WO2004011423A3 - Structural carotenoid analogs for the inhibition and amelioration of disease - Google Patents

Structural carotenoid analogs for the inhibition and amelioration of disease Download PDF

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Publication number
WO2004011423A3
WO2004011423A3 PCT/US2003/023706 US0323706W WO2004011423A3 WO 2004011423 A3 WO2004011423 A3 WO 2004011423A3 US 0323706 W US0323706 W US 0323706W WO 2004011423 A3 WO2004011423 A3 WO 2004011423A3
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WIPO (PCT)
Prior art keywords
analog
subject
combination
administered
amelioration
Prior art date
Application number
PCT/US2003/023706
Other languages
French (fr)
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WO2004011423A2 (en
Inventor
Samuel Fournier Lockwood
Sean O'malley
David G Watumull
Laura M Hix
Henry Jackson
Geoff Nadolski
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Hawaii Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hawaii Biotech Inc filed Critical Hawaii Biotech Inc
Priority to CA2495167A priority Critical patent/CA2495167C/en
Priority to EP03772051.3A priority patent/EP1532108B1/en
Priority to AU2003256982A priority patent/AU2003256982A1/en
Priority to CN03823260XA priority patent/CN1708480B/en
Priority to MXPA05001202A priority patent/MXPA05001202A/en
Priority to JP2005505633A priority patent/JP4601549B2/en
Priority to BRPI0313155A priority patent/BRPI0313155B8/en
Publication of WO2004011423A2 publication Critical patent/WO2004011423A2/en
Publication of WO2004011423A3 publication Critical patent/WO2004011423A3/en
Priority to NO20050619A priority patent/NO20050619L/en
Priority to HK06104731.0A priority patent/HK1084380A1/en

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Abstract

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cardiac arrhythmia and/or sudden cardiac death. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
PCT/US2003/023706 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease WO2004011423A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA2495167A CA2495167C (en) 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease
EP03772051.3A EP1532108B1 (en) 2002-07-29 2003-07-29 Astaxanthin esters for the inhibition and amelioration of disease
AU2003256982A AU2003256982A1 (en) 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease
CN03823260XA CN1708480B (en) 2002-07-29 2003-07-29 Carotenoid analogs for the inhibition and amelioration of disease
MXPA05001202A MXPA05001202A (en) 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease.
JP2005505633A JP4601549B2 (en) 2002-07-29 2003-07-29 Structural carotenoid analogues for disease control and amelioration
BRPI0313155A BRPI0313155B8 (en) 2002-07-29 2003-07-29 chemical compound derived or carotenoid analogue, pharmaceutical composition, and use of the compound
NO20050619A NO20050619L (en) 2002-07-29 2005-02-03 Structural corotenoid analogues for the inhibition and relief of disease
HK06104731.0A HK1084380A1 (en) 2002-07-29 2006-04-20 Structural carotenoid analogs for the inhibition and amelioration of disease

Applications Claiming Priority (10)

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US39919402P 2002-07-29 2002-07-29
US60/399,194 2002-07-29
US46797303P 2003-05-05 2003-05-05
US60/467,973 2003-05-05
US47283103P 2003-05-22 2003-05-22
US60/472,831 2003-05-22
US47374103P 2003-05-28 2003-05-28
US60/473,741 2003-05-28
US48530403P 2003-07-03 2003-07-03
US60/485,304 2003-07-03

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AU (1) AU2003256982A1 (en)
BR (1) BRPI0313155B8 (en)
CA (1) CA2495167C (en)
HK (2) HK1084380A1 (en)
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