nozzle system for liquid nebulizers, in which at least a part of the outer surface of the nozzle system or other components of the nebulizer, which can come into contact with the applied aerosol, has / have a micro- or nanostructured surface.
  • at least the outward-facing end face of the nozzle ie the side of the nozzle from which the aerosol cloud is discharged
  • the nozzle is a pinhole with at least one opening.
  • nozzles made of at least two plates lying one on top of the other, at least one of the plates having a second microstructure, so that the plates lying one above the other define a liquid inlet on one side, which is followed by a channel system and / or a filter system, which then connects into one , two or more liquid outlets opens.
  • all of the nozzle openings are preferably formed on a common side.
  • the nozzle openings can be oriented such that the liquid jets emerging therefrom collide in front of the nozzle opening.
  • Such systems require nozzles with at least two openings. Such nozzles are explained in more detail in the description of the Respimat® technology.
  • nozzles can be part of a nozzle system by which the nozzles are held at a defined location in the application device.
  • a nozzle system consists of a nozzle and a nozzle holder and / or a union nut, each with an end face. This is the side that is oriented away from the side of the nozzle with the nozzle opening.
  • the inside of the face of the nozzle holder or the union nut touches the liquid outlet side of the nozzle and thereby exerts the force required to hold the nozzle in the direction of the liquid inlet side of the nozzle.
  • the end face of the nozzle holder and / or the union nut have a continuous bore or hole through which the aerosol can escape from the nozzle.
  • the nozzle openings are therefore in or in a direct line below the bore.
  • the bore or the hole can be designed as an inner recess which widens continuously from the nozzle openings.
  • Embodiments are advantageous here of the nozzle system, in which the recess has a funnel-shaped shape, preferably a conical shape.
  • the point of impact at which the liquid jets are atomized to form an aerosol is preferably in the vicinity of the foot of the recess, i.e. near the nozzle opening. It is obvious that in such a case the recess is one of the areas particularly at risk of liquid precipitation.
  • At least some of the following areas are micro- or nano-structured:
  • the widening recess of the nozzle holder and / or the union nut or a structural combination of both parts preferably has the micro- or nanostructured surface.
  • the critical surface also includes the mouthpiece into which a nozzle usually sprays the pharmaceutical aerosol so that it can be inhaled from here.
  • a mouthpiece can be designed as a tubular projection, at the bottom of which the nozzle is located.
  • EP 772514 describes what the microstructures or nanostructures used according to the invention can look like, which is why the content of this document is hereby referred to.
  • critical surfaces are those of the nozzle holder or the union nut, at least 20% of their surface, more preferably at least 50%, even more preferably at least 75%, have a micro or nanostructure.
  • 20% of the outer surface of the nozzle outlet side can have a micro or nanostructure.
  • the critical surface is the inner surface of a mouthpiece, this surface can also be at least 20% micro or nanostructured, more preferably at least 50%, even more preferably at least 75%.
  • the critical surfaces of the nozzle holder and / or the union nut are preferably micro- or nanostructured.
  • the structuring of the critical surface according to the invention is achieved in that elevations and depressions are formed on the micro or nano-scale at least on parts of the critical surface.
  • the elevations and depressions can have the shape of tips, spheres, flat surfaces or be wedge-shaped, hemispherical, etc.
  • the distance between the elevations of the surface structure is in the range from 0.1 to 200 micrometers, preferably 0.1 to 100 micrometers. Distances from 0.1 to 10 micrometers are more preferred, distances from 0.1 to 1 micrometer are most preferred.
  • the height of the elevations or the depth of the depressions is in the range from 0.1 to 100 micrometers, preferably 0.1 to 50 micrometers. Distances of 0.1 to 10 micrometers are most preferred.
  • the elevations of the surface structures are preferably so close together that hydrophilic liquid drops, e.g. Drops of water on the bumps without really touching the surface.
  • the elevations of the surface structures must not be too close to one another or the depressions must not be too flat, so that they do not form a closed surface in relation to the droplet size of the liquid, in which the surface forces between the droplet and the surface take full effect. It should therefore be aimed at that with increasing distance the
  • Surveys should also increase the height of the surveys from the underground. Surfaces with elevations which have 0.1 to 50 micrometers and in which the distance between the elevations is 0.1 to 100 micrometers are preferred.
  • the critical surfaces preferably consist of hydrophobic materials or durable hydrophobic materials or they are coated with such materials.
  • the surveys cannot be removed by water or by water with detergents. Plastics, metals, ceramics, glasses etc. can be used as materials.
  • Preferred materials are glass and / or ceramics and / or metals and / or
  • Plastics such as polyethylene, polypropylene, polycarbonate, polyacrylates, polyesters, silanes etc. Plastics are preferred. Possibly. Such a plastic can be provided with a lacquer layer of another plastic which carries or forms the surface structure, e.g. B. during drying.
  • Such structured surfaces can either be produced by the
  • Surface structures can be created from hydrophobic materials during manufacture or can only be created subsequently by subtractive or additive treatment of the surfaces. These processes include subsequent embossing, etching, laser ablation, galvanic removal, sticking on a structured film, sticking on a powder, spraying with suspensions, deposition of sublimates etc.
  • Silanization can take place on all materials that are naturally hydrophilic but are able to react with the reactive groups of the silanes, so that the surface ultimately consists of the hydrophobic residues of the silanes.
  • the objects can be produced from the outset in forms which have the negative of the desired surface structure.
  • hydrophobic polymers in the form of solutions and / or dispersions which, when they dry and set, lead to the desired surface structures.
  • Structures of this type arise, for example, from self-organizing polymers or under conditions which are known in principle from the production of matt lacquer surfaces. If it is not possible or not desirable to create the desired surface structures from the outset, this can also be done subsequently, for example by subsequent embossing or etching.
  • the embossing can be done, for example, by heated or heatable stamps.
  • the etching can be carried out using the known chemical etching means or by physical methods such as ion etching with oxygen or other irradiations, which lead to a roughening of the surface and a surface structure that can be used according to the invention.
  • the way in which a surface structure is created depends on the material selected and the desired microstructure.
  • This invention is preferably used in a nebulizer ® technology the Respimat.
  • the preferred atomizer has a lower and an upper housing which is rotatably mounted relative to one another, a spring housing with a spring being formed in the upper part of the housing, which is preferably tensioned in the form of a screw thread or gear by rotating the two housing parts via a locking mechanism and by pressing a release button on Housing upper part is relaxed.
  • This moves an output flange, which is connected to a hollow piston, at the lower end of which a container can be attached, and at the upper end of which there is a valve and a pressure chamber which is connected to the nozzle or the nozzle system, which (up) open area of the upper housing part is formed in a liquid-conducting connection.
  • the liquid is sucked in by the hollow piston and pumped to the pressure chamber, from where it is discharged through the nozzle as an aerosol.
  • the hollow piston with valve body corresponds to a device disclosed in WO 97/12687. It projects partially into the cylinder of the pump housing and is arranged axially displaceably in the cylinder. In particular, reference is made to FIGS. 1-4 - in particular FIG. 3 - and the associated parts of the description.
  • Valve body exercises one on its high pressure side at the time the spring is triggered Pressure of 5 to 60 MPa (about 50 to 600 bar), preferably 10 to 60 MPa (about 100 to 600 bar) on the fluid, the measured active ingredient solution.
  • the valve body is preferably attached to the end of the hollow piston which faces the nozzle body.
  • the valve body is in fluid communication with the nozzle.
  • the nozzle in the nozzle body is preferably microstructured, i.e. made by microtechnology.
  • the microstructure mentioned in this context is - at least in terms of function - different from the microstructure according to the invention, as is clearly evident from the context.
  • Microstructured nozzle bodies are described, for example, in WO 94/07607 or WO 99/16530. Another embodiment is disclosed in WO 03/097139. We hereby expressly refer to all documents. With regard to WO 94/07607, reference is made in particular to FIG. 1 and its description.
  • the nozzle body is e.g. from two firmly connected plates made of glass and / or silicon, of which at least one plate has one or more microstructured channels which connect the nozzle inlet side to the nozzle outlet side.
  • the jet directions of the nozzles in the nozzle body can run parallel to one another or they are inclined towards one another in the direction of the nozzle opening.
  • the jet directions can be inclined at an angle of 20 degrees to 160 degrees, 60 to 150 degrees are preferred, and 70 to 100 degrees are particularly preferred.
  • the nozzle openings are preferably arranged at a distance of 10 to 200 micrometers, more preferably at a distance of 10 to 100 micrometers, particularly preferably 30 to 70 micrometers. Most preferred are 50 microns.
  • the jet directions meet in the vicinity of the nozzle openings.
  • an embodiment is described below in which only the base part of the nozzle body has relief-like microstructures, but not the ceiling part. In other embodiments, the situation is just reversed, or both parts have these microstructures.
  • a set of channels can be formed on the base part on the flat surface in order to create a plurality of filter passageways in cooperation with the substantially flat surface of the ceiling part (filter channels).
  • the base part can have a plenum chamber, the ceiling of which in turn is formed by the ceiling part. This plenum chamber can be connected upstream or downstream of the filter channels. Two plenum chambers of this type can also be formed.
  • Another set of channels on the substantially flat surface of the base portion downstream of the filter channels forms, together with the top portion, a set of channels that provide a plurality of nozzle outlet passageways.
  • the total cross-sectional area of the nozzle outlets is preferably 25 to 500 square micrometers.
  • the total cross-sectional area is preferably 30 to 200 square microns.
  • this nozzle construction also has only a single nozzle opening.
  • the filter channels and / or the plenum chamber are missing.
  • the filter channels are preferably formed by projections which are arranged in a zigzag shape.
  • at least two rows of the projections form such a zigzag configuration.
  • a plurality of rows of protrusions can also be formed, the protrusions each being laterally offset from one another, in order thereby to construct further rows obliquely to these rows, in which case the rows described last form the zigzag configuration.
  • the inlet and outlet may each have a longitudinal slot for unfiltered or filtered fluid, each of the slots being substantially the same width as the filter and being substantially the same height as the protrusions on the inlet and outlet sides of the filter, respectively ,
  • the cross section of the passage passages formed by the projections can be perpendicular to the direction of flow of the fluid and - viewed in the direction of flow - can decrease from row to row.
  • the projections, which are arranged closer to the inlet side of the filter can also be larger than the projections, which are arranged closer to the outlet side of the filter.
  • the distance between the base part and the cover part can taper in the area from the nozzle inlet side to the nozzle outlet side.
  • the zigzag configuration which is formed by the at least two rows of projections, has an inclination angle alpha of preferably 20 ° to 250 °.
  • the nozzle can be embedded in an elastomeric sleeve, as described in WO 97/12683.
  • a cuff is a ring or body with an opening into which the nozzle can be inserted.
  • This opening encompasses the nozzle block over its entire lateral surface, i.e. the surface which is perpendicular to the preferably linear axis which is formed by the nozzle inlet side and the nozzle outlet side.
  • the cuff is open at the top and bottom so as not to impede the liquid supply to the nozzle inlet side of the nozzle or the discharge of the liquid.
  • This cuff can in turn be inserted into a second cuff.
  • the outer shape of the first cuff is preferably conical.
  • the opening of the second sleeve is shaped accordingly.
  • the first cuff can be made of an elastomer.
  • the nozzle possibly including the sleeve, is held by a device for holding it from the outside in the direction of the hollow piston, as described above.
  • the atomiser's locking mechanism contains a spring, preferably a cylindrical helical compression spring, as a store for the mechanical energy.
  • the spring acts on the output flange as a jumping piece, the movement of which is determined by the position of a locking element is determined.
  • the path of the output flange is precisely limited by an upper and a lower stop.
  • the spring is preferably tensioned via a force-transmitting gear, for example a screw-push gear, by an external torque which is generated when the upper housing part is rotated against the spring housing in the lower housing part.
  • the upper part of the housing and the output flange contain a single or multi-speed wedge gear.
  • the locking member with engaging locking surfaces is arranged in a ring around the output flange.
  • the ring is arranged in a plane perpendicular to the atomizer axis. After tensioning the spring, the locking surfaces of the locking member slide into the path of the output flange and prevent the spring from relaxing.
  • the locking element is triggered by a button.
  • the trigger button is connected or coupled to the locking member.
  • the release button is moved parallel to the ring plane, and preferably into the atomizer; the deformable ring is deformed in the plane of the ring. Structural details of the locking mechanism are described in WO 97/20590.
  • the lower part of the housing is pushed in the axial direction over the spring housing and covers the bearing, the drive of the spindle and the reservoir for the fluid.
  • the upper housing part When the atomizer is actuated, the upper housing part is rotated against the lower housing part, the lower housing part taking the spring housing with it.
  • the spring is compressed and tensioned via the screw-type thrust gear, and the locking mechanism engages automatically.
  • the angle of rotation is preferably an integer fraction of 360 degrees, for example 180 degrees.
  • the driven part in the upper part of the housing is shifted by a predetermined distance, the hollow piston is withdrawn within the cylinder in the pump housing, whereby a part of the fluid is sucked from the reservoir into the high-pressure space in front of the nozzle.
  • Several interchangeable storage containers containing the fluid to be atomized can optionally be inserted and used in the atomizer.
  • the storage container contains the inventive aqueous aerosol preparation.
  • the atomization process is initiated by gently pressing the trigger button.
  • the barrage clears the way for the stripping section.
  • the tensioned spring pushes the hollow piston into the cylinder of the pump housing.
  • the fluid exits the atomizer nozzle in atomized form.
  • the liquid pharmaceutical preparation hits the nozzle body at an inlet pressure of up to 600 bar, preferably 200 to 300 bar, and is atomized into an inhalable aerosol via the nozzle openings.
  • the preferred particle sizes of the aerosol are up to 20 micrometers, preferably 3 to 10 micrometers.
  • Volumes of 10 to 50 microliters are preferably applied, volumes of 10 to 20 microliters are particularly preferred, and a volume of 15 microliters per stroke is very particularly preferred.
  • the components of the atomizer are made of a material that is suitable for their function.
  • the housing of the atomizer and - as far as the function allows - other parts are preferably made of plastic, e.g. manufactured by injection molding. Physiologically harmless materials are used for medical purposes.
  • a nebulizer according to the invention is preferably of a cylinder-like shape and has a handy size of less than 9 to 15 cm in length and 2 to 4 cm in width, so that it can be carried by the patient at any time.
  • the outer surface of the nozzle outlet side, parts of the nozzle holder and / or the union nut and, if appropriate, other surfaces in the vicinity of the nozzle opening on which liquid can flow the aerosol mist most likely to precipitate can be provided with the nano or micro structure.
  • other surfaces of the Respimat ® -Geräts can according to the invention having the microstructure or nanostructure. These include the inner and parts of the outer surface of the hollow piston, the inner surfaces of the components forming the nozzle, parts of the inner microstructured surface of the nozzle and others.
  • the present invention is applicable to all types of liquid nebulizers in which aqueous systems are nebulized.
  • the invention is neither limited to the technology on which the vebulization is based, nor to the purpose which such vebulizers are intended to serve.
  • FIGS. 2 show two embodiments of a nozzle system in a side view, partially in section
  • FIG. 3 shows an experimental example for a microstructured nozzle system.
  • FIG. 4 shows a schematic illustration of an embodiment of a nozzle body in a side view, in section.
  • FIGS. 5 to 9 show surface structures of polyester films with a structured acrylic layer.
  • Figure 1 a shows a longitudinal section through the atomizer with the spring tensioned.
  • Figure 1 b shows a longitudinal section through the atomizer with the spring relaxed.
  • the upper housing part (51) contains the pump housing (52), at the end of which the holder (53) for the atomizer nozzle is attached.
  • the widening recess (54) and the nozzle body (55) are located in the holder.
  • the hollow piston (57) fastened in the output flange (56) of the locking tension mechanism partially projects into the cylinder of the pump housing.
  • the hollow piston carries the valve body (58) at its end.
  • the hollow piston is sealed by means of the seal (59).
  • the stop (60) Inside the upper part of the housing is the stop (60), against which the output flange rests when the spring is relaxed.
  • the stop (61) is located on the output flange, against which the output flange rests when the spring is tensioned. After tensioning the spring, the locking member (62) slides between the stop (61) and a support (63) in the upper part of the housing.
  • the release button (64) is connected to the locking member.
  • the upper part of the housing ends in the mouthpiece (65) and is closed with the clip-on protective cap (66).
  • the spring housing (67) with compression spring (68) is rotatably mounted on the upper part of the housing by means of the snap lugs (69) and rotary bearings.
  • the lower housing part (70) is pushed over the spring housing.
  • the exchangeable storage container (71) for the fluid (72) to be atomized is located within the spring housing.
  • the storage container is closed with the stopper (73) through which the hollow piston protrudes into the storage container and with its end is immersed in the fluid (supply of active substance solution).
  • the spindle (74) for the mechanical counter is attached to the outer surface of the spring housing (optional).
  • the drive pinion (75) is located at the end of the spindle which faces the upper housing part.
  • the rider (76) sits on the spindle.
  • Figure 2a shows an embodiment of the system of nozzle (55) and nozzle holder in side view, partially in section.
  • the nozzle (55) or the nozzle body as an independent structural unit - so-called uniblock - is arranged in a conical sleeve (77), which in turn is placed in the nozzle holder (78).
  • the nozzle holder (78) is clamped to the housing (80) by means of a union nut (79) and the nozzle (55) is ultimately fixed with it.
  • the union nut (79) holds the nozzle holder (78) from the outside without engaging in its conical recess (81).
  • the recess (81) is of a conical shape in such a way that it widens continuously with increasing distance from the nozzle openings.
  • the recess (81) has a cone angle 2 ⁇ .
  • the recess (81) is formed exclusively by the nozzle holder (78).
  • Figure 2b shows an embodiment of the nozzle system (55) in side view, partially in section, which differs from Figure 2a in that this time the union nut also forms part of the conical shape (81). There are no steps in the recess (81) in the area of the transition from the nozzle holder (78) to the union nut (79). The particles of the atomizing cloud, which then deposit in such a stage and contribute to the mouthpiece portion, can no longer be carried away by actuating the nebulizer again.
  • a Respimat brand device is used, analogous to FIG. 1. This device was modified in such a way that the critical surface, i.e. the recess (81), the
  • Nozzle system analogous to that of Figure 2, with the silicone paint Lotusan ® of the company Dyckerhoff is coated.
  • the device is sprayed with an aqueous placebo solution and the amount of liquid deposited on the critical surface is measured compared to an uncoated device.
  • FIG. 4 shows a schematic illustration of a section of an embodiment of a nozzle body (55) with two nozzle openings in a side view.
  • Figures 5 to 9 show examples of surface structures of polyester films with a structured acrylic layer, which can be glued to the critical surface of the nozzle holder and or the union nut

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • Nozzles (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un système de buse pour un dispositif de distribution de liquide, constitué par une buse et par un dispositif fixant la buse dans le dispositif de distribution. Le dispositif de distribution comporte un réservoir de liquide d'où sort le liquide sous pression par une buse de distribution de liquide, la buse étant maintenue sur le dispositif de distribution par une fixation. Cette fixation peut elle-même être maintenue par une deuxième fixation, par ex. sous forme d'une collerette, ou bien cette collerette forme elle-même la fixation. Selon l'invention, au moins une partie de la surface externe du dispositif de fixation présente une microstructure ou une nanostructure.
PCT/EP2004/000082 2003-01-14 2004-01-09 Systeme de buse pour dispositif de distribution de liquide comportant une buse et une fixation de buse et/ou une collerette de fixation WO2004089551A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002513167A CA2513167A1 (fr) 2003-01-14 2004-01-09 Systeme de buse pour dispositif de distribution de liquide comportant une buse et une fixation de buse et/ou une collerette de fixation
EP04739056A EP1587629A2 (fr) 2003-01-14 2004-01-09 Systeme de buse pour dispositif de distribution de liquide comportant une buse et une fixation de buse et/ou une collerette de fixation
JP2006504383A JP2007517529A (ja) 2004-01-09 2004-01-09 ノズル、ノズル・ホルダ、及び／又はチェック・ナットを備えた液体用供給装置のためのノズル・システム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10300983A DE10300983A1 (de) 2003-01-14 2003-01-14 Düsensystem für eine Ausbringungsvorrichtung für Flüssigkeiten bestehend aus Düse und Düsenhalter und/oder Überwurfmutter
DE10300983.3 2003-01-14

Publications (2)

Publication Number Publication Date
WO2004089551A2 true WO2004089551A2 (fr) 2004-10-21
WO2004089551A3 WO2004089551A3 (fr) 2005-07-14

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PCT/EP2004/000082 WO2004089551A2 (fr) 2003-01-14 2004-01-09 Systeme de buse pour dispositif de distribution de liquide comportant une buse et une fixation de buse et/ou une collerette de fixation

Country Status (4)

Country Link
EP (1) EP1587629A2 (fr)
CA (1) CA2513167A1 (fr)
DE (1) DE10300983A1 (fr)
WO (1) WO2004089551A2 (fr)

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WO2009081199A1 (fr) * 2007-12-20 2009-07-02 42 Technology Limited Production d'aérosol
US9192734B2 (en) 2009-07-13 2015-11-24 Boehringer Ingelheim International Gmbh High-pressure chamber
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
WO2017060386A1 (fr) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Procédé de revêtement de composants microstructurés
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
GB2621810A (en) * 2022-05-16 2024-02-28 Merxin Ltd Fixing assembly

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JP4908419B2 (ja) 2004-10-06 2012-04-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ディスペンサ、貯蔵装置及び粉末の小出し方法
DE102013210539A1 (de) 2013-06-06 2014-12-11 Heraeus Medical Gmbh Medizinische Sprühvorrichtung mit Düse und Verfahren zum Erzeugen eines Sprühkegels
EP4209238A1 (fr) 2016-12-21 2023-07-12 Boehringer Ingelheim International GmbH Nébuliseur et cartouche
EP4058351A1 (fr) * 2019-11-14 2022-09-21 Paul NEISER Appareil et procédé de filtration

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WO1994007607A1 (fr) 1992-09-29 1994-04-14 Boehringer Ingelheim International Gmbh Ajutage de pulverisation et filtre, et dispositif generant une pulverisation
EP0772514A1 (fr) 1994-07-29 1997-05-14 Wilhelm Barthlott Surfaces autonettoyantes d'objets et leur procede de production
WO1997012683A1 (fr) 1995-10-04 1997-04-10 Boehringer Ingelheim International Gmbh Dispositif de fixation pour composant expose a un fluide sous pression
WO1997012687A1 (fr) 1995-10-04 1997-04-10 Boehringer Ingelheim International Gmbh Dispositif, sous forme miniature, destine a produire une pression elevee dans un fluide a atomiser
WO1997020590A1 (fr) 1995-12-05 1997-06-12 Boehringer Ingelheim International Gmbh Mecanisme de blocage destine a un dispositif actionne par un ressort
WO1999016530A1 (fr) 1997-09-26 1999-04-08 Boehringer Ingelheim International Gmbh Filtre a microstructure
WO2003097139A1 (fr) 2002-05-16 2003-11-27 Boehringer Ingelheim International Gmbh Systeme comprenant une buse et un dispositif de maintien

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009081199A1 (fr) * 2007-12-20 2009-07-02 42 Technology Limited Production d'aérosol
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9192734B2 (en) 2009-07-13 2015-11-24 Boehringer Ingelheim International Gmbh High-pressure chamber
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
WO2017060386A1 (fr) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Procédé de revêtement de composants microstructurés
US11701478B2 (en) 2015-10-09 2023-07-18 Boehringer Ingelheim International Gmbh Method for coating microstructured components
GB2621810A (en) * 2022-05-16 2024-02-28 Merxin Ltd Fixing assembly

Also Published As

Publication number Publication date
EP1587629A2 (fr) 2005-10-26
DE10300983A1 (de) 2004-07-22
WO2004089551A3 (fr) 2005-07-14
CA2513167A1 (fr) 2004-10-21

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