WO2004050029A3 - Novel activated polyethylene glycol compounds - Google Patents

Novel activated polyethylene glycol compounds Download PDF

Info

Publication number
WO2004050029A3
WO2004050029A3 PCT/US2003/038262 US0338262W WO2004050029A3 WO 2004050029 A3 WO2004050029 A3 WO 2004050029A3 US 0338262 W US0338262 W US 0338262W WO 2004050029 A3 WO2004050029 A3 WO 2004050029A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyethylene glycol
materials
attachment
glycol compounds
activated polyethylene
Prior art date
Application number
PCT/US2003/038262
Other languages
French (fr)
Other versions
WO2004050029A2 (en
Inventor
Adonis Stassinopoulos
Xue Min Zhou
Simeon G Bowers
Original Assignee
Cerus Corp
Adonis Stassinopoulos
Xue Min Zhou
Simeon G Bowers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp, Adonis Stassinopoulos, Xue Min Zhou, Simeon G Bowers filed Critical Cerus Corp
Priority to AU2003297614A priority Critical patent/AU2003297614A1/en
Publication of WO2004050029A2 publication Critical patent/WO2004050029A2/en
Publication of WO2004050029A3 publication Critical patent/WO2004050029A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention involves new polyethylene glycol derivatives that can be reacted with biological materials to covalently attach the polyethylene glycol derivative to the material. The biological materials may include proteins, liposomes, or cellular compositions. The attachment of the polyethylene glycol to the materials results in improved biological properties, such as reduced elimination of the materials by the immune system. In the case of red blood cells, the attachment of the compound provides either antigen masking of the red cells or improved viscosity of the red cells at low shear rates.
PCT/US2003/038262 2002-12-04 2003-12-03 Novel activated polyethylene glycol compounds WO2004050029A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003297614A AU2003297614A1 (en) 2002-12-04 2003-12-03 Novel activated polyethylene glycol compounds

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US43121602P 2002-12-04 2002-12-04
US43121302P 2002-12-04 2002-12-04
US43121502P 2002-12-04 2002-12-04
US43121402P 2002-12-04 2002-12-04
US60/431,216 2002-12-04
US60/431,214 2002-12-04
US60/431,213 2002-12-04
US60/431,215 2002-12-04

Publications (2)

Publication Number Publication Date
WO2004050029A2 WO2004050029A2 (en) 2004-06-17
WO2004050029A3 true WO2004050029A3 (en) 2004-10-21

Family

ID=32475715

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2003/038224 WO2004050848A2 (en) 2002-12-04 2003-12-03 Methods for antigen masking of red blood cells resulting in reduced hemolysis
PCT/US2003/038349 WO2004050897A2 (en) 2002-12-04 2003-12-03 Methods for preparing antigen masked red blood cells having reduced hemolysis by sera
PCT/US2003/038270 WO2004049914A2 (en) 2002-12-04 2003-12-03 Methods for reacting an antigen masking compound with red blood cells with high efficiency
PCT/US2003/038262 WO2004050029A2 (en) 2002-12-04 2003-12-03 Novel activated polyethylene glycol compounds

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PCT/US2003/038224 WO2004050848A2 (en) 2002-12-04 2003-12-03 Methods for antigen masking of red blood cells resulting in reduced hemolysis
PCT/US2003/038349 WO2004050897A2 (en) 2002-12-04 2003-12-03 Methods for preparing antigen masked red blood cells having reduced hemolysis by sera
PCT/US2003/038270 WO2004049914A2 (en) 2002-12-04 2003-12-03 Methods for reacting an antigen masking compound with red blood cells with high efficiency

Country Status (2)

Country Link
AU (4) AU2003297614A1 (en)
WO (4) WO2004050848A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521174B2 (en) * 2003-12-05 2009-04-21 Albert Einstein College Of Medicine Of Yeshiva University Universal red blood cells, methods of preparing same, and uses thereof
CN102108119A (en) * 2009-12-25 2011-06-29 天津键凯科技有限公司 Multi-arm polyethylene glycol derivative, combination thereof with medicine, and gel
CN108135936A (en) 2015-06-26 2018-06-08 塞鲁斯公司 Cryoprecipitate composition and preparation method thereof
WO2017070619A1 (en) 2015-10-23 2017-04-27 Cerus Corporation Plasma compositions and methods of use thereof
CN110573169A (en) 2017-03-03 2019-12-13 塞鲁斯公司 Kits and methods for preparing pathogen inactivated platelet compositions
IL275698B1 (en) 2017-12-29 2024-04-01 Cerus Corp Systems and methods for treating biological fluids
EP3991179A1 (en) 2019-06-28 2022-05-04 Cerus Corporation System and methods for implementing a biological fluid treatment device
WO2023172180A1 (en) * 2022-03-07 2023-09-14 Icoat Medical Ab New use of peg-phospholipid molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312685B1 (en) * 1998-03-13 2001-11-06 Timothy C. Fisher Red blood cells covalently bound with two different polyethylene glycol derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL292906A (en) * 1962-10-30
JP2003534383A (en) * 2000-05-31 2003-11-18 セラス コーポレイション Preparation of pathogen inactivation solution of erythrocytes with reduced immunogenicity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312685B1 (en) * 1998-03-13 2001-11-06 Timothy C. Fisher Red blood cells covalently bound with two different polyethylene glycol derivatives

Also Published As

Publication number Publication date
AU2003297614A1 (en) 2004-06-23
WO2004050897A3 (en) 2004-08-26
AU2003298827A8 (en) 2004-06-23
AU2003298827A1 (en) 2004-06-23
WO2004049914A3 (en) 2005-02-24
WO2004050029A2 (en) 2004-06-17
WO2004049914A2 (en) 2004-06-17
WO2004050848A3 (en) 2004-12-09
WO2004050897A2 (en) 2004-06-17
WO2004050848A2 (en) 2004-06-17
AU2003293237A8 (en) 2004-06-23
AU2003302499A1 (en) 2004-06-23
AU2003297614A8 (en) 2004-06-23
AU2003302499A8 (en) 2004-06-23
AU2003293237A1 (en) 2004-06-23

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