WO2003104441A3 - Bacterial strain, compositions derived therefrom and methods of using same for treating beta-amyloid peptide-associated deseases - Google Patents

Bacterial strain, compositions derived therefrom and methods of using same for treating beta-amyloid peptide-associated deseases Download PDF

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Publication number
WO2003104441A3
WO2003104441A3 PCT/IL2003/000485 IL0300485W WO03104441A3 WO 2003104441 A3 WO2003104441 A3 WO 2003104441A3 IL 0300485 W IL0300485 W IL 0300485W WO 03104441 A3 WO03104441 A3 WO 03104441A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial strain
methods
same
deseases
compositions derived
Prior art date
Application number
PCT/IL2003/000485
Other languages
French (fr)
Other versions
WO2003104441A2 (en
Inventor
Beka Solomon
Eugene Rosenberg
Original Assignee
Univ Tel Aviv Future Tech Dev
Beka Solomon
Eugene Rosenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tel Aviv Future Tech Dev, Beka Solomon, Eugene Rosenberg filed Critical Univ Tel Aviv Future Tech Dev
Priority to AU2003233175A priority Critical patent/AU2003233175A1/en
Publication of WO2003104441A2 publication Critical patent/WO2003104441A2/en
Publication of WO2003104441A3 publication Critical patent/WO2003104441A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

An isolated bacterial strain is provided. The isolated bacterial strain has a genome comprising a 16S nucleic acid sequence region being at least 97 % identical to SEQ ID NO: 1. Also provided are compositions derived from the isolated bacterial strains and methods of using same for treating betaAP-associated diseases.
PCT/IL2003/000485 2002-06-10 2003-06-10 Novel bacterial strain, compositions derived therefrom and methods of using same for treating beta-ap-associated deseases WO2003104441A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003233175A AU2003233175A1 (en) 2002-06-10 2003-06-10 Bacterial strain, compositions derived therefrom and methods of using same for treating beta-amyloid peptide-associated deseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38671202P 2002-06-10 2002-06-10
US60/386,712 2002-06-10

Publications (2)

Publication Number Publication Date
WO2003104441A2 WO2003104441A2 (en) 2003-12-18
WO2003104441A3 true WO2003104441A3 (en) 2004-03-25

Family

ID=29736199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000485 WO2003104441A2 (en) 2002-06-10 2003-06-10 Novel bacterial strain, compositions derived therefrom and methods of using same for treating beta-ap-associated deseases

Country Status (2)

Country Link
AU (1) AU2003233175A1 (en)
WO (1) WO2003104441A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100580078C (en) * 2007-03-02 2010-01-13 浙江工业大学 Bacillus circulans WZ-12 and its application in microorganism resolving treatment of dichloromethane
WO2017204321A1 (en) * 2016-05-26 2017-11-30 株式会社アミノアップ化学 Sleep improving agent

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL, HEIDELBERG, FRG [online] 9 June 2001 (2001-06-09), FRANCIS, C.A. & TEBO, B.M.: "Bacillus sp. MB-5 16S ribosomal RNA gene, partial sequence", XP002259686, Database accession no. AF326363 *
OZA, V.B. ET AL.: "Synthesis and Evaluation of Anthranilic Acid-Based Transthyretin Amyloid Fibril Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 1, 4 January 1999 (1999-01-04), pages 1 - 6, XP004154767 *
SOLOMON, B. ET AL.: "Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, no. 1, 9 January 1996 (1996-01-09), pages 452 - 455, XP002942850 *
SOLOMON, B. ETAL.: "Disaggregation of Alzheimer beta-amyloid by site-directed mAb", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, no. 8, 15 April 1997 (1997-04-15), pages 4109 - 4112, XP002942849 *
SOTO, C. ET AL.: "beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy", NATURE MEDICINE, vol. 4, no. 7, July 1998 (1998-07-01), pages 822 - 826, XP000914747 *

Also Published As

Publication number Publication date
AU2003233175A8 (en) 2003-12-22
WO2003104441A2 (en) 2003-12-18
AU2003233175A1 (en) 2003-12-22

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