WO2004028399A2 - Thoracic deployment device - Google Patents
Thoracic deployment device Download PDFInfo
- Publication number
- WO2004028399A2 WO2004028399A2 PCT/US2003/020496 US0320496W WO2004028399A2 WO 2004028399 A2 WO2004028399 A2 WO 2004028399A2 US 0320496 W US0320496 W US 0320496W WO 2004028399 A2 WO2004028399 A2 WO 2004028399A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stent graft
- deployment
- handle
- catheter
- fixed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/9517—Instruments specially adapted for placement or removal of stents or stent-grafts handle assemblies therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
- A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
Definitions
- This invention relates to a device for the deployment of a stent graft within the aorta and particularly in relation to deployment within the thoracic aorta.
- proximal will be used for that end of both the deployment device and the stent graft at that end which is closer to the heart of a patient and the term distal will be used for that end of the deployment device or stent graft which in use is furthest from the heart.
- Deployment of stent grafts within the thoracic aorta using an endovascular deployment method through the iliac arteries into the aorta can be done with a deployment device which has retained on it a stent graft which includes an exposed stent at the distal end of the graft.
- the stent graft has in one embodiment an exposed stent at the distal end preferably with barbs on it, it must be deployed in a device which keeps the barbs covered until deployment is required. This can be done with a capsule, which covers the exposed stent, but there is a problem.
- a proximal end retention system which uses trigger wires to retain the proximal end of the stent, can be released by pulling the trigger wires, thereby releasing part of the graft prematurely.
- a stent graft deployment device which holds a stent graft in a retained condition and is arranged to release a distal end of a stent graft before a proximal end of the stent graft
- the device having a proximal stent graft end release mechanism and a distal stent graft end release mechanism associated with a deployment catheter and an arrangement to allow movement of at least part of the deployment catheter including the distal stent graft end release mechanism independent of movement of the proximal stent graft release mechanism.
- the deployment catheter includes a capsule engaging the distal end of the stent graft or prosthesis or a distally extending exposed stent on the stent graft or prosthesis.
- the trigger wires may be used for both the proximal end and the distal end of the prosthesis or stent graft with separate trigger wire release mechanisms for each.
- the trigger wire release mechanism for the distal end is actuated before removing the distal exposed stent capsule.
- sheath over the deployment catheter to cover the stent graft during initial deployment with the sheath manipulatorfixed onto the deployment catheter. Movement of the sheath manipulator on the deployment catheter will move the sheath with respect to the deployment catheter and expose the stent graft.
- the arrangement to allow movement of the deployment catheter independently of movement of the trigger wire release mechanism may include a fixed handle associated with the trigger wire release mechanism and to which the trigger wires are fixed and a sliding handle to which the deployment catheter and the capsule are fixed.
- the sliding handle is preferably mounted on the fixed handle and can slide with respect to it from a position where the capsule on the deployment catheter covers the exposed stents at the distal end of the stent graft to a position where the exposed stents are released.
- moving the sliding handle with respect to the fixed handle moves the deployment catheter and the capsule without releasing the trigger wires for the proximal end of the stent graft.
- This arrangement may be provided by a thumbscrew fixed to the sliding handle which engages against a portion of the fixed handle to prevent inadvertent or early movement of the sliding handle with respect to the fixed handle. The thumbscrew is removed when it is desired to move the sliding handle.
- Such a mechanism may be provided by a spring loaded pin or plunger mechanism on one of the handles which engages the other of the handles and allows movement from the position where the capsule on the deployment catheter is engaged onto the exposed stents to a position where the deployment catheter is disengaged and at that time the spring loaded pin mechanism engages a recess in the other handle portion to prevent forward movement again.
- the hemostatic seal may include a guide tube fixed onto the deployment catheter and sliding into a central lumen in the fixed handle with an O ring around it to seal.
- the stages of operation of a deployment device are as follows. First once the deployment device is deployed in the correct position within the anatomy of the human or animal the sheath is withdrawn to expose the stent graft. At this stage the proximal end of the stent graft is retained by mooring loops actuated by a trigger wire and the distal end of the stent graft is retained by a capsule and a trigger wire.
- a stent graft deployment apparatus comprising a deployment catheter having a proximal end adapted to be introduced into a patient and a distal end adapted to remain outside a patient, the distal end including a handle arrangement, the catheter having at a proximal end thereof a region adapted in use to contain a stent graft; a sheath arrangement adapted in use to extend over and cover the region adapted to be moved with respect to the catheter to expose the region to thereby enable deployment of the stent graft; a nose cone dilator positioned at the proximal end of the deployment catheter; a distal retention arrangement for the stent graft at a distal end of the region and comprising a proximally facing capsule having a passageway and adapted to retain the distal end of a stent graft; the handle arrangement including a fixed handle and a sliding handle, at least the capsule being affixed to the sliding handle, whereby movement
- a stent graft deployment apparatus comprising a deployment catheter having a proximal end adapted to be introduced into a patient and a distal end adapted to remain outside a patient, the distal end including a handle arrangement; a longitudinal lumen through the deployment catheter; a guide wire catheter extending through the longitudinal lumen and extending proximally of the deployment catheter, the guide wire catheter having a proximal end and a distal end; and the guide wire catheter being movable longitudinally and rotationally with respect to the deployment catheter; a nose cone dilator being attached to proximal end of the guide wire catheter and extending proximally thereof; a sheath arrangement adapted in use to cover at least a portion of the deployment catheter and to extend to the nose cone dilator and adapted to be moved with respect to the catheter to enable deployment of a stent graft retianed on the deployment device; a distal retention arrangement for the stent graft at
- proximal retention arrangement on the guide wire catheter distal of the nose cone dilator for the proximal end of the stent graft and the proximal retention arrangement can include at least one proximal trigger wire.
- the proximal trigger wire can extend from the outside of the patient where it is retained by a trigger wire release mechanism on the fixed handle.
- the distal retention arrangement includes an aperture extending through the capsule and a distal trigger wire extending along the deployment catheter and extendable through the aperture.
- the distal trigger wire can extend from the outside of the patient where it is retained by a trigger wire release mechanism on the fixed handle.
- the sliding handle is mounted on the fixed handle and can slide longitudinally with respect to the fixed handle.
- the locking arrangement can comprise a thumbscrewfixed to the sliding handle which engages against a portion of the fixed handle to prevent inadvertent or early movement of the sliding handlewith respect to the fixed handle and wherein thethumbscrew can be removed when it is desired to move the sliding handle.
- a lock mechanism which prevents the sliding handle from being moved forward after an initial movement back.
- the lock mechanism can be provided by a spring loaded pin or plunger mechanism on one of the fixed handle or the sliding handle which engages the other of the fixed or sliding handles and allows movement of the deployment catheter from the position where the capsule on the deployment catheter is engaged onto the exposed stents to a position where the deployment catheter is disengaged and wherein at that time the spring loaded pin mechanism engages a recess in the other of the fixed or sliding handles to prevent further movement.
- the hemostatic seal can include a guide tube fixed onto the deployment catheter and sliding into a central lumen in the fixed handle with an O-ring in the fixed handle engaging around the guide tube.
- the stages of operation of deployment device are as follows. First once the deployment device is deployed in the correct position within the anatomy of the human or animal, the sheath is withdrawn to expose the stent graft. At this stage the proximal end of the stent graft is retained by mooring loops actuated by a trigger wire and the distal end of the stent graft is retained by a capsule and a trigger wire.
- the distal trigger wire release mechanism is operated and thetrigger wire release mechanism is completely withdrawn and discarded to remove the trigger wire from the distal end of the stent graft.
- the thumbscrew on the sliding handle is released and discarded.
- proximal trigger wire release mechanism is withdrawn and discarded to remove the trigger wire from the proximal end of the stent graft. This releases the mooring loops and the graft is then fully deployed. Finally the pin vice fixed to the fixed handle is released to withdraw the nose cone of the deployment device towards the capsule and then the deployment device is withdrawn.
- the sheath may be left in place and the deployment device less the sheath can be withdrawn so other devices such as an inflatable balloon to ensure complete engagement against the walls of the aorta may be deployed through the sheath.
- Fig. 1 shows a general external view of the deployment device according to one embodiment of this invention
- Fig. 2 shows a longitudinal cross-sectional view of the embodiment shown in Fig 1
- Fig. 3 shows the same view as Fig. 2 but after withdrawal of the sheath;
- Fig. 4 shows the same view as Fig. 3 but after activation of the sliding handle
- Fig. 5 shows a detailed longitudinal cross-sectional view of the sliding and fixed handle portion of one embodiment of a deployment device according to the invention
- Fig. 6 shows a view of the embodiment shown in Fig. 5 after withdrawal of the capsule
- Fig. 7 shows a side view of the embodiment shown in Fig. 5; and Fig. 8 shows a side view of the embodiment shown in Fig. 6 after withdrawal of the capsule.
- the deployment device generally comprises, working from the inside towards the outside, a guide wire catheter 1 which extends the full length of the device from a syringe socket 2 at the far distal end of the deployment device to a nose dilator 3 at the proximal end of the deployment device.
- the nose cone dilator 3 is fixed to the guide wire catheter 1 and moves with it.
- the nose cone dilator has a through bore 5 as an extension of the lumen of the guide wire catheter 1 so that the deployment device can be deployed over a guide wire (not shown).
- the trigger wire release mechanism generally shown as 6 at the distal end ofthe deployment device includes a distal end trigger wire release mechanism 7 and a proximal end trigger wire release mechanism 8.
- the trigger wire release mechanisms 7 and 8 slide on a portion of the fixed handle 10. Until such time as they are activated, the trigger wire mechanisms 7 and 8 which are fixed by thumbscrews 11 and remain fixed with respect to the fixed portion of the fixed handle.
- the sliding handle mechanism 15 generally includes a fixed handle extension 16 of the fixed handle 10 and a sliding portion 17. The sliding portion 17 slides over the fixed handle extension 16. A thumbscrew 18 fixes the sliding portion 17 with respect to the fixed portion 16.
- the fixed handle portion 16 is affixed to the trigger wire mechanism handle 10 by a screw threaded nut 24.
- the sliding portion of the handle 17 is fixed to the deployment catheter 19 by a mounting nut 20.
- a deployment catheter extends from the sliding handle 17 through to a capsule 21 at the proximal end of the deployment catheter 19.
- the sheath 23 assists in retaining the stent graft 25, which includes self-expanding stents 26 in a compressed condition.
- the proximal covered stent 27 is retained by a fastening at 28 which is locked by a trigger wire (not shown) which extends to trigger wire release mechanism 8.
- the distal exposed stent 29 on the stent graft 25 is retained within the capsule 21 on the deployment catheter 19 and is prevented from being released from the capsule by a distal trigger wire (not shown) which extends to the distal trigger wire release mechanism 7.
- Fig. 3 shows the same view as Fig. 2 but after withdrawal of sheath 23, and
- Fig. 4 shows the same view as Fig. 3, but after activation of sliding handle mechanism 15.
- Fig. 3 the sheath manipulator 22 has been moved distally so that its proximal end clears the stent graft 25 and lies over the capsule 21. Freed of constraint, the self expanding stents 26 of the stent graft 25 are able to expand.
- the fastening 28 still retains the proximal end of the proximal stent 27, and the capsule 21 still retains the distally extending exposed stent 29.
- the proximal and distal ends of the stent graft 25 can be independently repositioned, although if the proximal stent 27 included barbs as it has in some embodiments, the proximal end can only be moved proximally. Once repositioning has been done, the distal end of the stent graft 25 should be released first.
- the proximal trigger wire release mechanism 8 which is on the handle 10 does not move when moving the sliding handle, deployment catheter 19 and capsule 21 so the proximal end of the stent graft 25 remains in a retained position.
- the proximal end of the stent graft 25 can be again manipulated at this stage by manipulation of the handle.
- the proximal stent 27 included barbs as discussed above, the proximal end can only be moved proximally.
- the proximal fastening 28 can then be released by removal of the proximal trigger wire release mechanism 8.
- FIGs. 5 and 7 show the sliding handle mechanism in the ready to deploy condition.
- Figs. 6 and 8 show the mechanism when the deployment catheter and hence the capsule has been withdrawn by moving the sliding handle with respect to the fixed handle.
- the fixed handle extension 16 is joined to the trigger wire mechanism handle 10 by screw threaded nut 24.
- the sliding handle 17 is fixed to the deployment catheter 19 by screw threaded fixing nut 20 so that the deployment catheter moves along with the sliding handle 17.
- the sliding handle 17 fits over the fixed handle extension 16 and, in the ready to deploy situation, is fixed in relation to the fixed handle by locking thumbscrew 18, which engages into a recess 30 in the fixed handle extension 16.
- a longitudinal track 31 into which a plunger pin 32 spring loaded by means of spring 33 is engaged.
- a recess 34 At the distal end of the track 31 is a recess 34.
- a guide tube 35 is fixed into the proximal end of the sliding handle 17 at 36 and extends backto engage into a central lumen 41 in the fixed handle extension
- the trigger wire 38 which is fixed to the trigger wire releasing mechanism 8 by means of screw 39, passes through the annular recess 42 between the fixed handle extension 16 and the guide wire catheter 1 and then more proximally in the annular recess 44 between the guide wire catheter 1 and the guide tube 35 and forward to extend through the annular recess 46 between the guide wire catheter 1 and the deployment catheter 19 and continues forward to the proximal retaining arrangement.
- the distal trigger wire (not shown) extends to the distal retaining arrangement.
- a further hemostatic seal 40 is provided where the guide wire catheter 1 enters the trigger wire mechanism handle 10 and the trigger wires 38 pass through the hemostatic seal 40 to ensure a good blood seal.
- the proximal trigger wire 38 is not moved when the deployment catheter 19 and the sliding handle 17 is moved so that it remains in position and does not prematurely disengage.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Valve Device For Special Equipments (AREA)
- Memory System Of A Hierarchy Structure (AREA)
- Automatic Disk Changers (AREA)
- Massaging Devices (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Auxiliary Devices For And Details Of Packaging Control (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003288896A AU2003288896B2 (en) | 2002-06-28 | 2003-06-30 | Thoracic deployment device |
DE60318850T DE60318850T2 (en) | 2002-06-28 | 2003-06-30 | THORACAL STORAGE DEVICE |
DK03781283T DK1517654T3 (en) | 2002-06-28 | 2003-06-30 | Toracal insertion device |
EP03781283A EP1517654B1 (en) | 2002-06-28 | 2003-06-30 | Thoracic deployment device |
JP2004539796A JP4654032B2 (en) | 2002-06-28 | 2003-06-30 | Chest indwelling device |
CA2489434A CA2489434C (en) | 2002-06-28 | 2003-06-30 | Thoracic deployment device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39266702P | 2002-06-28 | 2002-06-28 | |
US60/392,667 | 2002-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004028399A2 true WO2004028399A2 (en) | 2004-04-08 |
WO2004028399A3 WO2004028399A3 (en) | 2004-08-19 |
Family
ID=32043154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/020496 WO2004028399A2 (en) | 2002-06-28 | 2003-06-30 | Thoracic deployment device |
Country Status (9)
Country | Link |
---|---|
US (1) | US6939370B2 (en) |
EP (2) | EP1517654B1 (en) |
JP (1) | JP4654032B2 (en) |
AT (2) | ATE384505T1 (en) |
AU (1) | AU2003288896B2 (en) |
CA (1) | CA2489434C (en) |
DE (1) | DE60318850T2 (en) |
DK (1) | DK1517654T3 (en) |
WO (1) | WO2004028399A2 (en) |
Cited By (62)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2006007389A1 (en) * | 2004-06-16 | 2006-01-19 | Cook Incorprated | Thoracic deployment device and stent graft |
WO2007076114A3 (en) * | 2005-12-23 | 2007-12-06 | Cook Inc | Prosthesis deployment system |
WO2008138584A1 (en) * | 2007-05-15 | 2008-11-20 | Jenavalve Technology Inc. | Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent |
US20100174354A1 (en) * | 2007-09-01 | 2010-07-08 | Sapporo Medical University | Stent placement device and stent placement method |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8012193B2 (en) | 2003-10-14 | 2011-09-06 | William A. Cook Australia Pty, Ltd | Introducer for an iliac side branch device |
US20110288626A1 (en) * | 2010-05-20 | 2011-11-24 | Helmut Straubinger | Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect |
WO2012058582A1 (en) | 2010-10-29 | 2012-05-03 | Cook Medical Technologies Llc | Medical device delivery system and deployment method |
US8317858B2 (en) | 2008-02-26 | 2012-11-27 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US8398704B2 (en) | 2008-02-26 | 2013-03-19 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
AU2012211487B2 (en) * | 2005-12-23 | 2013-04-04 | Cook Medical Technologies Llc | Introducer for a prosthesis |
US8465540B2 (en) | 2008-02-26 | 2013-06-18 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis |
US8468667B2 (en) | 2009-05-15 | 2013-06-25 | Jenavalve Technology, Inc. | Device for compressing a stent |
US8679174B2 (en) | 2005-01-20 | 2014-03-25 | JenaValve Technology, GmbH | Catheter for the transvascular implantation of prosthetic heart valves |
US8728148B2 (en) | 2011-11-09 | 2014-05-20 | Cook Medical Technologies Llc | Diameter reducing tie arrangement for endoluminal prosthesis |
US8808367B2 (en) | 2007-09-07 | 2014-08-19 | Sorin Group Italia S.R.L. | Prosthetic valve delivery system including retrograde/antegrade approach |
US8834561B2 (en) | 2005-10-28 | 2014-09-16 | Jenavalve Technology Gmbh | Device for the implantation and fixation of prosthetic valves |
US8968380B2 (en) | 2009-10-07 | 2015-03-03 | Cook Medical Technologies Llc | Deployment handle for an introducer |
US9034027B2 (en) | 2009-10-13 | 2015-05-19 | Cook Medical Technologies Llc | Paraplegia prevention stent graft |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
US9056008B2 (en) | 2006-12-19 | 2015-06-16 | Sorin Group Italia S.R.L. | Instrument and method for in situ development of cardiac valve prostheses |
US9060887B2 (en) | 2003-10-10 | 2015-06-23 | Cook Medical Technologies Llc | Fenestrated stent grafts |
US9095456B2 (en) | 2009-10-13 | 2015-08-04 | Cook Medical Technologies Llc | Paraplegia prevention stent graft |
EP2907485A1 (en) * | 2014-02-16 | 2015-08-19 | Cook Medical Technologies LLC | Deployment handle for a prosthesis delivery device |
US9138315B2 (en) | 2007-04-13 | 2015-09-22 | Jenavalve Technology Gmbh | Medical device for treating a heart valve insufficiency or stenosis |
US9149382B2 (en) | 2011-04-28 | 2015-10-06 | Cook Medical Technologies Llc | Endoluminal prosthesis having multiple branches or fenestrations and methods of deployment |
US9168130B2 (en) | 2008-02-26 | 2015-10-27 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US9168105B2 (en) | 2009-05-13 | 2015-10-27 | Sorin Group Italia S.R.L. | Device for surgical interventions |
US9510947B2 (en) | 2011-10-21 | 2016-12-06 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable heart valve stent into the body of a patient |
US20170049568A1 (en) * | 2010-05-20 | 2017-02-23 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect |
US9744031B2 (en) | 2010-05-25 | 2017-08-29 | Jenavalve Technology, Inc. | Prosthetic heart valve and endoprosthesis comprising a prosthetic heart valve and a stent |
US9770321B2 (en) | 2003-10-14 | 2017-09-26 | Cook Medical Technologies Llc | Introducer for a side branch device |
US9839515B2 (en) | 2005-12-22 | 2017-12-12 | Symetis, SA | Stent-valves for valve replacement and associated methods and systems for surgery |
US9867699B2 (en) | 2008-02-26 | 2018-01-16 | Jenavalve Technology, Inc. | Endoprosthesis for implantation in the heart of a patient |
US9867694B2 (en) | 2013-08-30 | 2018-01-16 | Jenavalve Technology Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US9878127B2 (en) | 2012-05-16 | 2018-01-30 | Jenavalve Technology, Inc. | Catheter delivery system for heart valve prosthesis |
US10058313B2 (en) | 2011-05-24 | 2018-08-28 | Sorin Group Italia S.R.L. | Transapical valve replacement |
US10195059B2 (en) | 2003-10-10 | 2019-02-05 | Cook Medical Technologies Llc | Composite stent graft |
US10709555B2 (en) | 2015-05-01 | 2020-07-14 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US10959826B2 (en) | 2014-10-16 | 2021-03-30 | Cook Medical Technology LLC | Support structure for scalloped grafts |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
US11291570B2 (en) | 2018-04-27 | 2022-04-05 | Cook Medical Technologies Llc | Hybrid stent and delivery system |
US11304804B2 (en) | 2017-09-19 | 2022-04-19 | Cardiovalve, Ltd. | Prosthetic valve with connecting struts of variable size and tissue anchoring legs of variable size that extend from junctions |
US11382746B2 (en) | 2017-12-13 | 2022-07-12 | Cardiovalve Ltd. | Prosthetic valve and delivery tool therefor |
US11426155B2 (en) | 2010-07-21 | 2022-08-30 | Cardiovalve Ltd. | Helical anchor implantation |
US11491011B2 (en) | 2018-09-17 | 2022-11-08 | Cardiovalve Ltd. | Leaflet-grouping system |
US11504231B2 (en) | 2018-05-23 | 2022-11-22 | Corcym S.R.L. | Cardiac valve prosthesis |
US11517436B2 (en) | 2011-08-05 | 2022-12-06 | Cardiovalve Ltd. | Implant for heart valve |
US11534298B2 (en) | 2015-02-05 | 2022-12-27 | Cardiovalve Ltd. | Prosthetic valve with s-shaped tissue anchors |
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CA2489434A1 (en) | 2004-04-08 |
ATE533436T1 (en) | 2011-12-15 |
DE60318850T2 (en) | 2009-01-22 |
EP1517654B1 (en) | 2008-01-23 |
US20040098079A1 (en) | 2004-05-20 |
EP1779810A1 (en) | 2007-05-02 |
CA2489434C (en) | 2012-02-07 |
ATE384505T1 (en) | 2008-02-15 |
JP4654032B2 (en) | 2011-03-16 |
US6939370B2 (en) | 2005-09-06 |
EP1517654A2 (en) | 2005-03-30 |
DK1517654T3 (en) | 2008-05-05 |
DE60318850D1 (en) | 2008-03-13 |
EP1779810B1 (en) | 2011-11-16 |
JP2006501890A (en) | 2006-01-19 |
AU2003288896A1 (en) | 2004-04-19 |
WO2004028399A3 (en) | 2004-08-19 |
AU2003288896B2 (en) | 2008-01-24 |
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