WO2003061538A1 - Pansements particulaires - Google Patents

Pansements particulaires Download PDF

Info

Publication number
WO2003061538A1
WO2003061538A1 PCT/GB2003/000197 GB0300197W WO03061538A1 WO 2003061538 A1 WO2003061538 A1 WO 2003061538A1 GB 0300197 W GB0300197 W GB 0300197W WO 03061538 A1 WO03061538 A1 WO 03061538A1
Authority
WO
WIPO (PCT)
Prior art keywords
wound
cellulose
water
particulate material
dressing
Prior art date
Application number
PCT/GB2003/000197
Other languages
English (en)
Inventor
Deborah Addison
Original Assignee
Johnson & Johnson Medical Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Medical Limited filed Critical Johnson & Johnson Medical Limited
Publication of WO2003061538A1 publication Critical patent/WO2003061538A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00072—Packaging of dressings
    • A61F13/00076—Packaging of adhesive dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0213—Adhesive bandages or dressings with fluid retention members the fluid retention member being a layer of hydrocolloid, gel forming material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0223—Adhesive bandages or dressings with fluid retention members characterized by parametric properties of the fluid retention layer, e.g. absorbency, wicking capacity, liquid distribution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules

Definitions

  • WO00/12144 describes particulate compositions capable of forming coherent, insoluble hydrogels in contact with wound fluid.
  • the compositions are mixtures of two water soluble polymers that react in the presence of water to form an insoluble gel, for example a mixture of sodium carboxymethyl cellulose and chitosan.
  • a further particulate composition of this type is COMFEEL (Registered Trade Mark) powder, supplied by Coloplast AS, which is a mixture of sodium carboxymethyl cellulose, guar gum and xanthan gum.
  • Coloplast AS which is a mixture of sodium carboxymethyl cellulose, guar gum and xanthan gum.
  • the powder is spread over the wound bed where it reacts with water to form an absorbent, insoluble gel.
  • the insoluble gel on the wound bed is physically removed along with the secondary dressing covering the wound.
  • the particulate materials are normally substantially free from water-insoluble components, or mixtures of components that react in solution to form insoluble gels, or support materials such as gauzes, films or foams that normally make up wound dressings.
  • the particulate material is selected from the group consisting of sodium carboxymethyl cellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose, methylhydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyproplyethyl cellulose, cetyl hydroxyl cellulose, carboxymethyl hydroxethyl cellulose, methyl cellulose, carrageenan, pectin, nitrocellulose, soluble polyacrylates, guar gum derivatives, sodium alginate, and mixtures thereof.
  • the particulate wound dressing according to the present invention is not a freeze-dried gel. That is to say, preferably the particulate wound dressing has not been made by freeze drying (lyophilizing) an aqueous solution or gel of the components.
  • the material is sprinkled onto the exuding wound at a generally uniform thickness, typically about 0.5 to 5 mm thick, preferably 1 to 3 mm dry thickness, corresponding to a density of 0.02 to 0.2 are preferably 0.05 to 0.1g/cm 2 .
  • the material absorbs the exudate to form a sticky gel layer that is flexible and breathable, and that swells and absorbs further exudate.
  • the hydrogel layer completely covers the wound, but can be removed easily by washing with water or saline.
  • a further advantage of this dressing is that, if exudate production exudes the capacity of the hydrogel, then instead of pooling under the hydrogel, the hydrogel layer simply dissolves and can be taken up in an absorbent secondary dressing over the hydrogel layer.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention a trait à un pansement constitué essentiellement d'un matériau particulaire à haute fluidité et sensiblement anhydre, le matériau particulaire formant un hydrogel hydrosoluble lorsqu'il est mis en contact avec de l'eau. Lors de l'utilisation, le pansement est pulvérisé sur une plaie suintante, où il absorbe le liquide issu de la plaie pour former une couche d'hydrogel continu sur cette dernière.
PCT/GB2003/000197 2002-01-22 2003-01-21 Pansements particulaires WO2003061538A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0201385A GB2384187A (en) 2002-01-22 2002-01-22 Particulate wound dressing
GB0201385.2 2002-01-22

Publications (1)

Publication Number Publication Date
WO2003061538A1 true WO2003061538A1 (fr) 2003-07-31

Family

ID=9929508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/000197 WO2003061538A1 (fr) 2002-01-22 2003-01-21 Pansements particulaires

Country Status (2)

Country Link
GB (1) GB2384187A (fr)
WO (1) WO2003061538A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696400B2 (en) 2002-12-31 2010-04-13 Ossur Hf Wound dressing
US7745682B2 (en) 2003-09-17 2010-06-29 Ossur Hf Wound dressing and method for manufacturing the same
US7939578B2 (en) 2007-02-23 2011-05-10 3M Innovative Properties Company Polymeric fibers and methods of making
CN102218154A (zh) * 2010-04-15 2011-10-19 郑明义 羧甲基羟乙基改性棉纤维止血织物及其制备方法
US8093445B2 (en) 2003-09-17 2012-01-10 Ossur Hf Wound dressing and method for manufacturing the same
CN105457080A (zh) * 2015-12-09 2016-04-06 安徽宇宁生物科技有限公司 一种果胶创可贴
US9970303B2 (en) 2014-05-13 2018-05-15 Entrotech, Inc. Erosion protection sleeve
CN109833512A (zh) * 2017-11-29 2019-06-04 江苏尚铖医疗器械有限公司 一种多功能创可贴
CN115382007A (zh) * 2022-09-14 2022-11-25 安徽农业大学 一种抗菌和抗生物膜水凝胶及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391799A (en) * 1980-02-15 1983-07-05 The United States Of America As Represented By The Secretary Of The Army Protective gel composition for treating white phosphorus burn wounds
US4393048A (en) * 1980-02-15 1983-07-12 The United States Of America As Represented By The Secretary Of The Army Protective gel composition for wounds
US5902600A (en) * 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
WO2000012144A1 (fr) * 1998-08-31 2000-03-09 Coloplast A/S Composition susceptible d'absorber un fluide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3036033A1 (de) * 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
GB8415188D0 (en) * 1984-06-14 1984-07-18 Geistlich Soehne Ag Absorbent polymer material
WO1993006802A1 (fr) * 1991-10-09 1993-04-15 David Rolf Pansement a gel aqueux pour plaie et conditionnement
US6635272B2 (en) * 2000-11-09 2003-10-21 Richard N. Leaderman Wound dressing and drug delivery system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391799A (en) * 1980-02-15 1983-07-05 The United States Of America As Represented By The Secretary Of The Army Protective gel composition for treating white phosphorus burn wounds
US4393048A (en) * 1980-02-15 1983-07-12 The United States Of America As Represented By The Secretary Of The Army Protective gel composition for wounds
US5902600A (en) * 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
WO2000012144A1 (fr) * 1998-08-31 2000-03-09 Coloplast A/S Composition susceptible d'absorber un fluide

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696400B2 (en) 2002-12-31 2010-04-13 Ossur Hf Wound dressing
US7910793B2 (en) 2002-12-31 2011-03-22 Ossur Hf Wound dressing
US8247635B2 (en) 2002-12-31 2012-08-21 Ossur Hf Wound dressing
US7745682B2 (en) 2003-09-17 2010-06-29 Ossur Hf Wound dressing and method for manufacturing the same
US8093445B2 (en) 2003-09-17 2012-01-10 Ossur Hf Wound dressing and method for manufacturing the same
US7939578B2 (en) 2007-02-23 2011-05-10 3M Innovative Properties Company Polymeric fibers and methods of making
CN102218154A (zh) * 2010-04-15 2011-10-19 郑明义 羧甲基羟乙基改性棉纤维止血织物及其制备方法
US9970303B2 (en) 2014-05-13 2018-05-15 Entrotech, Inc. Erosion protection sleeve
CN105457080A (zh) * 2015-12-09 2016-04-06 安徽宇宁生物科技有限公司 一种果胶创可贴
CN109833512A (zh) * 2017-11-29 2019-06-04 江苏尚铖医疗器械有限公司 一种多功能创可贴
CN115382007A (zh) * 2022-09-14 2022-11-25 安徽农业大学 一种抗菌和抗生物膜水凝胶及其制备方法和应用

Also Published As

Publication number Publication date
GB2384187A (en) 2003-07-23
GB0201385D0 (en) 2002-03-13

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