WO2003096020A3 - Diagnostic et traitement de maladies liees au recepteur 8 des chimiokines (ccr8) - Google Patents

Diagnostic et traitement de maladies liees au recepteur 8 des chimiokines (ccr8) Download PDF

Info

Publication number
WO2003096020A3
WO2003096020A3 PCT/EP2003/004496 EP0304496W WO03096020A3 WO 2003096020 A3 WO2003096020 A3 WO 2003096020A3 EP 0304496 W EP0304496 W EP 0304496W WO 03096020 A3 WO03096020 A3 WO 03096020A3
Authority
WO
WIPO (PCT)
Prior art keywords
ccr8
diseases
therapeutics
diagnostics
diseases associated
Prior art date
Application number
PCT/EP2003/004496
Other languages
English (en)
Other versions
WO2003096020A2 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003229753A priority Critical patent/AU2003229753A1/en
Publication of WO2003096020A2 publication Critical patent/WO2003096020A2/fr
Publication of WO2003096020A3 publication Critical patent/WO2003096020A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention porte sur un récepteur 8 des chimiokines (CCR8) humain associé aux troubles du système nerveux périphérique et central, aux maladies cardio-vasculaires, aux maladies gastro-intestinales, au cancer et aux maladies hématologiques. Cette invention porte sur des épreuves d'identification de composés utiles dans le traitement et la prévention de troubles du système nerveux périphérique et central, des maladies cardio-vasculaires, des maladies gastro-intestinales, du cancer et des maladie hématologiques. Cette invention a également trait à des composés qui se lient à et/ou activent ou inhibent l'activité du CCR8 ainsi qu'à des compositions pharmaceutiques contenant ces composés.
PCT/EP2003/004496 2002-05-13 2003-04-30 Diagnostic et traitement de maladies liees au recepteur 8 des chimiokines (ccr8) WO2003096020A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003229753A AU2003229753A1 (en) 2002-05-13 2003-04-30 Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02010147 2002-05-13
EP02010147.3 2002-05-13

Publications (2)

Publication Number Publication Date
WO2003096020A2 WO2003096020A2 (fr) 2003-11-20
WO2003096020A3 true WO2003096020A3 (fr) 2004-02-26

Family

ID=29414670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/004496 WO2003096020A2 (fr) 2002-05-13 2003-04-30 Diagnostic et traitement de maladies liees au recepteur 8 des chimiokines (ccr8)

Country Status (2)

Country Link
AU (1) AU2003229753A1 (fr)
WO (1) WO2003096020A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202216771A (zh) * 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體
EP4186926A4 (fr) * 2020-08-28 2024-06-05 Harbour Biomed US, Inc. Anticorps anti-ccr8 et application correspondante
CN114891117B (zh) * 2022-04-26 2023-09-05 深圳市体内生物医药科技有限公司 一种靶向ccr8的嵌合抗原受体t细胞及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776729A (en) * 1995-06-05 1998-07-07 Human Genome Sciences, Inc. Human G-protein receptor HGBER32
WO1999006561A2 (fr) * 1997-07-29 1999-02-11 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Adn de recepteur de chemokine ccr 8, et ses utilisations
WO1999025734A2 (fr) * 1997-11-13 1999-05-27 Schering Corporation APPAUVRISSEMENT DE LA CELLULE Th2, COMPOSITIONS ET METHODES EN RAPPORT
WO2001058484A2 (fr) * 2000-02-10 2001-08-16 Schering Corporation Nouvelles utilisations des recepteurs ccr8 de mammiferes et reactifs associes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776729A (en) * 1995-06-05 1998-07-07 Human Genome Sciences, Inc. Human G-protein receptor HGBER32
WO1999006561A2 (fr) * 1997-07-29 1999-02-11 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Adn de recepteur de chemokine ccr 8, et ses utilisations
WO1999025734A2 (fr) * 1997-11-13 1999-05-27 Schering Corporation APPAUVRISSEMENT DE LA CELLULE Th2, COMPOSITIONS ET METHODES EN RAPPORT
WO2001058484A2 (fr) * 2000-02-10 2001-08-16 Schering Corporation Nouvelles utilisations des recepteurs ccr8 de mammiferes et reactifs associes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERNARDINI ET AL: "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 28, no. 2, 1 February 1998 (1998-02-01), pages 582 - 588, XP002092743, ISSN: 0014-2980 *
HAQUE N S ET AL: "The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.", BLOOD. UNITED STATES 1 JAN 2001, vol. 97, no. 1, 1 January 2001 (2001-01-01), pages 39 - 45, XP002264851, ISSN: 0006-4971 *
RUCKES T ET AL: "Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309.", BLOOD. UNITED STATES 15 AUG 2001, vol. 98, no. 4, 15 August 2001 (2001-08-15), pages 1150 - 1159, XP002264850, ISSN: 0006-4971 *
TIFFANY ET AL: "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 186, no. 1, 7 July 1997 (1997-07-07), pages 165 - 170, XP002092538, ISSN: 0022-1007 *
TREBST CORINNA ET AL: "CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages.", AMERICAN JOURNAL OF PATHOLOGY, vol. 162, no. 2, February 2003 (2003-02-01), pages 427 - 438, XP009023102, ISSN: 0002-9440 (ISSN print) *

Also Published As

Publication number Publication date
AU2003229753A1 (en) 2003-11-11
WO2003096020A2 (fr) 2003-11-20

Similar Documents

Publication Publication Date Title
WO2003081258A3 (fr) Diagnostics et elements therapeutiques pour maladies associees au recepteur secretagogue de l'hormone de croissance (ghs)
WO2003074069A3 (fr) Diagnostic et therapeutique destines a des maladies associees au recepteur peptidique n-formyl 1 (fpr1)
WO2004042389A3 (fr) Moyens diagnostiques et therapeutiques destines a des maladies associees a la phosphodiesterase 4d (pde4d) humaine
WO2003093816A3 (fr) Diagnostics et therapeutiques pour lutter contre des maladies associees au recepteur de l'oxytocine (oxtr)
WO2003096020A3 (fr) Diagnostic et traitement de maladies liees au recepteur 8 des chimiokines (ccr8)
WO2003095967A3 (fr) Methodes diagnostiques et therapeutiques pour les maladies associees au recepteur 9 des chimiokines (ccr9)
WO2005106489A3 (fr) Diagnostics et therapies s'appliquant a des maladies associees aux recepteurs 5 des chimiokines c-c (ccr5)
WO2004042402A3 (fr) Moyens diagnostiques et therapeutiques destines a des maladies associees au mrgx1 humain
WO2004038405A3 (fr) Diagnostics et therapeutiques pour maladies liees au recepteur 43 couple a la proteine g (gpr43)
WO2003065044A3 (fr) Agents diagnostiques et therapeutiques destines a des maladies associees a gpr72
WO2004071378A3 (fr) Methodes diagnostiques et therapeutiques relatives a des etats pathologiques lies au recepteur hm74a couple a la proteine g
WO2004104574A3 (fr) Agents diagnostiques et therapeutiques destines a des maladies associees au recepteur de chimiokine c-c de type 7 (ccr7)
WO2003066077A3 (fr) Outil de diagnostic et therapeutique pour des maladies associees au recepteur de neuromedine u1 (nmu1)
WO2004015427A3 (fr) Methodes diagnostiques et therapeutiques s'adressant a des maladies associees au recepteur 19 couple a la proteine g (gpr19)
WO2003100433A3 (fr) Diagnostics et therapies pour maladies liees au recepteur 3 de l'arginine vasopressine (avpr3)
WO2003100436A3 (fr) Procede pour diagnostiquer et traiter des maladies associees au recepteur 10 de chimiokine (ccr10)
WO2003100435A3 (fr) Procede pour diagnostiquer et traiter des maladies associees au recepteur de neuromedine u2 (nmu2)
WO2004038421A3 (fr) Agents diagnostiques et therapeutiques pour maladies associees au recepteur 41 couple a une proteine g humaine (gpr41)
WO2004038407A3 (fr) Diagnostics et medicaments pour maladies associees au recepteur 12 humain couple a la proteine g (gpr12)
WO2003076945A3 (fr) Diagnostic et therapie de maladies associees au recepteur couple a la proteine g 105 (gpr105)
WO2004015422A3 (fr) Diagnostic et traitement de maladies associees au recepteur 1 couple a la proteine g (ogr-1) du cancer de l'ovaire
WO2004038416A8 (fr) Diagnostic et therapeutique de maladies associees au recepteur 6 couple a la proteine g humain (gpr6)
WO2004042405A3 (fr) Diagnostic et therapeutique pour maladies associees au recepteur 3 couples aux proteines g (gpr3) humain
WO2003080098A3 (fr) Diagnostics et therapeutiques associes au recepteur 2 du peptide de formyle humain
WO2004038408A3 (fr) Diagnostics et medicaments pour maladies associees au recepteur humain 14 couple a la proteine g (gpr14)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP