WO2004079007A3 - Time-lapse cell analysis method - Google Patents

Time-lapse cell analysis method Download PDF

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Publication number
WO2004079007A3
WO2004079007A3 PCT/JP2004/002694 JP2004002694W WO2004079007A3 WO 2004079007 A3 WO2004079007 A3 WO 2004079007A3 JP 2004002694 W JP2004002694 W JP 2004002694W WO 2004079007 A3 WO2004079007 A3 WO 2004079007A3
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WO
WIPO (PCT)
Prior art keywords
time
cell
lapse
present
presenting
Prior art date
Application number
PCT/JP2004/002694
Other languages
French (fr)
Other versions
WO2004079007A2 (en
Inventor
Masato Miyake
Tomohiro Yoshikawa
Eiichiro Uchimura
Jun Miyake
Original Assignee
Nat Inst Of Advanced Ind Scien
Masato Miyake
Tomohiro Yoshikawa
Eiichiro Uchimura
Jun Miyake
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Inst Of Advanced Ind Scien, Masato Miyake, Tomohiro Yoshikawa, Eiichiro Uchimura, Jun Miyake filed Critical Nat Inst Of Advanced Ind Scien
Priority to JP2006507660A priority Critical patent/JP2006522605A/en
Publication of WO2004079007A2 publication Critical patent/WO2004079007A2/en
Publication of WO2004079007A3 publication Critical patent/WO2004079007A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Computer Hardware Design (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention provides a method and system for accurately presenting an actual state of a cell. The present invention also provides a system and method for presenting information within a cell over time and/or in real time without modification or directly where the cell is considered as a complex system. A method of the present invention for determining a state of a cell comprises a) obtaining a time-lapse profile of the cell by time-lapse monitoring of a transcription level associated with at least one transcription contorl sequence selected from the group consisting of transcription control sequences derived form the cell; and b) presenting the time-lapse profile.
PCT/JP2004/002694 2003-03-04 2004-03-03 Time-lapse cell analysis method WO2004079007A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006507660A JP2006522605A (en) 2003-03-04 2004-03-03 Time-lapse cell analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003057870 2003-03-04
JP2003-057870 2003-03-04

Publications (2)

Publication Number Publication Date
WO2004079007A2 WO2004079007A2 (en) 2004-09-16
WO2004079007A3 true WO2004079007A3 (en) 2004-12-02

Family

ID=32958778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/002694 WO2004079007A2 (en) 2003-03-04 2004-03-03 Time-lapse cell analysis method

Country Status (2)

Country Link
JP (1) JP2006522605A (en)
WO (1) WO2004079007A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5670020B2 (en) * 2008-10-21 2015-02-18 株式会社ビーエムティーハイブリッド Three-dimensional cell culture chip and method of using the same
WO2019021472A1 (en) * 2017-07-28 2019-01-31 オリンパス株式会社 Cell identification method, method for producing cell population, and cell identification system
JP7046211B2 (en) 2018-09-28 2022-04-01 富士フイルム株式会社 Judgment method
JP7123155B2 (en) 2018-09-28 2022-08-22 富士フイルム株式会社 Judgment method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088165A1 (en) * 2001-04-30 2002-11-07 Doranz Benjamin J Elucidation of gene function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020006664A1 (en) * 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088165A1 (en) * 2001-04-30 2002-11-07 Doranz Benjamin J Elucidation of gene function

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BAILEY S N ET AL: "APPLICATIONS OF TRANSFECTED CELL MICROARRAYS IN HIGH-THROUGHPUT DRUG DISCOVERY", DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 7, no. 18, SUPPL, 2002, pages S113 - S118, XP008026706, ISSN: 1359-6446 *
CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, vol. 28, no. 1-2, 2000, 18TH SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE AND THE 2ND INTERNATIONAL CONFERENCE ON ETHICAL ISSU; CLEMSON, SOUTH CAROLINA, USA; MAY 21-23, 1999, pages 203 - 208, ISSN: 0278-940X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, WEBB KEN ET AL: "Fibronectin immobilized by a novel surface treatment regulates fibroblast attachment and spreading", XP009034748, Database accession no. PREV200000504258 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 28 April 2004 (2004-04-28), YOSHIKAWA TOMOHIRO ET AL: "Transfection microarray of human mesenchymal stem cells and on-chip siRNA gene knockdown", XP002291278, Database accession no. PREV200400300235 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 7 March 2001 (2001-03-07), PRECKEL TOBIAS ET AL: "The use of Lab-on-a-Chip technology for monitoring transfection efficiency in cells", XP009034806, Database accession no. PREV200100290293 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2000 (2000-09-01), GORE M A ET AL: "Gene expression changes associated with cytotoxicity identified using cDNA arrays.", XP002291277, Database accession no. NLM11793227 *
FASEB JOURNAL, vol. 15, no. 4, 7 March 2001 (2001-03-07), ANNUAL MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY ON EXPERIMENTAL BIOL; ORLANDO, FLORIDA, USA; MARCH 31-APRIL 04, 2001, pages A531, ISSN: 0892-6638 *
FUNCTIONAL & INTEGRATIVE GENOMICS. SEP 2000, vol. 1, no. 2, September 2000 (2000-09-01), pages 114 - 126, ISSN: 1438-793X *
JOURNAL OF CONTROLLED RELEASE, vol. 96, no. 2, 28 April 2004 (2004-04-28), pages 227 - 232, ISSN: 0168-3659 *
WU R Z ET AL: "Cell-biological applications of transfected-cell microarrays", TRENDS IN CELL BIOLOGY 01 OCT 2002 UNITED KINGDOM, vol. 12, no. 10, 1 October 2002 (2002-10-01), pages 485 - 488, XP002291276, ISSN: 0962-8924 *
ZIAUDDIN JUNAID ET AL: "Microarrays of cells expressing defined cDNAs", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 411, no. 6833, 2001, pages 107 - 110, XP002246363, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2004079007A2 (en) 2004-09-16
JP2006522605A (en) 2006-10-05

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