WO2004080407A3 - Nouveaux composes a modulation de serotinine et utilisations associees - Google Patents

Nouveaux composes a modulation de serotinine et utilisations associees Download PDF

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Publication number
WO2004080407A3
WO2004080407A3 PCT/US2004/007091 US2004007091W WO2004080407A3 WO 2004080407 A3 WO2004080407 A3 WO 2004080407A3 US 2004007091 W US2004007091 W US 2004007091W WO 2004080407 A3 WO2004080407 A3 WO 2004080407A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulating compounds
uses therefor
serotonin modulating
new serotonin
new
Prior art date
Application number
PCT/US2004/007091
Other languages
English (en)
Other versions
WO2004080407A2 (fr
Inventor
Dale S Dhanoa
Silvia Noiman
Oren Becker
Yael Marantz
Dongli Chen
Shacham Sharon
Boaz Inbal
Shay Bar-Haim
Alexander Heifetz
Srinivasa Rao Cheruku
Pradyumna Mohanty
Anurag Sharadendu
Original Assignee
Predix Pharmaceuticals Holding
Dale S Dhanoa
Silvia Noiman
Oren Becker
Yael Marantz
Dongli Chen
Shacham Sharon
Boaz Inbal
Shay Bar-Haim
Alexander Heifetz
Srinivasa Rao Cheruku
Pradyumna Mohanty
Anurag Sharadendu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Predix Pharmaceuticals Holding, Dale S Dhanoa, Silvia Noiman, Oren Becker, Yael Marantz, Dongli Chen, Shacham Sharon, Boaz Inbal, Shay Bar-Haim, Alexander Heifetz, Srinivasa Rao Cheruku, Pradyumna Mohanty, Anurag Sharadendu filed Critical Predix Pharmaceuticals Holding
Publication of WO2004080407A2 publication Critical patent/WO2004080407A2/fr
Publication of WO2004080407A3 publication Critical patent/WO2004080407A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des antagonistes du récepteur 5-HT ainsi que sur des nouveaux composés représentés par la formule I, II, III et la synthèse et les utilisations de ces composés pour traiter des maladies à médiation directe ou indirecte par des récepteurs 5-HT. Ces conditions comprennent des troubles du système nerveux central telle que l'anxiété, la dépression, la schizophrénie, les lésions neurales, les attaques, et la migraine. L'invention se rapporte aussi à des procédés de préparation et à de nouveaux intermédiaires et à des sels pharmaceutiques de ceux-ci.
PCT/US2004/007091 2003-03-07 2004-03-08 Nouveaux composes a modulation de serotinine et utilisations associees WO2004080407A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45299303P 2003-03-07 2003-03-07
US45276603P 2003-03-07 2003-03-07
US45276203P 2003-03-07 2003-03-07
US60/452,766 2003-03-07
US60/452,762 2003-03-07
US60/452,993 2003-03-07

Publications (2)

Publication Number Publication Date
WO2004080407A2 WO2004080407A2 (fr) 2004-09-23
WO2004080407A3 true WO2004080407A3 (fr) 2006-06-01

Family

ID=32995975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007091 WO2004080407A2 (fr) 2003-03-07 2004-03-08 Nouveaux composes a modulation de serotinine et utilisations associees

Country Status (1)

Country Link
WO (1) WO2004080407A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2061774B1 (fr) * 2006-08-17 2010-12-22 F. Hoffmann-La Roche AG Derives d'arylpiperazine et leurs utilisations
WO2009101018A2 (fr) 2008-02-15 2009-08-20 F. Hoffmann-La Roche Ag Dérivés de 3-alkyl-pipérazine et leurs utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262087B1 (en) * 1996-12-20 2001-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives
US6790848B2 (en) * 2001-06-15 2004-09-14 Syntex (U.S.A.) Llc 4-piperazinylindole derivatives with 5-HT6 receptor affinity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262087B1 (en) * 1996-12-20 2001-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives
US6790848B2 (en) * 2001-06-15 2004-09-14 Syntex (U.S.A.) Llc 4-piperazinylindole derivatives with 5-HT6 receptor affinity

Also Published As

Publication number Publication date
WO2004080407A2 (fr) 2004-09-23

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