WO2004087957A3 - Genes hypermethyles et cancer du col de l'uterus - Google Patents

Genes hypermethyles et cancer du col de l'uterus Download PDF

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Publication number
WO2004087957A3
WO2004087957A3 PCT/IB2004/001516 IB2004001516W WO2004087957A3 WO 2004087957 A3 WO2004087957 A3 WO 2004087957A3 IB 2004001516 W IB2004001516 W IB 2004001516W WO 2004087957 A3 WO2004087957 A3 WO 2004087957A3
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WO
WIPO (PCT)
Prior art keywords
cervical cancer
hypermethylated genes
genes
detecting
hypermethylated
Prior art date
Application number
PCT/IB2004/001516
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English (en)
Other versions
WO2004087957A2 (fr
Inventor
N Reesink-Peters
Der Zee Ate G J Van
Original Assignee
Oncomethylome Sciences S A
N Reesink-Peters
Der Zee Ate G J Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0307739A external-priority patent/GB0307739D0/en
Application filed by Oncomethylome Sciences S A, N Reesink-Peters, Der Zee Ate G J Van filed Critical Oncomethylome Sciences S A
Publication of WO2004087957A2 publication Critical patent/WO2004087957A2/fr
Publication of WO2004087957A3 publication Critical patent/WO2004087957A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

La prEsente invention concerne des mEthodes et des trousses perfectionnEes pour dEtecter le cancer du col de l'utErus dans un Echantillon. Ces procEdEs consistent A dEtecter l'Etat d'hypermEthylation d'un panel de gEnes.
PCT/IB2004/001516 2003-04-03 2004-04-05 Genes hypermethyles et cancer du col de l'uterus WO2004087957A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46003803P 2003-04-03 2003-04-03
GB0307739.3 2003-04-03
GB0307739A GB0307739D0 (en) 2003-04-03 2003-04-03 Hypermethylated genes and cervical cancer
US60/460,038 2003-04-03

Publications (2)

Publication Number Publication Date
WO2004087957A2 WO2004087957A2 (fr) 2004-10-14
WO2004087957A3 true WO2004087957A3 (fr) 2005-07-28

Family

ID=33133147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/001516 WO2004087957A2 (fr) 2003-04-03 2004-04-05 Genes hypermethyles et cancer du col de l'uterus

Country Status (1)

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WO (1) WO2004087957A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007531512A (ja) * 2003-11-10 2007-11-08 エピゲノミクス アーゲー 婦人科細胞増殖障害の分析方法
US20090023137A1 (en) * 2004-07-16 2009-01-22 Oncomethylome Sciences S.A. ESR1 and Cervical Cancer
WO2006088940A2 (fr) * 2005-02-14 2006-08-24 The Johns Hopkins University Compositions de depistage de neoplasie et procedes d'utilisation
WO2006113671A2 (fr) * 2005-04-15 2006-10-26 Oncomethylome Sciences, S.A. Marqueur de methylation pour le diagnostic et le traitement des cancers
US20070059753A1 (en) 2005-09-15 2007-03-15 Tatiana Vener Detecting gene methylation
JP5406839B2 (ja) * 2007-09-17 2014-02-05 オンコメチローム サイエンシズ ソシエテ アノニム Ｍａｇｅ−ａ発現の改良された検出
EP2271774B1 (fr) * 2008-03-21 2018-03-07 MDxHealth Détection et pronostic du cancer du col de l' utérus
WO2011036173A1 (fr) 2009-09-24 2011-03-31 Oncomethylome Sciences S.A. Détection et pronostic du cancer du col de l'utérus
US9096905B2 (en) * 2012-02-23 2015-08-04 Medical Diagnostic Laboratories, Llc Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans
PT3198034T (pt) 2014-09-22 2021-11-12 Univ Groningen Biomarcadores para cancro cervical
CN107287294A (zh) * 2017-06-14 2017-10-24 广州中心法则生物科技有限公司 一种宫颈癌相关基因甲基化程度的检测引物、探针、试剂盒及其应用
CN113718035B (zh) * 2021-09-30 2023-03-28 安徽同科生物科技有限公司 环状RNA hsa_circ_0003552的应用及检测其的试剂盒

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002674A1 (fr) * 1994-07-19 1996-02-01 The Johns Hopkins University School Of Medicine Diagnostic genetique du cancer de la prostate
WO1997046705A1 (fr) * 1996-06-03 1997-12-11 The Johns Hopkins University School Of Medicine Detection specifique de la methylation
US5976799A (en) * 1996-03-21 1999-11-02 The Board Of Trustees Of The University Of Arkansas Early detection of ovarian carcinoma using P16 gene products
WO2001042467A2 (fr) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits et techniques d'identification, d'evaluation, et de prevention du cancer du col de l'uterus et therapie
US6255293B1 (en) * 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
WO2001075172A1 (fr) * 2000-03-31 2001-10-11 University Of Southern California Sequences epigenetiques d'adenocarcinomes oesophagiens
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6335170B1 (en) * 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
WO2002070742A1 (fr) * 2001-03-01 2002-09-12 Epigenomics Ag Procede de mise au point de groupes d'echantillons de genes a des fins de diagnostic et de therapie qui sont bases sur l'expression et l'etat de methylation des genes
WO2004086949A2 (fr) * 2003-03-25 2004-10-14 John Wayne Cancer Institute Marqueurs d'adn utilises dans la gestion du cancer

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002674A1 (fr) * 1994-07-19 1996-02-01 The Johns Hopkins University School Of Medicine Diagnostic genetique du cancer de la prostate
US5976799A (en) * 1996-03-21 1999-11-02 The Board Of Trustees Of The University Of Arkansas Early detection of ovarian carcinoma using P16 gene products
WO1997046705A1 (fr) * 1996-06-03 1997-12-11 The Johns Hopkins University School Of Medicine Detection specifique de la methylation
US6255293B1 (en) * 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
US6335170B1 (en) * 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
WO2001042467A2 (fr) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits et techniques d'identification, d'evaluation, et de prevention du cancer du col de l'uterus et therapie
WO2001075172A1 (fr) * 2000-03-31 2001-10-11 University Of Southern California Sequences epigenetiques d'adenocarcinomes oesophagiens
WO2002070742A1 (fr) * 2001-03-01 2002-09-12 Epigenomics Ag Procede de mise au point de groupes d'echantillons de genes a des fins de diagnostic et de therapie qui sont bases sur l'expression et l'etat de methylation des genes
WO2004086949A2 (fr) * 2003-03-25 2004-10-14 John Wayne Cancer Institute Marqueurs d'adn utilises dans la gestion du cancer

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JERONIMO CARMEN ET AL: "Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 93, no. 22, 21 November 2001 (2001-11-21), pages 1747 - 1752, XP002316654, ISSN: 0027-8874 *
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