WO2004038416A8 - Diagnostic et therapeutique de maladies associees au recepteur 6 couple a la proteine g humain (gpr6) - Google Patents

Diagnostic et therapeutique de maladies associees au recepteur 6 couple a la proteine g humain (gpr6)

Info

Publication number
WO2004038416A8
WO2004038416A8 PCT/EP2003/011394 EP0311394W WO2004038416A8 WO 2004038416 A8 WO2004038416 A8 WO 2004038416A8 EP 0311394 W EP0311394 W EP 0311394W WO 2004038416 A8 WO2004038416 A8 WO 2004038416A8
Authority
WO
WIPO (PCT)
Prior art keywords
gpr6
disorders
human
therapeutics
diagnostics
Prior art date
Application number
PCT/EP2003/011394
Other languages
English (en)
Other versions
WO2004038416A1 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Holger Summer filed Critical Bayer Healthcare Ag
Priority to AU2003274005A priority Critical patent/AU2003274005A1/en
Publication of WO2004038416A1 publication Critical patent/WO2004038416A1/fr
Publication of WO2004038416A8 publication Critical patent/WO2004038416A8/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un récepteur GPR6 humain qui est associé aux maladies hématologiques, aux maladies cardiovasculaires, aux troubles du système nerveux central et périphérique, aux affections urologiques, aux troubes gastro-entérologiques, aux inflammations et au cancer. L'invention se rapporte également à des analyses permettant l'identification de composés utiles pour le traitement et la prévention des maladies hématologiques, des maladies cardiovasculaires, des troubles du système nerveux central et périphérique, des affections urologiques, des troubes gastro-entérologiques, des inflammations et du cancer. L'invention porte enfin sur des composés qui se lient au GPR6 et/ou stimulent ou inhibent l'activité du GPR6, et sur des compositions pharmaceutiques renfermant lesdits composés.
PCT/EP2003/011394 2002-10-24 2003-10-15 Diagnostic et therapeutique de maladies associees au recepteur 6 couple a la proteine g humain (gpr6) WO2004038416A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003274005A AU2003274005A1 (en) 2002-10-24 2003-10-15 Diagnostics and therapeutics for diseases associated with human g-protein coupled receptor 6 (gpr6)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2376902A 2002-10-24 2002-10-24
US02023769.9 2002-10-24

Publications (2)

Publication Number Publication Date
WO2004038416A1 WO2004038416A1 (fr) 2004-05-06
WO2004038416A8 true WO2004038416A8 (fr) 2005-03-17

Family

ID=32174049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011394 WO2004038416A1 (fr) 2002-10-24 2003-10-15 Diagnostic et therapeutique de maladies associees au recepteur 6 couple a la proteine g humain (gpr6)

Country Status (2)

Country Link
AU (1) AU2003274005A1 (fr)
WO (1) WO2004038416A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049040A1 (fr) * 1998-03-23 1999-09-30 Smithkline Beecham Corporation PROTEINE G HUMAINE COUPLEE AU RECEPTEUR GPR6sb
MXPA01008618A (es) * 1999-02-26 2002-03-20 Arena Pharm Inc Moduladores de molecula pequena de receptor seis acoplado de proteina g.

Also Published As

Publication number Publication date
WO2004038416A1 (fr) 2004-05-06
AU2003274005A1 (en) 2004-05-13

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