WO2003086255A1 - Apertured hydrogel wound dressing - Google Patents
Apertured hydrogel wound dressing Download PDFInfo
- Publication number
- WO2003086255A1 WO2003086255A1 PCT/GB2003/001588 GB0301588W WO03086255A1 WO 2003086255 A1 WO2003086255 A1 WO 2003086255A1 GB 0301588 W GB0301588 W GB 0301588W WO 03086255 A1 WO03086255 A1 WO 03086255A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogel
- absorbent article
- hydrogel layer
- cover sheet
- article according
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00748—Plasters means for wound humidity control with hydrocolloids or superabsorbers
Definitions
- the present invention relates to apertured hydrogel sheets for use as or in wound dressings and other absorbent articles.
- apertured hydrogel sheets as the wound contacting layer in multilayered wound dressing.
- the hydrogel absorbs water to form a moist, non- adherent wound facing layer in use.
- the apertures allow excess wound exudate to pass through the hydrogel layer into a more conventional secondary absorbent layer, such as a nonwoven fabric layer.
- US-A-5352508 describes an apertured substrate web coated with a hydrogel material for use as a wound facing layer in wound dressings.
- EP-A-0532275 describes a non-reinforced hydrogel dressing in the form of an apertured web.
- the dressing may be formed by casting an aqueous solution of a water-soluble polysaccharide or cellulose derivative and a humectant onto a mold comprising a plurality of interconnected grooves surrounding a plurality of upstanding bosses, and drying the solution in the mold to form the dressing having a pattern of apertures corresponding to the upstanding bosses of the mold.
- the web dressing is then separated from the mold before packaging, and the mold is reused.
- WO00/65143 describes a method of coating a perforated substrate with a gel without substantial occlusion of the perforations, which process comprises (i) forming a layer of a liquid pregel mixture, comprising one or more monomers, on a web coated with a coating having a surface energy less than the surface energy of the liquid pregel mixture; (ii) contacting the perforated substrate with the liquid pregel mixture; and (iii) curing the liquid pregel mixture.
- GB-A-2093702 describes open elastomeric webs for use as the wound facing layer in dressings for burns and other exuding wounds.
- the webs may be made by casting a precursor solution onto a plastic sheet that has been embossed with the pattern of the web, followed by curing and drying the precursor solution on the sheet and stripping the resulting web from the sheet.
- an absorbent foam layer and backing sheet may be laminated to the elastomeric net while the net is still on the embossed sheet carrier.
- US-A-5076265 describes a hydrogel sheet for use as a wound dressing having capillaries permitting wound exudate to pass through the sheet.
- the capillaries may be drilled out of the sheet using hollow needles or syringes, or they may be formed by casting the hydrogel sheets in molds having a series of upward projections such that on removal of the sheets from the mold, appropriate capillaries are formed.
- the present invention provides an absorbent article comprising: a continuous cover sheet having a plurality of projections formed therein; and a sterile hydrogel layer in contact with the cover sheet such that said projections extend through the hydrogel layer.
- the absorbent article may preferably be a wound dressing, especially for use on exuding wounds, in which case the hydrogel layer would normally be the wound contacting layer in use.
- the absorbent article may be suitable for absorbing other bodily fluids, including incontinence devices, catamenial devices, diapers and colostomy devices.
- the cover sheet is normally peeled from the hydrogel layer immediately before use.
- This construction provides support and protection to the hydrogel layer during manufacture and storage, and also provides a high degree of control over the final form of the hydrogel layer at low cost, since the cover sheet also forms part of the packaging of the hydrogel layer.
- the area of the hydrogel layer is from about 1cm 2 to about 400 cm 2 , more preferably from about 4cm 2 to about 100cm 2 .
- the cover sheet is larger than the hydrogel layer such that a marginal region of width 1mm to 50 mm, preferably 5mm to 20mm extends around the hydrogel layer.
- the article further comprises a protective sheet extending over the hydrogel layer and bonded to the cover sheet in a marginal region around the hydrogel layer so as to enclose the sterile hydrogel layer.
- the resulting enclosure keeps the hydrogel sterile until the cover layer is peeled off immediately before use.
- the absorbent article is packaged. That is to say, at least the cover sheet must be peeled from the hydrogel layer before the article can be used.
- the enclosure provided by the cover sheet and the protective sheet is microorganism- impermeable, and the hydrogel is sterile. This arrangement removes the need for any further microorganism-impermeable packaging, although such secondary packaging may be present in certain embodiments, in which case the whole article may be sterilized.
- the protective sheet is itself the backing sheet of the absorbent article.
- it may comprise a semipermeable film, such as a microporous polyurethane film, of the kind used in island-type wound dressings.
- the backing sheet is preferably coated with a pressure sensitive medical grade adhesive in at least its marginal region, and the cover sheet is provided with a release surface for the adhesive in at least its marginal region, so that the protective/backing sheet with the adhesive coating can be peeled from the cover sheet prior to application directly to the skin of a user.
- the resulting article is a self-contained sterile packaged hydrogel island wound dressing.
- the backing sheet is substantially liquid-impermeable.
- the backing sheet is preferably semipermeable. That is to say, the backing sheet is preferably permeable to water vapour, but not permeable to liquid water or wound exudate.
- the backing sheet is also microorganism-impermeable.
- Suitable continuous conformable backing sheets will preferably have a moisture vapor transmission rate (MVTR) of the backing sheet alone of 300 to 5000 g/m 2 /24hrs, preferably 500 to 2000 g/m 2 /24hrs at 37.5 ° C at 100% to 10% relative humidity difference.
- the backing sheet thickness is preferably in the range of 10 to 1000 micrometers, more preferably 100 to 500 micrometers.
- the MVTR of the dressing according to the present invention as a whole is lower than that of the backing sheet alone, because the apertured sheet partially obstructs moisture transfer through the dressing.
- the MVTR of the dressing (measured across the island portion of the dressing) is from 20% to 80% of the MVTR of the backing sheet alone, more preferably from 20% to 60% thereof, and most preferably about 40% thereof. It has been found that such moisture vapor transmission rates allow the wound under the dressing to heal under moist conditions without causing the skin surrounding the wound to macerate.
- Suitable polymers for forming the backing sheet include polyurethanes and poly alkoxyalkyl acrylates and methacrylates such as those disclosed in GB-A- 1280631.
- the backing sheet comprises a continuous layer of a high density blocked polyurethane foam that is predominantly closed-cell.
- a suitable backing sheet material is the polyurethane film available under the Registered Trade Mark ESTANE 5714F.
- the adhesive (where present) layer should be moisture vapor transmitting and/or patterned to allow passage of water vapor therethrough.
- the adhesive layer is preferably a continuous moisture vapor transmitting, pressure-sensitive adhesive layer of the type conventionally used for island-type wound dressings, for example, a pressure sensitive adhesive based on acrylate ester copolymers, polyvinyl ethyl ether and polyurethane as described for example in GB-A-1280631.
- the basis weight of the adhesive layer is preferably 20 to 250 g/m 2 , and more preferably 50 to 150 g/m 2 . Polyurethane-based pressure sensitive adhesives are preferred.
- the adhesive layer extends outwardly from the absorbent layer and the envelope to form an adhesive-coated margin on the backing sheet around the adhesive layer as in a conventional island dressing.
- a multilayer absorbent article may be built up between the hydrogel layer and the protective sheet.
- these layers may comprise an apertured plastic film to provide support for the hydrogel layer in use, in which case the apertures in the film are preferably aligned in register with the apertures in the hydrogel layer.
- the apertured film may be formed from any suitable thermoplastic film-forming polymer.
- the polymer is conformable but not substantially elastomeric. Suitable polymers include, but are not limited to, polyethylene, polypropylene, polyester, polyamides such as nylons, fluoropolymers such as polyvinylidene fluoride (PVDF) or polytetrafluoroethylene (PTFE), and mixtures thereof.
- the top sheet is preferably a polyolefin film.
- the film has a thickness by weight (ASTM E252-84) of from 10 to 200 micrometers, more preferably from 25 to 100 micrometers.
- the apertured support film in these embodiments is liquid permeable, but in certain preferred embodiments the film structure acts to block or restrict the flow of liquid from the back surface of the film to the wound-facing hydrogel side. That is to say, the apertured support film allows fluid to pass through the top sheet from the hydrogel, but blocks or restricts flow of the fluid back through the top sheet to the hydrogel side (also known as wet-back).
- the plastic film has greater liquid permeability to the flow of liquid away from the wound facing surface than to the flow of liquid towards the wound facing surface.
- such a film may be formed from a substantially liquid-impermeable sheet material provided with tapered capillaries, each capillary having a base substantially in the plane of the wound facing surface of the film and an apical opening remote from the wound facing surface of the film and preferably in contact with an absorbent layer.
- the conical capillaries provide rapid one-way wicking of fluid from the front of the top sheet, with minimal wet-back. Top sheets of this type are described in GB-A-1526778.
- the multilayer absorbent article according to the present invention may include one or more liquid-absorbent layers between the hydrogel layer and the protective sheet.
- the optional absorbent layer may be any of the layers conventionally used for absorbing wound fluids, serum or blood in the wound healing art, including gauzes, nonwoven fabrics, superabsorbents, hydrogels and mixtures thereof.
- the absorbent layer comprises a layer of absorbent foam, such as an open celled hydrophilic polyurethane foam prepared in accordance with EP-A-0541391 , the entire content of which is expressly incorporated herein by reference.
- the absorbent layer may be a nonwoven fibrous web, for example a carded web of viscose staple fibers.
- the basis weight of the absorbent layer may be in the range of 50- 500g/m 2 , such as 100-400g/m 2 .
- the uncompressed thickness of the absorbent layer may be in the range of from 0.5mm to 10mm, such as 1mm to 4mm.
- the free (uncompressed) liquid absorbency measured for physiological saline may be in the range of 5 to 30 g/g at 25°.
- the absorbent layer or layers are substantially coextensive with the hydrogel layer.
- the cover sheet is normally formed from flexible thermoplastic material. Suitable materials include polyesters and polyolefins.
- the hydrogel facing surface of the cover sheet is a release surface. That is to say, a surface that is only weakly adherent to the hydrogel to assist peeling of the hydrogel layer from the cover sheet.
- the cover sheet may be formed from a non- adherent plastic such as a fluoropolymer, or it may be provided with a release coating such as a silicone or fluoropolymer release coating.
- the cover sheet is provided with a recess in the central region, the projections in the cover sheet extend into the recess, and the hydrogel layer is received in the recess.
- the recess is typically a shallow recess dimensioned to receive the hydrogel layer and any additional layers such as perforated layers or absorbent layers that are coextensive with the hydrogel layer.
- the depth of the recess is from 1 to 10 mm, preferably from 2 to 8 mm.
- the recess may be provided by thermoforming.
- the cover sheet acts as a mold for the hydrogel, and the projections in the cover sheet define the shape of apertures in the hydrogel layer. It is a particular advantage of the present invention that this enables the porosity of the hydrogel layer to be controlled accurately.
- the projections may be square or cylindrical, but preferably the projections in the cover sheet are tapered, whereby apertures in the hydrogel layer are correspondingly tapered.
- the projections are substantially in the form of tapered geometric bodies such as truncated cones, pyramids or the like.
- the projections of such tapered projections have a base dimension of from 0.5 mm to 5 mm, and an apical dimension (at the top surface of the hydrogel layer) of from 0.05 to 2 mm. More preferably, the projections have a base dimension as herein defined of from 1 mm to 3 mm, and an apical dimension of from 0.1 to 1 mm.
- the projections have an average angle of taper (measured from the perpendicular to the plane of the cover sheet) of from 10 to 60 degrees.
- the height of the projections is from 0.1 to 5 mm, more preferably from 1 to 3 mm.
- the density of the projections is from 1 to 400 per cm 2 , more preferably from 10 to 100 per cm 2 .
- the mean cross sectional area of the projections at their mid-point (half height) is from about 1 to about 50%, preferably about 5 to about 50% of the total area of the central region of the top sheet, more preferably from about 10 to about 25% of the said total area.
- the projections are arranged in a regular array.
- Projections of this type may be manufactured, for example, by embossing or thermoforming or injection molding of the cover sheet.
- the cover sheet and/or the protective sheet is transparent to visible and/or ultraviolet light. This provides an attractive visual appearance, and also means that the certain hydrogels can be cured using visible and/or UV radiation through the cover sheet and/or through the protective sheet.
- the hydrogel layer has a dry basis weight of from 10 to 200g/m 2 , more preferably from 10 to lOOg/m 2 , and most preferably from 10 to 50g/m 2 .
- the hydrogel layer has a thickness as determined by ASTM D374-79 of from about 0.2 to about 4 mm.
- the hydrogel layer is sterile.
- the cover sheet and the protective sheet function as a primary packaging for the hydrogel layer, maintaining it sterile until use. The overall process to make the dressing is simplified, and there is no need for a separate mold to cast the apertured hydrogel sheet.
- hydrogel layer refers generally to layers that interact with the wound surface under physiological conditions to maintain an elevated moisture level at the wound surface.
- the hydrogel layer forms a gel with water under physiological conditions of temperature and pH.
- the hydrogel layer absorbs at least 50% w/w of water on immersion at 25°C for 60 minutes, based on the weight of the hydrogel before immersion.
- Such hydrogel layers can be formed by the inclusion of medically acceptable macromolecular materials that preferably have the ability to swell and absorb fluid while maintaining a strong integral structure.
- the hydrogel composition forms a gel that is substantially insoluble in water under physiological conditions, whereby the hydrogel is not washed away by the wound fluid.
- the hydrogel may be a biopolymer, and/or it may be bioabsorbable. That is to say, it may undergo gradual resorption in vivo.
- Exemplary insoluble gels include certain cross-linked polyacrylate gels, calcium alginate gels, cross-linked hyaluronate gels, wherein the hydrogel layer comprises a hydrogel material selected from gels formed from vinyl alcohols, vinyl esters, vinyl ethers and carboxy vinyl monomers, meth(acrylic) acid, acrylamide, N-vinyl pyrrolidone, acylamidopropane sulphonic acid, PLURONIC (Registered Trade Mark) (block polyethylene glycol, block polypropylene glycol) polystyrene-, maleic acid, NN-dimethylacrylamide diacetone acrylamide, acryloyl morpholine, and mixtures thereof.
- PLURONIC Registered Trade Mark
- the hydrogel layer comprises a hydrogel material selected from polyurethane gels, biopolymer gels, carboxymethyl cellulose gels, hydroxyethyl cellulose gels, hydroxy propyl methyl cellulose, modified acrylamide and mixtures thereof.
- Suitable biopolymer gels include alginates, pectins, galactomannans, chitosan, gelatin, hyaluronates and mixtures thereof. Some of these biopolymer materials also promote wound healing.
- the macromolecular materials making up the gels are cross-linked, and the cross-linking may be either covalent or ionic.
- the hydrogel material may further comprise from 5 to 50% by weight on a dry weight basis of one or more humectants such as glycerol
- the hydrogel layer comprise a hydrogel material of the kind described in WOOO/07638, the entire content of which is incorporated herein by reference.
- the hydrogel layer may comprise one or more emollients.
- Emollients are used to smooth the surface of skin and to increase the degree of hydration. They act either by occluding water loss from the outer layer of the skin, or by improving water binding to the skin. Emollients are particularly useful in the treatment of atopic eczemas and ichthyoses.
- Preferred emollients include White Soft Paraffin, Yellow Soft Paraffin, Liquid paraffin, Urea Creams, Lanolin, Sodium Pyrrolidone Carboxylate (PCA Na), Evening primrose extract (gamma linolenic acid), Soya Oil, Tea Tree Oil, coconut Oil, Almond Oil, Camomile Extract, Cod Liver Oil, Peanut Oil, Emu Oil, Aloe Vera, Sunflower oil, avocado Oil, Jojoba Oil, Cocoamide, and mixtures thereof.
- PCA Na Sodium Pyrrolidone Carboxylate
- Evening primrose extract gamma linolenic acid
- Soya Oil Tea Tree Oil, coconut Oil, Almond Oil, Camomile Extract, Cod Liver Oil, Peanut Oil, Emu Oil, Aloe Vera, Sunflower oil, avocado Oil, Jojoba Oil, Cocoamide, and mixtures thereof.
- the hydrogel layer may additionally comprise one or more active therapeutic or antimicrobial agents.
- Suitable therapeutic agents include growth factors, analgesics, local anaesthetics and steroids.
- Suitable antimicrobial agents include antiseptics such as silver compounds and chlorhexidine, and antibiotics.
- the therapeutic or antimicrobial agents are usually added in an amount of from 0.01% to 5% by weight, based on the dry weight of the hydrogel layer.
- the present invention further provides a packaged wound dressing comprising an absorbent article according to the present invention.
- a wound dressing is provided by peeling the hydrogel layer from the protective cover sheet.
- the present invention further provides a method of making an absorbent article comprising the steps of: providing a continuous cover sheet having a plurality of projections formed in a central region thereof; forming a hydrogel layer in contact with the central region of the cover sheet, with said projections extending through the hydrogel layer to define a plurality of apertures in the hydrogel layer; followed by sterilizing the hydrogel and the cover sheet.
- the method according to the present invention is adapted to provide an absorbent article according to the present invention.
- the step of providing a continuous cover sheet having projections in a central region thereof may be done by thermoforming, embossing or injection molding, as described above.
- continuous signifies that the cover sheet is substantially impermeable to liquids and microorganisms, but it may have some gas permeability.
- the step of forming a hydrogel layer in contact with the cover sheet typically comprises coating the central region of the cover sheet with a fluid pregel composition, followed by treating the pregel composition to form the hydrogel in situ.
- the pregel composition forms a hydrogel upon cooling, polymerisation or cross-linking. Examples include aqueous sodium alginate, which can be gelled by calcium salts. Another example is guar gum, which can be gelled by borate salts.
- the pregels are curable compositions that comprise one or more monomers and typically one or more crosslinking agents and/or polymerisation initiators. Preferred monomers are acrylate esters, such as 2- hydroxyethyl methacrylate, acrylamides such as N,N-dimethyIacrylamide.
- mixtures of salts or C1-C5 esters of 2-acrylamide-2- methylpropanesulfonic acid and salts or C1-C5 alkyl esters of acrylic acid (3- sulfopropyl) ester are also preferred.
- Suitable cross linking agents are polyethylene glycol diacrylates.
- Suitable initiators are conventional peroxide initiators.
- Suitable pregel materials are the UV-curable polyacrylate pregels described for example in WOOO/65143, the entire content of which is incorporated herein by reference.
- the pregel can be coated onto the cover sheet for example by spraying or slot coating or extrusion or by means of a doctor blade.
- Optional additional layers such as a perforated plastic film and/or absorbent layers can be laminated onto the hydrogel layer before, during or after curing/setting of the hydrogel layer is complete.
- the protective sheet can be applied over the cover sheet and hydrogel before, during or after setting of the hydrogel is complete.
- the absorbent article may then be sterilized, for example by gamma irradiation, or optionally packaged in secondary packaging and sterilized.
- Figure 1 shows a cross section through a cover sheet for use in an embodiment of the present invention (vertical dimensions have been enlarged for clarity);
- Figure 2 shows a cross section through the cover sheet of Figure 1 with a layer of hydrogel formed on the cover sheet;
- Figure 3 shows a cross sectional view through the whole absorbent article according to this embodiment of the invention
- Figure 4 shows a cross sectional view through the absorbent article of Figure 3 after removal of the cover sheet and prior to attachment of the article to the body.
- Example 1
- a hydrogel wound dressing according to the invention is prepared as follows.
- a cover sheet 1 consisting of a polyester film of thickness about 0.1mm that has been thermoformed to provide a central recess 2 of depth about 2mm and a plurality of projections 3 of height about 1mm extending into the recess 2.
- the upper surface 4 of the cover sheet is coated with a s ⁇ licone release coating.
- the bottom of the recess 2 is then coated with a layer of polyurethane hydropolymer pregel 5 as shown in Fig.2 that is applied by spraying.
- the pregel consists of a mixture of 25 parts by weight of an isocyanate-capped ethyleneoxy/propyleneoxy prepolymer (HYPOL PreMA G60 (Registered Trade Mark) from Dow Corning Ltd.) and 100 parts by weight of water.
- a layer of polyurethane foam is formed separately on a release sheet.
- the composition of the foam layer is:
- Acrylic copolymer b 12% Methanol 6% b PRIMAL B-15J or RHOPLEX N-560 ( Registered Trade Marks).
- the hydrogel and foam sheets are allowed to cure partially for about 90 seconds at ambient temperature, and then the foam layer is pressed gently onto the hydrogel in the cover sheet and the combination is placed in an oven for about 15 minutes to complete the curing and drying.
- the resulting laminate has the hydrogel layer 5 chemically bonded to the polyurethane foam absorbent layer 6.
- the cover sheet has about 10 conical projections per cm 2 , each perforation having a mid-height diameter in the range of about 0.8- 1.2 mm, resulting in an apertured area of about 5-10% of the total area of the hydrogel sheet.
- a protective backing layer 7 of microporous liquid-impermeable polyurethane foam such as ESTANE 5714F (Registered Trade Mark).
- the backing layer is permeable to water vapor, but impermeable to wound exudate and microorganisms.
- the backing layer 7 is coated with a substantially continuous layer 8 of pressure-sensitive polyurethane adhesive. The adhesive is adhered to the cover sheet around the margin 9 of the cover sheet to form a substantially microorganism-impermeable enclosure for the polyurethane foam and hydrogel layers.
- the dressing can be sterilized directly for use, for example by gamma irradiation, or it can be packaged in a secondary package and then sterilized by gamma irradiation.
- the dressing is removed from any secondary package, and the cover sheet is peeled from the backing sheet 7 and the hydrogel layer 5.
- the resulting dressing shown in Fig. 4, has an apertured hydrogel wound facing sheet ready for application to a wound.
- the apertured hydrogel sheet is applied to the wound with the hydrogel in contact with the wound to provide a sterile and absorbent dressing.
- the hydrogel sheet interacts with wound exudate to provide a moist but not wet wound environment for a wide range of wounds over an extended period.
- the adhesive-coated margin of the backing sheet is adhered to intact skin around the wound in the usual way for island-type dressings.
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- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003229902A AU2003229902A1 (en) | 2002-04-12 | 2003-04-11 | Apertured hydrogel wound dressing |
EP03722739A EP1496826A1 (de) | 2002-04-12 | 2003-04-11 | Perforierter, hydrogel enthaltender wundverband |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0208513.2 | 2002-04-12 | ||
GB0208513A GB2387331B (en) | 2002-04-12 | 2002-04-12 | Apertured hydrogel sheets |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003086255A1 true WO2003086255A1 (en) | 2003-10-23 |
Family
ID=9934778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/001588 WO2003086255A1 (en) | 2002-04-12 | 2003-04-11 | Apertured hydrogel wound dressing |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1496826A1 (de) |
AU (1) | AU2003229902A1 (de) |
GB (1) | GB2387331B (de) |
WO (1) | WO2003086255A1 (de) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004052414A1 (en) * | 2002-12-12 | 2004-06-24 | Johnson & Johnson Medical Limited | Absorbent multilayer hydrogel wound dressings |
WO2004052415A1 (en) * | 2002-12-12 | 2004-06-24 | First Water Limited | Absorbent hydrogel compositions |
DE102008031182A1 (de) * | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | Wundauflage mit Hydrogelmatrix |
DE102008031183A1 (de) | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | Wundauflage |
US7696400B2 (en) | 2002-12-31 | 2010-04-13 | Ossur Hf | Wound dressing |
US7745682B2 (en) | 2003-09-17 | 2010-06-29 | Ossur Hf | Wound dressing and method for manufacturing the same |
WO2010142959A2 (en) | 2009-06-10 | 2010-12-16 | Systagenix Wound Management Ip Co. B.V. | Hydrogel wound dressing for use with suction |
WO2011082772A1 (de) | 2009-12-24 | 2011-07-14 | Paul Hartmann Ag | Hydrogelmatrix mit erhöhter absorptionskapazität für flüssigkeiten |
WO2011095194A1 (de) | 2009-12-24 | 2011-08-11 | Paul Hartmann Ag | Hydrogelmatrix mit verbesserten klebeeigenschaften |
US8093445B2 (en) | 2003-09-17 | 2012-01-10 | Ossur Hf | Wound dressing and method for manufacturing the same |
WO2012171017A1 (en) * | 2011-06-09 | 2012-12-13 | Polyworks, Inc. | Hybrid cushioning articles and methods of making same |
DE102017131014A1 (de) | 2017-12-21 | 2019-06-27 | Paul Hartmann Ag | Verfahren zur Bearbeitung eines Substrats |
DE102017131013A1 (de) | 2017-12-21 | 2019-06-27 | Paul Hartmann Ag | Verfahren zur Herstellung einer Wundauflage |
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US8777883B2 (en) | 2007-01-09 | 2014-07-15 | Alessandro Aldo Barberio | Surgical cast venting device and material |
US20110077608A1 (en) * | 2009-09-25 | 2011-03-31 | Macedo Jr Carlos Da Silva | Cushioned adhesive bandage |
EP2658492B1 (de) * | 2010-12-29 | 2023-11-22 | 3M Innovative Properties Company | Hydrogel mit apertur |
US9554944B2 (en) | 2012-08-20 | 2017-01-31 | Alessandro Barberio | Medical protruded pads or dressings for wound care including use with orthopedic and prosthetic devices |
AU2015205809B2 (en) | 2014-01-10 | 2020-06-18 | Alessandro Barberio | Porous orthopedic or prosthetic support having removable cushioning and scaffolding layers |
GB201409252D0 (en) * | 2014-05-23 | 2014-07-09 | First Water Ltd | Apertured hydrogel compositions and wound dressings |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3723596A1 (de) * | 1987-07-16 | 1989-01-26 | Squibb & Sons Inc | Medizinisches pflaster |
EP0344913A1 (de) * | 1988-05-31 | 1989-12-06 | Minnesota Mining And Manufacturing Company | Alginatewundverband mit guter Integrität |
JPH05192363A (ja) * | 1991-11-07 | 1993-08-03 | Terumo Corp | 創傷被覆材 |
EP0571700A1 (de) * | 1992-04-21 | 1993-12-01 | Mli Acquisition Corp. Ii | Hydrogel Applikator und Verfahren zu seiner Herstellung |
WO1998017215A1 (en) * | 1996-10-24 | 1998-04-30 | Tyco Group S.A.R.L. | Hydrogel wound dressing and the method of making and using the same |
WO2001060296A1 (en) * | 2000-02-15 | 2001-08-23 | 3M Innovative Properties Company | Textured absorbent article for wound dressing |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8705985D0 (en) * | 1987-03-13 | 1987-04-15 | Geistlich Soehne Ag | Dressings |
JP3254013B2 (ja) * | 1991-09-10 | 2002-02-04 | ジョンソン・アンド・ジョンソン・メディカル・インコーポレイテッド | 包帯材料およびその製造方法 |
-
2002
- 2002-04-12 GB GB0208513A patent/GB2387331B/en not_active Expired - Fee Related
-
2003
- 2003-04-11 AU AU2003229902A patent/AU2003229902A1/en not_active Abandoned
- 2003-04-11 EP EP03722739A patent/EP1496826A1/de not_active Withdrawn
- 2003-04-11 WO PCT/GB2003/001588 patent/WO2003086255A1/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3723596A1 (de) * | 1987-07-16 | 1989-01-26 | Squibb & Sons Inc | Medizinisches pflaster |
EP0344913A1 (de) * | 1988-05-31 | 1989-12-06 | Minnesota Mining And Manufacturing Company | Alginatewundverband mit guter Integrität |
JPH05192363A (ja) * | 1991-11-07 | 1993-08-03 | Terumo Corp | 創傷被覆材 |
EP0571700A1 (de) * | 1992-04-21 | 1993-12-01 | Mli Acquisition Corp. Ii | Hydrogel Applikator und Verfahren zu seiner Herstellung |
WO1998017215A1 (en) * | 1996-10-24 | 1998-04-30 | Tyco Group S.A.R.L. | Hydrogel wound dressing and the method of making and using the same |
WO2001060296A1 (en) * | 2000-02-15 | 2001-08-23 | 3M Innovative Properties Company | Textured absorbent article for wound dressing |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 017, no. 622 (C - 1130) 17 November 1993 (1993-11-17) * |
Cited By (21)
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WO2004052415A1 (en) * | 2002-12-12 | 2004-06-24 | First Water Limited | Absorbent hydrogel compositions |
GB2396109B (en) * | 2002-12-12 | 2006-04-19 | Johnson & Johnson Medical Ltd | Absorbent multilayer hydrogel wound dressings |
WO2004052414A1 (en) * | 2002-12-12 | 2004-06-24 | Johnson & Johnson Medical Limited | Absorbent multilayer hydrogel wound dressings |
US7910793B2 (en) | 2002-12-31 | 2011-03-22 | Ossur Hf | Wound dressing |
US8247635B2 (en) | 2002-12-31 | 2012-08-21 | Ossur Hf | Wound dressing |
US7696400B2 (en) | 2002-12-31 | 2010-04-13 | Ossur Hf | Wound dressing |
US7745682B2 (en) | 2003-09-17 | 2010-06-29 | Ossur Hf | Wound dressing and method for manufacturing the same |
US8093445B2 (en) | 2003-09-17 | 2012-01-10 | Ossur Hf | Wound dressing and method for manufacturing the same |
EP3115033A1 (de) | 2008-07-03 | 2017-01-11 | Paul Hartmann AG | Wundauflage und verfahren zu ihrer herstellung |
DE102008031183A1 (de) | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | Wundauflage |
DE102008031182A1 (de) * | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | Wundauflage mit Hydrogelmatrix |
US10130521B2 (en) | 2008-07-03 | 2018-11-20 | Paul Hartmann Ag | Wound dressing |
WO2010142959A2 (en) | 2009-06-10 | 2010-12-16 | Systagenix Wound Management Ip Co. B.V. | Hydrogel wound dressing for use with suction |
US8992509B2 (en) | 2009-06-10 | 2015-03-31 | Kci Usa, Inc. | Hydrogel wound dressing for use with suction |
US10874556B2 (en) | 2009-06-10 | 2020-12-29 | Kci Usa, Inc. | Hydrogel wound dressing for use with suction |
WO2011082772A1 (de) | 2009-12-24 | 2011-07-14 | Paul Hartmann Ag | Hydrogelmatrix mit erhöhter absorptionskapazität für flüssigkeiten |
WO2011095194A1 (de) | 2009-12-24 | 2011-08-11 | Paul Hartmann Ag | Hydrogelmatrix mit verbesserten klebeeigenschaften |
US9579413B2 (en) | 2009-12-24 | 2017-02-28 | Paul Hartmann Ag | Hydrogel matrix having improved adhesive properties |
WO2012171017A1 (en) * | 2011-06-09 | 2012-12-13 | Polyworks, Inc. | Hybrid cushioning articles and methods of making same |
DE102017131014A1 (de) | 2017-12-21 | 2019-06-27 | Paul Hartmann Ag | Verfahren zur Bearbeitung eines Substrats |
DE102017131013A1 (de) | 2017-12-21 | 2019-06-27 | Paul Hartmann Ag | Verfahren zur Herstellung einer Wundauflage |
Also Published As
Publication number | Publication date |
---|---|
GB2387331A (en) | 2003-10-15 |
AU2003229902A1 (en) | 2003-10-27 |
GB2387331B (en) | 2005-03-23 |
GB0208513D0 (en) | 2002-05-22 |
EP1496826A1 (de) | 2005-01-19 |
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