WO2004072062A3 - Indolylmaleimide derivatives - Google Patents

Indolylmaleimide derivatives Download PDF

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Publication number
WO2004072062A3
WO2004072062A3 PCT/EP2004/001323 EP2004001323W WO2004072062A3 WO 2004072062 A3 WO2004072062 A3 WO 2004072062A3 EP 2004001323 W EP2004001323 W EP 2004001323W WO 2004072062 A3 WO2004072062 A3 WO 2004072062A3
Authority
WO
WIPO (PCT)
Prior art keywords
indolylmaleimide derivatives
indolylmaleimide
derivatives
treatement
gsk
Prior art date
Application number
PCT/EP2004/001323
Other languages
French (fr)
Other versions
WO2004072062A2 (en
Inventor
Matt Peter Von
Juergen Wagner
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Matt Peter Von
Juergen Wagner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Matt Peter Von, Juergen Wagner filed Critical Novartis Ag
Priority to BRPI0407512-9A priority Critical patent/BRPI0407512A/en
Priority to DE602004026415T priority patent/DE602004026415D1/en
Priority to US10/542,175 priority patent/US7820672B2/en
Priority to CA002513613A priority patent/CA2513613A1/en
Priority to JP2005518422A priority patent/JP2006515004A/en
Priority to EP04710393A priority patent/EP1597250B8/en
Priority to AT04710393T priority patent/ATE463491T1/en
Publication of WO2004072062A2 publication Critical patent/WO2004072062A2/en
Publication of WO2004072062A3 publication Critical patent/WO2004072062A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

Provided are compounds of formula (I) which are useful in the treatement or prevention of disorders or diseases mediated by T lymphocytes and/or PKC or GSK-3 BETA.
PCT/EP2004/001323 2003-02-13 2004-02-12 Indolylmaleimide derivatives WO2004072062A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BRPI0407512-9A BRPI0407512A (en) 2003-02-13 2004-02-12 indolylmaleimide derivatives
DE602004026415T DE602004026415D1 (en) 2003-02-13 2004-02-12 INDOLYLMALEIMIDE DERIVATIVES
US10/542,175 US7820672B2 (en) 2003-02-13 2004-02-12 Indolylmaleimide derivatives
CA002513613A CA2513613A1 (en) 2003-02-13 2004-02-12 Indolylmaleimide derivatives
JP2005518422A JP2006515004A (en) 2003-02-13 2004-02-12 Indolylmaleimide derivatives
EP04710393A EP1597250B8 (en) 2003-02-13 2004-02-12 Indolylmaleimide derivatives
AT04710393T ATE463491T1 (en) 2003-02-13 2004-02-12 INDOLYLMALEIMIDE DERIVATIVES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0303319.8 2003-02-13
GBGB0303319.8A GB0303319D0 (en) 2003-02-13 2003-02-13 Organic compounds

Publications (2)

Publication Number Publication Date
WO2004072062A2 WO2004072062A2 (en) 2004-08-26
WO2004072062A3 true WO2004072062A3 (en) 2004-11-04

Family

ID=9952961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001323 WO2004072062A2 (en) 2003-02-13 2004-02-12 Indolylmaleimide derivatives

Country Status (12)

Country Link
US (1) US7820672B2 (en)
EP (2) EP2075249B1 (en)
JP (2) JP2006515004A (en)
CN (1) CN100439359C (en)
AT (2) ATE463491T1 (en)
BR (1) BRPI0407512A (en)
CA (1) CA2513613A1 (en)
DE (1) DE602004026415D1 (en)
ES (2) ES2343115T3 (en)
GB (1) GB0303319D0 (en)
PT (1) PT1597250E (en)
WO (1) WO2004072062A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009501172A (en) * 2005-07-11 2009-01-15 ノバルティス アクチエンゲゼルシャフト Indolylmaleimide derivatives
JP2009506069A (en) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド Neurogenesis through modulation of muscarinic receptors
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
CN101558062A (en) 2006-12-19 2009-10-14 诺瓦提斯公司 Indolylmaleimide derivatives as kinase inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN101671329B (en) * 2009-06-17 2012-11-07 东华大学 Indolylmaleimide compound substituted with 3-amino alcohol, preparation method and application thereof
ES2845298T3 (en) * 2012-12-10 2021-07-26 Centogene Gmbh Use of maleimide derivatives to prevent and treat leukemia
CN104693198B (en) * 2014-12-13 2017-03-08 浙江工业大学 3 (1,2,4 triazoles simultaneously [4,3 a] 3 base of pyridine) 4 (3 base of 1H indoles) maleimide analog derivative and its preparation method and application
SG11201708804WA (en) 2015-05-07 2017-11-29 Agenus Inc Anti-ox40 antibodies and methods of use thereof
CN108883173B (en) 2015-12-02 2022-09-06 阿吉纳斯公司 Antibodies and methods of use thereof
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
WO2018132636A1 (en) * 2017-01-12 2018-07-19 The Research Foundation For The State University Of New York [18f]maleimide-based glycogen synthase kinase-3beta ligands for positron emission tomography imaging and radiosynthesis method
CN110551103B (en) * 2018-05-30 2022-08-23 北京大学深圳研究生院 JAK3 selective inhibitor
EP3920885A1 (en) 2019-02-08 2021-12-15 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders

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US5057614A (en) * 1988-02-10 1991-10-15 Hoffmann-La Roche Inc. Substituted pyrroles
WO2002038561A1 (en) * 2000-11-07 2002-05-16 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
WO2003076398A2 (en) * 2002-03-08 2003-09-18 Eli Lilly And Company Pyrrole-2, 5-dione derivatives and their use as gsk-3 inhibitors

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WO2002038561A1 (en) * 2000-11-07 2002-05-16 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
WO2003076398A2 (en) * 2002-03-08 2003-09-18 Eli Lilly And Company Pyrrole-2, 5-dione derivatives and their use as gsk-3 inhibitors

Also Published As

Publication number Publication date
CN1742005A (en) 2006-03-01
EP1597250B8 (en) 2010-05-19
EP2075249A2 (en) 2009-07-01
ES2343115T3 (en) 2010-07-23
PT1597250E (en) 2010-06-25
BRPI0407512A (en) 2006-02-14
CA2513613A1 (en) 2004-08-26
EP2075249A3 (en) 2009-09-02
WO2004072062A2 (en) 2004-08-26
EP2075249B1 (en) 2012-03-28
GB0303319D0 (en) 2003-03-19
CN100439359C (en) 2008-12-03
ATE463491T1 (en) 2010-04-15
ES2385071T3 (en) 2012-07-17
US7820672B2 (en) 2010-10-26
DE602004026415D1 (en) 2010-05-20
EP1597250B1 (en) 2010-04-07
JP2009280592A (en) 2009-12-03
US20060058356A1 (en) 2006-03-16
JP2006515004A (en) 2006-05-18
ATE551335T1 (en) 2012-04-15
EP1597250A2 (en) 2005-11-23

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