WO2004078916A3 - Micro-organes in vitro, et utilisations correspondantes - Google Patents

Micro-organes in vitro, et utilisations correspondantes Download PDF

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Publication number
WO2004078916A3
WO2004078916A3 PCT/IL2004/000202 IL2004000202W WO2004078916A3 WO 2004078916 A3 WO2004078916 A3 WO 2004078916A3 IL 2004000202 W IL2004000202 W IL 2004000202W WO 2004078916 A3 WO2004078916 A3 WO 2004078916A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
micro
organ
organ cultures
cultures
Prior art date
Application number
PCT/IL2004/000202
Other languages
English (en)
Other versions
WO2004078916A2 (fr
Inventor
Eduardo N Mitrani
Original Assignee
Yissum Res Dev Co
Eduardo N Mitrani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/376,506 external-priority patent/US20030152562A1/en
Application filed by Yissum Res Dev Co, Eduardo N Mitrani filed Critical Yissum Res Dev Co
Publication of WO2004078916A2 publication Critical patent/WO2004078916A2/fr
Publication of WO2004078916A3 publication Critical patent/WO2004078916A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention se rapporte à des cultures de micro-organes comprenant des populations isolées de cellules possédant des caractéristiques spécifiques. Les cultures de micro-organes de l'invention présentent notamment la particularité de pouvoir être maintenues en culture sur de relativement longues périodes, ainsi que de préserver une microarchitecture d'organe qui facilite, par exemple, des interactions cellule-cellule et cellule-matrice analogues à celles survenant dans l'organe source. Les cultures de micro-organes de l'invention peuvent être utilisées dans des procédés destinés à fournir des produits génétiques à des sujets receveurs, à identifier des agents de prolifération cellulaire et de différenciation cellulaire, et à identifier et isoler des cellules souches. De plus, les cultures de micro-organes de la présente invention peuvent être utilisées dans des procédés d'identification d'inhibiteurs de la prolifération cellulaire, de la différenciation cellulaire et de l'infectiosité virale. Dans d'autres modes de réalisation, les cultures de micro-organes peuvent servir à la transplantation.
PCT/IL2004/000202 2003-03-03 2004-03-02 Micro-organes in vitro, et utilisations correspondantes WO2004078916A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/376,506 2003-03-03
US10/376,506 US20030152562A1 (en) 2001-10-23 2003-03-03 Vitro micro-organs, and uses related thereto

Publications (2)

Publication Number Publication Date
WO2004078916A2 WO2004078916A2 (fr) 2004-09-16
WO2004078916A3 true WO2004078916A3 (fr) 2005-02-10

Family

ID=32961225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/000202 WO2004078916A2 (fr) 2003-03-03 2004-03-02 Micro-organes in vitro, et utilisations correspondantes

Country Status (1)

Country Link
WO (1) WO2004078916A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155749B2 (en) 2006-09-14 2015-10-13 Medgenics Medical Israel Ltd. Long lasting drug formulations

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
IL196820A0 (en) 2009-02-01 2009-11-18 Yissum Res Dev Co Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells
WO2013188851A1 (fr) * 2012-06-14 2013-12-19 Fred Hutchinson Cancer Research Center Expansion ex vivo de cellules souches myogéniques par l'activation notch
CN113604446B (zh) * 2021-08-16 2023-04-07 重庆大学 7α-羟基类固醇脱氢酶St-2-2的突变体R16Q
CN113813437B (zh) * 2021-09-28 2022-07-01 振德医疗用品股份有限公司 基于细菌非特异性粘附的抗感染防黏连创面敷料
CN115721716B (zh) * 2022-07-13 2024-06-14 苏州翊鹏医药科技有限公司 Mdh2抑制剂在雄激素性脱发治疗中的应用
CN116358954A (zh) * 2023-02-22 2023-06-30 深圳市昭蓝生物科技有限公司 复合质控品及其制备方法和产前筛查试剂盒
CN117618540A (zh) * 2023-12-05 2024-03-01 中南大学 一种在组织细胞移植抗排异反应中局部注射的趋化因子ccl28免疫调节剂及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030833A (en) * 1995-08-04 2000-02-29 The General Hospital Transgenic swine and swine cells having human HLA genes
US20020012661A1 (en) * 1999-12-10 2002-01-31 Norimitsu Saito Methods for introducing genes into mammalian subjects

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030833A (en) * 1995-08-04 2000-02-29 The General Hospital Transgenic swine and swine cells having human HLA genes
US20020012661A1 (en) * 1999-12-10 2002-01-31 Norimitsu Saito Methods for introducing genes into mammalian subjects

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155749B2 (en) 2006-09-14 2015-10-13 Medgenics Medical Israel Ltd. Long lasting drug formulations

Also Published As

Publication number Publication date
WO2004078916A2 (fr) 2004-09-16

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