WO2004077044A8 - Verfahren und vorrichtung zum selektiven nachweis ferromagnetischer oder superparamagnetischer partikel - Google Patents

Verfahren und vorrichtung zum selektiven nachweis ferromagnetischer oder superparamagnetischer partikel

Info

Publication number
WO2004077044A8
WO2004077044A8 PCT/DE2004/000149 DE2004000149W WO2004077044A8 WO 2004077044 A8 WO2004077044 A8 WO 2004077044A8 DE 2004000149 W DE2004000149 W DE 2004000149W WO 2004077044 A8 WO2004077044 A8 WO 2004077044A8
Authority
WO
WIPO (PCT)
Prior art keywords
particles
analytes
magnetic fields
selectively detecting
superparamagnetic
Prior art date
Application number
PCT/DE2004/000149
Other languages
English (en)
French (fr)
Other versions
WO2004077044A1 (de
Inventor
Peter Miethe
Hans-Joachim Krause
Yi Zhang
Norbert Wolters
Dmitry Plaksin
Original Assignee
Forschungszentrum Juelich Gmbh
Peter Miethe
Hans-Joachim Krause
Yi Zhang
Norbert Wolters
Dmitry Plaksin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh, Peter Miethe, Hans-Joachim Krause, Yi Zhang, Norbert Wolters, Dmitry Plaksin filed Critical Forschungszentrum Juelich Gmbh
Priority to EP04706604A priority Critical patent/EP1597573A1/de
Priority to JP2006501481A priority patent/JP2006519366A/ja
Priority to US10/547,444 priority patent/US8071027B2/en
Publication of WO2004077044A1 publication Critical patent/WO2004077044A1/de
Publication of WO2004077044A8 publication Critical patent/WO2004077044A8/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

Ein Verfahren zum selektiven Nachweis und/oder zur Quantifizierung superparamagnetischer und/oder ferromagnetischer Partikel an Analyten. Das Verfahren ist dadurch gekennzeichnet, dass eine aufgrund der Nichtlinearität der Magnetisierungskennlinie der Partikel erzeugte Frequenz-Komponente von Magnetfeldern (15, 18) bei einer Mischfrequenz gemessen wird. Eine Vorrichtung zum selektiven Nachweis und/oder zur Quantifizierung superparamagnetischer und/oder ferromagnetischer Partikel an Analyten umfasst: einen Behälter (12) mit nachzuweisendem und/oder zu quantifizierenden Partikeln am Analyten, mindestens einen Oszillator (13, 16; 25), zur Erzeugung von Frequenzen von Wechsel-Magnetfeldern (15, 18), mindestens einen Feldgenerator (14, 17) zur Beaufschlagung des Analyten mit Wechsel-Magnetfeldern (15, 18) , einen Magnetfeldsensor (20), zur Messung eines Antwort-Magnetfeldes (19) der Partikel, mindestens einen phasenempfindlichen Detektor (21, 23), wobei die Bauteile so konfiguriert sind, dass eine aufgrund der Nichtlinearität der Magnetisierungskennlinie der Partikel erzeugte Frequenz-Komponente der Magnetfelder (15, 18) bei einer Mischfrequenz gemessen wird.
PCT/DE2004/000149 2003-02-28 2004-01-30 Verfahren und vorrichtung zum selektiven nachweis ferromagnetischer oder superparamagnetischer partikel WO2004077044A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04706604A EP1597573A1 (de) 2003-02-28 2004-01-30 Verfahren und vorrichtung zum selektiven nachweis ferromagnetischer oder superparamagnetischer partikel
JP2006501481A JP2006519366A (ja) 2003-02-28 2004-01-30 強磁性粒子又は超磁性粒子を選択的に検出する方法及び装置
US10/547,444 US8071027B2 (en) 2003-02-28 2004-01-30 Method and device for selectively detecting ferromagnetic or superparamagnetic particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10309132A DE10309132A1 (de) 2003-02-28 2003-02-28 Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel
DE10309132.7 2003-02-28

Publications (2)

Publication Number Publication Date
WO2004077044A1 WO2004077044A1 (de) 2004-09-10
WO2004077044A8 true WO2004077044A8 (de) 2005-09-01

Family

ID=32920655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/000149 WO2004077044A1 (de) 2003-02-28 2004-01-30 Verfahren und vorrichtung zum selektiven nachweis ferromagnetischer oder superparamagnetischer partikel

Country Status (5)

Country Link
US (1) US8071027B2 (de)
EP (1) EP1597573A1 (de)
JP (1) JP2006519366A (de)
DE (1) DE10309132A1 (de)
WO (1) WO2004077044A1 (de)

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US8193804B2 (en) * 2005-11-16 2012-06-05 Rex Chin-Yih Hong Device for measuring AC magnetization of materials
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FR3038060B1 (fr) * 2015-06-26 2018-11-02 Atware Appareil de mesure d'une quantite de materiau superparamagnetique
KR101904784B1 (ko) * 2015-09-07 2018-10-05 한국전자통신연구원 단일 여기 코일 기반의 비선형 마그네틱 파티클 검출 장치 및 방법
KR101904781B1 (ko) 2016-10-12 2018-10-05 한국전자통신연구원 Fmmd 기술의 신호 분석을 위한 신호 송수신 방법 및 이를 이용한 장치
US11513115B2 (en) * 2016-12-23 2022-11-29 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic multi-bead assays
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Also Published As

Publication number Publication date
US8071027B2 (en) 2011-12-06
DE10309132A1 (de) 2004-11-18
WO2004077044A1 (de) 2004-09-10
EP1597573A1 (de) 2005-11-23
US20070155024A1 (en) 2007-07-05
JP2006519366A (ja) 2006-08-24

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