WO2004045460A1 - Implant comprenant une boucle fermee et un insert isole - Google Patents
Implant comprenant une boucle fermee et un insert isole Download PDFInfo
- Publication number
- WO2004045460A1 WO2004045460A1 PCT/NL2003/000821 NL0300821W WO2004045460A1 WO 2004045460 A1 WO2004045460 A1 WO 2004045460A1 NL 0300821 W NL0300821 W NL 0300821W WO 2004045460 A1 WO2004045460 A1 WO 2004045460A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insert
- thread
- inserts
- stent
- loops
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00902—Material properties transparent or translucent
- A61B2017/00911—Material properties transparent or translucent for fields applied by a magnetic resonance imaging system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
- A61F2002/91541—Adjacent bands are arranged out of phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Definitions
- the present invention relates to a device which can be introduced into a body, such as a stent, a filter or an electrode, and is formed from a metal-containing material, which device comprises at least one closed loop.
- a device which can be introduced into a body, such as a stent, a filter or an electrode, and is formed from a metal-containing material, which device comprises at least one closed loop.
- Such devices are generally known and comprise, as said, for instance stents, filters and electrodes.
- a significant drawback of such devices is that, in the vicinity thereof and in particular in the interior thereof, no imaging is possible during for instance RI ("Magnetic Resonance Imaging") when a volume is enclosed. This is because an electric current is induced in the loop or loops under the influence of the RF field applied in MRI. Regions in the interior of the device, or in any case in the vicinity thereof, are thereby screened, just as in a Faraday cage. The currents induced in the loop or loops create counter fields, thereby impeding or even preventing effective imaging.
- RI Magnetic Resonance Imaging
- the present invention has for its object to obviate or at least alleviate said drawbacks of the known art, for which purpose a device according to the present invention is distinguished in that the loop comprises an insert of insulating material.
- This is understood to mean electrically insulating properties of the material used for the insert.
- a circuit in a loop thereof is effectively interrupted and no counter fields are generated as long as no currents can flow. It has hereby become possible using imaging techniques to map regions in the close vicinity of the device, and even in the interior thereof, when a determined space is enclosed. It is noted that this can be particularly favourable in the case of a stent, where this is being used to remedy narrowing of an artery.
- Such artery narrowing can be combatted with a stent but can continue to grow through or along the stent, about which no information can be obtained as long as the stent prevents effective imaging.
- the same is substantially the case for a filter, where it is for instance used to at least catch a clot.
- the quantity of clot intercepted by the filter can be imaged when a filter, which must normally comprise a number of loops and according to the invention has inserts, does not impede such imaging.
- the present invention also relates to diverse preferred embodiments.
- a device according to the invention can be stretched in order to be expanded after insertion and then retain the expanded form, whereby the device is for instance formed from a memory material, metal etc.
- memory materials are for instance generally formed mainly from metal-containing materials, particularly in the case of stents, which makes such devices particularly sensitive to loss of imaging in the interior and the immediate vicinity thereof.
- the device can also be produced in diverse ways. It is thus possible for the insert to be arranged in a substantially tubular or plate-like basic element, from which the device can be formed by arranging incisions therein. This is per se a standard method of forming stents, even though in the known art no use is made of tubular basic elements having therein at least one insert, the production and final design of which follows by making the incisions in the tubular element. Particularly because of the fact that insulating materials generally have an inadequate form-retention after expansion thereof, a device according to the present invention preferably comprises the feature that the insert is arranged in a part of this device which is not subject to stretch when it expands. The choice of usable materials is hereby increased considerably, and even ceramic materials, silicon and the like can be applied for the insert.
- the device is formed from at least one thread-like element, in which the insert is arranged at a location along the thread-like element corresponding with a loop.
- This is another standard production method with thread-like, substantially metal-containing elements, but then these thread-like elements are therefore adapted by the inserts of insulating material in a manner according to the present invention.
- it can be particularly favourable to arrange at least the same number of inserts as loops at fixed distances in the thread-like element, wherein the distance between the inserts along the thread-like element is shorter than the circumference of the smallest of the loops.
- a uniform production process of thread-like elements is thus ensured, which results in a simplification compared to a situation in which inserts are arranged only at selected positions corresponding with the loops to be actually formed.
- the inserts can then still be rigid and stiff and not strip-elastic, without essentially influencing the expansion function desired in the case of a stent.
- devices according to the present invention can also be applied as electrode in a method of electrophysiology based on a number of electrodes.
- Use can very advantageously be further made of threads and sheets, of for instance metal or other material to be used as electrode, to form the device according to the invention herefrom, if the inserts have already been provided beforehand therein - before the actual production of the device.
- the inserts do not then have to be arranged later, after production of a device, by cutting pieces of material out of the device and replacing these with pieces of insulating material as insert.
- the freedom in design for manufacturers of such devices is hereby also considerably increased and improved, particularly if the inserts are arranged with great regularity in the pieces of material serving as basic elements.
- fig. 1 shows a side view of a stent as embodiment of the present invention
- fig. 2 shows a plate-like element as possible basis from which the stent shown in fig. 1 can be formed
- fig. 3 shows a thread-like element as alternative to the plate-like element shown in fig. 2
- fig. 4 shows a detail of a possible embodiment such as can be designed from the thread-like element shown in fig. 3
- fig. 5 is a perspective view of production of a stent according to the invention.
- Fig. 1 shows a stent 1 according to the present invention in the expanded state thereof into which this stent 1 is brought after introduction thereof into a human body.
- Stent 1 comprises ribs 2 of substantially metal-containing material, which is for instance favourable when it has a memory action for the purpose of retaining the assumed expanded form after expansion.
- inserts 4 Arranged in longitudinal ribs 3 of stent 1 are inserts 4, which are manufactured from an insulating material. This ensures that induced currents, which could impede a possible imaging as a result of the thereby generated counter-field, cannot flow in the loops formed along longitudinal ribs 3. Both the flow of electrical currents and the generation of counter-fields are thus effectively prevented with the inserts 4 of insulating material.
- Fig. 2 shows a plate-like element 5.
- Incisions 6 can be arranged in plate-like element 5.
- the thus formed device is ready to be used as stent and is then not (yet) expanded. After expansion such a device formed from plate-like element 5 will have approximately the form of the expanded stent shown in fig. 1.
- a strip 7 of insulating material is further arranged in plate-like element 5 prior to this latter being connected all along the sides as according to arrow A in fig. 2 and incisions 6 being arranged therein.
- Strip 7 provides the inserts of insulating material as designated with reference numeral 4 in fig. 1 after the incisions 6 have been made, plate-like element 5 has been given a round form by connecting the outer ends along arrow A, and the thus formed stent is expanded.
- the longitudinal ribs 3, in which inserts 4 of insulating material are arranged, are per se not subject to stretch or stretching when a thus formed stent is expanded.
- This is favourable when use is made for instance of metals or materials with a memory effect, and the insulating material for the inserts does not have such a memory action or stretchability and is for instance stiff or rigid.
- an insert without the required memory action and with a degree of elasticity could reduce the effectiveness of the stent itself, this being obviated by positioning inserts 4 in a manner such that such a reduction in the effectiveness of the stent is prevented. This is particularly the case for parts of the stent 1 which are not subject to stretch.
- Fig. 3 shows a thread-like element 8.
- a thread-like element 8 As an alternative to the plate-like element 5 shown in fig. 2, use can be made of such a thread-like element 8 to form therefrom a stent as shown for instance in fig. 1.
- the thread-like element is provided with inserts 9 of insulating material. Inserts 9 are positioned at mutual distances which can be adapted to the stents or electrodes to be finally formed therefrom. This means that an insert 9 as interruption of a circuit formed from thread-like element 8 can be realized in each case at a location specifically determined for this purpose. Alternatively however, it is also possible to place inserts 9 at a position such that any circuit can be broken with certainty.
- Fig. 4 shows a number of thread-like elements 8 which are mutually connected at connection 12 and each form two loops.
- a configuration can be a detail of a stent or electrode, which can be a device according to the present invention.
- the middle thread-like element in fig. 4 forms two loops 10 and 11, wherein loop 10 is smaller in size than loop 11.
- the inserts 9 are arranged at mutually equal distances, wherein an insert 9 is also arranged with certainty in the smaller of the two loops, i.e. loop 10, in order to break the circuit there.
- the mutual distance between inserts 9 is smaller than the circumference of the smallest of the loops, again loop 10.
- inserts 9 can be arranged at mutually equal distances along the length of thread-like element 8, which results in a standard production process, wherein circuits in the device to be formed with thread-like element 8 are broken with certainty.
- the production process of thread-like element 8 can then take place in a manner not dependent on the final form of the device.
- a plate-like element 5 with incisions 6 therein, the edges of which are mutually connected along arrow A in order to obtain a cylindrical whole.
- a sleeve-like or tubular element 14 This is then arranged for instance round a rod 13 in order to form the incisions therein using a knife 17 so as to produce the final, desired form of the stent.
- the incisions with blade 17 are arranged along the lines shown with dotted line 18.
- sleeve 14 is provided with at least one band 16 with a material according to the present invention. After making the incisions with blade 17, the inserts 15 then remain in the ribs of the thus formed stent.
- fig. 1 it will be apparent that many additional and alternative embodiments are possible, all of which will be apparent to a skilled person who can realize these additional and alternative embodiments without inventive work of his/her own. It is thus possible in the configuration of fig. 1 to also provide ribs other than the longitudinal ribs with inserts, for instance in the loops on the left and right-hand side in fig. 1. Ceramic material is for instance mentioned as an example of materials used for the insert. It is noted that ceramic material can be a highly suitable carrier, for instance for medication, to thus enable very local and precise administering of drugs. Use can also be made of insulating materials other than the stated materials for the inserts.
- insulating materials with a memory action whereby inserts can also be positioned at positions which will be subject to stretch when the device is expanded.
- the present invention can also be applied in production methods other than those discussed above (plate-like and/or tubular elements with incisions and thread-like elements) , as long as circuits in the form of loops are broken at the desired positions, which circuits could otherwise impede or even prevent imaging.
- Devices according to the present invention can also find particular application in the field of electrophysiology, wherein a number of electrodes are applied, thus demonstrating that the present invention is not limited to the field of application of stents alone.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003284841A AU2003284841A1 (en) | 2002-11-21 | 2003-11-21 | Implant comprising a closed loop and an insulated insert |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1021969A NL1021969C2 (nl) | 2002-11-21 | 2002-11-21 | Inrichting voor inbrenging in een menselijk lichaam. |
NL1021969 | 2002-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004045460A1 true WO2004045460A1 (fr) | 2004-06-03 |
Family
ID=32322555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2003/000821 WO2004045460A1 (fr) | 2002-11-21 | 2003-11-21 | Implant comprenant une boucle fermee et un insert isole |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003284841A1 (fr) |
NL (1) | NL1021969C2 (fr) |
WO (1) | WO2004045460A1 (fr) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5588443A (en) * | 1989-07-25 | 1996-12-31 | Smith & Nephew Richards, Inc. | Zirconium oxide and zirconium nitride coated guide wires |
WO1999042176A1 (fr) * | 1998-02-23 | 1999-08-26 | Vascusense, Inc. | Implant endoluminal a capacites therapeutique et diagnostique |
WO2002026314A1 (fr) * | 2000-09-27 | 2002-04-04 | Cvrx, Inc. | Dispositifs et procedes de controle reflexe du systeme cardiovasculaire |
EP1236447A2 (fr) * | 2001-03-02 | 2002-09-04 | Cordis Corporation | Stent flexible et procédé de fabrication |
-
2002
- 2002-11-21 NL NL1021969A patent/NL1021969C2/nl not_active IP Right Cessation
-
2003
- 2003-11-21 WO PCT/NL2003/000821 patent/WO2004045460A1/fr not_active Application Discontinuation
- 2003-11-21 AU AU2003284841A patent/AU2003284841A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5588443A (en) * | 1989-07-25 | 1996-12-31 | Smith & Nephew Richards, Inc. | Zirconium oxide and zirconium nitride coated guide wires |
WO1999042176A1 (fr) * | 1998-02-23 | 1999-08-26 | Vascusense, Inc. | Implant endoluminal a capacites therapeutique et diagnostique |
WO2002026314A1 (fr) * | 2000-09-27 | 2002-04-04 | Cvrx, Inc. | Dispositifs et procedes de controle reflexe du systeme cardiovasculaire |
EP1236447A2 (fr) * | 2001-03-02 | 2002-09-04 | Cordis Corporation | Stent flexible et procédé de fabrication |
Also Published As
Publication number | Publication date |
---|---|
AU2003284841A1 (en) | 2004-06-15 |
NL1021969C2 (nl) | 2004-05-26 |
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