WO2004003561A1 - Amphiphiles a batonnets peptidiques et autoassemblage de ces derniers - Google Patents

Amphiphiles a batonnets peptidiques et autoassemblage de ces derniers Download PDF

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Publication number
WO2004003561A1
WO2004003561A1 PCT/US2003/020618 US0320618W WO2004003561A1 WO 2004003561 A1 WO2004003561 A1 WO 2004003561A1 US 0320618 W US0320618 W US 0320618W WO 2004003561 A1 WO2004003561 A1 WO 2004003561A1
Authority
WO
WIPO (PCT)
Prior art keywords
rod
peptide
composition
amphiphiles
amphiphile
Prior art date
Application number
PCT/US2003/020618
Other languages
English (en)
Other versions
WO2004003561A9 (fr
Inventor
Samuel I. Stupp
Randal C. Claussen
Original Assignee
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwestern University filed Critical Northwestern University
Priority to AU2003279912A priority Critical patent/AU2003279912A1/en
Publication of WO2004003561A1 publication Critical patent/WO2004003561A1/fr
Publication of WO2004003561A9 publication Critical patent/WO2004003561A9/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Abstract

La présente invention se rapporte à la gélification et à l'autoassemblage d'amphiphiles à bâtonnets peptidiques. On décrit également un procédé qui permet d'incorporer le gel d'amphiphiles à bâtonnets peptidiques autoassemblés dans des applications de génie tissulaire et de réparation tissulaire. On peut également l'utiliser en tant que squelette tridimensionnel pour le génie tissulaire.
PCT/US2003/020618 2002-06-27 2003-06-27 Amphiphiles a batonnets peptidiques et autoassemblage de ces derniers WO2004003561A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003279912A AU2003279912A1 (en) 2002-06-27 2003-06-27 Peptide rod amphiphiles and self-assembly of same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39261902P 2002-06-27 2002-06-27
US60/392,619 2002-06-27

Publications (2)

Publication Number Publication Date
WO2004003561A1 true WO2004003561A1 (fr) 2004-01-08
WO2004003561A9 WO2004003561A9 (fr) 2004-08-12

Family

ID=30000904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020618 WO2004003561A1 (fr) 2002-06-27 2003-06-27 Amphiphiles a batonnets peptidiques et autoassemblage de ces derniers

Country Status (2)

Country Link
AU (1) AU2003279912A1 (fr)
WO (1) WO2004003561A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006079036A2 (fr) 2005-01-21 2006-07-27 Northwestern University Methodes et compositions d'encapsulation de cellules
EP1696944A2 (fr) * 2003-12-05 2006-09-06 Northwestern University Amphphiles peptides ramifies, composes epitopes les concernant, et certaines de leurs structures auto-assemblees
GB2434363A (en) * 2005-10-14 2007-07-25 Dewan Fazlul Hoque Chowdhury Amphiphilic nanotubes and micelles comprising them for use in the delivery of biologically active agents
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7390526B2 (en) 2003-02-11 2008-06-24 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7544661B2 (en) 2003-12-05 2009-06-09 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
US7851445B2 (en) 2005-03-04 2010-12-14 Northwestern University Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use
EP2269624A2 (fr) 2007-01-12 2011-01-05 Intercell AG Protéines protectrices de S. agalactia, combinaisons associées et procédés d'utilisation
WO2011060528A1 (fr) * 2009-11-17 2011-05-26 Universite De Montreal Peptides à structure binaire et leurs utilisations dans des applications de biocapteur
EP2361969A1 (fr) 2004-09-28 2011-08-31 Ethicon, Inc. Échafaudages d'ingénierie de tissus contenant des hydrogels de peptides auto-assemblés
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8450271B2 (en) 2009-04-13 2013-05-28 Northwestern University Peptide-based scaffolds for cartilage regeneration and methods for their use
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
US9717763B2 (en) 2003-06-27 2017-08-01 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
CN110665008A (zh) * 2019-11-19 2020-01-10 南京智能高端装备产业研究院有限公司 强效溶瘤的棒状纳米组装体及其制备方法和应用

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US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods

Patent Citations (1)

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US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARUSO ET AL.: "Pregnancy outcome in relation to uterine artery flow velocity waveforms and clinical characteristics in women with antiphospholipid syndrome", OBSTETRICS & GYNECOLOGY, vol. 82, no. 6, 1993, pages 970 - 976, XP002967882 *
GALLI MONICA ET AL.: "Kaolin clotting and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta2-glycoprotein I-dependent antiphospholipid antibodies", BLOOD, vol. 86, no. 2, 15 July 1995 (1995-07-15), pages 617 - 623, XP002967878 *
IZUMI ET AL.: "The role of prothrombin and beta 2-glycoprotein I in the generation of abnormal waveform parameters in the prothrombin times from patients with antiphospholipid antibodies", BLOOD, vol. 98, no. 11, PART 2, pages 77B, XP002967880 *
POPOV ET AL.: "Comparison of DRVVT and PTT-based testing for the detection of lupus anticoagulants", CLINICAL CHEMISTRY, vol. 47, no. 6, 2001, pages A171, XP002967881 *
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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838491B2 (en) 2001-11-14 2010-11-23 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US8063014B2 (en) 2002-02-15 2011-11-22 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7745708B2 (en) 2002-02-15 2010-06-29 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US8124583B2 (en) 2002-11-12 2012-02-28 Northwestern University Composition and method for self-assembly and mineralization of peptide-amphiphiles
US7683025B2 (en) 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
US7390526B2 (en) 2003-02-11 2008-06-24 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US10383898B2 (en) 2003-06-27 2019-08-20 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US10500234B2 (en) 2003-06-27 2019-12-10 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US11000554B2 (en) 2003-06-27 2021-05-11 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US10220059B2 (en) 2003-06-27 2019-03-05 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US10195233B2 (en) 2003-06-27 2019-02-05 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US9717763B2 (en) 2003-06-27 2017-08-01 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US7544661B2 (en) 2003-12-05 2009-06-09 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
US7452679B2 (en) 2003-12-05 2008-11-18 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
EP1696944A4 (fr) * 2003-12-05 2008-11-05 Univ Northwestern Amphphiles peptides ramifies, composes epitopes les concernant, et certaines de leurs structures auto-assemblees
US8580923B2 (en) 2003-12-05 2013-11-12 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
EP1696944A2 (fr) * 2003-12-05 2006-09-06 Northwestern University Amphphiles peptides ramifies, composes epitopes les concernant, et certaines de leurs structures auto-assemblees
US8138140B2 (en) 2003-12-05 2012-03-20 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
EP2361969A1 (fr) 2004-09-28 2011-08-31 Ethicon, Inc. Échafaudages d'ingénierie de tissus contenant des hydrogels de peptides auto-assemblés
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
WO2006079036A2 (fr) 2005-01-21 2006-07-27 Northwestern University Methodes et compositions d'encapsulation de cellules
US7851445B2 (en) 2005-03-04 2010-12-14 Northwestern University Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use
US9149495B2 (en) 2005-10-14 2015-10-06 Neumara Pharma Ltd. Amphiphilic nanotubes and micelles and method of delivery of biologically active agents
GB2434363B (en) * 2005-10-14 2008-08-13 Dewan Fazlul Hoque Chowdhury Amphiphilic nanotubes and micelles comprising them for use in the delivery of biologically active agents
GB2434363A (en) * 2005-10-14 2007-07-25 Dewan Fazlul Hoque Chowdhury Amphiphilic nanotubes and micelles comprising them for use in the delivery of biologically active agents
EP2269624A2 (fr) 2007-01-12 2011-01-05 Intercell AG Protéines protectrices de S. agalactia, combinaisons associées et procédés d'utilisation
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8450271B2 (en) 2009-04-13 2013-05-28 Northwestern University Peptide-based scaffolds for cartilage regeneration and methods for their use
US8680233B2 (en) 2009-11-17 2014-03-25 Valorisation-Recherche, Limited Partnership Heteropeptides useful for reducing nonspecific adsorption
WO2011060528A1 (fr) * 2009-11-17 2011-05-26 Universite De Montreal Peptides à structure binaire et leurs utilisations dans des applications de biocapteur
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
CN110665008A (zh) * 2019-11-19 2020-01-10 南京智能高端装备产业研究院有限公司 强效溶瘤的棒状纳米组装体及其制备方法和应用

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Publication number Publication date
AU2003279912A8 (en) 2004-01-19
AU2003279912A1 (en) 2004-01-19
WO2004003561A9 (fr) 2004-08-12

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