WO2004006826A1

WO2004006826A1 - Chemical container and method of manufacturing the container

Info

Publication number: WO2004006826A1
Application number: PCT/JP2003/009001
Authority: WO
Inventors: Susumu Senda; Tomio Maenaka
Original assignee: Senju Pharmaceutical Co., Ltd.; Hanshin Yoki Co., Ltd.
Priority date: 2002-07-16
Filing date: 2003-07-15
Publication date: 2004-01-22
Also published as: JPWO2004006826A1; AU2003248070A1; JP4402591B2; AU2003248070A8

Abstract

A chemical container (A) and a method of manufacturing the container, the container formed of a thermoplastic resin having a container body (23) and a mouth part (61) formed integrally with each other and having chemical (31) filled therein, comprising a mouth part structure capable of assuring safety at the time of instillation, maintaining constant the dripped or dispensed amount of the chemical, and providing excellent sanitation and continuous production stability, wherein a droplet forming face (64) finished in projected or plane shape for forming the chemical (31) discharged from the inside of the container in the droplets of a specified size is formed at the tip of the mouth part (61), and a chemical discharging small hole (65) passed through the droplet forming face is formed at the center part of the droplet forming face.

Description

Description Chemical liquid container and its manufacturing method

The present invention relates to a drug solution container and a method for manufacturing the same, and in particular, a droplet forming surface that is processed into a convex shape or a flat shape for forming a drug solution discharged from the inside of the container as droplets of a predetermined size, The present invention relates to a drug solution container in which a mouth portion and a container main body are formed in a central portion of the droplet forming surface and a pore for discharging a drug solution penetrating the droplet forming surface, and a method of manufacturing the same. Background art

For liquid medicine containers such as eye drops, ear drops, and nasal drops, blow molding parisons made by melting the raw resin to produce hollow molded products in which the container body and screw holes are integrally formed. It is generally known that a drug solution is filled from the opening of the screw hole 91 and then a drug solution administration nozzle 92 is mounted on the upper surface of the screw hole (see FIG. 5). However, in such a chemical container, there is a possibility that the liquid tightness of the chemical solution is reduced due to a dimensional error between the screw port and the chemical liquid dispensing nozzle due to a change in room temperature or the like, and the screw hole or the chemical liquid dispensing nozzle may be cracked. There was a problem with one point. In addition, the droplet forming part of the conventional nozzle is formed by the top surface of the nozzle and the hole for discharging the chemical solution provided in the nozzle surface. There is a danger of eye damage, especially when instilling. Further, in the conventional nozzle, since the opening wall of the pore for discharging the chemical liquid has a recessed droplet forming portion in the outward direction, the recessed droplet forming portion is easily contaminated by the outside air and the like. When the liquid chemical is dropped below, the liquid chemical contacts the concave droplet forming part and is dropped, and then the liquid droplets remaining in the concave liquid forming part flow back into the liquid medicine container. Therefore, there is a problem in hygiene. L In addition, the above-mentioned drug solution container is required to be particularly safe and sanitary because the drug solution is directly administered to human eyes, ears, and nose. For this reason, chemicals and the containers that contain them need to be sterilized at the manufacturing plant.With conventional chemical containers, whether the chemical solution nozzle is manufactured in-house or purchased from another company However, the costs associated with sterilization were not negligible.

As another type of chemical liquid container, a parison made by melting the raw material resin is blow-molded to produce a hollow molded product in which the container body and the screw opening are integrally formed, and then the screw opening is opened. There is known a drug solution container in which a screw opening is fused after a drug solution is filled. As shown in Fig. 6, this chemical solution container uses a spike pin 96 provided inside the screw-in cap 95 to allow the consumer to screw the cap into the screw hole 97 during use, and attach the cap to the top surface of the screw hole. It is used by opening a pore for drug solution administration.

Certainly, this type of liquid container does not require a liquid nozzle to be mounted on the top of the screw hole, so it can solve the problem of the liquid container above, but consumers screw in the cap. At that time, there was a problem in that the safety and hygiene could not always be sufficiently ensured because the cut resin waste could enter the inside of the container. Further, in this type of chemical solution container, as the number of times the spike pins 96 are attached and detached increases, the pores for administering the chemical solution gradually widen, and the droplets formed during the administration of the chemical solution increase. There was also a problem that it was difficult to maintain a constant dose of the solution.

The present invention has been made in view of the above-mentioned problems found in a conventional drug solution container in which a mouth and a container body are formed into a body, and has a main object at the time of dropping a drug solution, particularly at the time of instillation. A mouth structure that is safe without harming the eyes, can keep the drug solution dripped and the dose constant even after repeated use, is excellent in hygiene, and is also excellent in continuous production stability. It is an object of the present invention to provide a chemical solution container having the same and a method for manufacturing the same. Disclosure of the invention

In the chemical solution container of the present invention, the container body and the mouth are formed into a body, and A liquid medicine container made of a thermoplastic resin in which a liquid medicine is filled in a liquid container, wherein a convex or planar liquid is formed at a tip of the mouth to form a liquid medicine discharged from the inside of the container as droplets of a predetermined size. A liquid droplet forming surface is formed, and a central portion of the liquid droplet forming surface is formed with a pore for discharging a chemical solution penetrating the liquid droplet forming surface.

The convex shape of the droplet forming surface is preferably in the range of 30 degrees from the plane, more preferably in the range of 20 degrees from the plane, and more preferably in the range of 12 degrees from the plane. Is particularly preferred.

According to the liquid medicine container of the present invention, by pressing the container body, the liquid medicine inside the container is smoothly discharged from the pores without collecting at the tip of the mouth, and the discharged liquid medicine has its own surface tension. As a result, droplets of a predetermined size can be formed on the droplet forming surface, so that the dose of the drug solution can be constantly maintained at a constant level, and the drug solution can be safely dropped without injuring eyes, especially when instilling. It is also excellent in hygiene. Further, according to the mouth structure of the chemical solution container, it is not necessary to fit a complicated shaped member into the tip of the mouth at the time of secondary processing of the mouth, and only the pores need to be formed. The liquid medicine container can be manufactured continuously and stably.

In the present invention, the entire surface constituting the tip of the mouth may be a droplet forming surface, or a part thereof may be a droplet forming surface. In particular, in the latter case, it is preferable to provide a convex portion at the center of the tip of the mouth, and use the top surface as a droplet forming surface. By providing such a convex portion, a droplet of a predetermined size can be formed regardless of the diameter of the upper peripheral side surface of the mouth. In other words, when the entire surface forming the tip of the mouth is the droplet forming surface, even when the diameter of the upper peripheral side surface of the mouth is large, the droplet forming surface is controlled to a predetermined size in order to control the size of the droplet. However, in such a case, the upper peripheral side surface of the mouth is tapered toward the droplet forming surface, so that a droplet is formed on the periphery of the droplet forming surface. ,

In some cases, the necessary amount of edges cannot be secured. However, if a convex portion is provided at the center of the front end of the mouth and its top surface is used as a droplet forming surface, the above problem is solved, and a droplet of a predetermined size can be formed.

When adopting such a novel droplet forming means, it is preferable to set the outer diameter of the droplet forming surface to a range of 1 to 6 mm, and particularly to a range of 2 to 4 mm. Preferred. By setting such a range, it is possible to form a droplet having a suitable size (a size corresponding to a drop amount of 25 to 1001). The outer diameter of the droplet formation surface shown above can be set to an optimum value by using the surface tension of the chemical as an index.Specifically, when the surface tension of the chemical is large, the outer diameter is reduced. On the other hand, when the surface tension of the chemical is small, the outer diameter can be set according to each chemical by increasing the outer diameter. Further, it is preferable to set the diameter of the tip end side of the pore for discharging the chemical solution in the range of 0.05 to 0.9 mm in accordance with the amount of dripping. That is, the diameter of the pores may be formed mainly for the purpose of discharging the chemical solution, and from such a viewpoint, it is preferable that the diameter be as small as possible as described above.

As the raw material resin constituting the chemical solution container of the present invention, those having a flexural modulus in the range of 500 to 500 OOMPa are preferable, and those having a flexural modulus in the range of 150 to 400 MPa are preferable. More preferred. By using a thermoplastic resin having such a bending elastic modulus, a liquid droplet forming surface processed into a convex shape or a planar shape can be easily formed. According to the study by the present inventors, polyethylene terephthalate (PET) can be mentioned as a thermoplastic resin satisfying such a requirement.

The liquid medicine container of the present invention, in addition to the above configuration, further comprises a pedestal portion which is slightly raised from the periphery at the tip of the mouth, and the top surface of the pedestal portion has a predetermined size for the liquid medicine discharged from the inside of the container. A droplet forming surface processed into a planar shape for forming a droplet is formed, and a flange protruding in a substantially horizontal direction with respect to a side wall of the pedestal portion is provided on a periphery of the droplet forming surface. Characterized by being formed Set to 0. By adopting such a configuration, when the chemical liquid container is dropped and the chemical liquid container is to be erected from the inclined state, the chemical liquid remaining on the droplet forming surface runs down the peripheral edge of the liquid liquid to form a liquid. Sagging can be effectively prevented.

In addition to the above-described configuration, a drug solution container having an excellent effect of preventing liquid dripping is provided with a pedestal portion which is slightly raised from the periphery at the tip of the mouth, and the top surface of the pedestal portion is discharged from the inside of the container. The surface of the pedestal portion is formed with an annular flange portion that protrudes in a substantially horizontal direction, and is formed on a flat surface of a droplet forming surface for forming a chemical solution to be formed as droplets of a predetermined size. It may be done. By adopting such a configuration, in addition to the above-described effect of preventing dripping, the droplet forming surface that forms droplets when the chemical liquid is dropped, and the dripping of the chemical liquid remaining on the droplet forming surface after the chemical liquid is dropped, Since the annular flanges to be prevented can be configured independently of each other, the degree of freedom in designing the chemical solution container can be increased in accordance with the tip shape and size of the liquid injection portion of the chemical solution container.

In the present invention, as described below, as one of manufacturing methods for forming pores for discharging a chemical solution, a pin member is lowered from above a droplet forming surface at the tip of a mouth processed into a convex or planar shape. It is driven vertically into the direction to penetrate the inside of the mouth, and then the pin member is pulled out.

More specifically, in the method for producing a drug solution container of the present invention, the container body and the mouth are formed into a body, and the tip of the portion B is provided with a liquid droplet forming surface processed into a convex shape or a flat shape, And, using a molding container made of a thermoplastic resin filled with a chemical liquid therein as a work piece, fitting a molding member having a cavity having substantially the same shape as the upper portion of the mouth including the tip of the mouth into the cavity. While the upper part of the mouth is melted by heat, a pin member is driven into the center of the tip of the mouth to penetrate the inside of the mouth, and then the pin member and the molded member are separated from the part. I do. „

0 By adopting such a manufacturing method, the secondary processing of the tip of the mouth is practically only the formation of pores using a pin member, which is very simple. Can be manufactured stably with good yield.

Further, instead of the above-mentioned pin member, the chemical liquid container of the present invention can also be manufactured by irradiating a laser beam to the center of the tip of the mouth to form a fine hole for discharging the chemical liquid. . By employing such laser processing, the processing accuracy of the pores can be improved.

The liquid medicine container of the present invention is characterized in that, in addition to the above configuration, the diameter of the hole for discharging the liquid medicine is larger at the rear end side of the mouth than at the tip side of the mouth. In addition to the above effects, the conventional nozzle has a droplet forming portion in which the opening wall of the pore for discharging the chemical liquid has a concave shape in the outward direction in addition to the above-described effects by adopting such a substantially C-shaped cross section. Therefore, the concave-shaped droplet forming portion is easily contaminated by the outside air or the like. When a chemical solution is dropped in such an environment, the chemical solution contacts the concave-shaped droplet forming portion and is dropped. In contrast to the structure in which the droplets remaining in the droplet forming portion flow back into the chemical solution container, there is a problem in hygiene. Since all of the liquid is oriented toward the inside of the chemical container, a small amount of the chemical remaining on the opening walls of the pores will come into contact with the outside of the liquid container when the container body is depressed after the dripping of the liquid. And is used for subsequent use while maintaining a high sanitary condition Together, after dropping the drug solution, for the chemical to the opening wall of the pores leaving only trace amounts, can also be avoided effectively risk from drug deposition of crystal.

As a method for reliably manufacturing the chemical solution container having the above-mentioned pores having a substantially eight-shaped cross section, a container body and a mouth are formed into a body, and the tip of the portion is convex or flat. With a liquid droplet forming surface that has been processed into Using a molded container made of thermoplastic resin as a workpiece, a laser beam is applied to the center of the droplet forming surface while the irradiation angle of the laser beam to the droplet forming surface of the mouth is kept constant. While irradiating, a method of changing the irradiation direction of the laser light on the droplet forming surface may be used. Here, the “irradiation angle” means an angle between a laser beam incident on the droplet forming surface and a normal line of the droplet forming surface. Further, “changing the irradiation direction of the laser beam” means that one laser beam is emitted from at least two or more different irradiation directions from a number of irradiation directions from the circumferential direction to the center of the droplet forming surface. Irradiation.

'More specifically, for example, the container body and the mouth are formed into a body, and the tip of the b is provided with a droplet forming surface that is processed into a convex shape or a flat shape, and the inside is filled with a chemical solution. While a molding container made of a thermoplastic resin is used as a workpiece, and the laser beam irradiation angle with respect to the droplet forming surface of the mouth is kept constant, the central portion of the droplet forming surface is irradiated with laser light. And a method of rotating the workpiece using a straight line passing through the center of the droplet forming surface in a direction perpendicular to the droplet forming surface as a rotation axis. According to this method, the workpiece can be rotated around the normal line of the droplet forming surface as a rotation axis while the laser oscillator serving as the laser light source is fixed, so that the manufacturing equipment can be downsized. be able to.

As another example, for example, a container body and a mouth are formed into a body, and the tip of the b has a droplet forming surface that is processed into a convex shape or a flat shape, and the inside is filled with a chemical solution. A molded container made of a thermoplastic resin is used as a workpiece. In a state where the irradiation angle of the laser beam with respect to the liquid droplet forming surface of the mouth is kept constant, the center of the liquid droplet forming surface is defined as the apex angle, and the laser is formed. While emitting a light, when a light source is rotated to form a cone, a laser beam is applied to the center of the droplet forming surface from a plurality of points on a circular orbit forming the bottom of the cone. A method of holding the molded object with a fixed axis set to a straight line passing through the center of the droplet forming surface in a direction perpendicular to the droplet forming surface.

According to this method, if a plurality of laser oscillators serving as light sources of laser light are used, it is not necessary to rotate both the laser oscillator and the molded object during manufacturing, so that the chemical solution container of the present invention can be more reliably. It can be manufactured stably. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a cross-sectional view showing an example of the drug solution container of the present invention. FIG. 2 is an enlarged cross-sectional view showing an example of the mouth structure of the drug solution container A. FIG. 3 is a manufacturing process diagram showing an example of a method for manufacturing a molded container filled with a chemical solution, which is a starting container of the chemical solution container of the present invention. FIG. 4 is a manufacturing process diagram showing an example of a method for manufacturing a chemical solution container according to the present invention. FIG. 5 is an enlarged sectional view showing a screw opening of a conventional chemical solution container. FIG. 6 is an enlarged sectional view showing a screw opening of a conventional chemical solution container. FIG. 7 is an enlarged sectional view showing an example of the mouth structure of the chemical solution container B. FIG. 8 is an enlarged cross-sectional view showing an example of the embodiment of the mouth structure of the drug solution container having a flange. FIG. 9 is a schematic view showing an example of a method for manufacturing the chemical solution container B. BEST MODE FOR CARRYING OUT THE INVENTION

FIG. 1 is a cross-sectional view showing an example of the drug solution container of the present invention. The chemical container A is made of thermoplastic resin as a raw material resin, and the container main body 23 and an opening 61 provided on the upper part thereof are integrally formed by blow molding, and the chemical liquid 31 is contained therein. Is filled. The mouth 61 is composed of a body 62 for attaching a cap (not shown) and a liquid injection section 63 provided on an upper portion thereof. A convex thread portion 62 a for attaching a cap is spirally formed on the outer peripheral side surface of the body portion 62, and the liquid injection portion 63 has a peripheral side surface of the mouth. It is a conical cylindrical body that tapers to the tip and is cut at the tip. The tip of the liquid injection part 63 has a convex shape or a flat shape and is viewed from above. _A droplet forming surface ₆₄ having a circular shape is formed. At the center of the droplet forming surface 64, there is formed a pore 65 for discharging a chemical solution which vertically penetrates the droplet forming surface. ing.

In the present invention, the pore 65 serves as an outlet for discharging the chemical solution 31 inside the container to the outside of the container by the pressure applied to the inside of the container when the body of the container body 23 is pressed. Things. Therefore, as shown in FIGS. 2 (a) and 2 (b), the cross-sectional shape of the pore 65 in the vertical direction must have a constant opening diameter in the vertical direction and penetrate the droplet formation surface. Is generally preferred.

Further, in the present invention, the droplet forming surface 64 mainly has a role of forming the chemical liquid 31 discharged from the pores 65 as droplets of a predetermined size.

The vertical cross-sectional shape of the pores 65 is determined from the viewpoint of maintaining the hygiene of the drug solution when used repeatedly and avoiding the danger due to crystal precipitation of the drug, from the mouth tip side. It is preferable to increase the diameter at the rear end side of the part (see FIGS. 7 (a) and 7 (b)). That is, in the conventional nozzle, since the opening wall of the pore for discharging the chemical liquid has the concave-shaped droplet forming portion in the external direction, the concave-shaped droplet forming portion is easily contaminated by outside air and the like. When the chemical solution is dropped in the environment, the chemical solution comes into contact with the concave-shaped droplet forming portion and is dropped, and then flows back into the inside of the liquid droplet container remaining in the concave-shaped droplet forming portion. Although there is a problem in hygiene due to the use of such a hole, the adoption of such a pore having a substantially figure-eight-shaped cross section allows the opening wall that constitutes the pore to face the inside of the chemical container, so that the When the container body is depressed after dripping and administration, a small amount of the drug solution remaining on the opening wall of the pores remains in a highly hygienic state without contacting the outside of the drug solution container. When used repeatedly for a long time because it is used for later use Hygienic chemical liquid is close to the initial state is effectively maintained. Also, since only a trace amount of the drug solution remains on the opening walls of the pores after dropping or administering the drug solution, there is a danger of, for example, dropping of solids onto the eyeball due to drug crystallization and incorrect usage of the component amount. Can be effectively avoided. In the following description, when the chemical solution container having the above-mentioned pores having a substantially eight-shaped cross section is referred to as “chemical solution container B”. j _Q Next, the reason for creating the mouth structure of the drug solution container of the present invention will be described. First, in the liquid medicine container of the present invention, it is necessary to drop and administer certain droplets at the time of use, so that when the container body is pressed, droplets of a certain size are always formed, and a certain amount of droplets are formed. It is necessary to adopt a mouth structure that can administer the drug dropwise. Further, in the present invention, a molded container in which a container body and a mouth portion are formed into a body, and the inside thereof is filled with a drug solution, is once manufactured by blow molding, and then a solution for discharging a drug solution is provided at the tip of the mouth portion. A manufacturing process in which pores are separately formed is adopted. For this reason, when the container body is pressed, droplets of a certain size are always formed, and a mouth structure that can dispense a certain amount of droplets and that has excellent continuous productivity is adopted. The point is that.

The inventor first fitted a molding member at the tip of the mouth portion of the molded container once manufactured to form a concave portion, and examined a mouth structure in which a pore was formed at the lowermost portion of the concave portion. When used, the drug solution tends to accumulate more than necessary in the space inside the container formed around the recess with bubbles, and when the container body is pressed, the drug solution is filled with the bubbles. It was found that since the liquid was discharged to the outside of the container, smooth discharge of the chemical solution accompanying the pressing was easily hindered, and it became difficult to form droplets of a certain size.

Therefore, the inventor of the present invention has proposed a method in which the mouth end of the container does not have the bubble forming space as described above, as shown in FIG. 1 or FIG. 2 (a) and (b). When the upper surface of the tip was processed into a convex shape (see Fig. 2 (a)) or a flat shape (see Fig. 2 (b)), the chemical solution inside the container hardly accumulated in the inside of the tip of the mouth. It was smoothly discharged from the pore 65, and in addition, a droplet of a certain size was formed on the droplet forming surface 64 at the tip of the mouth, and it was confirmed that a certain amount of droplets could be dispensed. .

Further, in the present invention, in addition to the configuration in which the entire surface forming the front end of the mouth portion 61 is used as the droplet forming surface as shown in FIGS. 2 (a) and 2 (b), the configuration shown in FIG. As described above, a part thereof can be used as the droplet forming surface 64. In this case, a projection should be provided at the center of the tip of the mouth, and the top surface should be the droplet formation surface 64. j ^ is preferred. The overall shape of the projection may be a columnar shape as shown in Fig. 2 (c), or a shape that tapers toward the droplet formation surface (for example, a trapezoidal shape). Good. By providing such a convex portion, a droplet of a predetermined size can be formed regardless of the diameter of the peripheral side surface of the liquid injection portion 63 of the mouth portion 61. That is, when the entire surface constituting the tip of the mouth is the droplet forming surface, the size of the droplet is controlled even when the diameter of the peripheral side surface constituting the liquid injection portion 63 of the mouth 61 is large. In such a case, it is necessary to keep the droplet forming surface at a predetermined size, but in such a case, the liquid injection section 63 is tapered toward the droplet forming surface, and as a result, the droplet at the periphery of the droplet forming surface is reduced. It may not be possible to secure the required amount of edge necessary to form the surface. However, if a convex portion is provided at the center of the tip of the mouth and the top surface is the droplet forming surface 64, the size of the droplet forming surface can be arbitrarily controlled, and the above problem is solved. As a result, droplets of a predetermined size can be formed.

In the present invention, it is preferable that the diameter of the liquid injection part 63 is larger than the amount of the liquid droplet. With this, when the liquid medicine container is used, the liquid medicine can be dropped and administered without bubbles remaining in the liquid injection section 63.

In the present invention, the size of the droplet can be controlled by the outer diameter of the droplet forming surface 64. Here, in the present specification, the “outer diameter of the droplet forming surface” refers to a portion along the droplet forming surface from one end of the droplet forming surface to the other end through the central portion. In the present invention, the length is preferably set to a range of 1 to 6 mm. In addition, it is preferable that the diameter of the tip end side of the pore for discharging the chemical liquid is as small as possible. In the present invention, it is preferable to set the diameter in the range of 0.05 to 0.9 mm.

Further, in the present invention, as shown in FIGS. 2 (a) and 2 (b), it is preferable that the periphery of the droplet forming surface 64 is subjected to chamfering.

According to the present invention, in addition to the droplet forming surfaces shown in FIGS. 2 and 7 above, a flange portion for effectively preventing dripping after the completion of dropping of the chemical solution is provided as the tip structure of the mouth portion of the chemical solution container. Together j ^ is preferred. FIG. 8 (a) shows a first embodiment of a chemical solution container having a force and a bulge. In FIG. 8 (a), a pedestal part 66 slightly protruding from the periphery is provided at the tip of the mouth, and the top surface of the pedestal part 66 is a liquid droplet forming surface 64 processed into a planar shape. ing. A flange 67 projecting in a substantially horizontal direction with respect to the side wall 68 of the pedestal 66 is formed on the periphery of the droplet forming surface 64. By adopting such a flange portion 67, when the chemical solution is dropped and the chemical solution container is to be erected from an inclined state, the chemical solution remaining on the droplet forming surface is below the flange portion 67. The dripping along the side can be effectively prevented.

FIG. 8 (b) shows a second embodiment of the chemical solution container having an excellent liquid dripping prevention effect. In FIG. 8 (b), a pedestal part 66 slightly protruding from the periphery is provided at the tip of the mouth, and the top surface of the pedestal part 66 is the same as the droplet forming surface 64 processed in a planar shape. Have been. On the side wall 68 of the droplet forming surface 64, an annular flange portion 69 protruding in a substantially horizontal direction is formed. In addition to the above-described liquid dripping prevention effect, the liquid forming surface 64 that forms liquid droplets when the chemical liquid is dropped, and the chemical liquid remaining on the liquid droplet forming surface after the chemical liquid is dropped by adopting a force and a curl configuration. Since the annular flanges 69 for preventing liquid dripping can be configured independently of each other, the degree of freedom in the design of the chemical solution container can be increased in accordance with the shape and size of the tip of the liquid injection section of the chemical solution container. Can be.

In each of (a) and (b) of FIG. 8, the thickness of the flange portion 67 and the annular flange portion 69 is preferably as thin as possible and more preferably from the viewpoint of exhibiting an excellent liquid dripping prevention effect. Is from 0.05 to 3.0 mm, more preferably from 0 :! to 0.3 mm.

In the present invention, it is not always necessary to provide the above-mentioned convex thread portion 62, and a form in which the outer peripheral side surface of the mouth body portion 62 is flattened and a cap is fitted may be adopted. In addition, as for the shape of the outer peripheral side surface of the liquid injection part 63, other shapes, for example, a cylindrical shape can be adopted in addition to the shape tapered toward the tip as described above.

Subsequently, a method for manufacturing the chemical solution container of the present invention will be described. Fig. 3 shows the chemical solution container of the present invention. The starting container j _3, in which the drug solution is shown an example of a method of manufacturing the molded container filled. FIG. 4 shows an example of a method for producing a chemical solution container according to the present invention. In the following, an embodiment of the method of manufacturing the chemical solution container A shown in FIG. 1 will be taken as an example. First, a method of manufacturing a molded container filled with the chemical solution shown in FIG. 3 will be described. Next, the chemical solution container shown in FIG. A method for manufacturing the same is described.

[Method of manufacturing molded container filled with chemical solution]

In the present invention, the method of manufacturing the molded container 26 filled with the chemical solution (hereinafter simply referred to as “molded container”) is not particularly limited, but a known molding and filling apparatus is considered in view of productivity, cost, and the like. It is preferable to use a molding and filling system (BFS system) that uses a sphere. Further, the molding and filling device is preferably installed in a sterile room from the viewpoint of safety and hygiene.

The manufacturing process shown in FIG. 3 schematically shows only the molding and filling portion centering on the mold. The mold 11 includes mold bodies 12 and 13 for molding the container body 23, and an upper portion thereof. The crimping seal dies 14, 15 for forming the mouth 61 of the container provided. These crimping seal dies 14 and 15 are provided with cavities (spaces) 14a and 15a corresponding to the mouth of the container, and the dies 12 and 13 have the shape of the container itself. The cavities (spaces) 12a and 13a corresponding to are provided.

The series of steps can be roughly divided into (1) extrusion of molten resin, (2) blow molding, (3) filling with a chemical solution, (4) sealing step, and (5) removal step. .

(1) First, a molten resin is extruded from an extruder (not shown) and supplied to a blow head 41 for blow molding. The molten resin is extruded downward from the crosshead 41 as a cylindrical parison 21 to the lowermost portions of the cavities 12 a and 13 a of the mold bodies 12 and 13.

(2) After closing the left and right mold bodies 12 and 13 and moving the cross head 41 upward, the blowing nozzle 42 is inserted from above the mold 11. And blow nozzle 42 ,,

By blowing air from 14, a hollow molded product 22 having a container body 23 and a mouth 24 is formed. An opening 25 whose diameter increases upward is formed at the mouth 24 of the hollow molded product 22.

The blowing nozzle 42 is usually a double pipe of a supply / exhaust passage for both supplying and discharging blowing air and a chemical supply nozzle for filling a chemical liquid described later.

(3) A predetermined amount of the chemical solution 31 is filled into the hollow molded product 22 from the filling nozzle 42 a for supplying the chemical solution inside the blowing nozzle 42. The liquid medicine 31 to be filled in the present invention is not limited by the components and types of the liquid medicine as long as they are used as eye drops, ear drops or nasal drops.

(4) After the blowing nozzle 42 moves above the mold 11, the crimping seal molds 14 and 15 close, and the opening 25 above the mouth of the hollow molded product 22 melts with the crimping force. A new mouth portion 61 is formed by the sealing. In addition, the chemical solution 31 inside the container is sealed by this step.

(5) The mold 11 is opened, and the molding container 26 is removed. From the viewpoint of the production stability of the secondary processing described later, it is preferable that all the structures except the pores are formed at this stage, as shown in FIG.

[Manufacturing method of chemical solution container]

FIG. 4 shows an example of a method of manufacturing the chemical solution container A. In the present embodiment, the chemical liquid container A is manufactured by newly forming a fine hole for discharging the chemical liquid at the center of the droplet forming surface 64.

A series of steps are outlined, (1) a step of fitting the molding member 51 into the liquid injection part 63 and heating.

(2) a step of driving a pin member 57 into the droplet forming surface 64 to form a pore for discharging a chemical solution,

(3) It can be divided into a removal step of separating the molded member 51 and the pin member 57. The manufacturing equipment that performs this series of molding steps may be a production line that is independent of the above-described molding vessel 26 manufacturing equipment, or may be incorporated into the molding vessel 26 production line to perform a series of manufacturing: . _

1 Regardless of which of the above production lines is adopted, it is preferable that the equipment for manufacturing the chemical solution container A be installed in a sterile room. Hereinafter, each step will be described with reference to FIG.

The molding member 51 moves downward from above the liquid injection part 63 provided at the tip of the molding container 26 and is fitted into the liquid injection part 63 (see FIGS. 4 (a) and 4 (b)). In FIG. 4, the molding container 26 as the object of molding in the present embodiment and the chemical solution container A after molding are front views centered on the mouth 61, respectively. For the part 63, a cross-sectional view is schematically shown for convenience of explanation. The molded member 51 mainly has a role of finish-molding the entire liquid injection portion 63, and includes a main body 51a, heating means 53 mounted around the main body 51a, and The cavity 52 has a shape substantially the same as that of the liquid injection part 63 provided at the center of the main body 51a, and is formed from the center of the upper end of the cavity 52 to the upper end of the molding member 51. An insertion hole 54 for inserting a pin member 57 described later is provided so as to penetrate vertically.

When the molding member 51 is fitted into the liquid injection section 63, the entire liquid injection section 63 is heated by the heating means 53. In this embodiment, the term “heating means” refers to a means capable of heating the object to be heated by heat conduction so as to be able to control the temperature, regardless of direct heating by surface contact or indirect heating by a heat medium. A heater, a water bath, an oil bath, hot air or the like is preferably used. In addition, molding conditions such as temperature and time can be appropriately designed depending on the type of the raw material resin, so that conditions cannot be uniformly determined. For example, the molding temperature is generally preferably in the range of 80 to 150 ° C.

Next, in a state where the molding member 51 is fitted into the liquid injection part 63, a pin member 57 is inserted through the insertion hole 54 of the molding member 51. Then, the pin member 57 is driven into the center of the droplet forming surface 64 and penetrated into the liquid injection portion 63 (see FIG. 4 (c)). Then, after a lapse of a predetermined time, the pin member 57 and the molding member 51 are detached from the liquid injection section 63, and a fine hole 65 is formed through the center of the droplet forming surface 64 to form a chemical solution. Container A is manufactured (see Fig. 4 (d)).

In this embodiment, the pin member 57 has a role of forming a pore 65 for discharging a chemical solution. , „

1 o member. The shape of the pin member 57 is not particularly limited as long as the droplet forming surface 64 can be pierced to a predetermined size, but in general, the body is a cylindrical body, and the tip is formed in a conical body. Are preferred. The diameter of the cylindrical body is preferably in the range of 0.05 to 1.0 mm. The material of the pin member can be any metal, ceramic, or plastic as long as the droplet forming surface 64 can be pierced to a predetermined size. Further, in order to maintain continuous molding stability, it is preferable to use the pin member 57 at a room temperature of about 20 ° C.

As described above, the pin member 57 is pierced and penetrated by being driven without being rotated with respect to the liquid droplet forming surface 64, and the fine pores formed by this are small, so that no resin dust is generated. . For this reason, there is no fear that cutting dust of the resin will enter the container during molding, and a chemical solution container excellent in safety and hygiene can be provided.

In this embodiment, the above-mentioned pin member 57 is configured to be connected to the molding member 51. Specifically, the pin member 57 is fixed to the support 56 at the other end. The support 56 has substantially the same size as the above-mentioned molded member 51, and a connecting member 55 is provided on one peripheral edge thereof. On the other hand, the molding member 51 is provided with a fitting groove 55a at the periphery thereof, into which the connecting member 55 is fitted. Then, the connecting member 55 is fitted into the fitting groove 55a, and slides in the fitting groove 55a to move up and down. By adopting a method of connecting the pin member 57 and the forming member 51 via the connecting member 55 in this way, the control member (not shown) fits the forming member 51 into the liquid injection portion 63. The joining process, the driving process using the pin member 57, and the removal process are efficiently controlled.

In the embodiment, it is naturally possible to sequentially perform the steps of this embodiment as separate and independent members without connecting the pin member 57 and the molding member 51.

Further, in the present embodiment, the heating means 53 is attached to the molded member 51, but the present invention is not limited to this, and other embodiments can be adopted. For example, before the molding member 51 is fitted to the liquid injection part 63, independent heating means (for example, hot air heater ^ 飞 etc.) to heat the liquid injection section 63, and then, using the molding member 51 to which the heating means is not attached, the same hot melt molding as in this embodiment can be performed.

The resin used in the chemical solution container of the present invention is a thermoplastic resin that can be blow-molded, and has a flexural modulus of 500 to 500 obtained by a flexural property test according to ASTM D790. Resins in the range of MPa are preferred, and resins in the range of 150 to 400 MPa are more preferred. Specifically, semi-rigid plastics or hard plastics excluding soft plastics such as low-density polyethylene (LDPE) and vinyl chloride resin (PVC) having a flexural modulus of less than 500 MPa are preferably used. Further, a resin having a flexural modulus of more than 500 MPa is generally not suitable for the present invention in terms of production cost, moldability and the like.

Specific raw material resins include high-density polyethylene (HDPE), polypropylene (PP), polyethylene terephthalate (PET), polystyrene, ABS resin, methacrylyl resin, and polybutylene terephthalate (PBT). One or more resins selected from polyamide (PA), polycarbonate (PC), polyacetal, modified polyphenylene ether (m-PPE), polyethylene naphthate (PEN), and polyarylate (PAR) It is preferably used. In addition, these raw material resins may be copolymers such as random copolymers and block copolymers, or may be polymer blends of these, as long as they are within the above range of the flexural modulus. Among the above resins, polyethylene terephthalate (PET) can be mentioned as a resin particularly suitable for the present invention. Also, in the present invention, the pores can be formed by irradiating the central part of the mouth with laser light instead of using the above-mentioned pin member. The type of laser is not particularly limited as long as it is commonly used for resin processing.However, in the present invention, from the viewpoint of excellent processing suitability of the obtained chemical solution container, CO ₂ laser, which is a type of infrared laser, is used. A YAG laser is preferably used. By forming the pores using this laser processing, the diameter of the pores can be made even smaller than when the above-mentioned pin members are used. It is possible to reduce the diameter by 1 o (for example, the pore diameter is 0.01 mm), and the processing accuracy can be improved.

Next, a method of manufacturing the chemical solution container B having the above-described pores having a substantially eight-shaped cross section will be described. As a method of manufacturing the chemical solution container B, for example, the molding container obtained in the manufacturing process of FIG. 3 is used as a workpiece, and the laser beam irradiation angle with respect to the droplet forming surface of the mouth is kept constant. The laser beam is applied to the center of the droplet forming surface, and the object to be rotated is a straight line passing through the center of the droplet forming surface in a direction perpendicular to the droplet forming surface. Is rotated. According to this method, it is only necessary to rotate the workpiece around the normal line of the droplet forming surface as the rotation axis while the laser oscillator serving as the light source of the laser beam is fixed. Can be achieved.

As a method of rotating the workpiece, for example, a method of continuously rotating the workpiece at a predetermined speed around the rotation axis while continuously irradiating the laser beam, or a method of fixing the workpiece. In this state, the workpiece is irradiated with laser light, and then the workpiece is rotated around the rotation axis by a predetermined angle (for example, 60 degrees, 90 degrees, 120 degrees, or 180 degrees) and then fixed. And re-irradiating the laser beam again until the rotation axis of the workpiece rotates once. In the former method, the cross section of the obtained pores can be processed into a clean circular shape, so that the amount of the drug solution remaining in the pores after dropping and administration of the drug solution can be further reduced. In the latter method, the laser beam may be irradiated at a necessary timing, so that the manufacturing cost can be reduced.

The latter method will be specifically described with reference to the drawings. In FIG. 9, for example, the workpiece 26 obtained in the manufacturing process of FIG. 3 has a laser beam 1 from above, with the body 62 of the mouth fixed by a container rotating jig 101. Irradiation by 10 Here, the container rotating jig 101 is composed of a substantially rectangular fixed jig 102 and a movable jig 103, and the fixed jig 102 and the movable jig 103 are both formed. Is rotatably joined at one end thereof via a fixing member 104. The movable jig 103 is set in advance in accordance with the irradiation angle (for example, 10 degrees) of the laser beam 110 to the droplet forming surface 64 of the workpiece 26. ^ 9 Relative angle to fixture 102 is determined.

A bearing 105 rotatable at a predetermined speed is fitted in the movable jig 103, and a body 6 2 of a workpiece 26 is fitted on an inner peripheral surface of the bearing 105. A positioning member 106 for holding the lens at a predetermined position is fitted. The workpiece 26 is held on the inner peripheral surface of the positioning member 106 such that the focal point of the laser beam is on the droplet forming surface 64. In this state, for example, the center of the droplet forming surface 64 is irradiated with one laser beam 110 under the conditions of a pulse width of 0.3 to 0.1 milliseconds and an irradiation time of 0.3 to 0.7 seconds. I do. After the irradiation with the laser beam 110, the bearing 105 is rotated to fix the workpiece 26 in a state rotated, for example, 120 degrees around the rotation axis 120. Then, a laser beam 110 is irradiated under the same conditions as above, and the above-described series of steps is repeated until the rotation axis 120 of the work piece 26 is rotated S1 once, whereby the obtained pores are longitudinally cut. A chemical solution container B having a substantially eight-shaped surface and a three-lobe cross section is manufactured.

Through the above manufacturing process, a drug solution container having a mouth structure particularly suitable for administration of drug solutions such as eye drops, ear drops, and nasal drops is manufactured. In the present invention, if a cap is attached to the mouth of the drug solution container in a sterile room after the end of the process, the manufacturing process of the drug solution container can be performed from the beginning to the end in the sterile room, and safety and hygiene can be achieved. It is possible to provide a drug solution container having excellent properties.

Industrial applicability

As described above, according to the liquid medicine container of the present invention, by pressing the container body, the liquid medicine inside the container is smoothly discharged from the pores without accumulating inside the tip of the mouth, and the discharged liquid medicine Since a liquid droplet of a predetermined size can be formed on the droplet forming surface by its own surface tension, it is possible to always maintain a constant amount of the liquid medicine, and to drop the liquid medicine, especially when instilling the liquid. It is safe without damaging it and has excellent hygiene.

Claims

The scope of the claims

1. A container formed of a thermoplastic resin in which a container body and a mouth are formed into a body and filled with a drug solution, and the tip of the mouth is provided with a drug solution discharged from the inside of the container. A convex or planar processed droplet forming surface is formed to form a droplet of a predetermined size, and a central portion of the droplet forming surface is for discharging a chemical liquid penetrating the droplet forming surface. Chemical container with pores formed.

2. The drug solution container according to claim 1, wherein the top surface of the projection provided at the center of the tip of the mouth is a droplet formation surface.

3. The drug solution container according to claim 1 or 2, wherein an outer diameter of the droplet forming surface is in a range of 1 to 6 mm.

4. The chemical solution container according to any one of claims 1 to 3, wherein a diameter of the fine hole for discharging the chemical solution at a tip end side of the mouth is in a range of 0.05 to 0.9 mm.

5. The chemical solution container according to any one of claims 1 to 4, wherein the thermoplastic resin has a flexural modulus in a range of 500 to 500 MPa.

6. The chemical solution container according to any one of claims 1 to 5, wherein the thermoplastic resin is polyethylene terephthalate (PET).

7. At the tip of the mouth is provided a pedestal part slightly elevated from the periphery, and the top surface of this pedestal part is processed into a planar shape to form a chemical liquid discharged from the inside of the container as droplets of a predetermined size. 7. A liquid droplet forming surface, wherein a flange is formed on a peripheral edge of the liquid droplet forming surface so as to protrude substantially horizontally with respect to a side wall of the pedestal portion. Chemical solution container _t described in any

8. At the tip of the mouth is provided a pedestal part that is slightly raised from the surroundings, and the top surface of the pedestal part is processed into a flat shape to form the liquid medicine discharged from the inside of the container as droplets of a predetermined size. Droplet forming surface, and the table The chemical solution container according to any one of claims 1 to 6, wherein an annular collar portion protruding in a substantially horizontal direction is formed on a side wall of the seat portion.

9. The drug solution container according to claim 1, wherein the diameter of the pores for discharging the drug solution is larger on the rear end side of the mouth than on the front end side of the mouth.

10. Thermoplastic resin in which the container body and mouth are formed into a body, and the tip of the b has a convex or flat processed droplet forming surface and is filled with a chemical solution. A molding member having a cavity having substantially the same shape as the upper portion of the mouth including the tip of the mouth is fitted into the lower portion, and the upper portion of the mouth is thermally melted. 9. The method according to claim 1, wherein a pin member is driven into the center of the tip of the mouth to penetrate the inside of the mouth, and then the pin member and the molded member are detached from the part. The method for manufacturing a drug solution container described in (1).

1 1. Thermoplastic resin in which the container body and the mouth are formed into a body, and the tip of the b has a convex or flat processed droplet forming surface and is filled with a chemical solution. The method according to any one of claims 1 to 9, characterized in that a forming container made of is used as a workpiece, and a laser beam is applied to the center of the tip of the mouth to form a pore for discharging a chemical solution. The manufacturing method of the drug solution container described,

1 2. Thermoplastic resin in which a container body and a mouth are formed into a body, and the tip of the b has a convex or flat processed droplet forming surface and is filled with a chemical solution. A laser beam is applied to the center of the droplet forming surface while maintaining the laser beam irradiation angle on the droplet forming surface of the mouth constant while using the molding container made of 10. The method according to claim 9, wherein an irradiation direction of the laser beam on the droplet forming surface is changed.

1 3. The container body and the mouth were formed into a body, and the tip of the b was provided with a droplet forming surface that was processed into a convex or flat shape, and the inside was filled with a chemical solution. A laser beam is applied to the center of the droplet forming surface while the irradiation angle of the laser beam to the droplet forming surface of the mouth is kept constant while using a molding container made of a thermoplastic resin as a workpiece. 10. The method according to claim 9, wherein the workpiece is rotated around a straight line passing through the center of the droplet forming surface in a direction perpendicular to the droplet forming surface. Method,

14. Thermoplastic resin in which the container body and the mouth are formed into a body, the tip of the b is provided with a droplet forming surface that is processed into a convex or flat shape, and the inside is filled with a chemical solution. The laser light is emitted with the center of the droplet-forming surface as the apex angle while maintaining the irradiation angle of the laser beam on the droplet-forming surface of the mouth as a workpiece with the molding container made of When a light source is rotated to form a cone, a laser beam is applied to the center of the droplet forming surface from a plurality of points on a circular orbit forming the bottom of the cone, while the droplet forming surface is 10. The method according to claim 9, wherein the workpiece is held by using a straight line passing through the center of the droplet forming surface in a direction perpendicular to the workpiece as a fixed axis.