WO2003080100A3 - Diagnostic et therapie des maladies associees au recepteur 63 couple a la proteine g chez homo sapiens (gpr63) - Google Patents

Diagnostic et therapie des maladies associees au recepteur 63 couple a la proteine g chez homo sapiens (gpr63) Download PDF

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Publication number
WO2003080100A3
WO2003080100A3 PCT/EP2003/002686 EP0302686W WO03080100A3 WO 2003080100 A3 WO2003080100 A3 WO 2003080100A3 EP 0302686 W EP0302686 W EP 0302686W WO 03080100 A3 WO03080100 A3 WO 03080100A3
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WO
WIPO (PCT)
Prior art keywords
gpr63
diseases
therapeutics
diagnostics
protein
Prior art date
Application number
PCT/EP2003/002686
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English (en)
Other versions
WO2003080100A2 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003227065A priority Critical patent/AU2003227065A1/en
Publication of WO2003080100A2 publication Critical patent/WO2003080100A2/fr
Publication of WO2003080100A3 publication Critical patent/WO2003080100A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un récepteur humain GPR63, associé aux maladies hématologiques, aux troubles des systèmes nerveux périphérique et central, à la B.P.C.O., à l'asthme, aux troubles génito-urologiques, aux maladies gastro-intestinales ou inflammatoires ou au cancer. L'invention concerne aussi des dosages destinés à l'identification des composés utiles dans le traitement ou la prévention des troubles hématologiques, des troubles des systèmes nerveux périphérique et central, de la B.P.C.O., de l'asthme, des troubles génito-urologiques, des maladies gastro-intestinales ou inflammatoires ou du cancer, ainsi que des composés qui se lient à GPR63 et/ou favorisent ou inhibent l'activité de GPR63 ainsi que les compositions pharmaceutiques comprenant ces composés.
PCT/EP2003/002686 2002-03-26 2003-03-14 Diagnostic et therapie des maladies associees au recepteur 63 couple a la proteine g chez homo sapiens (gpr63) WO2003080100A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003227065A AU2003227065A1 (en) 2002-03-26 2003-03-14 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 63 (gpr63)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02006651 2002-03-26
EP02006651.0 2002-03-26

Publications (2)

Publication Number Publication Date
WO2003080100A2 WO2003080100A2 (fr) 2003-10-02
WO2003080100A3 true WO2003080100A3 (fr) 2004-03-25

Family

ID=28051731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002686 WO2003080100A2 (fr) 2002-03-26 2003-03-14 Diagnostic et therapie des maladies associees au recepteur 63 couple a la proteine g chez homo sapiens (gpr63)

Country Status (2)

Country Link
AU (1) AU2003227065A1 (fr)
WO (1) WO2003080100A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031104A1 (fr) * 1998-11-19 2000-06-02 Smithkline Beecham Corporation Nouveau recepteur de 7tm couple a une proteine g (axor15)
DE19928417A1 (de) * 1999-06-22 2000-12-28 Michael Brues RLPALR1: Gen,eDNA, Experession und Aminosäuresequenz
WO2001085935A2 (fr) * 2000-05-09 2001-11-15 Bayer Aktiengesellschaft Recepteur couple a une proteine g du type du gene 6 de differenciation endotheliale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031104A1 (fr) * 1998-11-19 2000-06-02 Smithkline Beecham Corporation Nouveau recepteur de 7tm couple a une proteine g (axor15)
DE19928417A1 (de) * 1999-06-22 2000-12-28 Michael Brues RLPALR1: Gen,eDNA, Experession und Aminosäuresequenz
WO2001085935A2 (fr) * 2000-05-09 2001-11-15 Bayer Aktiengesellschaft Recepteur couple a une proteine g du type du gene 6 de differenciation endotheliale

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRAELER MARKUS H ET AL: "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 53, no. 2, 15 October 1998 (1998-10-15), pages 164 - 169, XP002137156, ISSN: 0888-7543 *
HEISE C E ET AL: "Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 60, no. 6, December 2001 (2001-12-01), pages 1173 - 1180, XP002957641, ISSN: 0026-895X *

Also Published As

Publication number Publication date
AU2003227065A8 (en) 2003-10-08
AU2003227065A1 (en) 2003-10-08
WO2003080100A2 (fr) 2003-10-02

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