WO2003099812A8 - Derives de phenyl-furane ou de phenyl-thiophene, leur preparation et leur application a titre de medicament - Google Patents

Derives de phenyl-furane ou de phenyl-thiophene, leur preparation et leur application a titre de medicament

Info

Publication number
WO2003099812A8
WO2003099812A8 PCT/FR2003/001567 FR0301567W WO03099812A8 WO 2003099812 A8 WO2003099812 A8 WO 2003099812A8 FR 0301567 W FR0301567 W FR 0301567W WO 03099812 A8 WO03099812 A8 WO 03099812A8
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
furan
medicine
preparation
thiophene derivatives
Prior art date
Application number
PCT/FR2003/001567
Other languages
English (en)
Other versions
WO2003099812A1 (fr
Inventor
Michel Perez
Marie Lamothe
Bridget Hill
Original Assignee
Pf Medicament
Michel Perez
Marie Lamothe
Bridget Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament, Michel Perez, Marie Lamothe, Bridget Hill filed Critical Pf Medicament
Priority to AU2003260566A priority Critical patent/AU2003260566A1/en
Publication of WO2003099812A1 publication Critical patent/WO2003099812A1/fr
Publication of WO2003099812A8 publication Critical patent/WO2003099812A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Composés repondant à la formule générale (I) dans laquelle notamment W représente : H, SO2R4 , CO(CH2)nR4, (CH2)pR5, CS(CH2)nR4 5 X représente : 0 ou S, Y représente : (CH2)p, Z représente : Imidazole, benzimidazole ou pyridine, R1 représente : CO-NH-(CH2)q-NR5R6, (I), ou CO-NH-(CH2)q-NR5R6,, R2 et R3 représentent un atome d'hydrogène R4 représente un phenyle ou un naphtyle n représente 0 à 10, p représente 1 à 6, q représente 2 à 6.
PCT/FR2003/001567 2002-05-24 2003-05-23 Derives de phenyl-furane ou de phenyl-thiophene, leur preparation et leur application a titre de medicament WO2003099812A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003260566A AU2003260566A1 (en) 2002-05-24 2003-05-23 Phenyl-furan or phenyl-thiophene derivatives, their preparation and their use as medicine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0206347A FR2839974B1 (fr) 2002-05-24 2002-05-24 Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament
FR02/06347 2002-05-24

Publications (2)

Publication Number Publication Date
WO2003099812A1 WO2003099812A1 (fr) 2003-12-04
WO2003099812A8 true WO2003099812A8 (fr) 2004-05-27

Family

ID=29415048

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/001567 WO2003099812A1 (fr) 2002-05-24 2003-05-23 Derives de phenyl-furane ou de phenyl-thiophene, leur preparation et leur application a titre de medicament

Country Status (3)

Country Link
AU (1) AU2003260566A1 (fr)
FR (1) FR2839974B1 (fr)
WO (1) WO2003099812A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10703712B2 (en) 2015-09-16 2020-07-07 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
AU2018236275B2 (en) 2017-03-15 2022-05-12 Organovo, Inc. Farnesoid X receptor agonists and uses thereof
JP7174709B2 (ja) 2017-03-15 2022-11-17 メタクリン，インク． ファルネソイドｘ受容体アゴニストおよびその使用
US11084817B2 (en) 2018-09-18 2021-08-10 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1529997A (en) * 1996-01-16 1997-08-11 Warner-Lambert Company Substituted histidine inhibitors of protein farnesyltransferase
FR2796947A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
FR2815032B1 (fr) * 2000-10-10 2003-08-08 Pf Medicament Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations
FR2825706B1 (fr) * 2001-06-06 2003-12-12 Pf Medicament Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase

Also Published As

Publication number Publication date
FR2839974B1 (fr) 2004-07-16
AU2003260566A1 (en) 2003-12-12
FR2839974A1 (fr) 2003-11-28
WO2003099812A1 (fr) 2003-12-04

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