WO2004073613A2 - A medicine and food - Google Patents

A medicine and food Download PDF

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Publication number
WO2004073613A2
WO2004073613A2 PCT/US2004/003816 US2004003816W WO2004073613A2 WO 2004073613 A2 WO2004073613 A2 WO 2004073613A2 US 2004003816 W US2004003816 W US 2004003816W WO 2004073613 A2 WO2004073613 A2 WO 2004073613A2
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WO
WIPO (PCT)
Prior art keywords
food
medicine
brown rice
sod
substance
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PCT/US2004/003816
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French (fr)
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WO2004073613A3 (en
Inventor
Fuyuki Mitsuyama
Original Assignee
Fuyuki Mitsuyama
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Application filed by Fuyuki Mitsuyama filed Critical Fuyuki Mitsuyama
Publication of WO2004073613A2 publication Critical patent/WO2004073613A2/en
Publication of WO2004073613A3 publication Critical patent/WO2004073613A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C11/00—Milk substitutes, e.g. coffee whitener compositions
    • A23C11/02—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
    • A23C11/10—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing or not lactose but no other milk components as source of fats, carbohydrates or proteins
    • A23C11/103—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing or not lactose but no other milk components as source of fats, carbohydrates or proteins containing only proteins from pulses, oilseeds or nuts, e.g. nut milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
    • A23L11/60—Drinks from legumes, e.g. lupine drinks
    • A23L11/65—Soy drinks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/20—Malt products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • This invention is as to medicine and food that is beneficial as medicine or health- maintaining food.
  • stent This is equipped at the tip of catheter surrounding balloon in folded up position. This can be left in opened position in stenotic arteries by blowing up a balloon.
  • the surgical treatments need the high expertise of surgeons and have certain surgical risk and high reoccurrence rate.
  • anticoagulants have strong side effects. For example, more than 10 people died annually by using a kind of anticoagulant, Ticlopidine.
  • This invention is trying to provide new substances that satisfies not only to maintain health but also to prevent and treat diseases, adjusting intestine, high nutrition and high safety. Especially, this invention is trying to provide medicine and food that has high curable effect against vascular diseases due to atherosclerosis like stenosis or occlusion of arteries.
  • the medicine and food written in the range of invention No. 1 has the feature that it consists of low temperature-roasted and milled sprouted brown rice to accomplish the purpose written above.
  • 20 range of invention No. 2 has the feature that include more than one of sprouting brown rice and milled sprouting brown rice, and more than one of beneficial intestinal bacteria, proliferation-promoting substance of beneficial intestinal bacteria, SOD like substance, stabilizer of activity of SOD like substance and drinks made from soybeans.
  • the medicine and food written in the range of invention No. 3 has the feature that 25 consists of the medicine and food written in the range of invention No. 2 in which sprouting brown rice and/or milled sprouting brown rice are roasted at low temperature.
  • the medicine and food written in the range of invention No. 4 has the feature that consists of the medicine and food written in the range of invention No. 2 in which drink made from soybeans are soy milk made from low temperature-roasted soybeans.
  • the medicine and food written in the range of invention No. 5 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 4 in which grain other than sprouting brown rice are included.
  • the medicine and food written in the range of invention No. 6 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 5 in which each constituting elements other than beneficial bacteria contain less than 4 % of water.
  • the medicine and food written in the range of invention No. 7 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 6
  • the medicine and food written in the range of invention No. 8 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 7 in which they are processed like cheese partially or all.
  • Brown rice has rich nutrition like vitamins, iron, minerals and it also include phytic acid that is thought to be anti-cancerous substance. So, brown rice is one of the good foods, but people often avoid brown rice due to its sticky preparation and bad taste. Recently, sprouted brown rice attracts the attention of people instead of conventional brown rice. The sprouting brown rice, that is slightly sprouted, is easy to cook and has better nutrition than brown rice,
  • sprouting brown rice contains much GABA (gamma-aminobutyric acid). GABA has effects of anti-hypertension, lowering blood triglyceride, activation of kidney and liver etc. GABA contents in sprouting brown rice is 1.6 times of that in brown
  • Sprouting brown rice also contains much inositol that prevents fatty liver and atherosclerosis, vitamins, minerals and diet fibers. Much diet fibers in sprouting brown rice prevent constipation. Phytic acid and tocotrienol induce effect to make human's skin white. There is the try to dry and mill sprouting brown rice.
  • sprouting brown rice is the best for health in rice, but it is difficult to say that even nutrients in sprouting rice are readily absorbed into human cells via digestive system. Milling does not make so improvement of absorption.
  • the medicine and food written in the range of invention No. 1 consist of low temperature-roasted and milled sprouted brown rice. This sprouting brown rice has rich
  • Lactobacillus including bifidobacterium con-espond to beneficial bacteria It is medical common sense that lactobacillus is beneficial intestinal bacteria. It is well known that lactobacillus is predominant in intestines of healthy people and less in intestines of people with bad conditions. When lactobacillus becomes predominant in intestinal bacterial flora, maintaining health, prevention and treatment of infectious diseases, prevention of
  • Proliferation-promoting substances of beneficial intestinal bacteria which include purified oligosaccharide and its compound, are saccharides used by lactobacillus. In another word, it is feed of beneficial bacteria.
  • Compound of oligosaccharide and sucrose is one of the examples.
  • the saccharides include glycoprotein like lactoferrin.
  • oligosaccharide used in this invention is superior concept that includes isomaltooligosaccharide, galactooligosaccharide, fructooligosaccharide, raffinose, lactulose, and fluid that contains oligosaccharide (like oligosaccharides from steamed soybean) etc.
  • These proliferation-promoting substances of beneficial intestinal bacteria are not digested by human digestive enzymes and reach to colon, where only lactobacilli but bad bacteria
  • SOD super oxide dismutase
  • SOD like substances in this invention means the substances that have SOD like effect. Flavonoid, polyphenol, tannin, tocopherol, vitamin Bl and other well-known substances are mentioned as SOD like substances.
  • SOD like substances As substances that include SOD like substances, grain, fruit, vegetable, seed, leaf of green tea, 5 mushroom, sea weed, algae including Chlorella, tree, bamboo, bamboo grass, grass including herb, etc can be mentioned.
  • kale has excellent substances in vegetables. part of these substances like bark, the rind of fruit, flower, leaf, stem, root, sprout, germ, rice bran and juice can be added as SOD like substances. Rice, wheat, soybean, adzuki bean, corn, adlay, pea, leaf of green tea, 10 sea weed and Chlorella are preferable as additives of SOD like substances. Juice of citrus fruits like a Chinese lemon is also preferable. SOD like substances can be added as fluid, powder or granule. SOD like substances are also extracted from natural ingredients. These substances have effects to delete super oxide to protect human tissue.
  • Trehalose, Vitamin C, vitamin E, maltose etc. are mentioned as stabilizer of activity 15 of SOD like substance. More than one of these are used as stabilizer of activity of SOD like substance, it is preferable to use trehalose when more than two are used.
  • trehalose When medicine and food is made by adding SOD like substance as an ingredient, sometimes activity of SOD like substance decreases during process of production or reservation of intermediate product and final product. This stabilizer of activity of SOD like substance protects SOD 20 like substance from losing its activity and keep it in high activity level for a long time.
  • Food and drink made from soybeans are, for example, soymilk (including fermented soymilk) or bean-curd refuse. In this case, it is preferable that soybeans should be roasted at low temperature. It is well known that these food and drink made from soybeans are good and safe in nutrition as they contain rich protein, lipid, saccharide, mineral and dietary fiber.
  • soymilk made from low temperature-roasted soybeans.
  • This soymilk has higher function than conventional soymilk in the view of prevention for diseases, because it contains more low molecular SOD like substances.
  • the grain includes rice, barley, wheat, kinds of bean, foxtail millet seed, Japanese millet, African millet, corn, buckwheat, sesame, other miscellaneous cereals, and their processed goods. They can be mixed. Foxtail millet seed, Japanese millet, adlay and amaranthaceae can be actually mentioned as miscellaneous cereals. Among them, amaranthaceae has rich protein, mineral and calcium comparing other miscellaneous cereals. These miscellaneous cereals are preferable to be milled.
  • Perilla oil that is extracted from perilla ocimoides can be added. It is said that alpha-linolenic acid in perilla oil has potent effect against heart disease, diabetes, cerebrovascular disease, cancer, allergic dermatitis, asthma and Alzheimer's disease like they say contemporary disease.
  • beneficial bacteria when one of the constituents is beneficial bacteria, other constituents should have less than 4 % of water. It is the reason that beneficial bacteria like bifidobacteria will be killed easily by little water in materials.
  • the medicine and food written in the range of invention No. 7 are consist of one of the medicine and food written in the range of inventions from No. 1-No. 6 in which fe ⁇ nentation process is added partially or all.
  • Methods of fermentation are well known fermentation by microorganisms. Partial fe ⁇ nentation process means that partial constituent receives fe ⁇ nentation process. Because molecules of ingredients are changed into small ones and flavor and taste may be improved by fermentation process, it is preferable that medicine and food are fermented partially or all.
  • the medicine and food written in the range of invention No. 8 consist of one of the medicine and food written in the range of inventions from No. 1-No. 7 in which they are processed like cheese partially or all. Partial process like cheese means that partial constituent receives process like cheese. Food that is processed like cheese is easily taken orally for any people.
  • the medicine and food of 1 st fulfillment form consisted of milled sprouting brown 5 rice.
  • Sprouting brown rice is made by culture of brown rice and water in sprouting equipment that is maintained at 23°C-25°C for about 24 hours.
  • This sprouting brown rice is low temperature-roasted at 40°C-100°C (50°C-95°C is preferable).
  • roasting by far infrared rays, ultrasonic roasting, high-frequency roasting, low-frequency roasting, roasting by heated wind etc. can be used. It can be roasted by using more than 2 methods.
  • the SOD 10 like molecules in sprouting brown rice are changed into smaller molecules by this low temperature-roasting.
  • Low temperature-roasted sprouting brown rice is milled by a manufactured mill.
  • the medicine and food of 1 st fulfillment form (milled sprouting brown rice) 15 are functional food that has good nutrition and effective ingredients can be reached intracellularly, it is useful and profitable as medicine and food as described above. This medicine and food become an effective ingredient when more functional medicine and food will be made. In this case, water content can be suppressed less than 4 % due to the reason that have already described.
  • the medicine and food of 2nd fulfillment form of this invention consist of sprouting brown rice and/or milled sprouting brown rice, beneficial intestinal bacteria, proliferation- promoting substance of beneficial intestinal bacteria and SOD like substance.
  • Sprouting brown rice is the one roasted by the method that has already described.
  • Milled sprouting brown rice is the one described in the medicine and food of 1st fulfillment fo ⁇ n. These can be added alone or by mixture. Further, these are preferable that water content can be suppressed less than 4 % by low temperature-roasting or roasting with hot wind. It is the reason that beneficial bacteria like bifidobacteria will be killed easily by little water in
  • beneficial intestinal bacteria live lactobacillus in which bifidobacterium is representative should be adopted.
  • Bifidobacterium adolescentis, B. bifidum, B. breve, B. infantis, B. longum should be adopted. It is optional to adopt freeze-dry method, but freeze-dried live bifidobacteria are preferable.
  • these beneficial intestinal bacteria like bifidobacteria should have resistance for drugs.
  • the resistance for a drug or one for many drugs can be adopted. This resistance for drugs includes resistance for antibiotics and anti-cancerous drugs.
  • antibiotics penicillin, colistin, polymyxin, cycloserine, griseofulvin, streptomycin, kanamycin, chloramphenicol, 5 tetracycline, mitomycin, bleomycin, actinomycin, erythromycin, oxitetracycline, chlortetracycline, chloromycetin, trichomycin etc.
  • the well known drugs other than mentioned above can be included.
  • beneficial intestinal bacteria that have the resistance against penicillin, cephalosporin, aminoglycoside and tetracycline etc. should be adopted. These beneficial intestinal bacteria described above should be adopted after the examination
  • the drug sensitivity is examined by co- culture of beneficial bacteria and disks that contains certain concentration of antibiotics on agar. Only drug-resistant colony can be selected by its suppressive effect of bacterial proliferation. The resistance for drug must be not transmitted. This is ascertained by co- culture of drug-resistant bacteria and normal bacteria that is well known.
  • purified oligosaccharide As proliferation-promoting substance of beneficial intestinal bacteria, purified oligosaccharide, its compound and fluid that contains oligosaccharide (like oligosaccharides from steamed soybean) etc can be mentioned as described above. Among them, purified oligosaccharide is often used due to its preference. In this case, water content should be suppressed less than 4 % due to the reason that have already described.
  • Beneficial intestinal bacteria are live bifidobacteria. Proliferation- promoting substance of beneficial intestinal bacteria is purified (97%) lactosucurose. As SOD like substance, roasted rice bran at low temperature is fermented by rice koji that contains koji mold (Aspergillus oryzae), and dried kale powder is added. It is suspected that this medicine and food may be effective to maintain health and to prevent and treat diseases by contents of the description, but it was clear that it had remarkable clinical effects by fulfillment cases that will be shown below.
  • the medicine and food of 3rd fulfillment form of this invention mainly consist of sprouting brown rice and milled sprouting brown rice and food and drink made from soybeans.
  • sprouting brown rice and milled sprouting brown rice has already described. So, food and drink made from soybeans will be explained as follows.
  • soymilk and bean-curd refuse can be mentioned, but soymilk is mainly used. It is preferable that these soymilk and bean-curd refuse are made from soybeans that is roasted at low temperature. Soymilk is made by the method as follows.
  • the method to make soymilk is basically not different from well known one, but the process in which soybeans are roasted at low temperature is added.
  • An example of the process to make soymilk made from soybeans is shown as follows. It consists of selection process, roasting process, washing process, soaking process, crushing process, heating process, squeezing process and mixing process. Final volume of soymilk should be adjusted to 4-6 L / Kg of soybeans.
  • soybeans are checked. Impurities are removed. Cracked or wa ⁇ n-eaten soybeans are removed.
  • soybeans are roasted at low temperature. Actually, roasting by far infrared rays, ultrasonic roasting, high-frequency roasting, low-frequency roasting, roasting by heated wind etc. can be used. Actually, roasting by far infrared rays or ultrasonic roasting are preferable. One or both of these two methods should be adopted. In roasting by far infrared rays and/or ultrasonic roasting, soybeans are roasted at 40°C-100°C (50°C-95°C is preferable) for a long time. The SOD like molecules in soybeans are changed into smaller molecules by this low temperature-roasting.
  • soybeans after the roasting are washed by water many times to remove dust on surface of soybeans. This process can also be done by a washing machine.
  • soybeans after washing are soaked in water.
  • the soaking time is different depend on temperature. For about 12 hours in summer and about 24 hours in winter are preferable.
  • soybean slurry that contains water. This process is useful to extract proteins etc. because cell membranes of soybeans are torn. The concentration of soymilk is adjusted by changing water volume in this process.
  • soybean slurry In heating process, soybean slurry is heated by steam at about 100 °C.
  • steamed slurry is squeezed by a squeezing machine and soymilk is divided from bean-curd refuse.
  • the medicine and food of 4th fulfillment form of this invention consist of sprouting brown rice and/or milled sprouting brown rice (for example, milled sprouting brown rice), food and drink made from soybeans (for example, soymilk) and stabilizer for activity of
  • SOD like substance 15 SOD like substance.
  • milled sprouting brown rice and soymilk have already described.
  • stabilizer for activity of SOD like substance more than one of trehalose, Vitamin C, vitamin E, maltose etc can be used. Actually, trehalose is used.
  • soymilk trehalose is 1 : 0.1-1 (in representative case, 0.5) in weight.
  • soymilk, milled sprouting brown rice and trehalose are mixed homogeneously.
  • the medicine and food of 4 th fulfillment form of this invention are good as those of 25 3 ld fulfillment fo ⁇ n. Further, the activity of SOD like substance is maintained for long time because they contain stabilizer of activity.
  • fermented soymilk is adopted instead of soymilk in medicine and food of 3rd and 4th fulfillment form of this invention.
  • fermentation is performed by microorganisms. It is preferable that
  • Fermented soymilk made from roasted soybeans at low temperature is more preferable because of double processes. Fe ⁇ nented soymilk has good flavor. Lactobacillus or koji mold can be adopted as microorganisms to ferment soymilk, but lactobacillus is preferable. Fermented soymilk by lactobacilli contains live bacilli and lactic acid. This fermented soymilk can be used as supplements and people can take it to maintain or enhance their health.
  • the medicine and food of 6th fulfillment form of this invention proliferation- promoting substance of beneficial intestinal bacteria (oligosaccharide) is added to fermented soymilk in the medicine and food of 5th fulfillment form of this invention.
  • the medicine and food of 6th fulfillment fo ⁇ n of this invention consist of sprouting brown rice and/or milled sprouting brown rice, beneficial bacteria, proliferation-promoting substance of beneficial intestinal bacteria, stabilizer for activity of SOD like substance and food and drink made from soybeans. Because sprouting brown rice and food and drink made from soybeans are one of SOS like substances, the medicine and food of 6th fulfillment form also contains SOD like substance.
  • fermented soymilk and oligosaccharide are as follows. Oligosaccharide reaches to colons because it can not be digested and cannot be absorbed in intestines. Because only beneficial bacteria (lactobacilli) but bad bacteria can use oligosaccharide, proliferation of lactobacilli in colon is enhanced. Fermented soymilk added oligosaccharide is low calorie food.
  • fe ⁇ nented soymilk added lactulose is effective to maintaining health and treating diseases by the effect of enhancement for absorption of calcium and magnesium, intestinal adjustment, proliferation of lactobacilli, improvement of intra-intestinal environment and improvement of high blood ammonia level and hepatic coma. It is expected that the medicine and food of 6th fulfillment fo ⁇ n of this invention should have remarkable effect to maintain health and treat diseases, because the effects of sprouting brown rice and stabilizer for activity of SOD like substance are added to these effects of fe ⁇ nented soymilk added oligosaccharide.
  • SOD like substances other than sprouting brown rice and those made from soybeans can be added.
  • soymilk is fe ⁇ nented. This means that a part of medicines and foods has process of fermentation. In this case, constituents other than soymilk or all constituents can be fermented.
  • the medicine and food of 7th fulfillment form of this invention are those of a part or all of constituents in the medicine and food of 1 st to 6th fulfillment form are processed like cheese.
  • the medicine and food of 1st fulfillment fo ⁇ n consist of only milled sprouting brown rice, milled sprouting brown rice is processed like cheese.
  • more than one constituent is processed like cheese. So, cheese like constituent and other constituent that is not processed like cheese can be mixed.
  • the medicine and food of 8th fulfillment form of this invention are those added oil. These are obtained by adding oil to the medicine and food of 1 st to 6th fulfillment form of this invention. Sesame oil, olive oil, com oil, soybean oil, rapeseed oil, cottonseed oil, rice- bran oil, sunflower oil, palm oil, peanut oil, oil from snapping turtle, liver oil, fish oil, kanpo-animal oil, mixed vegetable oil, mixed animal oil, mixed oil from vegetable and animal oil and powdered oil etc. are mentioned. The oil that is obtained from far infrared- roasted and/or ultrasonic-roasted sesame seeds is preferable. Mixed oil containing this roasted sesame oil is also preferable. The proportion of fermented substances and oil is 1: 1- 2 in weight. By adding oil, the medicine and food may be able to reach into cells, because its affinity to cell membranes becomes higher.
  • Oligosaccharide-containing fluid used in this invention is as follows.
  • Original ingredient of the oligosaccharide-containing fluid used in this invention is soybean that is roasted at low temperature. So, this fluid also contains low molecular SOD like substances.
  • This fluid can enhance intestinal lactobacilli and can function to maintain health or treat diseases more effectively due to its SOD like substances. It is preferable because it enhance physical function. Because this fluid can be obtained secondarily when soybean products are made, this is a preferable constituent to make the medicines and foods in this invention. Stabilizer of activity for SOD like substance can be added to this fluid. This fluid can be purified.
  • 0068 When the medicine and food in this invention contain beneficial bacteria, it is preferable that 1-10 billion cells/day of live bifidobacteria should be taken orally.
  • the lower limit is determined as 1 billion cells/day, because if it is lesser, the effect will be remarkably reduced.
  • the upper limit is dete ⁇ nined as 10 billion cells /day because of capability by recent technique.
  • the medicine and food of this investment include proliferation- promoting substances of beneficial intestinal bacteria (oligosaccharide), 1.5 -10 g/day of oligosaccharide should be taken orally. In this range, over calorie can be avoided with sufficient effect.
  • the medicine and food of this investment include SOD like substances, 0.5-2 g/day of SOD like substance should be taken orally.
  • the lower limit is determined as 0.5 g/day, because if it is lesser, the effect will be remarkably reduced.
  • the upper limit is dete ⁇ nined as 2 g/day because of avoidance for side effects like that of 5 caffeine
  • the 1 st fulfillment example In the medicine and food of 1 st fulfillment example, milled sprouting brown rice, lactosucrose, live bifidobacteria and SOD like substance are homogeneously mixed as follows. A dosage / one time is 5 g. As SOD like substances, 1.5 g 10 of rice bran was roasted by far infra-red ray at 95°C for 2 hours, and 0.2 g of rice koji was added and fe ⁇ nented for 24 hours, and finally 0.5 g of kale powder was added.
  • the 2 nd fulfillment example consist of milled sprouting brown rice, soymilk, lactosucrose and bifidobacteria.
  • Soymilk is made from soybeans that are roasted at low temperature as the 1 st fiilfillment example.
  • Milled sprouting brown rice is 5 made from sprouting brown rice roasted at low temperature.
  • Milled sprouting brown rice is added to the soybean slurry.
  • Milled sprouting brown rice that is 1/20 of soybeans in weight was added.
  • the grain milk is made from this soybean slurry added milled sprouting brown rice by the same method as described in 0051-0052.
  • Purified lactosucrose (97%) and live bifidobacteria are added and cultured at 37°C for 12 hours.
  • the medicine and food of this invention may be able to satisfactorily attain the purpose in maintaining health, prevention and treatment of infectious diseases, prevention and 25 treatment of allergic diseases, prevention of cancer and prevention of aging. This may be also effective to AIDS and infectious diseases by pathogenic E. coli. Further, it is preferable that this is very effective to vascular diseases due to atherosclerosis. So, severe vascular diseases can be restored safely avoiding surgical risk.

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Abstract

Purpose; This invention tries to provide the medicine and food that satisfy the remarkable effects in prevention and treatment of diseases, adjustment of intestine, high nutrition and safety. Especially, this invention tries to provide the medicine and food that have curable effect against vascular diseases due to atherosclerosis like stenosis and occlusion of arteries. The methods of resolution; It is featured that the medicine and food consist of more than one of sprouting brown rice or milled sprouting brown rice, and more than one of beneficial intestinal bacteria, proliferation-promoting substance of beneficial intestinal bacteria, SOD like substance, stabilizer of activity of SOD like substance and foods and drinks made from soybeans.

Description

Title A MEDICINE AND FOOD
Detailed Description of the Invention
0001, Technical field of the invention
This invention is as to medicine and food that is beneficial as medicine or health- maintaining food.
0002, Conventional techniques The inventor of this invention had developed and applied the patents about medicine and food for maintaining health to Japan Patent Office, a part is opened to the public as follows.
1, 2000-060541
2, 2000-224970
3, 2000-245447 4, 2000-302694
5, 2001-288116
6, 2002-153268
7, 2002-
0003, The inventions shown above satisfies maintaining health, preventing and treating diseases, adjustment of intestine and high nutrition.
The combination of femiented food, intestinal beneficial bacteria and food from soybean, which is developed by this investor, is also beneficial medicine and food.
0004, The theme which this investment try to solve.
The investments that this investor developed are good because they are effective not only to maintain health but also to some diseases, but it is not ascertained that they have remarkable effect against the diseases due to atherosclerosis.
0005, In general for atherosclerosis, surgical and/or internal treatment are performed as described below.
0006, In surgery, bypass surgery is main treatment. Endovascular procedures are also adopted. One is balloon technique. A catheter which tip has balloon is inserted into a femoral artery and the tip is brought to the stenotic portion of an artery via aortic arch. Then, the balloon is blown up and the stenotic artery is dilated.
Another is stent. This is equipped at the tip of catheter surrounding balloon in folded up position. This can be left in opened position in stenotic arteries by blowing up a balloon. The surgical treatments need the high expertise of surgeons and have certain surgical risk and high reoccurrence rate.
0007, In internal treatment, sometimes the methods that reduce potency of blood coagulation are adopted. They are performed actually by administration of anticoagulants
5 orally or by injection. Meanwhile, because this method induces ease of bleeding, it may become fatal in the case of cerebral hemorrhage and subarachnoideal hemorrhage etc. Further, anticoagulants have strong side effects. For example, more than 10 people died annually by using a kind of anticoagulant, Ticlopidine.
0008, Purpose of the invention
10 This invention is trying to provide new substances that satisfies not only to maintain health but also to prevent and treat diseases, adjusting intestine, high nutrition and high safety. Especially, this invention is trying to provide medicine and food that has high curable effect against vascular diseases due to atherosclerosis like stenosis or occlusion of arteries.
0009, The method to solve the theme
15 The medicine and food written in the range of invention No. 1 has the feature that it consists of low temperature-roasted and milled sprouted brown rice to accomplish the purpose written above.
0010, The medicine and food written in the range of invention No. 2 has the feature as follows to accomplish the purpose written above. The medicine and food written in the
20 range of invention No. 2 has the feature that include more than one of sprouting brown rice and milled sprouting brown rice, and more than one of beneficial intestinal bacteria, proliferation-promoting substance of beneficial intestinal bacteria, SOD like substance, stabilizer of activity of SOD like substance and drinks made from soybeans.
0011, The medicine and food written in the range of invention No. 3 has the feature that 25 consists of the medicine and food written in the range of invention No. 2 in which sprouting brown rice and/or milled sprouting brown rice are roasted at low temperature.
0012, The medicine and food written in the range of invention No. 4 has the feature that consists of the medicine and food written in the range of invention No. 2 in which drink made from soybeans are soy milk made from low temperature-roasted soybeans.
30 0013, The medicine and food written in the range of invention No. 5 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 4 in which grain other than sprouting brown rice are included.
0014, The medicine and food written in the range of invention No. 6 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 5 in which each constituting elements other than beneficial bacteria contain less than 4 % of water.
0015, The medicine and food written in the range of invention No. 7 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 6
5 in which fermentation process is added partially or all.
0016, The medicine and food written in the range of invention No. 8 has the feature that consists of one of the medicine and food written in the range of inventions from No. 1-No. 7 in which they are processed like cheese partially or all.
0017, Action
10 Brown rice has rich nutrition like vitamins, iron, minerals and it also include phytic acid that is thought to be anti-cancerous substance. So, brown rice is one of the good foods, but people often avoid brown rice due to its sticky preparation and bad taste. Recently, sprouted brown rice attracts the attention of people instead of conventional brown rice. The sprouting brown rice, that is slightly sprouted, is easy to cook and has better nutrition than brown rice,
15 because many nutrients that is needed for sprouting are generated by activation of enzymes in sprouting brown rice.
It should be noted that sprouting brown rice contains much GABA (gamma-aminobutyric acid). GABA has effects of anti-hypertension, lowering blood triglyceride, activation of kidney and liver etc. GABA contents in sprouting brown rice is 1.6 times of that in brown
20 rice, and is 10 times of that in polished rice.
Sprouting brown rice also contains much inositol that prevents fatty liver and atherosclerosis, vitamins, minerals and diet fibers. Much diet fibers in sprouting brown rice prevent constipation. Phytic acid and tocotrienol induce effect to make human's skin white. There is the try to dry and mill sprouting brown rice.
25 0018, From these aspects, sprouting brown rice is the best for health in rice, but it is difficult to say that even nutrients in sprouting rice are readily absorbed into human cells via digestive system. Milling does not make so improvement of absorption. 0019, The medicine and food written in the range of invention No. 1 consist of low temperature-roasted and milled sprouted brown rice. This sprouting brown rice has rich
30 nutrients. By low temperature-roasting, the molecules of effective nufrients become small via detaching polymerization of molecules. Low temperature-roasted and milled sprouting brown rice is readily absorbed into cells via digestive system. So, when man take the medicine and food written in the range of invention No. 1, effective nutrients can reach into cells. The medicine and food written in the range of invention No. 1 become the original stuff to make the medicine and food written in the range of invention of No.2 to No. 8. 0020, Medicine and food written in the range of invention No. 2 include more than one of sprouting brown rice and milled sprouting brown rice, and more than one of beneficial intestinal bacteria, proliferation-promoting substance of beneficial intestinal bacteria, SOD 5 like substance, stabilizer of activity of SOD like substance and drink made from soybeans. Because sprouting brown rice and milled sprouting brown rice have already explained, beneficial intestinal bacteria, proliferation-promoting substance of beneficial intestinal bacteria, SOD like substance, stabilizer of activity of SOD like substance and drink made from soybeans will be explained as follows.
10 0021, Lactobacillus including bifidobacterium con-espond to beneficial bacteria. It is medical common sense that lactobacillus is beneficial intestinal bacteria. It is well known that lactobacillus is predominant in intestines of healthy people and less in intestines of people with bad conditions. When lactobacillus becomes predominant in intestinal bacterial flora, maintaining health, prevention and treatment of infectious diseases, prevention of
15 cancer causing and prevention of aging may be done. Because this condition also suppresses fixation and proliferation of pathogenic E. coli, it is effective to prevent or treat infection of pathogenic E.coli like 0-157. It is also effective to prevent infections in immunodeficiency syndrome. Further, it may be also effective against allergic diseases because immunity becomes normal when the intestinal bacterial flora is maintained in
20 lactobacillus-predominant state.
0022, Proliferation-promoting substances of beneficial intestinal bacteria, which include purified oligosaccharide and its compound, are saccharides used by lactobacillus. In another word, it is feed of beneficial bacteria. Compound of oligosaccharide and sucrose is one of the examples. The saccharides include glycoprotein like lactoferrin. The term
25 "oligosaccharide" used in this invention is superior concept that includes isomaltooligosaccharide, galactooligosaccharide, fructooligosaccharide, raffinose, lactulose, and fluid that contains oligosaccharide (like oligosaccharides from steamed soybean) etc. These proliferation-promoting substances of beneficial intestinal bacteria are not digested by human digestive enzymes and reach to colon, where only lactobacilli but bad bacteria
30 can use it, resulting in proliferation of lactobacilli.
0023, The relationship among SOD (super oxide dismutase), super oxide and lipid peroxide will be described as follows. Super oxide, which is thought to be cause of allergic diseases, autoimmune diseases, diseases by life customs and other incurable diseases, is generated more by aging in human body. SOD can delete superfluous superoxide and can protect human body from destruction by super oxide. SOD like substances in this invention means the substances that have SOD like effect. Flavonoid, polyphenol, tannin, tocopherol, vitamin Bl and other well-known substances are mentioned as SOD like substances. As substances that include SOD like substances, grain, fruit, vegetable, seed, leaf of green tea, 5 mushroom, sea weed, algae including Chlorella, tree, bamboo, bamboo grass, grass including herb, etc can be mentioned. Anything can be selected among these substances. Especially, kale has excellent substances in vegetables. part of these substances like bark, the rind of fruit, flower, leaf, stem, root, sprout, germ, rice bran and juice can be added as SOD like substances. Rice, wheat, soybean, adzuki bean, corn, adlay, pea, leaf of green tea, 10 sea weed and Chlorella are preferable as additives of SOD like substances. Juice of citrus fruits like a Chinese lemon is also preferable. SOD like substances can be added as fluid, powder or granule. SOD like substances are also extracted from natural ingredients. These substances have effects to delete super oxide to protect human tissue.
0024, Trehalose, Vitamin C, vitamin E, maltose etc. are mentioned as stabilizer of activity 15 of SOD like substance. More than one of these are used as stabilizer of activity of SOD like substance, it is preferable to use trehalose when more than two are used. When medicine and food is made by adding SOD like substance as an ingredient, sometimes activity of SOD like substance decreases during process of production or reservation of intermediate product and final product. This stabilizer of activity of SOD like substance protects SOD 20 like substance from losing its activity and keep it in high activity level for a long time.
0025, Food and drink made from soybeans are, for example, soymilk (including fermented soymilk) or bean-curd refuse. In this case, it is preferable that soybeans should be roasted at low temperature. It is well known that these food and drink made from soybeans are good and safe in nutrition as they contain rich protein, lipid, saccharide, mineral and dietary fiber.
25 0026, Medicine and food written in the range of invention No. 2 include sprouting brown rice and/or milled sprouting brown rice as indispensable constituents, and more than one of beneficial intestinal bacteria, proliferation-promoting substance of beneficial intestinal bacteria, SOD like substance, stabilizer of activity of SOD like substance and drinks made from soybeans are added as other constituents. These constituents have effects to maintain
30 healthy condition or to prevent or cure diseases by their high nutrition, SOD activity or adjusting effect for intestine. So, medicine and food made of these constituents keep good and stable homeostasis and maintain high function of human body when they are taken. 0027, In medicine or food written in the range of invention No. 2, low temperature-roasting and milling of sprouting brown rice are not indispensable condition, but it is preferable to receive low temperature-roasting and milling as described in the range of invention No. 3. It is the reason that effective constituents should be easily absorbed into cells when they are taken orally.
0028, In the case that medicine and food written in the range of invention No. 2 that include food and drink made from soybeans, for example, they consist of soymilk made from low temperature-roasted soybeans. This soymilk has higher function than conventional soymilk in the view of prevention for diseases, because it contains more low molecular SOD like substances.
0029, Medicine and food written in the range of invention No. 1 to No. 4 can include grain other than sprouting brown rice. The grain includes rice, barley, wheat, kinds of bean, foxtail millet seed, Japanese millet, African millet, corn, buckwheat, sesame, other miscellaneous cereals, and their processed goods. They can be mixed. Foxtail millet seed, Japanese millet, adlay and amaranthaceae can be actually mentioned as miscellaneous cereals. Among them, amaranthaceae has rich protein, mineral and calcium comparing other miscellaneous cereals. These miscellaneous cereals are preferable to be milled. Perilla oil that is extracted from perilla ocimoides can be added. It is said that alpha-linolenic acid in perilla oil has potent effect against heart disease, diabetes, cerebrovascular disease, cancer, allergic dermatitis, asthma and Alzheimer's disease like they say contemporary disease.
0030, The medicine and food written in the range of invention No. 6 are the one in which each constituting elements other than beneficial bacteria contain less than 4 % of water.
This means that when one of the constituents is beneficial bacteria, other constituents should have less than 4 % of water. It is the reason that beneficial bacteria like bifidobacteria will be killed easily by little water in materials.
0031, The medicine and food written in the range of invention No. 7 are consist of one of the medicine and food written in the range of inventions from No. 1-No. 6 in which feπnentation process is added partially or all. Methods of fermentation are well known fermentation by microorganisms. Partial feπnentation process means that partial constituent receives feπnentation process. Because molecules of ingredients are changed into small ones and flavor and taste may be improved by fermentation process, it is preferable that medicine and food are fermented partially or all.
0032, The medicine and food written in the range of invention No. 8 consist of one of the medicine and food written in the range of inventions from No. 1-No. 7 in which they are processed like cheese partially or all. Partial process like cheese means that partial constituent receives process like cheese. Food that is processed like cheese is easily taken orally for any people.
0033, The form of fulfillment of this invention
At first, the medicine and food of 1st fulfillment form will be described.
0034, The medicine and food of 1st fulfillment form consisted of milled sprouting brown 5 rice. Sprouting brown rice is made by culture of brown rice and water in sprouting equipment that is maintained at 23°C-25°C for about 24 hours. This sprouting brown rice is low temperature-roasted at 40°C-100°C (50°C-95°C is preferable). Actually, roasting by far infrared rays, ultrasonic roasting, high-frequency roasting, low-frequency roasting, roasting by heated wind etc. can be used. It can be roasted by using more than 2 methods. The SOD 10 like molecules in sprouting brown rice are changed into smaller molecules by this low temperature-roasting. Low temperature-roasted sprouting brown rice is milled by a manufactured mill. By these processes, the medicine and food of 1st fulfillment form are obtained.
0035, Because the medicine and food of 1st fulfillment form (milled sprouting brown rice) 15 are functional food that has good nutrition and effective ingredients can be reached intracellularly, it is useful and profitable as medicine and food as described above. This medicine and food become an effective ingredient when more functional medicine and food will be made. In this case, water content can be suppressed less than 4 % due to the reason that have already described.
20 0036, Next, the medicine and food of 2nd fulfillment form of this invention will be explained.
0037, The medicine and food of 2nd fulfillment form of this invention consist of sprouting brown rice and/or milled sprouting brown rice, beneficial intestinal bacteria, proliferation- promoting substance of beneficial intestinal bacteria and SOD like substance.
25 Sprouting brown rice is the one roasted by the method that has already described. Milled sprouting brown rice is the one described in the medicine and food of 1st fulfillment foπn. These can be added alone or by mixture. Further, these are preferable that water content can be suppressed less than 4 % by low temperature-roasting or roasting with hot wind. It is the reason that beneficial bacteria like bifidobacteria will be killed easily by little water in
30 materials.
0039, As beneficial intestinal bacteria, live lactobacillus in which bifidobacterium is representative should be adopted. Actually, Bifidobacterium adolescentis, B. bifidum, B. breve, B. infantis, B. longum should be adopted. It is optional to adopt freeze-dry method, but freeze-dried live bifidobacteria are preferable. Further, It is preferable that these beneficial intestinal bacteria like bifidobacteria should have resistance for drugs. The resistance for a drug or one for many drugs can be adopted. This resistance for drugs includes resistance for antibiotics and anti-cancerous drugs. As actual antibiotics, penicillin, colistin, polymyxin, cycloserine, griseofulvin, streptomycin, kanamycin, chloramphenicol, 5 tetracycline, mitomycin, bleomycin, actinomycin, erythromycin, oxitetracycline, chlortetracycline, chloromycetin, trichomycin etc. can be mentioned. The well known drugs other than mentioned above can be included.
Against the infection of 0-157 (pathogenic E. coli), the beneficial bacteria that have resistance against fosfomycin and quinolon should be adopted, because 0-157 is sensitive
10 against these drugs.
Against the therapy for diaπhea in immunodeficiency like AIDS, beneficial intestinal bacteria that have the resistance against penicillin, cephalosporin, aminoglycoside and tetracycline etc. should be adopted. These beneficial intestinal bacteria described above should be adopted after the examination
15 of drug sensitivity that is well known. For example, the drug sensitivity is examined by co- culture of beneficial bacteria and disks that contains certain concentration of antibiotics on agar. Only drug-resistant colony can be selected by its suppressive effect of bacterial proliferation. The resistance for drug must be not transmitted. This is ascertained by co- culture of drug-resistant bacteria and normal bacteria that is well known.
20 0040, As proliferation-promoting substance of beneficial intestinal bacteria, purified oligosaccharide, its compound and fluid that contains oligosaccharide (like oligosaccharides from steamed soybean) etc can be mentioned as described above. Among them, purified oligosaccharide is often used due to its preference. In this case, water content should be suppressed less than 4 % due to the reason that have already described.
25 0041, As SOD like substances, one of the previously described materials should be selected. Actually, some of grain, seeds and vegetables should be selected. In this case, water content should be suppressed less than 4 % due to the reason that have already described. 0042, The medicines and foods of 2nd fulfillment form of this invention are actually described as follows. Milled sprouting brown rice is low temperature-roasted one that
30 contains 3.5 % of water. Beneficial intestinal bacteria are live bifidobacteria. Proliferation- promoting substance of beneficial intestinal bacteria is purified (97%) lactosucurose. As SOD like substance, roasted rice bran at low temperature is fermented by rice koji that contains koji mold (Aspergillus oryzae), and dried kale powder is added. It is suspected that this medicine and food may be effective to maintain health and to prevent and treat diseases by contents of the description, but it was clear that it had remarkable clinical effects by fulfillment cases that will be shown below.
0043, The medicine and food of 3rd fulfillment form of this invention mainly consist of sprouting brown rice and milled sprouting brown rice and food and drink made from soybeans. In this case, sprouting brown rice and milled sprouting brown rice has already described. So, food and drink made from soybeans will be explained as follows.
0044, As food and drink made from soybeans, soymilk and bean-curd refuse can be mentioned, but soymilk is mainly used. It is preferable that these soymilk and bean-curd refuse are made from soybeans that is roasted at low temperature. Soymilk is made by the method as follows.
0045, The method to make soymilk is basically not different from well known one, but the process in which soybeans are roasted at low temperature is added. An example of the process to make soymilk made from soybeans is shown as follows. It consists of selection process, roasting process, washing process, soaking process, crushing process, heating process, squeezing process and mixing process. Final volume of soymilk should be adjusted to 4-6 L / Kg of soybeans.
0046, In selection process, soybeans are checked. Impurities are removed. Cracked or waπn-eaten soybeans are removed.
0047, In roasting process, soybeans are roasted at low temperature. Actually, roasting by far infrared rays, ultrasonic roasting, high-frequency roasting, low-frequency roasting, roasting by heated wind etc. can be used. Actually, roasting by far infrared rays or ultrasonic roasting are preferable. One or both of these two methods should be adopted. In roasting by far infrared rays and/or ultrasonic roasting, soybeans are roasted at 40°C-100°C (50°C-95°C is preferable) for a long time. The SOD like molecules in soybeans are changed into smaller molecules by this low temperature-roasting.
0048, In washing process, soybeans after the roasting are washed by water many times to remove dust on surface of soybeans. This process can also be done by a washing machine.
0049, In soaking process, soybeans after washing are soaked in water. The soaking time is different depend on temperature. For about 12 hours in summer and about 24 hours in winter are preferable.
0050, Soybeans after soaking are crushed by a crashing machine with adding water. The resulting product is called soybean slurry that contains water. This process is useful to extract proteins etc. because cell membranes of soybeans are torn. The concentration of soymilk is adjusted by changing water volume in this process. 0051, In heating process, soybean slurry is heated by steam at about 100 °C.
0052, In squeezing process, steamed slurry is squeezed by a squeezing machine and soymilk is divided from bean-curd refuse.
0053, The soymilk got by these processes and milled sprouting brown rice as described are 5 mixed. Fluidity is changed by proportion of each ingredients.
0053, The medicine and food of 3rd fulfillment form of this invention are also satisfactory to prevent and treat diseases, effect for intestinal adjustment and good nutrition. The soymilk made from roasted soybeans has good flavor and its absorption at intracellular level is good because its molecules are changed into small molecules. 10 0055, The medicine and food of 4th fulfillment foπn of this invention will be explained as follows.
0056, The medicine and food of 4th fulfillment form of this invention consist of sprouting brown rice and/or milled sprouting brown rice (for example, milled sprouting brown rice), food and drink made from soybeans (for example, soymilk) and stabilizer for activity of
15 SOD like substance. In this case, milled sprouting brown rice and soymilk have already described. As stabilizer for activity of SOD like substance, more than one of trehalose, Vitamin C, vitamin E, maltose etc can be used. Actually, trehalose is used.
0057, As the medicine and food of 4th fulfillment form of this invention, proportion of mixture between soymilk and milled sprouting brown rice is varied. The proportion of
20 stabilizer for activity of SOD like substance can be determined by relationship with soymilk. Actually, soymilk : trehalose is 1 : 0.1-1 (in representative case, 0.5) in weight. In mixing process, soymilk, milled sprouting brown rice and trehalose are mixed homogeneously.
0058, The medicine and food of 4th fulfillment form of this invention are good as those of 25 3ld fulfillment foπn. Further, the activity of SOD like substance is maintained for long time because they contain stabilizer of activity.
0059, In the medicine and food of 5th fulfillment form of this invention, fermented soymilk is adopted instead of soymilk in medicine and food of 3rd and 4th fulfillment form of this invention. In this case, fermentation is performed by microorganisms. It is preferable that
30 molecules of SOD like substances in soymilk are changed into small ones by fermentation process. Fermented soymilk made from roasted soybeans at low temperature is more preferable because of double processes. Feπnented soymilk has good flavor. Lactobacillus or koji mold can be adopted as microorganisms to ferment soymilk, but lactobacillus is preferable. Fermented soymilk by lactobacilli contains live bacilli and lactic acid. This fermented soymilk can be used as supplements and people can take it to maintain or enhance their health.
0060, In the medicine and food of 6th fulfillment form of this invention, proliferation- promoting substance of beneficial intestinal bacteria (oligosaccharide) is added to fermented soymilk in the medicine and food of 5th fulfillment form of this invention. So, the medicine and food of 6th fulfillment foπn of this invention consist of sprouting brown rice and/or milled sprouting brown rice, beneficial bacteria, proliferation-promoting substance of beneficial intestinal bacteria, stabilizer for activity of SOD like substance and food and drink made from soybeans. Because sprouting brown rice and food and drink made from soybeans are one of SOS like substances, the medicine and food of 6th fulfillment form also contains SOD like substance.
0061, In the medicine and food of 6th fulfillment form of this invention, fermented soymilk and oligosaccharide are as follows. Oligosaccharide reaches to colons because it can not be digested and cannot be absorbed in intestines. Because only beneficial bacteria (lactobacilli) but bad bacteria can use oligosaccharide, proliferation of lactobacilli in colon is enhanced. Fermented soymilk added oligosaccharide is low calorie food. Among them, feπnented soymilk added lactulose is effective to maintaining health and treating diseases by the effect of enhancement for absorption of calcium and magnesium, intestinal adjustment, proliferation of lactobacilli, improvement of intra-intestinal environment and improvement of high blood ammonia level and hepatic coma. It is expected that the medicine and food of 6th fulfillment foπn of this invention should have remarkable effect to maintain health and treat diseases, because the effects of sprouting brown rice and stabilizer for activity of SOD like substance are added to these effects of feπnented soymilk added oligosaccharide.
0062, In the medicine and food of 6th fulfillment foπn of this invention, SOD like substances other than sprouting brown rice and those made from soybeans can be added.
0063, In the medicine and food of 5th and 6th fulfillment foπn of this invention, soymilk is feπnented. This means that a part of medicines and foods has process of fermentation. In this case, constituents other than soymilk or all constituents can be fermented.
0064, Next, the medicine and food of 7th fulfillment foπn of this invention will be explained.
0065, The medicine and food of 7th fulfillment form of this invention are those of a part or all of constituents in the medicine and food of 1st to 6th fulfillment form are processed like cheese. For example, because the medicine and food of 1st fulfillment foπn consist of only milled sprouting brown rice, milled sprouting brown rice is processed like cheese. Otherwise, in the case of the medicine and food of 2nd to 6th fulfillment forms, more than one constituent is processed like cheese. So, cheese like constituent and other constituent that is not processed like cheese can be mixed.
Further, we can control the foπn of medicine and food from liquid to solid by adjusting its viscosity. Other ingredients of food can be added. Actually, we can make the medicine and food like yogurt, cheese, butter, cake, ice-cream, freeze-dried cake and freeze-dried candy. Among these, those like cheese should be feπnented by Agalikusu brasei muriru. Other than this can be made from soymilk.
0066, The medicine and food of 8th fulfillment form of this invention are those added oil. These are obtained by adding oil to the medicine and food of 1st to 6th fulfillment form of this invention. Sesame oil, olive oil, com oil, soybean oil, rapeseed oil, cottonseed oil, rice- bran oil, sunflower oil, palm oil, peanut oil, oil from snapping turtle, liver oil, fish oil, kanpo-animal oil, mixed vegetable oil, mixed animal oil, mixed oil from vegetable and animal oil and powdered oil etc. are mentioned. The oil that is obtained from far infrared- roasted and/or ultrasonic-roasted sesame seeds is preferable. Mixed oil containing this roasted sesame oil is also preferable. The proportion of fermented substances and oil is 1: 1- 2 in weight. By adding oil, the medicine and food may be able to reach into cells, because its affinity to cell membranes becomes higher.
0067, Oligosaccharide-containing fluid used in this invention is as follows. Original ingredient of the oligosaccharide-containing fluid used in this invention is soybean that is roasted at low temperature. So, this fluid also contains low molecular SOD like substances. This fluid can enhance intestinal lactobacilli and can function to maintain health or treat diseases more effectively due to its SOD like substances. It is preferable because it enhance physical function. Because this fluid can be obtained secondarily when soybean products are made, this is a preferable constituent to make the medicines and foods in this invention. Stabilizer of activity for SOD like substance can be added to this fluid. This fluid can be purified.
0068, When the medicine and food in this invention contain beneficial bacteria, it is preferable that 1-10 billion cells/day of live bifidobacteria should be taken orally. The lower limit is determined as 1 billion cells/day, because if it is lesser, the effect will be remarkably reduced. The upper limit is deteπnined as 10 billion cells /day because of capability by recent technique. When the medicine and food of this investment include proliferation- promoting substances of beneficial intestinal bacteria (oligosaccharide), 1.5 -10 g/day of oligosaccharide should be taken orally. In this range, over calorie can be avoided with sufficient effect. When the medicine and food of this investment include SOD like substances, 0.5-2 g/day of SOD like substance should be taken orally. The lower limit is determined as 0.5 g/day, because if it is lesser, the effect will be remarkably reduced. The upper limit is deteπnined as 2 g/day because of avoidance for side effects like that of 5 caffeine. 0069,
The 1st fulfillment example; In the medicine and food of 1st fulfillment example, milled sprouting brown rice, lactosucrose, live bifidobacteria and SOD like substance are homogeneously mixed as follows. A dosage / one time is 5 g. As SOD like substances, 1.5 g 10 of rice bran was roasted by far infra-red ray at 95°C for 2 hours, and 0.2 g of rice koji was added and feπnented for 24 hours, and finally 0.5 g of kale powder was added.
(1) milled sprouting brown rice roasted at low temperature (3.5 % of water): 1.0 g
(2) 97 % lactosucrose (3.5 % of water): 1.5 g
(3) live bifidobacteria (10 billion cells/g): 0.1 g 15 (4) SOD like substance (3.5 % of water): 2.4 g
0070, The medicine and food of the 1st fulfillment example was administrated for 73 years old male. He was examined under magnetic resonance imaging because he had transient left hemiparesis. There was no sign of cerebral infarction in MRI, but his magnetic resonance angiograph showed severe stenosis of right middle cerebral artery. The medicine and food
20 of the 1st fulfillment example are administrated for him 2 times a day orally. 4 months after the start of administration, his stenotic area of cerebral artery was remarkably improved. 12 months after the start of administration, the stenotic area was almost re-opened normally. He had no re-occuπence of hemiparesis for 2 years after the start of administration. After the treatment, he enjoys his life very much.
25 0071, It can be possible to say about the medicine and food of this invention as follows from the result of 1st fulfillment example. One is severely stenotic artery can be reopened by this invention. Another is systemic cerebral arteries are improved. In the case of 1st fulfillment example, the peripheral arteries of his stenotic portion are remarkably dilated 4 months after the start of administration. The middle cerebral arteries on his opposite side
30 were also remarkably dilated 4 months after the start of administration. Further, this might improve blood viscosity by lowering blood fat. It is suggested that cerebral blood flow was enhanced by these effects. Meanwhile, it can be mentioned systemic improvement. Because this treatment is perfonned by oral administration, the systemic effects should be expected. Atherosclerosis of systemic arteries should be improved. This may pave the way to prevent aging.
0072, The 2nd fulfillment example; The 2nd fulfillment example consist of milled sprouting brown rice, soymilk, lactosucrose and bifidobacteria. Soymilk is made from soybeans that are roasted at low temperature as the 1st fiilfillment example. Milled sprouting brown rice is 5 made from sprouting brown rice roasted at low temperature. Milled sprouting brown rice is added to the soybean slurry. Milled sprouting brown rice that is 1/20 of soybeans in weight was added. The grain milk is made from this soybean slurry added milled sprouting brown rice by the same method as described in 0051-0052. Purified lactosucrose (97%) and live bifidobacteria are added and cultured at 37°C for 12 hours.
10 0073, The medicine and food of 2nd fulfillment example were administrated for 63 years male, who had right hemiparesthesia. This symptom was due to severe stenosis of his left middle cerebral artery. Despite he was administrated oral anticoagulants and anti-super oxide DIV, his right hemiparesis progressed and he became not to be able to walk. Then, the medicine and food of 2n fulfillment example were administrated to him 3 times a day as
15 food. From after 2 days from the start of administration, right upper and lower extremities started to move and he became to be able to walk 3 weeks after the start of administration. It was proved that severely stenotic portion of his left middle cerebral artery was almost reopened 3 weeks after the start of administration by MRA.
0074, About the medicine and food of this invention, it can be said as follows by the result 20 of the 2nd fulfillment example. It is that the medicine and food of this invention can cure or improve the symptoms of patients who have severe vascular disease.
0075, The effect of this invention:
The medicine and food of this invention may be able to satisfactorily attain the purpose in maintaining health, prevention and treatment of infectious diseases, prevention and 25 treatment of allergic diseases, prevention of cancer and prevention of aging. This may be also effective to AIDS and infectious diseases by pathogenic E. coli. Further, it is preferable that this is very effective to vascular diseases due to atherosclerosis. So, severe vascular diseases can be restored safely avoiding surgical risk.

Claims

Claims The range of the invention is:
1) Medicine or food made from low temperature-roasted and milled sprouting brown rice.
2) Medicine or food that include more than one of sprouting brown rice and milled sprouting brown rice, and more than one of beneficial intestinal bacteria, proliferation- promoting substance of beneficial intestinal bacteria, SOD like substance, stabilizer of activity of SOD like substance and food and drink made from soybeans.
3) The claim of No.2) in which sprouting brown rice and/or milled sprouting brown rice are roasted at low temperature.
4) The claim of No.2) in which food and drink made from soy beans are soy milk made from low temperature-roasted soybeans.
5) Medicine or food of claims No. 1 to No. 4, further including grain other than sprouting brown rice.
6) Medicine or food of claims No. 1 to No. 5, in which each constituting elements other than beneficial bacteria contain less than 4 % of water.
7) Medicine or food of claims No. 1 to No. 6, which receive fermentation process partially or all.
8) Medicine or food of claims No. 1 to No. 7, which are processed like cheese partially or all.
PCT/US2004/003816 2003-02-18 2004-02-09 A medicine and food WO2004073613A2 (en)

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EP1820408A1 (en) * 2006-02-17 2007-08-22 Satake Corporation Brown rice having increased contents of functional components and method for manufacturing the same
EP1935253A1 (en) * 2005-09-20 2008-06-25 Idemitsu Kosan Co., Ltd. Additive for animal feed

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JP4636596B2 (en) * 2004-11-17 2011-02-23 きく枝 橋本 Cereal processed food and its secondary processed food
JP2008295380A (en) * 2007-05-31 2008-12-11 Ikari Super Market:Kk Foodstuff containing gaba and its preparation method
JP7122727B2 (en) * 2016-07-07 2022-08-22 株式会社東洋新薬 Beverage containing ferulic acid
JP7072930B2 (en) * 2021-01-12 2022-05-23 株式会社東洋新薬 Ferulic acid-containing beverage

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Publication number Priority date Publication date Assignee Title
EP1935253A1 (en) * 2005-09-20 2008-06-25 Idemitsu Kosan Co., Ltd. Additive for animal feed
EP1935253A4 (en) * 2005-09-20 2009-09-02 Idemitsu Kosan Co Additive for animal feed
EP1820408A1 (en) * 2006-02-17 2007-08-22 Satake Corporation Brown rice having increased contents of functional components and method for manufacturing the same

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