WO2004043422A1 - Composition cosmetique amelioree - Google Patents

Composition cosmetique amelioree Download PDF

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Publication number
WO2004043422A1
WO2004043422A1 PCT/EP2003/011795 EP0311795W WO2004043422A1 WO 2004043422 A1 WO2004043422 A1 WO 2004043422A1 EP 0311795 W EP0311795 W EP 0311795W WO 2004043422 A1 WO2004043422 A1 WO 2004043422A1
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WO
WIPO (PCT)
Prior art keywords
weight
skin
vitamin
cosmetic composition
acid
Prior art date
Application number
PCT/EP2003/011795
Other languages
English (en)
Inventor
James Prabhanand Bhaskar
Parag Goyal
Indu Mani
Vilas Pandurang Sinkar
Original Assignee
Unilever Plc
Unilever Nv
Hindustan Lever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever Nv, Hindustan Lever Limited filed Critical Unilever Plc
Priority to AU2003282046A priority Critical patent/AU2003282046A1/en
Publication of WO2004043422A1 publication Critical patent/WO2004043422A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group

Definitions

  • the present invention relates to a synergistic skin composition comprising a skin lightening active.
  • the invention relates to synergistic skin compositions comprising vitamin B12 (cyanocobalamin) and its functional and structural analogues (e.g. hydroxocobalamin) as skin lightening actives.
  • the invention also pertains to synergistic skin compositions comprising vitamin B12 and skin lightening actives/sunscreens.
  • the compositions of the invention are suitable for controlling skin colour.
  • melanin The endogenous pigment of skin and hair is called melanin.
  • melanin The endogenous pigment of skin and hair.
  • melanin In all pigmented animals there are two basic types of melanin; the brown/red type, or pheomelanin, and the black type, or -eumelanin.
  • Melanin is synthesized in melanosomes from the amino acid tyrosine via DOPA and dopaquinone .
  • the enzyme tyrosinase is required in these early steps. After the tyrosinase steps, the pathways to produce black, brown and red pigments diverge, and involve many other enzymes.
  • the melanogenesis process also involves the development of melanosomes, the organelle of the melanocyte in which the melanin is synthesised, and the subsequent transfer of the melanosomes to keratinocytes .
  • Skin colour is dependent on the amount and type of melanin, and the size and distribution patterns of melanosomes within keratinocytes .
  • External agents are known to alter skin colour.
  • Agents that lighten or whiten skin colour are reported in the prior art, and are used extensively in cosmetic formulations. These include niacinamide, carboxylic acids like azelaic acid and kojic acid, plant extracts and hydroquinone etc.
  • Vitamin B3 (nicotinic acid or its amide) is one of the most effective and safe skin-lightening agents.
  • Other vitamins like Vitamin C or its derivatives, and Vitamin B6 are also known to effect skin lightening.
  • UVR Ultraviolet radiation
  • Organic sunscreens are molecules that absorb in the UV region, and thus prevent the action of UVR. Sunscreens can therefore help in controlling skin colour.
  • EP0396422 discloses a skin lightening composition, comprising niacinamide, Parsol MCX and Parsol 1789, UV-B and UV-A sunscreens, as well as silicone oil in the skin lightening composition.
  • the composition gives enhanced skin lightening.
  • US20020006418 discloses skin compositions comprising a polymeric emulsifier and a sugar that enhance the penetration of topical benefit agents into the skin.
  • Cosmetic benefit agents that can be effectively delivered by the composition include vitamin B6 and B12.
  • WO0191715 PatentaPharm Ltd., Ezaki Glico Co. Ltd.
  • WO0191715 PatentaPharm Ltd., Ezaki Glico Co. Ltd.
  • JP04009325 (SunStar Inc.) and JP60188306 (Shiseido Co. Ltd.) also disclose skin whitening compositions comprising pyridoxine .
  • the prior art is generally directed towards treatment of conditions like hyper-pigmentation with vitamin B12. Further, skin compositions comprising vitamin B12 as disclosed in the prior art do not teach that topical application of vitamin B12 can promote skin lightening.
  • compositions comprising vitamin B12 can lighten the skin significantly, and in combination with a benefit agent selected from other skin lightening vitamins and sunscreens shows enhanced and synergistic skin lightening.
  • the topical compositions are useful both for normal skin as well as skin damaged by UVR.
  • the compositions are also useful in treating freckles, hyper-pigmented skin, blotchy skin, age spots etc.
  • synergistic skin lightening composition comprising:
  • vitamin B12 or derivative thereof b. a cosmetically acceptable vehicle or 15-85% detergent active
  • a skin lightening composition comprising:
  • vitamin B12 a. 0.05-5% by weight of vitamin B12 or a derivative thereof
  • a skin lightening vitamin chosen from niacinamide, pyridoxine or their precursors thereof
  • a sunscreen and/or a sun-block d. a cosmetically acceptable vehicle or 15-85% detergent active.
  • a skin lightening composition comprising
  • vitamin B12 a. 0.1 to 1 % by weight vitamin B12 or a derivative thereof b. 0.1% to 10% by weight of a skin lightening vitamin chosen from niacinamide, pyridoxine or their precursors thereof c. 0.1 to 10 % sunscreen d. a cosmetically acceptable vehicle or 15-85% soap.
  • the present invention pertains to synergistic skin lightening compositions comprising vitamin B12 and a benefit agent chosen from other skin lightening vitamins and sunscreens or their mixtures thereof.
  • the compositions according to the invention give enhanced skin lightening.
  • compositions of the invention can be leave on products in the form of lotions, creams, gels, mousses etc. or in the form of rinse off products like soap bar, detergent powders, flakes, face wash, body wash etc.
  • Vitamin B12 or its derivative thereof be present in the skin lightening composition of the invention.
  • Vitamin B12 is exclusively synthesised by bacteria and naturally found in animal foods including fish, milk and milk products, eggs, meat, and poultry. Fermented soya products, seaweeds, and algae such as spirulina have all been suggested as containing significant B12.
  • Fermented soya products, seaweeds, and algae such as spirulina have all been suggested as containing significant B12.
  • any B12 present in plant foods is likely to be unavailable to humans, and so these foods should not be relied upon as safe sources .
  • Spirulina an algae available as a dietary supplement in tablet form, and nori, a seaweed, have both appeared to contain significant amounts of B12 after analysis.
  • B12 analogues compounds structurally similar to B12, known as B12 analogues. These cannot be utilised to satisfy dietary needs.
  • B12 supplements such as spirulina may in fact increase the risk of B12 deficiency disease, as the B12 analogues can compete with B12 and inhibit metabolism. It is thus possible to choose B12 available from any known source that may be natural or synthetic commercially available source.
  • Vitamin B12 is typically incorporated at 0.05% to 5 % by weight of the composition, and is preferably present in an amount from 0.1 % to 1 % by weight of the cosmetic composition.
  • vitamins can be advantageously included in the composition to provide for synergistic skin lightening effects. These include vitamin B3 , vitamin B6, vitamin C, vitamin A or their precursors. Mixtures of the vitamins can also be employed in the composition of the invention. Especially preferred vitamins are vitamin B3 and vitamin B6.
  • composition of the invention preferably includes an effective amount of a sunscreen or sun-block agent to enhance synergistically the benefit of the composition in providing for skin lightening.
  • a sunscreen or sun-block agent to enhance synergistically the benefit of the composition in providing for skin lightening.
  • Organic and inorganic sunscreens/sun-blocks may be suitably employed in the composition.
  • UVA and/or UVB sunscreen are desirable.
  • sunscreen agents include, p- aminobenzoic acid, its salts and its derivatives (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic acid); anthranilates (i.e., o-aminobenzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl esters); salicylates (amyl, phenyl, benzyl, menthyl, glyceryl, and dipropyleneglycol esters); Cinnamic acid derivatives (menthyl and benzyl esters, a-phenyl cinnamonitrile; butyl cinnamoyl pyruvate) ; dihydroxycinnamic acid derivatives (umbelli
  • 2-ethylhexyl-p-methoxycinnamate 4,4'-t-butyl methoxydibenzoyl-methane , 2 -hydroxy-4-methoxybenzophenone, octyldimethyl- p-aminobenzoic acid, digalloyltrioleate, 2,2- dihydroxy-4- methoxybenzophenone, ethyl-4- (bis (hydroxypropyl) ) aminobenzoate, 2- ethylhexyl-2-cyano- 3 , 3-diphenylacrylate, 2-ethylhexylsalicylate, glyceryl- p- aminobenzoate, 3,3, 5-trimethylcyclohexylsalicylate, methylanthranilate, p-dimethyl-aminobenzoic acid or aminobenzoate, 2-ethylhexyl-p-dimethyl- amino-benzoate, 2- phenylbenzimi
  • sunscreens useful in the compositions useful in the subject invention are 2-ethylhexyl-p- methoxycinnamate, butylmethoxydibenzoylmethane, 2 -hydroxy-4- methoxybenzophenone, octyldimethyl-p-aminobenzoic acid and mixtures thereof .
  • sunscreens such as those disclosed in U.S. Pat. No. 4,937,370 issued to Sabatelli on Jun. 26, 1990, and U.S. Pat. No. 4,999,186 issued to Sabatelli & Spirnak on Mar. 12, 1991, both of which are incorporated herein by reference .
  • the sunscreen agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultraviolet radiation absorption spectra. One of the chromophore moieties absorbs predominantly in the UVB radiation range and the other absorbs strongly in the UVA radiation range.
  • a safe and effective amount of sunscreen may be used in the compositions useful in the subject invention.
  • the composition preferably comprises from about 0.1% to about 10%, more preferably from about 0.1% to about 5%, of a sunscreen agent .
  • Useful inorganic sun-sreens include, for example, zinc oxide iron oxide, silica, such as fumed silica, and titanium dioxide .
  • Ultrafine titanium dioxide in either of its two forms namely water-dispersible titanium dioxide and oil- dispersible titanium dioxide, are especially suitable for use according to the invention.
  • Water-dispersible titanium dioxide is ultra-fine titanium dioxide, the particles of which are non-coated or which are coated with a material to impart a hydrophilic surface property to the particles. Examples of such materials include aluminium oxide and aluminium silicate.
  • Oil-dispersible titanium dioxide is ultrafine titanium dioxide, the particles of which exhibit a hydrophobic surface property, and which, for this purpose, can be coated with metal soaps such as aluminium stearate, aluminium laurate or zinc stearate, or with organosilicone compounds.
  • ultra titanium dioxide particles of titanium dioxide having an average particle size of less than 100 nm, preferably 70 nm or less, more preferably from 10 to 40 nm and most preferably from 15 to 25 nm.
  • the total amount of sun screen that is preferably incorporated in the composition according to the invention is from 0.1 to 5% by weight of the composition.
  • composition according to the invention also preferably comprises a cosmetically acceptable vehicle to act as a diluant, dispersant or carrier for other materials present in the composition, so as to facilitate their distribution when the composition is applied to the skin.
  • Vehicles other than water can include liquid or solid emollients, solvents, humectants, thickeners and powders. Examples of each of these types of vehicle, which can be used singly or as mixtures of one or more vehicles, are as follows :
  • Emollients such as stearyl alcohol, glyceryl monoricinoleate, mink oil, cetyl alcohol, isopropyl isostearate, stearic acid, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecan-2-ol, isocetyl alcohol, eicosanyl alcohol, behenyl alcohol, cetyl palmitate, silicone oils such as dimethylpolysiloxane, di-n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, butyl stearate, polyethylene glycol, triethylene glycol, lanolin, cocoa butter, corn oil, cotton seed oil, olive oil, palm kernel oil, rapeseed oil, safflower seed oil, evening primrose oil, soybean oil,
  • Propellants such as propane, butane, isobutane, dimethyl ether, carbon dioxide, nitrous oxide;
  • Solvents such as ethyl alcohol, isopropanol, acetone, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether; Powders, such as chalk, talc, fullers earth, kaolin, starch, gums, colloidal silica sodium polyacrylate, tetra alkyl and/or trialkyl aryl ammonium smectites, chemically modified magnesium aluminium silicate, organically modified montmorillonite clay, hydrated aluminium silicate, fumed silica, carboxyvinyl polymer, sodium carboxymethyl cellulose, ethylene glycol monostearate .
  • Powders such as chalk, talc, fullers earth, kaolin, starch, gums, colloidal silica sodium polyacrylate, tetra alkyl and/or trialkyl aryl ammonium smectites, chemically modified magnesium aluminium silicate, organically modified montmorillonit
  • the cosmetically acceptable vehicle will usually form from 10 to 99.9%, preferably from 50 to 99% by weight of the emulsion, and can, in the absence of other cosmetic adjuncts, form the balance of the composition.
  • skin lightening actives known in the art can also be employed in the invention.
  • skin lightening actives useful herein include adapalene, aloe extract, ammonium lactate, anethole derivatives, apple extract, arbutin, azelaic acid, bamboo extract, bearberry extract, bletilla tuber, bupleurum falcatum extract, burnet extract, butyl hydroxy anisole, butyl hydroxy toluene, citrate esters, Chuanxiong, Dang-Gui, deoxyarbutin, 1,3 diphenyl propane derivatives, 2, 5 dihydroxybenzoic acid and its derivatives, 2- (4-acetoxyphenyl) -1, 3 dithane, 2- (4- hydroxyphenyl)-1 , 3 dithane, ellagic acid, escinol, estragole derivatives, FADEOUT (available from Pentapharm) , Fangfeng, fennel extract, ganoderma extract, gaoben,
  • the skin lightening composition of the invention is the form of a personal wash formulation, for example in the form of a soap bar, additionally including for example soap and fatty matter.
  • total fatty matter usually abbreviated to TFM is used to denote the percentage by weight of fatty acid and triglyceride residues present, without taking into account the accompanying cations.
  • an accompanying sodium cation will generally amount to about 8% by weight.
  • Other cations may be employed as desired for example zinc, potassium, magnesium, alkyl ammonium and aluminium.
  • soap denotes salts of carboxylic fatty acids.
  • the soap may be derived from any of the triglycerides conventionally used in soap manufacture - consequently the carboxylate anions in the soap may contain from 8 to 22 carbon atoms .
  • the soap may be obtained by saponifying a fat and/or a fatty acid.
  • the fats or oils generally used in soap manufacture may be such as tallow, tallow stearines, palm oil, palm stearines, soya bean oil, fish oil, caster oil, rice bran oil, sunflower oil, coconut oil, babassu oil, palm kernel oil, and others.
  • the fatty acids are derived from oils/fats selected from coconut, rice bran, groundnut, tallow, palm, palm kernel, cotton seed, soya bean, castor etc.
  • the fatty acid soaps can also be synthetically prepared (e.g. by the oxidation of petroleum or by the hydrogenation of carbon monoxide by the Fischer- Tropsch process) .
  • Resin acids, such as those present in tall oil may be used. Naphthenic acids are also suitable.
  • Tallow fatty acids can be derived from various animal sources and generally comprise about 1-8% myristic acid, about 21-32% palmitic acid, about 14-31% stearic acid, about 0-4% palmitoleic acid, about 36-50% oleic acid and about 0- 5% linoleic acid.
  • a typical distribution is 2.5% myristic acid, 29% palmitic acid, 23% stearic acid, 2% palmitoleic acid, 41.5% oleic acid, and 3% linoleic acid.
  • Other similar mixtures, such as those from palm oil and those derived from various animal tallow and lard are also included.
  • coconut oil refers to fatty acid mixtures having an approximate carbon chain length distribution of 8% C ⁇ , 7% Cio, 48% C ⁇ 2 , 17% C i4 , 8% C 16 , 2% C ⁇ 8 , 7% oleic and 2% linoleic acids (the first six fatty acids listed being saturated) .
  • Other sources having similar carbon chain length distributions, such as palm kernel oil and babassu kernel oil, are included within the term coconut oil.
  • detergent actives like synthetic anionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants or their mixtures thereof may also be present in the composition.
  • Such actives are disclosed in standard detergent textbooks for example "Surface Active Agents", Volume I by Schwartz and Perry and “Surface Active Agents and Detergents", Volume II by Schwartz, Perry and Berch.
  • compositions of the present invention can comprise a wide range of other optional cosmetic components.
  • CTFA Cosmetic Ingredient Handbook Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention. Examples include: antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, humectants, opacifying agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, and skin healing agents.
  • Each of the forearms (area from wrist to elbow) 8 - 10 sites were identified for treatment.
  • the distribution of products over the various sites was randomized.
  • the initial skin colour reading on each site served as the untreated control .
  • the details of the skin composition are presented in Table 1
  • Days 1 subjects who qualified were marked to identify the test sites and evaluated clinically and read on the Minolta chromameter CM 2500D.
  • Study personnel applied 3 mg of the products to the test sites five times daily for 10 days.
  • the subjects will be clinically evaluated and skin measurements with the CM 2500D will be done.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition cosmétique pour le soin de la peau contenant : a. 0,05 % à 5 % en poids de vitamine B12 ou d'un dérivé de cette dernière, b. 0,1 % à 10 % en poids d'une vitamine éclaircissante pour la peau sélectionnée parmi le nicotinamide, la pyridoxine ou des précurseurs de ces derniers, c. jusqu'à 10 % en poids d'écran solaire et d. 10 % à 99 % en poids d'un excipient cosmétiquement acceptable ou 15 % à 85 % en poids d'un actif détergent.
PCT/EP2003/011795 2002-11-13 2003-10-21 Composition cosmetique amelioree WO2004043422A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003282046A AU2003282046A1 (en) 2002-11-13 2003-10-21 Improved cosmetic composition

Applications Claiming Priority (2)

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IN978MU2002 2002-11-13
IN978/MUM/02 2002-11-13

Publications (1)

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WO2004043422A1 true WO2004043422A1 (fr) 2004-05-27

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044214A1 (fr) * 2003-11-06 2005-05-19 Unilever Plc Composition cosmetique amelioree comportant de la vitamine b3, de la vitamine b6 et un acide organique
EP2522331A1 (fr) * 2011-05-09 2012-11-14 DSM IP Assets B.V. Utilisation de resvératrol et nicotinamide
US20140170091A1 (en) * 2012-12-12 2014-06-19 Thomas Christopher Balshi Composition for Correcting Skin Pigment Conditions
CN113924323A (zh) * 2019-06-04 2022-01-11 联合利华知识产权控股有限公司 聚合物和包含该聚合物的化妆品组合物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1446584A (en) * 1973-06-26 1976-08-18 Kohler V Agent for deodorising and influencing perspiration
DE4401274A1 (de) * 1994-01-18 1995-07-20 Rooyan Behdasht Co Flüssiges Mittel zur Förderung des Wachstums und zur Erhaltung der Haare
DE19509354A1 (de) * 1994-12-08 1996-06-13 Klett Loch Lore M Kombinationspräparat zur Förderung des Haarwachstums und ggf. des Haut- und Nagelwachstums sowie zur Verhinderung bzw. zur Beseitigung von Haarausfall
US5554647A (en) * 1989-10-12 1996-09-10 Perricone; Nicholas V. Method and compositions for treatment and/or prevention of skin damage and aging
JPH107541A (ja) * 1996-06-20 1998-01-13 Noevir Co Ltd 皮膚外用剤
EP0998914A1 (fr) * 1998-10-13 2000-05-10 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Composition pour améliorer la perméation d'agents topiques cutanés
WO2002003942A2 (fr) * 2000-07-06 2002-01-17 Planet Biotech Inc. Compositions a complexe de la vitamine b utilisee pour la protection contre les lesions cellulaires provoquees par le rayonnement ultraviolet
WO2002015873A2 (fr) * 2000-08-22 2002-02-28 The Procter & Gamble Company Compositions pour les soins personnels contenant un polymere elastomere adhesif et un colloide inorganique

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1446584A (en) * 1973-06-26 1976-08-18 Kohler V Agent for deodorising and influencing perspiration
US5554647A (en) * 1989-10-12 1996-09-10 Perricone; Nicholas V. Method and compositions for treatment and/or prevention of skin damage and aging
DE4401274A1 (de) * 1994-01-18 1995-07-20 Rooyan Behdasht Co Flüssiges Mittel zur Förderung des Wachstums und zur Erhaltung der Haare
DE19509354A1 (de) * 1994-12-08 1996-06-13 Klett Loch Lore M Kombinationspräparat zur Förderung des Haarwachstums und ggf. des Haut- und Nagelwachstums sowie zur Verhinderung bzw. zur Beseitigung von Haarausfall
JPH107541A (ja) * 1996-06-20 1998-01-13 Noevir Co Ltd 皮膚外用剤
EP0998914A1 (fr) * 1998-10-13 2000-05-10 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Composition pour améliorer la perméation d'agents topiques cutanés
WO2002003942A2 (fr) * 2000-07-06 2002-01-17 Planet Biotech Inc. Compositions a complexe de la vitamine b utilisee pour la protection contre les lesions cellulaires provoquees par le rayonnement ultraviolet
WO2002015873A2 (fr) * 2000-08-22 2002-02-28 The Procter & Gamble Company Compositions pour les soins personnels contenant un polymere elastomere adhesif et un colloide inorganique

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* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 05 30 April 1998 (1998-04-30) *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044214A1 (fr) * 2003-11-06 2005-05-19 Unilever Plc Composition cosmetique amelioree comportant de la vitamine b3, de la vitamine b6 et un acide organique
US7332152B2 (en) 2003-11-06 2008-02-19 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic composition
EP2522331A1 (fr) * 2011-05-09 2012-11-14 DSM IP Assets B.V. Utilisation de resvératrol et nicotinamide
US20140170091A1 (en) * 2012-12-12 2014-06-19 Thomas Christopher Balshi Composition for Correcting Skin Pigment Conditions
US9351922B2 (en) 2012-12-12 2016-05-31 Thomas Christopher Balshi Composition for correcting skin pigment conditions
CN113924323A (zh) * 2019-06-04 2022-01-11 联合利华知识产权控股有限公司 聚合物和包含该聚合物的化妆品组合物

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