WO2004075847A3 - METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS - Google Patents

METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS Download PDF

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Publication number
WO2004075847A3
WO2004075847A3 PCT/US2004/005391 US2004005391W WO2004075847A3 WO 2004075847 A3 WO2004075847 A3 WO 2004075847A3 US 2004005391 W US2004005391 W US 2004005391W WO 2004075847 A3 WO2004075847 A3 WO 2004075847A3
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WO
WIPO (PCT)
Prior art keywords
compounds
disorders
treatment
conditions
methods
Prior art date
Application number
PCT/US2004/005391
Other languages
French (fr)
Other versions
WO2004075847A2 (en
Inventor
Nigel H Creig
Qian-Sheng Yu
Tadanobu Utsuki
Anthony Giordano
Michael A Sturgess
Ke Yang
Gordon D Powers
Original Assignee
Message Pharmaceuticals Inc
Nat Inst Health
Nigel H Creig
Qian-Sheng Yu
Tadanobu Utsuki
Anthony Giordano
Michael A Sturgess
Ke Yang
Gordon D Powers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Message Pharmaceuticals Inc, Nat Inst Health, Nigel H Creig, Qian-Sheng Yu, Tadanobu Utsuki, Anthony Giordano, Michael A Sturgess, Ke Yang, Gordon D Powers filed Critical Message Pharmaceuticals Inc
Publication of WO2004075847A2 publication Critical patent/WO2004075847A2/en
Publication of WO2004075847A3 publication Critical patent/WO2004075847A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The invention features compounds and methods of the treatment of Aß­associated diseases, disorders, or conditions. The compounds are generically represented by the following formulae (I, II, III, IV) and, wherein the substituents are as described in the specification.
PCT/US2004/005391 2003-02-21 2004-02-23 METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS WO2004075847A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44929503P 2003-02-21 2003-02-21
US60/449,295 2003-02-21

Publications (2)

Publication Number Publication Date
WO2004075847A2 WO2004075847A2 (en) 2004-09-10
WO2004075847A3 true WO2004075847A3 (en) 2005-06-30

Family

ID=32927507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/005391 WO2004075847A2 (en) 2003-02-21 2004-02-23 METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS

Country Status (1)

Country Link
WO (1) WO2004075847A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5014983B2 (en) * 2004-05-07 2012-08-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (en) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv OXYSTEROID DEHYDROGENASE INHIBITORS
NZ553159A (en) 2004-08-30 2010-05-28 Janssen Pharmaceutica Nv N-Adamantan-2-yl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
EP1786774B1 (en) 2004-08-30 2009-10-14 Janssen Pharmaceutica N.V. Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROSENMUND P. AND SADRI E.: "Contributions to the Chemistry of Indole, XII. Syntheses of Compounds Similar to Eserine,III;New Derivatives of Desoxyeseroline Substituted at N-1 and N-8 and a Novel Synthesis of Eserethole", LIEBIGS ANNALEN DER CHEMIE, vol. 7, 1979, pages 927 - 943, XP002029415 *
YU Q-S. ET AL: "Syntheses and Anticholinesterase Activities of (3aS)-N1, N8-Bisnorpheserine, (3aS)-N1, N8-Bisnorphysostigmine, Theur Antipodal Isomers, and Other Potential Metabolites of Phenserine", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 13, 1998, pages 2371 - 2379, XP001015264 *

Also Published As

Publication number Publication date
WO2004075847A2 (en) 2004-09-10

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