WO2003073843A3 - Inbred embryonic stem-cell derived mice - Google Patents
Inbred embryonic stem-cell derived mice Download PDFInfo
- Publication number
- WO2003073843A3 WO2003073843A3 PCT/EP2003/002180 EP0302180W WO03073843A3 WO 2003073843 A3 WO2003073843 A3 WO 2003073843A3 EP 0302180 W EP0302180 W EP 0302180W WO 03073843 A3 WO03073843 A3 WO 03073843A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inbred
- mice
- embryonic stem
- cell derived
- derived mice
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT03743372T ATE306810T1 (en) | 2002-03-05 | 2003-03-04 | INBREEDED EMBRYONAL STEM CELL-DERIVED MICE |
EP03743372A EP1480515B1 (en) | 2002-03-05 | 2003-03-04 | Inbred embryonic stem-cell derived mice |
DE60301953T DE60301953T2 (en) | 2002-03-05 | 2003-03-04 | MICE DERIVED FROM INNOVATION MALE DERIVED FROM EMBRYONIC STEM CELLS |
AU2003210405A AU2003210405A1 (en) | 2002-03-05 | 2003-03-04 | Inbred embryonic stem-cell derived mice |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36216302P | 2002-03-05 | 2002-03-05 | |
US60/362,163 | 2002-03-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003073843A2 WO2003073843A2 (en) | 2003-09-12 |
WO2003073843A3 true WO2003073843A3 (en) | 2004-01-22 |
Family
ID=27789146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/002180 WO2003073843A2 (en) | 2002-03-05 | 2003-03-04 | Inbred embryonic stem-cell derived mice |
Country Status (6)
Country | Link |
---|---|
US (1) | US20030204862A1 (en) |
EP (1) | EP1480515B1 (en) |
AT (1) | ATE306810T1 (en) |
AU (1) | AU2003210405A1 (en) |
DE (1) | DE60301953T2 (en) |
WO (1) | WO2003073843A2 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
EP1999249B8 (en) * | 2006-03-30 | 2012-02-15 | The University Court Of The University of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
GB0615327D0 (en) * | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
WO2007127254A2 (en) * | 2006-04-25 | 2007-11-08 | President And Fellows Of Harvard College | Compositions and methods for generating transgenic animals |
SG10201607710UA (en) * | 2008-03-17 | 2016-11-29 | Scripps Research Inst | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
US9149026B2 (en) | 2010-06-11 | 2015-10-06 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY animals from XY ES cells |
KR20140063501A (en) | 2010-12-22 | 2014-05-27 | 페이트 세러퓨틱스, 인코포레이티드 | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
EP2471554A1 (en) | 2010-12-28 | 2012-07-04 | Hexal AG | Pharmaceutical formulation comprising a biopharmaceutical drug |
EP2511293A1 (en) | 2011-04-13 | 2012-10-17 | LEK Pharmaceuticals d.d. | A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins |
CU24312B1 (en) | 2013-07-23 | 2018-02-08 | Biocon Ltd | METHODS TO CONTROL FUCOSILATION LEVELS IN PROTEINS |
EP3604499A1 (en) | 2014-03-04 | 2020-02-05 | Fate Therapeutics, Inc. | Improved reprogramming methods and cell culture platforms |
DK3161128T3 (en) | 2014-06-26 | 2018-11-05 | Regeneron Pharma | METHODS AND COMPOSITIONS FOR TARGETED GENTICAL MODIFICATIONS AND PROCEDURES FOR USE THEREOF |
RU2729407C1 (en) | 2015-09-17 | 2020-08-06 | Регенерон Фармасьютикалз, Инк. | Selection of pluripotent cells for producing fertile xy female mice |
JP7263005B2 (en) | 2015-10-16 | 2023-04-24 | フェイト セラピューティクス,インコーポレイテッド | A platform for the induction and maintenance of ground-state pluripotency |
EP3403649A1 (en) | 2017-05-16 | 2018-11-21 | Bayer Pharma Aktiengesellschaft | Inhibitors and antagonists of gpr84 for the treatment of endometriosis |
EP3406253A1 (en) | 2017-05-24 | 2018-11-28 | Bayer Aktiengesellschaft | Inhibitors and antagonists of human pycr1 |
WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | Use of activators and stimulators of sgc comprising a beta2 subunit |
EP3801613A1 (en) | 2018-06-04 | 2021-04-14 | Bayer Aktiengesellschaft | Inhibitors of shp2 |
KR102398485B1 (en) | 2019-02-18 | 2022-05-16 | 에이티비 테라퓨틱스 | Methods of Production of Binder-Toxin Fusion Proteins in Plant Cells or Whole Plants |
EP3946416A2 (en) | 2019-04-04 | 2022-02-09 | Bayer Aktiengesellschaft | Agonists of adiponectin |
SG11202109901TA (en) | 2019-04-09 | 2021-10-28 | Hospital For Special Surgery | Protein binders for irhom2 |
AU2020360849A1 (en) | 2019-09-30 | 2022-04-14 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Protein binders to iRhom2 epitopes |
EP4069301A1 (en) | 2019-12-04 | 2022-10-12 | Bayer Aktiengesellschaft | Inhibitors of shp2 |
CA3187245A1 (en) | 2020-08-17 | 2022-02-24 | Sebastien Mercx | Recombinant immunotoxin comprising a ribotoxin or rnase |
KR20230150287A (en) | 2021-02-26 | 2023-10-30 | 바이엘 악티엔게젤샤프트 | Inhibitors of IL-11 or IL-11RA for use in the treatment of abnormal uterine bleeding |
BR112023017035A2 (en) | 2021-03-01 | 2024-02-06 | New York Soc For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surger | HUMANIZED ANTIBODIES AGAINST IRHOM2, NUCLEIC ACID, USE OF THE ANTIBODY, PHARMACEUTICAL COMPOSITION, COMPOSITION, TREATMENT METHOD AND THERAPEUTIC KIT |
CA3213771A1 (en) | 2021-03-29 | 2022-10-06 | Scirhom Gmbh | Methods of treatment using protein binders to irhom2 epitopes |
US20230190807A1 (en) | 2021-10-06 | 2023-06-22 | Immatics Biotechnologies Gmbh | Tcr compounds, compositions, and methods of treating |
US20230192886A1 (en) | 2021-11-08 | 2023-06-22 | Immatics Biotechnologies Gmbh | Adoptive cell therapy combination treatment and compositions thereof |
WO2023156634A1 (en) | 2022-02-17 | 2023-08-24 | Atb Therapeutics | Recombinant immunotoxin comprising a ribosome inactivating protein |
WO2024023246A1 (en) | 2022-07-28 | 2024-02-01 | Philogen S.P.A. | Antibody binding to pd1 |
WO2024033362A1 (en) | 2022-08-08 | 2024-02-15 | Atb Therapeutics | Humanized antibodies against cd79b |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000015764A2 (en) * | 1998-09-11 | 2000-03-23 | University Of Edinburgh | Propagation and/or derivation of embryonic stem cells |
-
2003
- 2003-03-04 US US10/379,370 patent/US20030204862A1/en not_active Abandoned
- 2003-03-04 EP EP03743372A patent/EP1480515B1/en not_active Expired - Lifetime
- 2003-03-04 WO PCT/EP2003/002180 patent/WO2003073843A2/en not_active Application Discontinuation
- 2003-03-04 AT AT03743372T patent/ATE306810T1/en not_active IP Right Cessation
- 2003-03-04 AU AU2003210405A patent/AU2003210405A1/en not_active Abandoned
- 2003-03-04 DE DE60301953T patent/DE60301953T2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000015764A2 (en) * | 1998-09-11 | 2000-03-23 | University Of Edinburgh | Propagation and/or derivation of embryonic stem cells |
Non-Patent Citations (3)
Title |
---|
BURDON T ET AL: "SUPPRESSION OF SHP-2 AND ERK SIGNALLING PROMOTES SELF-RENEWAL OF MOUSE EMBRYONIC STEM CELLS", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 210, 1 June 1999 (1999-06-01), pages 30 - 43, XP000901724, ISSN: 0012-1606 * |
EGGAN KEVIN ET AL: "Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 98, no. 11, 22 May 2001 (2001-05-22), pages 6209 - 6214, XP002206043, ISSN: 0027-8424 * |
NAGY A ET AL: "DERIVATION OF COMPLETELY CELL CULTURE-DERIVED MICE FROM EARLY-PASSAGE EMBRYONIC STEM CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 90, September 1993 (1993-09-01), pages 8424 - 8428, XP002938900, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
ATE306810T1 (en) | 2005-11-15 |
US20030204862A1 (en) | 2003-10-30 |
WO2003073843A2 (en) | 2003-09-12 |
AU2003210405A1 (en) | 2003-09-16 |
DE60301953T2 (en) | 2006-07-27 |
EP1480515A2 (en) | 2004-12-01 |
EP1480515B1 (en) | 2005-10-19 |
DE60301953D1 (en) | 2005-11-24 |
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