WO2003084557A1 - Procede d'extraction d'un nouveau compose a partir de la racine d'une plante de la famille des pentadiplandracees - Google Patents
Procede d'extraction d'un nouveau compose a partir de la racine d'une plante de la famille des pentadiplandracees Download PDFInfo
- Publication number
- WO2003084557A1 WO2003084557A1 PCT/OA2003/000001 OA0300001W WO03084557A1 WO 2003084557 A1 WO2003084557 A1 WO 2003084557A1 OA 0300001 W OA0300001 W OA 0300001W WO 03084557 A1 WO03084557 A1 WO 03084557A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- brazzeana
- plant
- extracting
- family
- pentadiplandraceae
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Definitions
- the present invention relates to a process for extracting a compound, NN 'DIBENZYLTHIOUREE from the root of a plant in the family of PENTADIPLANDRACEES, genus PENTADIPLANDRA BRAZZEANA, variety BRAZZEANA This plant is a liana which is found in Central African forests.
- the extraction process linked to the present invention makes it possible to isolate NN 'DIBENZYLTHIOUREE.
- 1kg of crushed and dried roots are put in a 2-liter yellow bottle.
- 1 liter of 95% ethyl alcohol is added as a solvent.
- This stoppered bottle is mounted on a mechanical shaker, the apparatus is left to shake the bottle for 4 hours to extract the compound well.
- the device is stopped and the bottle is left to stand for 1 hour.
- the lemon yellow filtrate is filtered and collected.
- the alcohol is removed by vacuum distillation at approximately 15 mm HG in a rotary evaporator in a water bath Thermostat set at 40 °. Avoid reaching a dry residue.
- NN 'DIBENZYLTHIOUREE the concentrated alcoholic solution is placed in a separatory funnel into which 250 ml of carbon TETRACHLORIDE are introduced, and the mixture is stirred by hand for 1 hour. At rest, 2 phases appear in the separating funnel. The hydroalcoholic phase contains the NN 'DIBENZYLTHIOUREE, which is not soluble in Carbon TETRACHLORIDE
- This method is based on the degradation of deoxyribose by free radicals generated by the xanthine / xanthine oxidase system. This degradation leads to the formation of malondialdehyde which is dosed by colorimetry. In this technique, the scavenging effect of free hydroxyl radicals results in a reduction in the formation of malondiadehyde.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03746009A EP1501528B1 (fr) | 2002-04-05 | 2003-03-27 | Procede d'extraction de nn' dibenzylthiouree a partir de la racine d'une plante de la famille des pentadiplandracees |
AU2003232697A AU2003232697A1 (en) | 2002-04-05 | 2003-03-27 | Method for extracting a novel compound from the root of a plant of the pentadiplandraceae family |
JP2003581797A JP4641725B2 (ja) | 2002-04-05 | 2003-03-27 | Pentadiplandraceae族の植物の根から新規な化合物を抽出する方法 |
CN038077582A CN1646149B (zh) | 2002-04-05 | 2003-03-27 | 从瘤药树科植物根中提取新型化合物的方法 |
KR1020047015864A KR100882379B1 (ko) | 2002-04-05 | 2003-03-27 | 펜타디플랜드라세이 과의 식물의 뿌리로부터 신규한화합물을 추출하는 방법 |
US10/959,458 US20060167104A1 (en) | 2002-04-05 | 2004-10-05 | Method for extracting a novel compound from the root of a plant of the pentadiplandraceae family and use of N,N'-dibenzylthiourea as a medicine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
OA1200200098A OA12055A (fr) | 2002-04-05 | 2002-04-05 | Procédé d'extraction d'un nouveau composé à partirde la racine d'une plante de la famille des penta diplandracées. |
OA1200200098 | 2002-04-05 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/959,458 Continuation-In-Part US20060167104A1 (en) | 2002-04-05 | 2004-10-05 | Method for extracting a novel compound from the root of a plant of the pentadiplandraceae family and use of N,N'-dibenzylthiourea as a medicine |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003084557A1 true WO2003084557A1 (fr) | 2003-10-16 |
Family
ID=34102065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/OA2003/000001 WO2003084557A1 (fr) | 2002-04-05 | 2003-03-27 | Procede d'extraction d'un nouveau compose a partir de la racine d'une plante de la famille des pentadiplandracees |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060167104A1 (fr) |
EP (1) | EP1501528B1 (fr) |
JP (1) | JP4641725B2 (fr) |
KR (1) | KR100882379B1 (fr) |
CN (1) | CN1646149B (fr) |
AU (1) | AU2003232697A1 (fr) |
OA (1) | OA12055A (fr) |
WO (1) | WO2003084557A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2893252B1 (fr) * | 2005-11-17 | 2008-02-15 | Engelhard Lyon Sa | Extraits vegetaux stimulant has2 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB887174A (en) * | 1957-05-28 | 1962-01-17 | Dunlop Rubber Co | Antiozonants for rubber articles |
US3391107A (en) * | 1967-02-15 | 1968-07-02 | Eldon E Stahly | Antiozonants and antiozonant compositions for elastomers |
FR2157779A1 (en) | 1971-08-19 | 1973-06-08 | Wandji Thomas | Alkaloids 1,ii and iii from pentadiplandra brazzeana - - by ethanolic extraction of the root |
FR2693106A1 (fr) * | 1992-10-02 | 1994-01-07 | Wandji Thomas | Association de trois principes actifs extraits du pentadiplandra brazzeana. |
WO2001085681A2 (fr) * | 2000-05-10 | 2001-11-15 | The Fanning Corporation | Derives 3-methoxybenzyl thiouree et compositions lipidiques perfectionnees contenant ces derives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3763089A (en) * | 1970-09-30 | 1973-10-02 | Goodrich Co B F | Stabilizer system for stereoregular rubbers |
US5589154A (en) * | 1994-11-22 | 1996-12-31 | Rutgers, The State University Of New Jersey | Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease |
-
2002
- 2002-04-05 OA OA1200200098A patent/OA12055A/fr unknown
-
2003
- 2003-03-27 EP EP03746009A patent/EP1501528B1/fr not_active Expired - Lifetime
- 2003-03-27 JP JP2003581797A patent/JP4641725B2/ja not_active Expired - Fee Related
- 2003-03-27 AU AU2003232697A patent/AU2003232697A1/en not_active Abandoned
- 2003-03-27 WO PCT/OA2003/000001 patent/WO2003084557A1/fr active Application Filing
- 2003-03-27 CN CN038077582A patent/CN1646149B/zh not_active Expired - Fee Related
- 2003-03-27 KR KR1020047015864A patent/KR100882379B1/ko not_active IP Right Cessation
-
2004
- 2004-10-05 US US10/959,458 patent/US20060167104A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB887174A (en) * | 1957-05-28 | 1962-01-17 | Dunlop Rubber Co | Antiozonants for rubber articles |
US3391107A (en) * | 1967-02-15 | 1968-07-02 | Eldon E Stahly | Antiozonants and antiozonant compositions for elastomers |
FR2157779A1 (en) | 1971-08-19 | 1973-06-08 | Wandji Thomas | Alkaloids 1,ii and iii from pentadiplandra brazzeana - - by ethanolic extraction of the root |
FR2693106A1 (fr) * | 1992-10-02 | 1994-01-07 | Wandji Thomas | Association de trois principes actifs extraits du pentadiplandra brazzeana. |
WO2001085681A2 (fr) * | 2000-05-10 | 2001-11-15 | The Fanning Corporation | Derives 3-methoxybenzyl thiouree et compositions lipidiques perfectionnees contenant ces derives |
Non-Patent Citations (2)
Title |
---|
BATTERA-ARELLANO D ET AL: "ANTIOXIDANT ACTIVITY OF BRAZILIAN PLANT EXTRACT", SOFW-JOURNAL SEIFEN, OELE, FETTE, WACHSE, VERLAG FUR CHEMISCHE INDUSTRIE, H. ZIOLKOWSKY K.G. AUGSBURG, DE, vol. 116, no. 2, 1 February 1990 (1990-02-01), pages 56 - 58, XP000136050, ISSN: 0942-7694 * |
MIGIRAB EL S ET AL: "ISOTHIOCYANATES, THIOUREES ET THIOCARBAMATES ISOLES DE PENTADIPLANDRA BRAZZEANA", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 16, 1977, pages 1719 - 1721, XP009014830, ISSN: 0031-9422 * |
Also Published As
Publication number | Publication date |
---|---|
CN1646149B (zh) | 2012-03-21 |
EP1501528B1 (fr) | 2013-01-09 |
JP4641725B2 (ja) | 2011-03-02 |
US20060167104A1 (en) | 2006-07-27 |
AU2003232697A1 (en) | 2003-10-20 |
KR100882379B1 (ko) | 2009-02-05 |
JP2005524681A (ja) | 2005-08-18 |
OA12055A (fr) | 2003-10-24 |
CN1646149A (zh) | 2005-07-27 |
KR20040106320A (ko) | 2004-12-17 |
EP1501528A1 (fr) | 2005-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0663909B1 (fr) | Procede d'obtention de la desacetyl-10 baccatine iii | |
EP0307626A1 (fr) | Procédé d'obention d'un extrait antioxydant d'épices | |
EP0037319A1 (fr) | Mucopolysaccharides possédant des propriétés biologiques, leur préparation et leur application en tant que médicaments | |
JP2003509506A (ja) | アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用 | |
CA1064907A (fr) | Procede de separation du cholesterol | |
KR101769280B1 (ko) | 아조엔의 제조방법 | |
JPH02247196A (ja) | アスパラガスから精製サポニンを回収する方法 | |
EP1501528B1 (fr) | Procede d'extraction de nn' dibenzylthiouree a partir de la racine d'une plante de la famille des pentadiplandracees | |
FR2745718A1 (fr) | Composition antidiabetique a base de 4-hydroxyisoleucine | |
WO1983003951A1 (fr) | Extraction d'insecticides de plantes | |
FR2620702A1 (fr) | Procede de preparation d'irones naturelles | |
FR2582941A1 (fr) | Composition cosmetique a base d'extraits de feuilles du murier | |
Kare et al. | Isolation, identification et tests antibacteriens des chalcones et rotenoïdes de Tephrosia deflexa baker | |
US20220125869A1 (en) | Method for obtaining oleocanthal type secoiridoids and for producing respective pharmaceutical preparations | |
SU955929A1 (ru) | Способ получени производных хлорофилла | |
JP6294259B2 (ja) | β−アルブチンの製造方法 | |
EP2320726B1 (fr) | Utilisation d'une plante myrica gale pour la production d'un agent herbicide | |
RU2176994C1 (ru) | Способ получения миртенола | |
FR2908770A1 (fr) | Procede d'extraction d'aloine | |
WO2019026230A1 (fr) | Procédé de production de céramide | |
WO2020021711A1 (fr) | Procédé de décomposition de flavonoïde glycoside et procédé de production de flavonoïde | |
BE885558A (fr) | Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique | |
FR2636331A1 (fr) | Procede de preparation d'acides lysophosphatidiques et de sels de ceux-ci | |
EP2125692A1 (fr) | Procede d'enrichissement d'un extrait contenant de l'oleocanthal | |
FR2491473A1 (fr) | Procede pour l'extraction de silymarine a partir des plantes, silymarine ainsi obtenue et son utilisation en therapeutique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003581797 Country of ref document: JP Ref document number: 10959458 Country of ref document: US Ref document number: 1020047015864 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20038077582 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003746009 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020047015864 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2003746009 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 10959458 Country of ref document: US |