WO2004055052A3 - Nucleic acid sequences for use as biomarker for damage to the intestinal epithilum - Google Patents

Nucleic acid sequences for use as biomarker for damage to the intestinal epithilum Download PDF

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Publication number
WO2004055052A3
WO2004055052A3 PCT/NL2003/000901 NL0300901W WO2004055052A3 WO 2004055052 A3 WO2004055052 A3 WO 2004055052A3 NL 0300901 W NL0300901 W NL 0300901W WO 2004055052 A3 WO2004055052 A3 WO 2004055052A3
Authority
WO
WIPO (PCT)
Prior art keywords
mptx
biomarker
nucleic acids
damage
intestinal
Prior art date
Application number
PCT/NL2003/000901
Other languages
French (fr)
Other versions
WO2004055052A2 (en
Inventor
Der Meer Roelof Van
Jacob Keijer
Der Meer-Van Kraaij Sindy Van
Everarda Helena Maria Kramer
Original Assignee
Stichting Top Inst Voedselwete
Der Meer Roelof Van
Jacob Keijer
Der Meer-Van Kraaij Sindy Van
Everarda Helena Maria Kramer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Top Inst Voedselwete, Der Meer Roelof Van, Jacob Keijer, Der Meer-Van Kraaij Sindy Van, Everarda Helena Maria Kramer filed Critical Stichting Top Inst Voedselwete
Priority to AU2003295262A priority Critical patent/AU2003295262A1/en
Publication of WO2004055052A2 publication Critical patent/WO2004055052A2/en
Publication of WO2004055052A3 publication Critical patent/WO2004055052A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a mucosal pentraxin (MPtx) and nucleic acids encoding the MPtx polypeptide, the expression of which in intestinal epithelium is down regulated in response to cytotoxic dieatary components such as herne. The MPtx nucleic acids and polypeptides may be used as biomarker for damage of the intestinal epithelium and/or as biomarker for increased risk of colon cancer. The MPtx nucleic acids and polypeptides may further be used as biomarker in assays for indentification of substances that modulate the condition of the intestinal epithelium. The invention further relates to pharmaceutical compositions comprising the MPtx nucleic acids, polypeptides or antibodies thereto for use in methods for treating a MPtx deficiency.
PCT/NL2003/000901 2002-12-17 2003-12-17 Nucleic acid sequences for use as biomarker for damage to the intestinal epithilum WO2004055052A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003295262A AU2003295262A1 (en) 2002-12-17 2003-12-17 Nucleic acid sequences for use as biomarker for damage to the intestinal epithilum

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02080399 2002-12-17
EP02080399.5 2002-12-17

Publications (2)

Publication Number Publication Date
WO2004055052A2 WO2004055052A2 (en) 2004-07-01
WO2004055052A3 true WO2004055052A3 (en) 2004-09-23

Family

ID=32524057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2003/000901 WO2004055052A2 (en) 2002-12-17 2003-12-17 Nucleic acid sequences for use as biomarker for damage to the intestinal epithilum

Country Status (2)

Country Link
AU (1) AU2003295262A1 (en)
WO (1) WO2004055052A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2592095C (en) 2004-12-24 2013-07-30 Basf Aktiengesellschaft Use of nonionic surfactants in metal extraction
US20190263912A1 (en) * 2016-11-11 2019-08-29 The Broad Institute, Inc. Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
CN113773364B (en) * 2021-08-25 2023-04-28 无锡市儿童医院 Small molecule peptide and preparation method and application thereof
CN114369150B (en) * 2022-01-24 2023-10-31 上海市儿科医学研究所 Mptx2 protein and application thereof in treating methicillin-resistant staphylococcus aureus infection related diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 14 March 2002 (2002-03-14), XP002238603, retrieved from EBI Database accession no. BC024348 *
DATABASE EMBL [online] 18 September 2001 (2001-09-18), XP002238605, retrieved from EBI Database accession no. AC094833 *
DATABASE EMBL [online] 31 January 2001 (2001-01-31), XP002238606, retrieved from EBI Database accession no. AL513323 *
DATABASE SWISSPROT [online] 1 June 2002 (2002-06-01), XP002238604, retrieved from EBI Database accession no. Q8R1M8 *
GEWURZ HENRY ET AL: "Structure and function of the pentraxins.", CURRENT OPINION IN IMMUNOLOGY, vol. 7, no. 1, 1995, pages 54 - 64, XP002238601, ISSN: 0952-7915 *
SESINK ALOYS L A ET AL: "Red meat and colon cancer: Dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium.", CARCINOGENESIS (OXFORD), vol. 21, no. 10, October 2000 (2000-10-01), pages 1909 - 1915, XP002238602, ISSN: 0143-3334 *

Also Published As

Publication number Publication date
AU2003295262A1 (en) 2004-07-09
WO2004055052A2 (en) 2004-07-01

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