WO2004049914A3 - Methods for reacting an antigen masking compound with red blood cells with high efficiency - Google Patents

Methods for reacting an antigen masking compound with red blood cells with high efficiency Download PDF

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Publication number
WO2004049914A3
WO2004049914A3 PCT/US2003/038270 US0338270W WO2004049914A3 WO 2004049914 A3 WO2004049914 A3 WO 2004049914A3 US 0338270 W US0338270 W US 0338270W WO 2004049914 A3 WO2004049914 A3 WO 2004049914A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction
methods
red blood
reacting
masking compound
Prior art date
Application number
PCT/US2003/038270
Other languages
French (fr)
Other versions
WO2004049914A2 (en
Inventor
Adonis Stassinopoulos
Basha Clark
Original Assignee
Cerus Corp
Adonis Stassinopoulos
Basha Clark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp, Adonis Stassinopoulos, Basha Clark filed Critical Cerus Corp
Priority to AU2003293237A priority Critical patent/AU2003293237A1/en
Publication of WO2004049914A2 publication Critical patent/WO2004049914A2/en
Publication of WO2004049914A3 publication Critical patent/WO2004049914A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Methods are provided for the reaction of high hematocrit red cells with an activated antigen masking compound. The reaction at high hematocrit provides a more efficient reaction for producing an antigen masked red blood cell. The resulting RBC compositions are of particular use for introduction into an individual in cases where the potential for an immune reaction is high, for example in alloimmunized blood recipients or in trauma situations where the possibility of transfusion of a mismatched unit of blood is higher. The RBC compositions provide a much lower risk of a transfusion associated immune reaction.
PCT/US2003/038270 2002-12-04 2003-12-03 Methods for reacting an antigen masking compound with red blood cells with high efficiency WO2004049914A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003293237A AU2003293237A1 (en) 2002-12-04 2003-12-03 Methods for reacting an antigen masking compound with red blood cells with high efficiency

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US43121602P 2002-12-04 2002-12-04
US43121402P 2002-12-04 2002-12-04
US43121502P 2002-12-04 2002-12-04
US43121302P 2002-12-04 2002-12-04
US60/431,213 2002-12-04
US60/431,216 2002-12-04
US60/431,215 2002-12-04
US60/431,214 2002-12-04

Publications (2)

Publication Number Publication Date
WO2004049914A2 WO2004049914A2 (en) 2004-06-17
WO2004049914A3 true WO2004049914A3 (en) 2005-02-24

Family

ID=32475715

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2003/038224 WO2004050848A2 (en) 2002-12-04 2003-12-03 Methods for antigen masking of red blood cells resulting in reduced hemolysis
PCT/US2003/038270 WO2004049914A2 (en) 2002-12-04 2003-12-03 Methods for reacting an antigen masking compound with red blood cells with high efficiency
PCT/US2003/038349 WO2004050897A2 (en) 2002-12-04 2003-12-03 Methods for preparing antigen masked red blood cells having reduced hemolysis by sera
PCT/US2003/038262 WO2004050029A2 (en) 2002-12-04 2003-12-03 Novel activated polyethylene glycol compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038224 WO2004050848A2 (en) 2002-12-04 2003-12-03 Methods for antigen masking of red blood cells resulting in reduced hemolysis

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2003/038349 WO2004050897A2 (en) 2002-12-04 2003-12-03 Methods for preparing antigen masked red blood cells having reduced hemolysis by sera
PCT/US2003/038262 WO2004050029A2 (en) 2002-12-04 2003-12-03 Novel activated polyethylene glycol compounds

Country Status (2)

Country Link
AU (4) AU2003297614A1 (en)
WO (4) WO2004050848A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521174B2 (en) * 2003-12-05 2009-04-21 Albert Einstein College Of Medicine Of Yeshiva University Universal red blood cells, methods of preparing same, and uses thereof
CN103755949B (en) * 2009-12-25 2016-04-13 天津键凯科技有限公司 Multi-arm polyethylene glycol derivative and with the binding substances of medicine and gel
EA201890149A1 (en) 2015-06-26 2018-07-31 Сирус Корпорейшн COMPOSITIONS OF CRYOPRECIPLES AND METHODS OF THEIR RECEPTION
US10799533B2 (en) 2015-10-23 2020-10-13 Cerus Corporation Plasma compositions and methods of use thereof
US11235090B2 (en) 2017-03-03 2022-02-01 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
AU2018395525B2 (en) 2017-12-29 2023-09-14 Cerus Corporation Systems and methods for treating biological fluids
WO2020263759A2 (en) 2019-06-22 2020-12-30 Cerus Corporation Biological fluid treatment systems
WO2020264421A1 (en) 2019-06-28 2020-12-30 Cerus Corporation System and methods for implementing a biological fluid treatment device
WO2023172180A1 (en) * 2022-03-07 2023-09-14 Icoat Medical Ab New use of peg-phospholipid molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312685A (en) * 1962-10-30 1967-04-04 Rayonier Inc Solubilizing hydroxyethylcellulose
WO2001091775A2 (en) * 2000-05-31 2001-12-06 Cerus Corporation Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312685B1 (en) * 1998-03-13 2001-11-06 Timothy C. Fisher Red blood cells covalently bound with two different polyethylene glycol derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312685A (en) * 1962-10-30 1967-04-04 Rayonier Inc Solubilizing hydroxyethylcellulose
WO2001091775A2 (en) * 2000-05-31 2001-12-06 Cerus Corporation Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity

Also Published As

Publication number Publication date
AU2003297614A1 (en) 2004-06-23
AU2003298827A1 (en) 2004-06-23
WO2004050029A3 (en) 2004-10-21
WO2004049914A2 (en) 2004-06-17
AU2003298827A8 (en) 2004-06-23
WO2004050897A3 (en) 2004-08-26
WO2004050848A2 (en) 2004-06-17
WO2004050848A3 (en) 2004-12-09
AU2003293237A8 (en) 2004-06-23
AU2003302499A1 (en) 2004-06-23
AU2003297614A8 (en) 2004-06-23
AU2003293237A1 (en) 2004-06-23
AU2003302499A8 (en) 2004-06-23
WO2004050029A2 (en) 2004-06-17
WO2004050897A2 (en) 2004-06-17

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