WO2004001103A3 - Biomateriaux a base de soie et procedes d'utilisation - Google Patents

Biomateriaux a base de soie et procedes d'utilisation Download PDF

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Publication number
WO2004001103A3
WO2004001103A3 PCT/US2003/019893 US0319893W WO2004001103A3 WO 2004001103 A3 WO2004001103 A3 WO 2004001103A3 US 0319893 W US0319893 W US 0319893W WO 2004001103 A3 WO2004001103 A3 WO 2004001103A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomaterials
silk
processed
methods
avoids
Prior art date
Application number
PCT/US2003/019893
Other languages
English (en)
Other versions
WO2004001103A2 (fr
Inventor
David L Kaplan
Hyoung-Joon Jin
Gregory Rutledge
Sergei Fridrikh
Original Assignee
Univ Tufts
Massachusetts Inst Technology
David L Kaplan
Hyoung-Joon Jin
Gregory Rutledge
Sergei Fridrikh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tufts, Massachusetts Inst Technology, David L Kaplan, Hyoung-Joon Jin, Gregory Rutledge, Sergei Fridrikh filed Critical Univ Tufts
Priority to AU2003253690A priority Critical patent/AU2003253690A1/en
Publication of WO2004001103A2 publication Critical patent/WO2004001103A2/fr
Publication of WO2004001103A3 publication Critical patent/WO2004001103A3/fr

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Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D1/00—Treatment of filament-forming or like material
    • D01D1/02—Preparation of spinning solutions
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • D01F4/02—Monocomponent artificial filaments or the like of proteins; Manufacture thereof from fibroin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Textile Engineering (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Mechanical Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)

Abstract

la présente invention concerne un procédé tout aqueux de fabrication de biomatériaux à base de soie sous forme de fibres, de films, de mousse et de tapis, notamment. Au moins un polymère biocompatible tel qu'un poly(éthylene oxyde) (EPO) (matériau biocompatible bien connu), a été mélangé avec la protéine de la soi avant traitement (électrofilage). Il est apparu que cette étape permettait d'éviter certains problèmes en rapport avec des transitions conformationnelle de la fibroïne pendant la solubilisation et le re-travail à partir de la solution aqueuse qui produisent des matériaux fragilisés. De plus, ce procédé évite l'emploi de solvants organiques qui peuvent poser des problèmes lorsque les biomatériaux traités sont exposés à des cellules in vitro ou in vivo.
PCT/US2003/019893 2002-06-24 2003-06-24 Biomateriaux a base de soie et procedes d'utilisation WO2004001103A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003253690A AU2003253690A1 (en) 2002-06-24 2003-06-24 Silk biomaterials and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39092902P 2002-06-24 2002-06-24
US60/390,929 2002-06-24

Publications (2)

Publication Number Publication Date
WO2004001103A2 WO2004001103A2 (fr) 2003-12-31
WO2004001103A3 true WO2004001103A3 (fr) 2004-04-08

Family

ID=30000648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/019893 WO2004001103A2 (fr) 2002-06-24 2003-06-24 Biomateriaux a base de soie et procedes d'utilisation

Country Status (2)

Country Link
AU (1) AU2003253690A1 (fr)
WO (1) WO2004001103A2 (fr)

Cited By (8)

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US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
US9012784B2 (en) 2008-10-07 2015-04-21 Mc10, Inc. Extremely stretchable electronics
US9159635B2 (en) 2011-05-27 2015-10-13 Mc10, Inc. Flexible electronic structure
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US9450043B2 (en) 2004-06-04 2016-09-20 The Board Of Trustees Of The University Of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces

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EP3231846A1 (fr) 2003-04-10 2017-10-18 Tufts University Solution aqueuse concentrée de fibroïne de soie et son utilisation
JP2008502739A (ja) 2004-06-11 2008-01-31 トラスティーズ オブ タフツ カレッジ 絹に基づく薬物送達システム
CN100382772C (zh) * 2005-09-28 2008-04-23 南通大学 含蚕丝丝素的医用神经移植物的制备方法
CN100404081C (zh) * 2006-06-09 2008-07-23 浙江大学 一种网状组织工程支架
WO2010042798A2 (fr) 2008-10-09 2010-04-15 Trustees Of Tufts College Films en soie améliorés contenant du glycérol
US9723122B2 (en) 2009-10-01 2017-08-01 Mc10, Inc. Protective cases with integrated electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
JP6046491B2 (ja) 2009-12-16 2016-12-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ コンフォーマル電子機器を使用した生体内での電気生理学
CN102892356B (zh) 2010-03-17 2016-01-13 伊利诺伊大学评议会 基于生物可吸收基质的可植入生物医学装置
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
EP2611492A2 (fr) 2010-09-03 2013-07-10 Tufts University/Trustees of Tufts College Matériaux à base de soie dopés aux nanoparticules plasmoniques
EP4218891A1 (fr) 2010-10-19 2023-08-02 Trustees Of Tufts College Micro-aiguilles à base de fibroïne de soie et leurs procédés de fabrication
EP2678022A2 (fr) 2011-02-23 2014-01-01 Allergan, Inc. Compositions et procédés de remplacement de tissu mou améliorés
WO2012158709A1 (fr) 2011-05-16 2012-11-22 The Board Of Trustees Of The University Of Illinois Barrettes de del à gestion thermique assemblées par impression
US20140370094A1 (en) 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
MX2014005704A (es) 2011-11-09 2015-02-17 Tufts College Espumas de fibroina de seda inyectables y sus usos.
KR20230066481A (ko) 2011-11-09 2023-05-15 트러스티즈 오브 터프츠 칼리지 주사가능한 실크 피브로인 입자 및 그의 용도
KR101979354B1 (ko) 2011-12-01 2019-08-29 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 프로그램 변형을 실행하도록 설계된 과도 장치
EP2797641B1 (fr) 2011-12-29 2019-07-10 Trustees Of Tufts College Fonctionnalisation de biomatériaux pour commander la régénération et des réponses à une inflammation
WO2013123275A1 (fr) 2012-02-16 2013-08-22 Allergan, Inc. Compositions et procédés perfectionnés de remplacement de tissu mou
EP2814482A1 (fr) 2012-02-16 2014-12-24 Allergan, Inc. Compositions et procédés perfectionnés de remplacement de tissu mou
WO2013123272A1 (fr) 2012-02-16 2013-08-22 Allergan, Inc. Compositions et procédés perfectionnés de remplacement de tissu mou
EP2814526B1 (fr) 2012-02-16 2016-11-02 Allergan, Inc. Compositions et procédés perfectionnés de remplacement de tissu mou
WO2013163407A1 (fr) 2012-04-25 2013-10-31 Trustees Of Tufts College Microsphères de soie et procédés de lubrification de surface
CN103083224A (zh) * 2013-02-06 2013-05-08 东华大学 一种地塞米松缓释型药物载体的制备方法
KR20180034342A (ko) 2015-06-01 2018-04-04 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 대안적인 자외선 감지방법
BR112017025609A2 (pt) 2015-06-01 2018-08-07 The Board Of Trustees Of The University Of Illinois sistemas eletrônicos miniaturizados com potência sem fio e capacidades de comunicação de campo próximo
CN108290368A (zh) * 2015-09-17 2018-07-17 罗伯特·维洛兹·赫雷斯 承载复合面板、材料、产品及其制造和使用方法
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
US10857262B2 (en) 2016-10-31 2020-12-08 Sofregen Medical, Inc. Compositions comprising low molecular weight silk fibroin fragments and plasticizers
WO2019195350A1 (fr) 2018-04-03 2019-10-10 Vaxess Technologies, Inc. Micro-aiguille comprenant de la fibroïne de soie appliquée sur une base soluble
WO2021076798A1 (fr) 2019-10-15 2021-04-22 Sofregen Medical, Inc. Dispositifs de distribution pour l'administration et procédés de distribution de compositions
WO2023250117A2 (fr) 2022-06-24 2023-12-28 Vaxess Technologies, Inc. Applicateur pour timbre de médicament

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9450043B2 (en) 2004-06-04 2016-09-20 The Board Of Trustees Of The University Of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US9012784B2 (en) 2008-10-07 2015-04-21 Mc10, Inc. Extremely stretchable electronics
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US9159635B2 (en) 2011-05-27 2015-10-13 Mc10, Inc. Flexible electronic structure
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer

Also Published As

Publication number Publication date
AU2003253690A8 (en) 2004-01-06
AU2003253690A1 (en) 2004-01-06
WO2004001103A2 (fr) 2003-12-31

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