WO2003086361A1 - Compositions orales solides a dispersion rapide - Google Patents

Compositions orales solides a dispersion rapide Download PDF

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Publication number
WO2003086361A1
WO2003086361A1 PCT/IB2002/001272 IB0201272W WO03086361A1 WO 2003086361 A1 WO2003086361 A1 WO 2003086361A1 IB 0201272 W IB0201272 W IB 0201272W WO 03086361 A1 WO03086361 A1 WO 03086361A1
Authority
WO
WIPO (PCT)
Prior art keywords
starch
composition
group
amount
microcrystalline cellulose
Prior art date
Application number
PCT/IB2002/001272
Other languages
English (en)
Inventor
Muralikrishna Divi
Abhijit Mukund Deshmukh
Vipin Tatyasaheb Dhanorkar
Mailatur Sivaraman Mohan
Original Assignee
Dr. Reddy's Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd. filed Critical Dr. Reddy's Laboratories Ltd.
Priority to PCT/IB2002/001272 priority Critical patent/WO2003086361A1/fr
Priority to AU2002255196A priority patent/AU2002255196A1/en
Publication of WO2003086361A1 publication Critical patent/WO2003086361A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Definitions

  • the present invention relates to the rapidly dispersing solid oral composition and process for manufacture of such compositions.
  • Oral administration in the form of a conventional tablet, pill or capsule constitutes the generally preferred route for administration of pharmaceuticals since this route is generally convenient and acceptable to patients.
  • Such compositions may be associated with certain disadvantages, particularly in the treatment of pediatric or geriatric patients, who may dislike or have difficulty in swallowing such compositions, or where administration of a conventional tablet, pill or capsule is not feasible.
  • freeze dried dosage forms due to the inherent fragility, surface undulation, moisture sensitivity and chemical makeup of freeze-dried dosage forms, the application of compression for the purpose of embossing would cause deformation, reduced porosity and hence increased dispersion time, and possibly cracking of the dosage forms.
  • chemical makeup, moisture sensitivity, porosity and surface undulation of freeze dried dosage forms would cause ink to dissolve the dosage forms at the point of contact or to diffuse throughout the dosage forms leading to clarity problems.
  • the said freeze dried products are also generally not suited for packing and handling operations.
  • Yamanouch Pharmaceutical Co. Ltd. has disclosed into WO 99/47126 a rapidly dispersing tablet prepared by using a water-soluble non saccharide polymer as a binder together with an active ingredient; and humidifying the tablet.
  • WO 93/12769 discloses a rapidly dispersing tablet prepared by filling a mold with a suspension containing an active ingredient together with agar and sugar; and drying the suspension to remove the solvent at 30°C in a vacuum.
  • these processes suffer from low productivity and uneven product quality.
  • U.S.Pat.No. 3,885,026 discloses porous tablets prepared by adding a volatilizable adjuvant, e.g., urethane urea, ammonium carbonate or naphthalene, to other tablets components; tableting the resulting mixture; and heating the tablets to volatilize the adjuvant.
  • a volatilizable adjuvant e.g., urethane urea, ammonium carbonate or naphthalene
  • a residual amount of the adjuvant in the tablet may generate a deleterious effect on the patient.
  • U.S.Pat.No.4, 134,943 discloses porous tablets prepared by adding a liquid having a freezing temperature in the range of -30 to 25°C to other tablet components; cooling the mixture below the freezing temperature to solidify the liquid; tableting the cooled mixture; and then evaporating the liquid.
  • this process suffers from low productivity.
  • it is an object of the present invention to provide a rapidly dispersing solid oral composition comprising Ondansetron, Olanzapine along with pharmaceutically accepted salts, solvates, enantiomers or mixtures thereof including racemic mixture and method of producing such compositions.
  • the invention relates to the rapidly dispersing compositions and method of producing such compositions.
  • the present invention uses substantially simple and cost effective manufacturing technique.
  • the rapidly dispersible tablets prepared by such process has acceptable stability as per ICH guidelines and dispersed within 30 seconds preferably within 10 seconds and more preferably within 5 seconds.
  • the rapidly dispersible compositions obtainable according to the invention, in addition to being dispersed rapidly have the following further advantages: It has substantially good organoleptic characteristics; It is devoid of any need for the cautions and measures required during handling and packaging of the freeze dried formulations;
  • the active ingredient along with one or more pharmaceutical excipients was blended for 5-10 minutes, the powder blend thus obtained was granulated with solution of wetting agent/surfactant in water, the wet mass thus obtained was sieved to obtain granules. The granules after drying were compressed into the tablets. Alternatively the tablets can be prepared using direct compression technique.
  • the present invention therefore provides the rapidly dispersing tablet formulation for oral administration comprising an active ingredient, in the form of its free base or pharmaceutically accepted salts, solvate, enantiomers or mixtures thereof including racemic mixture and one or more pharmaceutically accepted excipients.
  • rapidly dispersing refers to the dosage form which disperses in water within 30 seconds, preferably within 10 seconds and more preferably within 5 seconds or less as per the test specified in United State Pharmacopoeia.
  • pharmaceutically active ingredient refers to any of the drug selected from ondansetron, olanzapine or pharmaceutically accepted salts, solvate, enantiomers or mixtures thereof including racemic mixture.
  • the term "pharmaceutically accepted excipients" as used in this description and in the appended claims comprise binders, dispersing agents, fillers, flavoring agents, sweetening agents, lubricants or glidants and such like.
  • the "dispersing agent” in accordance with the present invention comprises crosscarmellose sodium, crosscarmellose calcium, crosspovidone, sodium starch glycolate, sodium carboxymethyl cellulose, hydroxypropylcellulose, xanthan gum, alginic acid and alginates one or more clays selected from bentonite, hectorite, magnesium aluminium silicate, and such like, preferably the dispersing agent used in the present invention is crosspovidone.
  • the "binders" used in the present invention are selected from gelatin, pregelatinized starch, starch paste, starch DC, starch 1500, acacia, tragacanth, guar gum, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, glucose, sucrose, sorbitol, polyvinylpyrrolidone plasdone S-630 and such like.
  • the preferred binder of the present invention is pregelatinized starch.
  • Suitable "fillers” as used in this invention are selected from one or more starch derivatives selected from corn starch, potato starch or rice starch; one or more polysaccharides selected from the group consisting of dextrins or maltodextrins, microcrystalline cellulose, powdered cellulose, mixture of microcrystalline cellulose and guar gum, coprocessed blends of microcrystalline cellulose; one or more polyhydric alcohols selected from the group consisting of mannitol, xylitol, sorbitol and such like.
  • the preferred fillers used in this invention are mannitol, microcrystalline cellulose and mixture of microcrystalline cellulose and guar gum.
  • the "surfactant or wetting agent" as used in this specification and in the appended claims is selected from any of polyoxyethylene sorbitan fatty acid esters, e.g., polyoxyethylene 20 sorbitan monolaurate (TWEEN 20), polyoxyethylene (4) sorbitan monolaurate (TWEEN 21), polyoxyethylene 20 sorbitan monopalmitate (TWEEN 40), polyoxyethylene 20 sorbitan monooleate (TWEEN 80); polyoxyethylene alkyl ethers, e.g., polyoxyethylene 4 lauryl ether (BRIJ 30), polyoxyethylene 23 lauryl ether (BRIJ 35), polyoxyethylene 10 oleyl ether (BRIJ 97); and polyoxyethylene glycol esters, e.g., poloxyethylene 8 stearate (MYRJ 45), poloxyethylene 40 stearate (MYRJ 52) or mixtures thereof, or sodium lauryl sulphate and such like.
  • the suitable "lubricants” are talc, magnesium stearate, stearic acid or glyceryl behenate preferably magnesium stearate and suitable glidants includes colloidal silicon dioxide or talc preferably colloidal silicon dioxide.
  • Suitable “sweeteners” include, for example, sugars such as sucrose, lactose and glucose; cyclamate and salts thereof; saccharin and salts thereof; and aspartame.
  • sugars such as sucrose, lactose and glucose
  • cyclamate and salts thereof e.g., aspartame.
  • saccharin and salts thereof e.g., aspartame.
  • sweetener of the rapidly dispersing dosage form of the present invention is aspartame.
  • Suitable flavoring agent include strawberry, cherry, mint and caramel flavouring aids, preferably the flavoring agent of the present invention is strawberry flavour.
  • rapidly dispersing composition wherein the amount of active ingredient is in the range of 1 to 25 mg.
  • the pharmaceutically active ingredient is Ondansetron or a free base, salt, solvate, enantiomer or mixture thereof including racemic mixture
  • the preferred amount is 4, 8, 16 or 24 mg.
  • the pharmaceutically active ingredient is Olanzapine or a free base, salt, solvate, enantiomer or mixture thereof including racemic mixture
  • the preferred amount is 5, 10, 15 or 20 mg.
  • step (1) The powder blend obtained from step (1) was granulated with the solution of sodium lauryl sulphate (ingredient 11) in water to obtain wet mass.
  • step (3) The wet mass of step (2) was passed through mesh # 10 to obtain wet granules.
  • the wet granules were dried at suitable temperature from 40°C-65°C till the LOD (Loss on drying) of the granules was 2% or less.
  • step (3) The dried granules of step (3) were passed through mesh # 30.
  • step (2) The blend obtained from step (1) was granulated with solution of sodium lauryl sulphate (ingredient 6) in water in FBP (fluid bed processor) and dried.
  • Example 9 The similar method as described in example 1 was adopted for the preparation of above mentioned tablets. Example 9.
  • Example 11 The similar method as described in example 4 was adopted for the preparation of above mentioned tablets. Example 11.
  • ingredients 1-6 are passed through mesh # 40 and blended in suitable blender for 5-10 minutes and compressed into tablets using suitable punches.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne des compositions orales solides à dispersion rapide renfermant de l'Olanzapine ou de l'Ondansetron. Cette invention concerne également le procédé de production par granulation par voie humide ou par compression directe de ces compositions à dispersion rapide. Cette invention porte également sur un solvant, des sels, des énantiomères ou des mélanges de ceux-ci pharmaceutiquement acceptables comprenant un mélange racémique d'Olanzapine et d'Ondansetron.
PCT/IB2002/001272 2002-04-18 2002-04-18 Compositions orales solides a dispersion rapide WO2003086361A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2002/001272 WO2003086361A1 (fr) 2002-04-18 2002-04-18 Compositions orales solides a dispersion rapide
AU2002255196A AU2002255196A1 (en) 2002-04-18 2002-04-18 Rapidly dispersing solid oral compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/001272 WO2003086361A1 (fr) 2002-04-18 2002-04-18 Compositions orales solides a dispersion rapide

Publications (1)

Publication Number Publication Date
WO2003086361A1 true WO2003086361A1 (fr) 2003-10-23

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WO (1) WO2003086361A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035027A1 (fr) * 2002-10-18 2004-04-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Formulation pharmaceutique d'olanzapine
WO2005077341A1 (fr) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Compositions pharmaceutiques a desintegration orale d'ondansetron
WO2006074951A2 (fr) * 2005-01-14 2006-07-20 Krka, Tovarna Zdravil, D.D., Novo Mesto Composition d'olanzapine ou de donepezil a desintegration orale
WO2006081779A2 (fr) * 2005-02-02 2006-08-10 Zentiva, A.S. Preparation pharmaceutique contenant de l'olanzapine en tant que principe actif et son procede de preparation
WO2006087629A2 (fr) * 2005-02-21 2006-08-24 Aurobindo Pharma Limited Composition de medicament antipsychotique a delitement rapide
WO2007003020A1 (fr) * 2005-07-05 2007-01-11 Biolab Sanus Farmacêutica Ltda. Formules orales comprenant de l'ondasétron et un édulcorant à dose élevée
WO2008005345A2 (fr) * 2006-06-29 2008-01-10 Transcept Pharmaceuticals, Inc. Compositions d'antagonistes de 5-ht3 et d'antagonistes de dopamine d2 pour le traitement d'états chroniques associés à la dopamine
EP2062599A1 (fr) * 2006-09-14 2009-05-27 Astellas Pharma Inc. Comprimé se désintegrant oralement et procédé de fabrication de celui-ci
EP2246046A1 (fr) 2009-04-28 2010-11-03 Sanovel Ilac Sanayi ve Ticaret A.S. Comprimé d'olanzapine à désintégration orale
US7872095B2 (en) 2004-07-19 2011-01-18 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US9226918B2 (en) 2008-12-04 2016-01-05 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating or preventing narcotic withdrawal symptoms
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
CN107625740A (zh) * 2016-07-18 2018-01-26 北京科信必成医药科技发展有限公司 一种昂丹司琼无水吞服颗粒
US10456378B2 (en) 2014-06-24 2019-10-29 Taho Pharmaceuticals Ltd. Fast acting orally disintegrating film
CN110881555A (zh) * 2019-11-07 2020-03-17 哈尔滨梵境园生物科技有限公司 一种具有双降作用的分散糖果片
WO2024041876A1 (fr) * 2022-08-25 2024-02-29 Haleon UK IP Limited Composition de comprimé de dentifrice

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506248A (en) * 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
WO1998046213A1 (fr) * 1997-04-17 1998-10-22 Bristol-Myers Squibb Company Formulation de comprimes de monohydrate de cefadroxil
WO1999047126A1 (fr) * 1998-03-18 1999-09-23 Yamanouchi Shaklee Pharma Comprimes a dissolution rapide a base de polymeres et procede de production correspondant
WO2000057857A1 (fr) * 1999-03-25 2000-10-05 Yuhan Corporation Comprimé à administrer oralement se désagrégeant rapidement
US6190698B1 (en) * 1995-03-24 2001-02-20 Eli Lilly And Company Oral 2-methyl-thieno-benzodiazepine formulation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506248A (en) * 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
US6190698B1 (en) * 1995-03-24 2001-02-20 Eli Lilly And Company Oral 2-methyl-thieno-benzodiazepine formulation
WO1998046213A1 (fr) * 1997-04-17 1998-10-22 Bristol-Myers Squibb Company Formulation de comprimes de monohydrate de cefadroxil
WO1999047126A1 (fr) * 1998-03-18 1999-09-23 Yamanouchi Shaklee Pharma Comprimes a dissolution rapide a base de polymeres et procede de production correspondant
WO2000057857A1 (fr) * 1999-03-25 2000-10-05 Yuhan Corporation Comprimé à administrer oralement se désagrégeant rapidement

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035027A1 (fr) * 2002-10-18 2004-04-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Formulation pharmaceutique d'olanzapine
HRP20050342B1 (hr) * 2002-10-18 2013-11-08 Krka, Tovarna Zdravil, D.D. Novo Mesto Farmaceutska formulacija olanzapina
EA008516B1 (ru) * 2002-10-18 2007-06-29 Крка, Товарна Здравил, Д.Д., Ново Место Фармацевтический состав оланзапина
WO2005077341A1 (fr) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Compositions pharmaceutiques a desintegration orale d'ondansetron
US9101596B2 (en) 2004-07-19 2015-08-11 Biocon Limited Cation complexes of insulin compound conjugates, formulations and uses thereof
US9102758B2 (en) 2004-07-19 2015-08-11 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US7875700B2 (en) 2004-07-19 2011-01-25 Biocon Limited Cation complexes of insulin compound conjugates, formulation and uses thereof
US7872095B2 (en) 2004-07-19 2011-01-18 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
EA013742B1 (ru) * 2005-01-14 2010-06-30 Крка, Товарна Здравил, Д.Д., Ново Место Распадающаяся при пероральном приеме композиция оланзапина или донепезила
WO2006074951A3 (fr) * 2005-01-14 2007-04-26 Krka Tovarna Zdravil D D Novo Composition d'olanzapine ou de donepezil a desintegration orale
WO2006074951A2 (fr) * 2005-01-14 2006-07-20 Krka, Tovarna Zdravil, D.D., Novo Mesto Composition d'olanzapine ou de donepezil a desintegration orale
WO2006081779A3 (fr) * 2005-02-02 2007-05-03 Zentiva As Preparation pharmaceutique contenant de l'olanzapine en tant que principe actif et son procede de preparation
WO2006081779A2 (fr) * 2005-02-02 2006-08-10 Zentiva, A.S. Preparation pharmaceutique contenant de l'olanzapine en tant que principe actif et son procede de preparation
WO2006087629A3 (fr) * 2005-02-21 2006-11-02 Aurobindo Pharma Ltd Composition de medicament antipsychotique a delitement rapide
WO2006087629A2 (fr) * 2005-02-21 2006-08-24 Aurobindo Pharma Limited Composition de medicament antipsychotique a delitement rapide
WO2007003020A1 (fr) * 2005-07-05 2007-01-11 Biolab Sanus Farmacêutica Ltda. Formules orales comprenant de l'ondasétron et un édulcorant à dose élevée
WO2008005345A3 (fr) * 2006-06-29 2008-03-20 Transcept Pharmaceuticals Inc Compositions d'antagonistes de 5-ht3 et d'antagonistes de dopamine d2 pour le traitement d'états chroniques associés à la dopamine
WO2008005345A2 (fr) * 2006-06-29 2008-01-10 Transcept Pharmaceuticals, Inc. Compositions d'antagonistes de 5-ht3 et d'antagonistes de dopamine d2 pour le traitement d'états chroniques associés à la dopamine
EP2062599A1 (fr) * 2006-09-14 2009-05-27 Astellas Pharma Inc. Comprimé se désintegrant oralement et procédé de fabrication de celui-ci
EP2062599A4 (fr) * 2006-09-14 2013-03-27 Astellas Pharma Inc Comprimé se désintegrant oralement et procédé de fabrication de celui-ci
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
US9226918B2 (en) 2008-12-04 2016-01-05 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating or preventing narcotic withdrawal symptoms
EP2246046A1 (fr) 2009-04-28 2010-11-03 Sanovel Ilac Sanayi ve Ticaret A.S. Comprimé d'olanzapine à désintégration orale
US10456378B2 (en) 2014-06-24 2019-10-29 Taho Pharmaceuticals Ltd. Fast acting orally disintegrating film
US11304933B2 (en) 2014-06-24 2022-04-19 Taho Pharmaceuticals Ltd. Fast acting orally disintegrating film
CN107625740A (zh) * 2016-07-18 2018-01-26 北京科信必成医药科技发展有限公司 一种昂丹司琼无水吞服颗粒
CN110881555A (zh) * 2019-11-07 2020-03-17 哈尔滨梵境园生物科技有限公司 一种具有双降作用的分散糖果片
WO2024041876A1 (fr) * 2022-08-25 2024-02-29 Haleon UK IP Limited Composition de comprimé de dentifrice

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